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Volumn 87, Issue 23-26, 2010, Pages 659-666

Functions of B56-containing PP2As in major developmental and cancer signaling pathways

Author keywords

B'; B56; Development; PP2A; PR61; Regulatory subunit; Signaling pathways; Tumorigenesis

Indexed keywords

BETA CATENIN; HOLOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN P53; PROTEIN PPP2R5A; PROTEIN PPP2R5B; PROTEIN PPP2R5C; PROTEIN PPP2R5D; PROTEIN PPP2R5E; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 78649448708     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.10.003     Document Type: Review
Times cited : (51)

References (117)
  • 1
    • 33847317020 scopus 로고    scopus 로고
    • Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit
    • Ahn J.H., McAvoy T., Rakhilin S.V., Nishi A., Greengard P., Nairn A.C. Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci USA 2007, 104(8):2979-2984.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.8 , pp. 2979-2984
    • Ahn, J.H.1    McAvoy, T.2    Rakhilin, S.V.3    Nishi, A.4    Greengard, P.5    Nairn, A.C.6
  • 2
    • 33746037296 scopus 로고    scopus 로고
    • Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues
    • Barrow J.R. Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues. Semin Cell Dev Biol 2006, 17(2):185-193.
    • (2006) Semin Cell Dev Biol , vol.17 , Issue.2 , pp. 185-193
    • Barrow, J.R.1
  • 3
    • 0037178863 scopus 로고    scopus 로고
    • Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest
    • Bennin D.A., Don A.S., Brake T., McKenzie J.L., Rosenbaum H., Ortiz L., et al. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem 2002, 277(30):27449-27467.
    • (2002) J Biol Chem , vol.277 , Issue.30 , pp. 27449-27467
    • Bennin, D.A.1    Don, A.S.2    Brake, T.3    McKenzie, J.L.4    Rosenbaum, H.5    Ortiz, L.6
  • 4
    • 0034660455 scopus 로고    scopus 로고
    • Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'
    • Berry M., Gehring W. Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'. EMBO J 2000, 19(12):2946-2957.
    • (2000) EMBO J , vol.19 , Issue.12 , pp. 2946-2957
    • Berry, M.1    Gehring, W.2
  • 6
    • 62049085783 scopus 로고    scopus 로고
    • Making a grade: sonic hedgehog signalling and the control of neural cell fate
    • Briscoe J. Making a grade: sonic hedgehog signalling and the control of neural cell fate. EMBO J 2009, 28(5):457-465.
    • (2009) EMBO J , vol.28 , Issue.5 , pp. 457-465
    • Briscoe, J.1
  • 7
    • 24944485819 scopus 로고    scopus 로고
    • Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity
    • Chen W., Arroyo J.D., Timmons J.C., Possemato R., Hahn W.C. Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity. Cancer Res 2005, 65(18):8183-8192.
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8183-8192
    • Chen, W.1    Arroyo, J.D.2    Timmons, J.C.3    Possemato, R.4    Hahn, W.C.5
  • 8
    • 33846943656 scopus 로고    scopus 로고
    • Multiple protein phosphatases are required for mitosis in Drosophila
    • Chen F., Archambault V., Kar A., Lio P., D'Avino P.P., Sinka R., et al. Multiple protein phosphatases are required for mitosis in Drosophila. Curr Biol 2007, 17(4):293-303.
    • (2007) Curr Biol , vol.17 , Issue.4 , pp. 293-303
    • Chen, F.1    Archambault, V.2    Kar, A.3    Lio, P.4    D'Avino, P.P.5    Sinka, R.6
  • 9
    • 34249876632 scopus 로고    scopus 로고
    • Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
    • Chen Y., Xu Y., Bao Q., Xing Y., Li Z., Lin Z., et al. Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40. Nat Struct Mol Biol 2007, 14(6):527-534.
    • (2007) Nat Struct Mol Biol , vol.14 , Issue.6 , pp. 527-534
    • Chen, Y.1    Xu, Y.2    Bao, Q.3    Xing, Y.4    Li, Z.5    Lin, Z.6
  • 10
    • 33846118688 scopus 로고    scopus 로고
    • Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
    • Cho U.S., Xu W. Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature 2007, 445(7123):53-57.
    • (2007) Nature , vol.445 , Issue.7123 , pp. 53-57
    • Cho, U.S.1    Xu, W.2
  • 12
    • 0030047451 scopus 로고    scopus 로고
    • High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms
    • Csortos C., Zolnierowicz S., Bako E., Durbin S.D., DePaoli-Roach A.A. High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms. J Biol Chem 1996, 271(5):2578-2588.
    • (1996) J Biol Chem , vol.271 , Issue.5 , pp. 2578-2588
    • Csortos, C.1    Zolnierowicz, S.2    Bako, E.3    Durbin, S.D.4    DePaoli-Roach, A.A.5
  • 13
    • 23444439656 scopus 로고    scopus 로고
    • Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear
    • Dabdoub A., Kelley M.W. Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear. J Neurobiol 2005, 64(4):446-457.
    • (2005) J Neurobiol , vol.64 , Issue.4 , pp. 446-457
    • Dabdoub, A.1    Kelley, M.W.2
  • 14
  • 15
    • 13144262832 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo
    • Eivers E., McCarthy K., Glynn C., Nolan C.M., Byrnes L. Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo. Int J Dev Biol 2004, 48(10):1131-1140.
    • (2004) Int J Dev Biol , vol.48 , Issue.10 , pp. 1131-1140
    • Eivers, E.1    McCarthy, K.2    Glynn, C.3    Nolan, C.M.4    Byrnes, L.5
  • 16
    • 1242351972 scopus 로고    scopus 로고
    • Planar polarity from flies to vertebrates
    • Fanto M., McNeill H. Planar polarity from flies to vertebrates. J Cell Sci 2004, 117(Pt 4):527-533.
