Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models

Acta Pharmacologica Sinica

Volumn 27, Issue 4, 2006, Pages 499-505

  Han, Min ^a   Fang, Xiao Ling ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Bioavailability; Caco 2; Ginsenoside Rg1; Panax; Pharmacokinetics

Indexed keywords

CYCLOSPORIN A; GINSENOSIDE RG 1; PANAX NOTOGINSENG EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG TRANSPORT; GINSENG; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; INTESTINE FUNCTION; INTESTINE MUCOSA; LIVER; MEMBRANE PERMEABILITY; NONHUMAN; RAT; STOMACH; TEMPERATURE DEPENDENCE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DRUGS, CHINESE HERBAL; GINSENOSIDES; HUMANS; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; INTESTINE, LARGE; LIVER; MALE; PANAX; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; TEMPERATURE;

EID: 33645214063     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00303.x     Document Type: Article

References (17)

1. 1 on cultured hippocampal neurons. Acta Pharm Sin 1995 30 674 8.
2. 1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res 2004 1021 41 53.
3. Yamaguchi Y Higashi M Kobayashi H. Effects of ginsenosides on impaired performance caused by scopolamine in rats. Eur J Pharmacol 1996 312 149 51.
4. Li X Chen JX Sun JJ. Protective effects of Panax notoginseng saponins on experimental myocardial injury induced by ischemia and reperfusion in rat. Acta Pharmacol Sin 1990 11 26 9.
5. 2 in rats. Yakugaku-Zasshi 1994 114 550 64.
6. Kanaoks M Akao T Kobashi K. Metabolism of ginseng saponins, ginsenoside, by human intestinal flora. Wakan Ryakugaku Zasshi 1994 11 241 6.
7. Hasegawa H Sung JH Matsumiya S Uchiyama M. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 1996 62 453 7.
8. 1 by intestinal bacteria and its absorbed me tabolites in rat and human serum. Acta Pharm Sin 2000 35 284 8.
9. 1 by intestinal flora. China J Chin Materia Med 2001 26 188 90.
10. 1 in the rat. Chem Pharm Bull 1983 31 292 8.
11. Artursson P Palm K Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 2001 46 27 43.
12. Azuma R Hirota T Manabe H Komuro M Kiwada H. First-pass of GTS-21 on canine gut wall and liver determined by portal-systemic concentration difference. Eur J Pharm Sci 2001 14 159 65.
13. Kim SH Lee MG. Pharmacokinetics of ipriflavone, an isoflavone derivative, after intravenous and oral administration to rats: hepatic and intestinal first-pass effects. Life Sci 2002 70 1299 315.
14. Yamaoka K Nakagava J Uno T. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 1978 6 547 57.
15. Yamashita S Furubayashi T Kataoka M Sakane T Sezaki H Tokuda H. Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. Pharm Sci 2000 10 195 204.
16. Brunet JL Maresca M Fantini J Belzunces LP. Human intestinal absorption of imidacloprid with Caco-2 cells as enterocyte model. Toxicol Appl Pharm 2004 192 1 9.
17. Rubas W Zezyk N Grass GM. Comparison of the permeability characterization of human colonic epithelium (Caco-2) cell line to colon of rabbit, monkey and dog intestine and human drug absorption. Pharm Res 1993 10 113 8.