Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism

Journal of Natural Medicines

Volumn 67, Issue 3, 2013, Pages 545-553

  Kawase, Atsushi ^a   Yamada, Ayano ^a   Gamou, Yuko ^a   Tahara, Chika ^a   Takeshita, Fumiaki ^b   Murata, Kazuya ^a   Matsuda, Hideaki ^a   Samukawa, Keiichi ^c   Iwaki, Masahiro ^a  

^a KINKI UNIVERSITY   (Japan)

^b Research and Development Division   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytochrome P450; Extract; Ginseng; Hepatocyte; Rat; Transporter

Indexed keywords

BILE SALT EXPORT PUMP; CARRIER PROTEIN; CHIKUSETSU SAPONIN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RH 1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; RED GINSENG EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG EFFECT; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; GINSENOSIDES; HEPATOCYTES; HYPERCHOLESTEROLEMIA; LIVER; MALE; ORPHAN NUCLEAR RECEPTORS; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; PRIMARY CELL CULTURE; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 84879235475     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-012-0713-4     Document Type: Article

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