    • (2004) J Cell Sci , vol.117 , Issue.PART 4 , pp. 527-533
    • Fanto, M.1    McNeill, H.2
  • 17
    • 0344616884 scopus 로고    scopus 로고
    • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation
    • Firulli B.A., Howard M.J., McDaid J.R., McIlreavey L., Dionne K.M., Centonze V.E., et al. PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell 2003, 12(5):1225-1237.
    • (2003) Mol Cell , vol.12 , Issue.5 , pp. 1225-1237
    • Firulli, B.A.1    Howard, M.J.2    McDaid, J.R.3    McIlreavey, L.4    Dionne, K.M.5    Centonze, V.E.6
  • 18
    • 77953300022 scopus 로고    scopus 로고
    • Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit
    • Flegg C.P., Sharma M., Medina-Palazon C., Jamieson C., Galea M., Brocardo M.G., et al. Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit. J Biol Chem 2010, 285(24):18144-18154.
    • (2010) J Biol Chem , vol.285 , Issue.24 , pp. 18144-18154
    • Flegg, C.P.1    Sharma, M.2    Medina-Palazon, C.3    Jamieson, C.4    Galea, M.5    Brocardo, M.G.6
  • 19
    • 33748951151 scopus 로고    scopus 로고
    • Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
    • Fuccillo M., Joyner A.L., Fishell G. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci 2006, 7(10):772-783.
    • (2006) Nat Rev Neurosci , vol.7 , Issue.10 , pp. 772-783
    • Fuccillo, M.1    Joyner, A.L.2    Fishell, G.3
  • 20
    • 0037022275 scopus 로고    scopus 로고
    • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex
    • Gao Z.H., Seeling J.M., Hill V., Yochum A., Virshup D.M. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci USA 2002, 99(3):1182-1187.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.3 , pp. 1182-1187
    • Gao, Z.H.1    Seeling, J.M.2    Hill, V.3    Yochum, A.4    Virshup, D.M.5
  • 21
    • 0036796741 scopus 로고    scopus 로고
    • Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle
    • Gentry M.S., Hallberg R.L. Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol Biol Cell 2002, 13(10):3477-3492.
    • (2002) Mol Biol Cell , vol.13 , Issue.10 , pp. 3477-3492
    • Gentry, M.S.1    Hallberg, R.L.2
  • 22
    • 21644448038 scopus 로고    scopus 로고
    • A B56 regulatory subunit of protein phosphatase 2A localizes to nuclear speckles in cardiomyocytes
    • Gigena M.S., Ito A., Nojima H., Rogers T.B. A B56 regulatory subunit of protein phosphatase 2A localizes to nuclear speckles in cardiomyocytes. Am J Physiol Heart Circ Physiol 2005, 289(1):H285-H294.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289 , Issue.1
    • Gigena, M.S.1    Ito, A.2    Nojima, H.3    Rogers, T.B.4
  • 23
    • 65949083750 scopus 로고    scopus 로고
    • Cytoplasmic functions of the tumour suppressor p53
    • Green D.R., Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature 2009, 458(7242):1127-1130.
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1127-1130
    • Green, D.R.1    Kroemer, G.2
  • 24
    • 70349656775 scopus 로고    scopus 로고
    • Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival
    • Grochola L.F., Vazquez A., Bond E.E., Wurl P., Taubert H., Muller T.H., et al. Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival. Clin Cancer Res 2009, 15(19):6301-6308.
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6301-6308
    • Grochola, L.F.1    Vazquez, A.2    Bond, E.E.3    Wurl, P.4    Taubert, H.5    Muller, T.H.6
  • 25
    • 0036638049 scopus 로고    scopus 로고
    • Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A
    • Hannus M., Feiguin F., Heisenberg C.P., Eaton S. Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Development 2002, 129(14):3493-3503.
    • (2002) Development , vol.129 , Issue.14 , pp. 3493-3503
    • Hannus, M.1    Feiguin, F.2    Heisenberg, C.P.3    Eaton, S.4
  • 26
    • 18044393595 scopus 로고    scopus 로고
    • Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2
    • Hauf S., Roitinger E., Koch B., Dittrich C.M., Mechtler K., Peters J.M. Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol 2005, 3(3):e69.
    • (2005) PLoS Biol , vol.3 , Issue.3
    • Hauf, S.1    Roitinger, E.2    Koch, B.3    Dittrich, C.M.4    Mechtler, K.5    Peters, J.M.6
  • 27
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
    • He X., Semenov M., Tamai K., Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 2004, 131(8):1663-1677.
    • (2004) Development , vol.131 , Issue.8 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 28
    • 33646133209 scopus 로고    scopus 로고
    • Patterning the early Xenopus embryo
    • Heasman J. Patterning the early Xenopus embryo. Development 2006, 133(7):1205-1217.
    • (2006) Development , vol.133 , Issue.7 , pp. 1205-1217
    • Heasman, J.1
  • 29
    • 0025275038 scopus 로고
    • Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure
    • Hemmings B.A., Adams-Pearson C., Maurer F., Muller P., Goris J., Merlevede W., et al. Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry 1990, 29(13):3166-3173.
    • (1990) Biochemistry , vol.29 , Issue.13 , pp. 3166-3173
    • Hemmings, B.A.1    Adams-Pearson, C.2    Maurer, F.3    Muller, P.4    Goris, J.5    Merlevede, W.6
  • 30
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: paradigms and principles
    • Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001, 15(23):3059-3087.
    • (2001) Genes Dev , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 31
    • 77951977823 scopus 로고    scopus 로고
    • Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase
    • Ishiguro T., Tanaka K., Sakuno T., Watanabe Y. Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase. Nat Cell Biol 2010, 12(5):500-506.
    • (2010) Nat Cell Biol , vol.12 , Issue.5 , pp. 500-506
    • Ishiguro, T.1    Tanaka, K.2    Sakuno, T.3    Watanabe, Y.4
  • 32
    • 39949083195 scopus 로고    scopus 로고
    • PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)
    • Janssens V., Longin S., Goris J. PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). Trends Biochem Sci 2008, 33(3):113-121.
    • (2008) Trends Biochem Sci , vol.33 , Issue.3 , pp. 113-121
    • Janssens, V.1    Longin, S.2    Goris, J.3
  • 33
    • 33646861115 scopus 로고    scopus 로고
    • Decoding the Hedgehog signal in animal development
    • Jia J., Jiang J. Decoding the Hedgehog signal in animal development. Cell Mol Life Sci 2006, 63(11):1249-1265.
    • (2006) Cell Mol Life Sci , vol.63 , Issue.11 , pp. 1249-1265
    • Jia, J.1    Jiang, J.2
  • 34
    • 62349102527 scopus 로고    scopus 로고
    • PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
    • Jia H., Liu Y., Yan W., Jia J. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 2009, 136(2):307-316.
    • (2009) Development , vol.136 , Issue.2 , pp. 307-316
    • Jia, H.1    Liu, Y.2    Yan, W.3    Jia, J.4
  • 35
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J., Hui C.C. Hedgehog signaling in development and cancer. Dev Cell 2008, 15(6):801-812.
    • (2008) Dev Cell , vol.15 , Issue.6 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 36
    • 65449139556 scopus 로고    scopus 로고
    • The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation
    • Jin Z., Shi J., Saraf A., Mei W., Zhu G.Z., Strack S., et al. The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation. J Biol Chem 2009, 284(11):7190-7200.
    • (2009) J Biol Chem , vol.284 , Issue.11 , pp. 7190-7200
    • Jin, Z.1    Shi, J.2    Saraf, A.3    Mei, W.4    Zhu, G.Z.5    Strack, S.6
  • 37
    • 78049410230 scopus 로고    scopus 로고
    • PP2A:B56epsilon, a substrate of caspase-3, regulates p53-dependent and -independent apoptosis during development
    • Jin Z., Wallace L., Harper S.Q., Yang J. PP2A:B56epsilon, a substrate of caspase-3, regulates p53-dependent and -independent apoptosis during development. J Biol Chem 2010, 285(45):34493-34502.
    • (2010) J Biol Chem , vol.285 , Issue.45 , pp. 34493-34502
    • Jin, Z.1    Wallace, L.2    Harper, S.Q.3    Yang, J.4
  • 38
    • 77950560161 scopus 로고    scopus 로고
    • Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis
    • Katis V.L., Lipp J.J., Imre R., Bogdanova A., Okaz E., Habermann B., et al. Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis. Dev Cell 2010, 18(3):397-409.
    • (2010) Dev Cell , vol.18 , Issue.3 , pp. 397-409
    • Katis, V.L.1    Lipp, J.J.2    Imre, R.3    Bogdanova, A.4    Okaz, E.5    Habermann, B.6
  • 39
    • 0036668475 scopus 로고    scopus 로고
    • Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein
    • Kimura S.H., Nojima H. Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein. Genes Cells 2002, 7(8):869-880.
    • (2002) Genes Cells , vol.7 , Issue.8 , pp. 869-880
    • Kimura, S.H.1    Nojima, H.2
  • 40
    • 1142298825 scopus 로고    scopus 로고
    • The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis
    • Kitajima T.S., Kawashima S.A., Watanabe Y. The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature 2004, 427(6974):510-517.
    • (2004) Nature , vol.427 , Issue.6974 , pp. 510-517
    • Kitajima, T.S.1    Kawashima, S.A.2    Watanabe, Y.3
  • 41
    • 33646795889 scopus 로고    scopus 로고
    • Shugoshin collaborates with protein phosphatase 2A to protect cohesin
    • Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., et al. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature 2006, 441(7089):46-52.
    • (2006) Nature , vol.441 , Issue.7089 , pp. 46-52
    • Kitajima, T.S.1    Sakuno, T.2    Ishiguro, K.3    Iemura, S.4    Natsume, T.5    Kawashima, S.A.6
  • 42
    • 49649085367 scopus 로고    scopus 로고
    • Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3
    • Krauss S., Foerster J., Schneider R., Schweiger S. Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res 2008, 68(12):4658-4665.
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4658-4665
    • Krauss, S.1    Foerster, J.2    Schneider, R.3    Schweiger, S.4
  • 43
    • 77954367131 scopus 로고    scopus 로고
    • The B56gamma3 regulatory subunit of PP2A regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition
    • Lee T.Y., Lai T.Y., Lin S.C., Wu C.W., Ni I.F., Yang Y.S., et al. The B56gamma3 regulatory subunit of PP2A regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition. J Biol Chem 2010, 285(28):21567-22180.
    • (2010) J Biol Chem , vol.285 , Issue.28 , pp. 21567-22180
    • Lee, T.Y.1    Lai, T.Y.2    Lin, S.C.3    Wu, C.W.4    Ni, I.F.5    Yang, Y.S.6
  • 44
    • 33644524383 scopus 로고    scopus 로고
    • B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK
    • Letourneux C., Rocher G., Porteu F. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J 2006, 25(4):727-738.
    • (2006) EMBO J , vol.25 , Issue.4 , pp. 727-738
    • Letourneux, C.1    Rocher, G.2    Porteu, F.3
  • 45
    • 0036161826 scopus 로고    scopus 로고
    • Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A
    • Li X., Virshup D.M. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem 2002, 269(2):546-552.
    • (2002) Eur J Biochem , vol.269 , Issue.2 , pp. 546-552
    • Li, X.1    Virshup, D.M.2
  • 46
    • 0035423033 scopus 로고    scopus 로고
    • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus
    • Li X., Yost H.J., Virshup D.M., Seeling J.M. Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J 2001, 20(15):4122-4131.
    • (2001) EMBO J , vol.20 , Issue.15 , pp. 4122-4131
    • Li, X.1    Yost, H.J.2    Virshup, D.M.3    Seeling, J.M.4
  • 47
    • 0036096778 scopus 로고    scopus 로고
    • B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster
    • Li X., Scuderi A., Letsou A., Virshup D.M. B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol Cell Biol 2002, 22(11):3674-3684.
    • (2002) Mol Cell Biol , vol.22 , Issue.11 , pp. 3674-3684
    • Li, X.1    Scuderi, A.2    Letsou, A.3    Virshup, D.M.4
  • 48
    • 33846542682 scopus 로고    scopus 로고
    • A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
    • Li H.H., Cai X., Shouse G.P., Piluso L.G., Liu X. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J 2007, 26(2):402-411.
    • (2007) EMBO J , vol.26 , Issue.2 , pp. 402-411
    • Li, H.H.1    Cai, X.2    Shouse, G.P.3    Piluso, L.G.4    Liu, X.5
  • 49
    • 33747368704 scopus 로고    scopus 로고
    • PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum
    • Lin S.S., Bassik M.C., Suh H., Nishino M., Arroyo J.D., Hahn W.C., et al. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 2006, 281(32):23003-23012.
    • (2006) J Biol Chem , vol.281 , Issue.32 , pp. 23003-23012
    • Lin, S.S.1    Bassik, M.C.2    Suh, H.3    Nishino, M.4    Arroyo, J.D.5    Hahn, W.C.6
  • 50
    • 33847621298 scopus 로고    scopus 로고
    • A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A
    • Liu W., Silverstein A.M., Shu H., Martinez B., Mumby M.C. A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A. Mol Cell Proteomics 2007, 6(2):319-332.
    • (2007) Mol Cell Proteomics , vol.6 , Issue.2 , pp. 319-332
    • Liu, W.1    Silverstein, A.M.2    Shu, H.3    Martinez, B.4    Mumby, M.C.5
  • 51
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004, 20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 52
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms, and diseases
    • MacDonald B.T., Tamai K., He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009, 17(1):9-26.
    • (2009) Dev Cell , vol.17 , Issue.1 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 53
    • 58949083857 scopus 로고    scopus 로고
    • The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle
    • Magnusdottir A., Stenmark P., Flodin S., Nyman T., Kotenyova T., Graslund S., et al. The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle. Proteins 2009, 74(1):212-221.
    • (2009) Proteins , vol.74 , Issue.1 , pp. 212-221
    • Magnusdottir, A.1    Stenmark, P.2    Flodin, S.3    Nyman, T.4    Kotenyova, T.5    Graslund, S.6
  • 54
  • 55
    • 33751212191 scopus 로고    scopus 로고
    • Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis
    • Margolis S.S., Perry J.A., Forester C.M., Nutt L.K., Guo Y., Jardim M.J., et al. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell 2006, 127(4):759-773.
    • (2006) Cell , vol.127 , Issue.4 , pp. 759-773
    • Margolis, S.S.1    Perry, J.A.2    Forester, C.M.3    Nutt, L.K.4    Guo, Y.5    Jardim, M.J.6
  • 56
    • 1042298807 scopus 로고    scopus 로고
    • Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice
    • Martens E., Stevens I., Janssens V., Vermeesch J., Gotz J., Goris J., et al. Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. J Mol Biol 2004, 336(4):971-986.
    • (2004) J Mol Biol , vol.336 , Issue.4 , pp. 971-986
    • Martens, E.1    Stevens, I.2    Janssens, V.3    Vermeesch, J.4    Gotz, J.5    Goris, J.6
  • 57
    • 0028832251 scopus 로고
    • Identification of a new family of protein phosphatase 2A regulatory subunits
    • McCright B., Virshup D.M. Identification of a new family of protein phosphatase 2A regulatory subunits. J Biol Chem 1995, 270(44):26123-26128.
    • (1995) J Biol Chem , vol.270 , Issue.44 , pp. 26123-26128
    • McCright, B.1    Virshup, D.M.2
  • 58
    • 0030586955 scopus 로고    scopus 로고
    • Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12
    • McCright B., Brothman A.R., Virshup D.M. Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. Genomics 1996, 36(1):168-170.
    • (1996) Genomics , vol.36 , Issue.1 , pp. 168-170
    • McCright, B.1    Brothman, A.R.2    Virshup, D.M.3
  • 59
    • 0029834655 scopus 로고    scopus 로고
    • The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm
    • McCright B., Rivers A.M., Audlin S., Virshup D.M. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem 1996, 271(36):22081-22089.
    • (1996) J Biol Chem , vol.271 , Issue.36 , pp. 22081-22089
    • McCright, B.1    Rivers, A.M.2    Audlin, S.3    Virshup, D.M.4
  • 60
    • 33745623123 scopus 로고    scopus 로고
    • Mechanistic insight into how Shh patterns the vertebrate limb
    • McGlinn E., Tabin C.J. Mechanistic insight into how Shh patterns the vertebrate limb. Curr Opin Genet Dev 2006, 16(4):426-432.
    • (2006) Curr Opin Genet Dev , vol.16 , Issue.4 , pp. 426-432
    • McGlinn, E.1    Tabin, C.J.2
  • 61
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon A.P., Ingham P.W., Tabin C.J. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 2003, 53:1-114.
    • (2003) Curr Top Dev Biol , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 62
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through beta-catenin
    • Moon R.T., Bowerman B., Boutros M., Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science 2002, 296(5573):1644-1646.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 63
    • 0036199651 scopus 로고    scopus 로고
    • Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit
    • Muneer S., Ramalingam V., Wyatt R., Schultz R.A., Minna J.D., Kamibayashi C. Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit. Genomics 2002, 79(3):344-348.
    • (2002) Genomics , vol.79 , Issue.3 , pp. 344-348
    • Muneer, S.1    Ramalingam, V.2    Wyatt, R.3    Schultz, R.A.4    Minna, J.D.5    Kamibayashi, C.6
  • 64
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287(5785):795-801.
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 65
    • 28444451148 scopus 로고    scopus 로고
    • A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
    • Nybakken K., Vokes S.A., Lin T.Y., McMahon A.P., Perrimon N. A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet 2005, 37(12):1323-1332.
    • (2005) Nat Genet , vol.37 , Issue.12 , pp. 1323-1332
    • Nybakken, K.1    Vokes, S.A.2    Lin, T.Y.3    McMahon, A.P.4    Perrimon, N.5
  • 66
    • 0029827632 scopus 로고    scopus 로고
    • P53-dependent association between cyclin G and the B'' subunit of protein phosphatase 2A
    • Okamoto K., Kamibayashi C., Serrano M., Prives C., Mumby M.C., Beach D. p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol 1996, 16(11):6593-6602.
    • (1996) Mol Cell Biol , vol.16 , Issue.11 , pp. 6593-6602
    • Okamoto, K.1    Kamibayashi, C.2    Serrano, M.3    Prives, C.4    Mumby, M.C.5    Beach, D.6
  • 68
    • 33645734474 scopus 로고    scopus 로고
    • Hedgehog signalling: how to get from Smo to Ci and Gli
    • Osterlund T., Kogerman P. Hedgehog signalling: how to get from Smo to Ci and Gli. Trends Cell Biol 2006, 16(4):176-180.
    • (2006) Trends Cell Biol , vol.16 , Issue.4 , pp. 176-180
    • Osterlund, T.1    Kogerman, P.2
  • 69
    • 61349123235 scopus 로고    scopus 로고
    • A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation
    • Padmanabhan S., Mukhopadhyay A., Narasimhan S.D., Tesz G., Czech M.P., Tissenbaum H.A. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell 2009, 136(5):939-951.
    • (2009) Cell , vol.136 , Issue.5 , pp. 939-951
    • Padmanabhan, S.1    Mukhopadhyay, A.2    Narasimhan, S.D.3    Tesz, G.4    Czech, M.P.5    Tissenbaum, H.A.6
  • 70
    • 0035512635 scopus 로고    scopus 로고
    • Neural and head induction by insulin-like growth factor signals
    • Pera E.M., Wessely O., Li S.Y., De Robertis E.M. Neural and head induction by insulin-like growth factor signals. Dev Cell 2001, 1(5):655-665.
    • (2001) Dev Cell , vol.1 , Issue.5 , pp. 655-665
    • Pera, E.M.1    Wessely, O.2    Li, S.Y.3    De Robertis, E.M.4
  • 71
    • 0346594337 scopus 로고    scopus 로고
    • Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    • Pera E.M., Ikeda A., Eivers E., De Robertis E.M. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev 2003, 17(24):3023-3028.
    • (2003) Genes Dev , vol.17 , Issue.24 , pp. 3023-3028
    • Pera, E.M.1    Ikeda, A.2    Eivers, E.3    De Robertis, E.M.4
  • 72
    • 0034680788 scopus 로고    scopus 로고
    • A positive role for the PP2A catalytic subunit in Wnt signal transduction
    • Ratcliffe M.J., Itoh K., Sokol S.Y. A positive role for the PP2A catalytic subunit in Wnt signal transduction. J Biol Chem 2000, 275(46):35680-35683.
    • (2000) J Biol Chem , vol.275 , Issue.46 , pp. 35680-35683
    • Ratcliffe, M.J.1    Itoh, K.2    Sokol, S.Y.3
  • 73
    • 0037090903 scopus 로고    scopus 로고
    • The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus
    • Richard-Parpaillon L., Heligon C., Chesnel F., Boujard D., Philpott A. The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus. Dev Biol 2002, 244(2):407-417.
    • (2002) Dev Biol , vol.244 , Issue.2 , pp. 407-417
    • Richard-Parpaillon, L.1    Heligon, C.2    Chesnel, F.3    Boujard, D.4    Philpott, A.5
  • 74
    • 33646819227 scopus 로고    scopus 로고
    • Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
    • Riedel C.G., Katis V.L., Katou Y., Mori S., Itoh T., Helmhart W., et al. Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature 2006, 441(7089):53-61.
    • (2006) Nature , vol.441 , Issue.7089 , pp. 53-61
    • Riedel, C.G.1    Katis, V.L.2    Katou, Y.3    Mori, S.4    Itoh, T.5    Helmhart, W.6
  • 75
    • 34247142858 scopus 로고    scopus 로고
    • Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity
    • Rocher G., Letourneux C., Lenormand P., Porteu F. Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity. J Biol Chem 2007, 282(8):5468-5477.
    • (2007) J Biol Chem , vol.282 , Issue.8 , pp. 5468-5477
    • Rocher, G.1    Letourneux, C.2    Lenormand, P.3    Porteu, F.4
  • 76
    • 33846811415 scopus 로고    scopus 로고
    • PP2A:B56epsilon is required for eye induction and eye field separation
    • Rorick A.M., Mei W., Liette N.L., Phiel C., El-Hodiri H.M., Yang J. PP2A:B56epsilon is required for eye induction and eye field separation. Dev Biol 2007, 302(2):477-493.
    • (2007) Dev Biol , vol.302 , Issue.2 , pp. 477-493
    • Rorick, A.M.1    Mei, W.2    Liette, N.L.3    Phiel, C.4    El-Hodiri, H.M.5    Yang, J.6
  • 77
    • 70449115555 scopus 로고    scopus 로고
    • Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway
    • Roszko I., Sawada A., Solnica-Krezel L. Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Semin Cell Dev Biol 2009, 20(8):986-997.
    • (2009) Semin Cell Dev Biol , vol.20 , Issue.8 , pp. 986-997
    • Roszko, I.1    Sawada, A.2    Solnica-Krezel, L.3
  • 78
    • 0025895590 scopus 로고
    • Constant expression and activity of protein phosphatase 2A in synchronized cells
    • Ruediger R., Van Wart Hood J.E., Mumby M., Walter G. Constant expression and activity of protein phosphatase 2A in synchronized cells. Mol Cell Biol 1991, 11(8):4282-4285.
    • (1991) Mol Cell Biol , vol.11 , Issue.8 , pp. 4282-4285
    • Ruediger, R.1    Van Wart Hood, J.E.2    Mumby, M.3    Walter, G.4
  • 79
    • 0026661827 scopus 로고
    • Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus
    • Ruediger R., Roeckel D., Fait J., Bergqvist A., Magnusson G., Walter G. Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus. Mol Cell Biol 1992, 12(11):4872-4882.
    • (1992) Mol Cell Biol , vol.12 , Issue.11 , pp. 4872-4882
    • Ruediger, R.1    Roeckel, D.2    Fait, J.3    Bergqvist, A.4    Magnusson, G.5    Walter, G.6
  • 80
    • 0028082299 scopus 로고
    • Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens
    • Ruediger R., Hentz M., Fait J., Mumby M., Walter G. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. J Virol 1994, 68(1):123-129.
    • (1994) J Virol , vol.68 , Issue.1 , pp. 123-129
    • Ruediger, R.1    Hentz, M.2    Fait, J.3    Mumby, M.4    Walter, G.5
  • 81
    • 0032889238 scopus 로고    scopus 로고
    • Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens
    • Ruediger R., Fields K., Walter G. Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. J Virol 1999, 73(1):839-842.
    • (1999) J Virol , vol.73 , Issue.1 , pp. 839-842
    • Ruediger, R.1    Fields, K.2    Walter, G.3
  • 82
    • 58149083332 scopus 로고    scopus 로고
    • PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells
    • Ruvolo V.R., Kurinna S.M., Karanjeet K.B., Schuster T.F., Martelli A.M., McCubrey J.A., et al. PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells. J Biol Chem 2008, 283(51):35474-35485.
    • (2008) J Biol Chem , vol.283 , Issue.51 , pp. 35474-35485
    • Ruvolo, V.R.1    Kurinna, S.M.2    Karanjeet, K.B.3    Schuster, T.F.4    Martelli, A.M.5    McCubrey, J.A.6
  • 83
    • 43049099609 scopus 로고    scopus 로고
    • SV40 small T antigen and PP2A phosphatase in cell transformation
    • Sablina A.A., Hahn W.C. SV40 small T antigen and PP2A phosphatase in cell transformation. Cancer Metastasis Rev 2008, 27(2):137-146.
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.2 , pp. 137-146
    • Sablina, A.A.1    Hahn, W.C.2
  • 84
    • 34249291096 scopus 로고    scopus 로고
    • The tumor suppressor PP2A Abeta regulates the RalA GTPase
    • Sablina A.A., Chen W., Arroyo J.D., Corral L., Hector M., Bulmer S.E., et al. The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell 2007, 129(5):969-982.
    • (2007) Cell , vol.129 , Issue.5 , pp. 969-982
    • Sablina, A.A.1    Chen, W.2    Arroyo, J.D.3    Corral, L.4    Hector, M.5    Bulmer, S.E.6
  • 85
    • 75749140882 scopus 로고    scopus 로고
    • Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit
    • Saraf A., Oberg E.A., Strack S. Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit. Biochemistry 2010, 49(5):986-995.
    • (2010) Biochemistry , vol.49 , Issue.5 , pp. 986-995
    • Saraf, A.1    Oberg, E.A.2    Strack, S.3
  • 86
    • 0025641204 scopus 로고
    • Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas
    • Sasaki K., Shima H., Kitagawa Y., Irino S., Sugimura T., Nagao M. Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Jpn J Cancer Res 1990, 81(12):1272-1280.
    • (1990) Jpn J Cancer Res , vol.81 , Issue.12 , pp. 1272-1280
    • Sasaki, K.1    Shima, H.2    Kitagawa, Y.3    Irino, S.4    Sugimura, T.5    Nagao, M.6
  • 87
    • 1342285689 scopus 로고    scopus 로고
    • Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A
    • Sathyanarayanan S., Zheng X., Xiao R., Sehgal A. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 2004, 116(4):603-615.
    • (2004) Cell , vol.116 , Issue.4 , pp. 603-615
    • Sathyanarayanan, S.1    Zheng, X.2    Xiao, R.3    Sehgal, A.4
  • 88
    • 0033605639 scopus 로고    scopus 로고
    • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
    • Seeling J.M., Miller J.R., Gil R., Moon R.T., White R., Virshup D.M. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 1999, 283(5410):2089-2091.
    • (1999) Science , vol.283 , Issue.5410 , pp. 2089-2091
    • Seeling, J.M.1    Miller, J.R.2    Gil, R.3    Moon, R.T.4    White, R.5    Virshup, D.M.6
  • 89
    • 0034958237 scopus 로고    scopus 로고
    • P53-dependent apoptosis pathways
    • Shen Y., White E. p53-dependent apoptosis pathways. Adv Cancer Res 2001, 82:55-84.
    • (2001) Adv Cancer Res , vol.82 , pp. 55-84
    • Shen, Y.1    White, E.2
  • 90
    • 70350340056 scopus 로고    scopus 로고
    • Serine/threonine phosphatases: mechanism through structure
    • Shi Y. Serine/threonine phosphatases: mechanism through structure. Cell 2009, 139(3):468-484.
    • (2009) Cell , vol.139 , Issue.3 , pp. 468-484
    • Shi, Y.1
  • 91
    • 37549003306 scopus 로고    scopus 로고
    • Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A
    • Shouse G.P., Cai X., Liu X. Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. Mol Cell Biol 2008, 28(1):448-456.
    • (2008) Mol Cell Biol , vol.28 , Issue.1 , pp. 448-456
    • Shouse, G.P.1    Cai, X.2    Liu, X.3
  • 92
    • 0037007096 scopus 로고    scopus 로고
    • Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits
    • Silverstein A.M., Barrow C.A., Davis A.J., Mumby M.C. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Proc Natl Acad Sci USA 2002, 99(7):4221-4226.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.7 , pp. 4221-4226
    • Silverstein, A.M.1    Barrow, C.A.2    Davis, A.J.3    Mumby, M.C.4
  • 93
    • 0033523282 scopus 로고    scopus 로고
    • Wnt signaling and dorso-ventral axis specification in vertebrates
    • Sokol S.Y. Wnt signaling and dorso-ventral axis specification in vertebrates. Curr Opin Genet Dev 1999, 9(4):405-410.
    • (1999) Curr Opin Genet Dev , vol.9 , Issue.4 , pp. 405-410
    • Sokol, S.Y.1
  • 94
    • 0023658640 scopus 로고
    • Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A
    • Stone S.R., Hofsteenge J., Hemmings B.A. Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A. Biochemistry 1987, 26(23):7215-7220.
    • (1987) Biochemistry , vol.26 , Issue.23 , pp. 7215-7220
    • Stone, S.R.1    Hofsteenge, J.2    Hemmings, B.A.3
  • 95
    • 0037036389 scopus 로고    scopus 로고
    • Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits
    • Strack S., Ruediger R., Walter G., Dagda R.K., Barwacz C.A., Cribbs J.T. Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. J Biol Chem 2002, 277(23):20750-20755.
    • (2002) J Biol Chem , vol.277 , Issue.23 , pp. 20750-20755
    • Strack, S.1    Ruediger, R.2    Walter, G.3    Dagda, R.K.4    Barwacz, C.A.5    Cribbs, J.T.6
  • 96
    • 9144223779 scopus 로고    scopus 로고
    • Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival
    • Strack S., Cribbs J.T., Gomez L. Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival. J Biol Chem 2004, 279(46):47732-47739.
    • (2004) J Biol Chem , vol.279 , Issue.46 , pp. 47732-47739
    • Strack, S.1    Cribbs, J.T.2    Gomez, L.3
  • 97
    • 0030035065 scopus 로고    scopus 로고
    • Molecular cloning of a 74-kDa regulatory subunit (B' or delta) of human protein phosphatase 2A
    • Tanabe O., Nagase T., Murakami T., Nozaki H., Usui H., Nishito Y., et al. Molecular cloning of a 74-kDa regulatory subunit (B' or delta) of human protein phosphatase 2A. FEBS Lett 1996, 379(1):107-111.
    • (1996) FEBS Lett , vol.379 , Issue.1 , pp. 107-111
    • Tanabe, O.1    Nagase, T.2    Murakami, T.3    Nozaki, H.4    Usui, H.5    Nishito, Y.6
  • 98
    • 0030977373 scopus 로고    scopus 로고
    • Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B' or delta) of human protein phosphatase 2A
    • Tanabe O., Gomez G.A., Nishito Y., Usui H., Takeda M. Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B' or delta) of human protein phosphatase 2A. FEBS Lett 1997, 408(1):52-56.
    • (1997) FEBS Lett , vol.408 , Issue.1 , pp. 52-56
    • Tanabe, O.1    Gomez, G.A.2    Nishito, Y.3    Usui, H.4    Takeda, M.5
  • 99
    • 0035024548 scopus 로고    scopus 로고
    • Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin
    • Tanabe O., Hirata D., Usui H., Nishito Y., Miyakawa T., Igarashi K., et al. Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin. Genes Cells 2001, 6(5):455-473.
    • (2001) Genes Cells , vol.6 , Issue.5 , pp. 455-473
    • Tanabe, O.1    Hirata, D.2    Usui, H.3    Nishito, Y.4    Miyakawa, T.5    Igarashi, K.6
  • 100
    • 33646098667 scopus 로고    scopus 로고
    • PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation
    • Tang Z., Shu H., Qi W., Mahmood N.A., Mumby M.C., Yu H. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell 2006, 10(5):575-585.
    • (2006) Dev Cell , vol.10 , Issue.5 , pp. 575-585
    • Tang, Z.1    Shu, H.2    Qi, W.3    Mahmood, N.A.4    Mumby, M.C.5    Yu, H.6
  • 101
    • 0029915709 scopus 로고    scopus 로고
    • Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle
    • Tehrani M.A., Mumby M.C., Kamibayashi C. Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. J Biol Chem 1996, 271(9):5164-5170.
    • (1996) J Biol Chem , vol.271 , Issue.9 , pp. 5164-5170
    • Tehrani, M.A.1    Mumby, M.C.2    Kamibayashi, C.3
  • 103
    • 0032479215 scopus 로고    scopus 로고
    • Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B' (delta) regulatory subunit in vitro and identification of the phosphorylation sites
    • Usui H., Inoue R., Tanabe O., Nishito Y., Shimizu M., Hayashi H., et al. Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B' (delta) regulatory subunit in vitro and identification of the phosphorylation sites. FEBS Lett 1998, 430(3):312-316.
    • (1998) FEBS Lett , vol.430 , Issue.3 , pp. 312-316
    • Usui, H.1    Inoue, R.2    Tanabe, O.3    Nishito, Y.4    Shimizu, M.5    Hayashi, H.6
  • 104
    • 59249085423 scopus 로고    scopus 로고
    • The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation
    • Van Kanegan M.J., Strack S. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol 2009, 29(3):662-674.
    • (2009) Mol Cell Biol , vol.29 , Issue.3 , pp. 662-674
    • Van Kanegan, M.J.1    Strack, S.2
  • 105
    • 27744512550 scopus 로고    scopus 로고
    • Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
    • Van Kanegan M.J., Adams D.G., Wadzinski B.E., Strack S. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem 2005, 280(43):36029-36036.
    • (2005) J Biol Chem , vol.280 , Issue.43 , pp. 36029-36036
    • Van Kanegan, M.J.1    Adams, D.G.2    Wadzinski, B.E.3    Strack, S.4
  • 106
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: functions and mechanisms
    • Varjosalo M., Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008, 22(18):2454-2472.
    • (2008) Genes Dev , vol.22 , Issue.18 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 107
    • 67349086630 scopus 로고    scopus 로고
    • The mitochondrial p53 pathway
    • Vaseva A.V., Moll U.M. The mitochondrial p53 pathway. Biochim Biophys Acta 2009, 1787(5):414-420.
    • (2009) Biochim Biophys Acta , vol.1787 , Issue.5 , pp. 414-420
    • Vaseva, A.V.1    Moll, U.M.2
  • 108
    • 56349087537 scopus 로고    scopus 로고
    • The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila
    • Vereshchagina N., Ramel M.C., Bitoun E., Wilson C. The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. J Cell Sci 2008, 121(Pt 20):3383-3392.
    • (2008) J Cell Sci , vol.121 , Issue.PART 20 , pp. 3383-3392
    • Vereshchagina, N.1    Ramel, M.C.2    Bitoun, E.3    Wilson, C.4
  • 109
    • 61649127812 scopus 로고    scopus 로고
    • From promiscuity to precision: protein phosphatases get a makeover
    • Virshup D.M., Shenolikar S. From promiscuity to precision: protein phosphatases get a makeover. Mol Cell 2009, 33(5):537-545.
    • (2009) Mol Cell , vol.33 , Issue.5 , pp. 537-545
    • Virshup, D.M.1    Shenolikar, S.2
  • 110
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: the cell's response to p53
    • Vousden K.H., Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002, 2(8):594-604.
    • (2002) Nat Rev Cancer , vol.2 , Issue.8 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 111
    • 0035846951 scopus 로고    scopus 로고
    • Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p
    • Wei H., Ashby D.G., Moreno C.S., Ogris E., Yeong F.M., Corbett A.H., et al. Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. J Biol Chem 2001, 276(2):1570-1577.
    • (2001) J Biol Chem , vol.276 , Issue.2 , pp. 1570-1577
    • Wei, H.1    Ashby, D.G.2    Moreno, C.S.3    Ogris, E.4    Yeong, F.M.5    Corbett, A.H.6
  • 112
    • 37749046873 scopus 로고    scopus 로고
    • Maternal control of pattern formation in Xenopus laevis
    • White J.A., Heasman J. Maternal control of pattern formation in Xenopus laevis. J Exp Zool B Mol Dev Evol 2008, 310(1):73-84.
    • (2008) J Exp Zool B Mol Dev Evol , vol.310 , Issue.1 , pp. 73-84
    • White, J.A.1    Heasman, J.2
  • 113
    • 0034331296 scopus 로고    scopus 로고
    • Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
    • Wu J., Tolstykh T., Lee J., Boyd K., Stock J.B., Broach J.R. Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo. EMBO J 2000, 19(21):5672-5681.
    • (2000) EMBO J , vol.19 , Issue.21 , pp. 5672-5681
    • Wu, J.1    Tolstykh, T.2    Lee, J.3    Boyd, K.4    Stock, J.B.5    Broach, J.R.6
  • 114
    • 33845404441 scopus 로고    scopus 로고
    • Structure of the protein phosphatase 2A holoenzyme
    • Xu Y., Xing Y., Chen Y., Chao Y., Lin Z., Fan E., et al. Structure of the protein phosphatase 2A holoenzyme. Cell 2006, 127(6):1239-1251.
    • (2006) Cell , vol.127 , Issue.6 , pp. 1239-1251
    • Xu, Y.1    Xing, Y.2    Chen, Y.3    Chao, Y.4    Lin, Z.5    Fan, E.6
  • 115
    • 68949206308 scopus 로고    scopus 로고
    • Structure and function of the PP2A-shugoshin interaction
    • Xu Z., Cetin B., Anger M., Cho U.S., Helmhart W., Nasmyth K., et al. Structure and function of the PP2A-shugoshin interaction. Mol Cell 2009, 35(4):426-441.
    • (2009) Mol Cell , vol.35 , Issue.4 , pp. 426-441
    • Xu, Z.1    Cetin, B.2    Anger, M.3    Cho, U.S.4    Helmhart, W.5    Nasmyth, K.6
  • 116
    • 77649269312 scopus 로고    scopus 로고
    • PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR
    • Yan L., Mieulet V., Burgess D., Findlay G.M., Sully K., Procter J., et al. PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. Mol Cell 2010, 37(5):633-642.
    • (2010) Mol Cell , vol.37 , Issue.5 , pp. 633-642
    • Yan, L.1    Mieulet, V.2    Burgess, D.3    Findlay, G.M.4    Sully, K.5    Procter, J.6
  • 117
    • 0348013155 scopus 로고    scopus 로고
    • PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development
    • Yang J., Wu J., Tan C., Klein P.S. PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development. Development 2003, 130(23):5569-5578.
    • (2003) Development , vol.130 , Issue.23 , pp. 5569-5578
    • Yang, J.1    Wu, J.2    Tan, C.3    Klein, P.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.