Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits

Phytotherapy Research

Volumn 22, Issue 6, 2008, Pages 778-783

  Hwang, Seock Yeon ^a   Son, Dong Ju ^b   Kim, Il Woong ^c   Kim, Dong Man ^c   Sohn, Sang Hyun ^c   Lee, Jung Jin ^b   Kim, Si Kwan ^c  

^a Juseong College   (South Korea)

^b Chungbuk National University   (South Korea)

^c Konkuk University   (South Korea)

Author keywords

1,2 diacylglycerol; Arachidonic acid; Atherosclerosis; Hypercholesterolemia; Korean red ginseng; Platelet aggregation

Indexed keywords

ARACHIDONIC ACID; CHOLESTEROL; COLLAGEN; DIACYLGLYCEROL; GINSENOSIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; KOREAN RED GINSENG EXTRACT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; PLANT EXTRACT; SAPONIN; THROMBIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROMA; ATHEROSCLEROSIS; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; GINSENG; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; MALE; NONHUMAN; PHOSPHOLIPID METABOLISM; RABBIT; THROMBOCYTE AGGREGATION INHIBITION; THROMBUS;

ANIMALS; ARACHIDONIC ACID; BLOOD PLATELETS; CHOLESTEROL, DIETARY; DIGLYCERIDES; GINSENOSIDES; HYPERCHOLESTEROLEMIA; KOREA; LIPID METABOLISM; MALE; PANAX; PHOSPHOLIPIDS; PLATELET AGGREGATION; RABBITS;

ORYCTOLAGUS CUNICULUS; PANAX GINSENG;

EID: 46849103623     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2363     Document Type: Article

References (30)

1. Andrews HE, Aitken JW, Hassall DG, Skinner VO, Bruckdorfer KR. 1987. Intracellular mechanisms in the activation of human platelets by low-density lipoproteins. Biochem J 242: 559-564.
2. Aviram M, Hussein O, Rosenblat M, Schlezinger S, Hayek T, Keidar S. 1998. Interactions of platelets, macrophages, and lipoproteins in hypercholesterolemia: antiatherogenic effects of HMG-CoA reductase inhibitor therapy. J Cardiovasc Pharmacol 31: 39-45.
3. Bell RL, Kennerly DA, Stanford N, Majerus PW. 1979. Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci USA 76: 3238-3241.
4. Block LH, Knorr M, Vogt E et al. Low density lipoprotein causes general cellular activation with increased phosphatidy-linositol turnover and lipoprotein catabolism. Proc Natl Acad Sci USA 85: 885-889.
5. 2 from Swiss 3T3 fibroblasts. FEBS Lett 234: 283-286.
6. Cassar K, Bachoo P, Brittenden J. 2003. The role of platelets in peripheral vascular disease. Eur J Vasc Endovasc Surg 25: 6-15.
7. Council of Europe. 2005. Supplement 5.1. In European Pharmacopoeia, 5th edn. European Directorate for the Quality of Medicines & HealthCare, 2935-2936.
8. Hassall DG, Owen JS, Bruckdorfer KR. 1983. The aggregation of isolated human platelets in the presence of lipoproteins and prostacyclin. Biochem J 216: 43-49.
9. Inoue M, Wu CZ, Dou DQ, Chen YJ, Ogihara Y. 1999. Lipoprotein lipase activation by red ginseng saponins in hyperlipidemia model animals. Phytomedicine 6: 257-265.
10. Jin YR, Yu JY, Lee JJ et al. 2007. Antithrombotic and antiplatelet activities of Korean red ginseng extract. Basic Clin Pharmacol Toxicol 100: 170-175.
11. Lacoste L, Lam JY, Hung J, Letchacovski G, Solymoss CB, Waters D. 1995. Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction. Circulation 92: 3172-3177.
12. 2 formation. Arterioscler Thromb 14: 1379-1385.
13. 2 and prostacyclin. Pharmacol Rev 30: 293-331.
14. Nishizuka Y. 1986. Studies and perspectives of protein kinase C. Science 233: 305-312.
15. Olas B, Wachowicz B, Holmsen H, Fukami MH. 2005. Resveratrol inhibits polyphosphoinositide metabolism in activated platelets. Biochim Biophys Acta 1714: 125-133.
16. Park MY, Lee KS, Sung MK. 2005. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life Sci 77: 3344-3354.
17. Reilly MP, Taylor SM, Franklin C et al. 2006. Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model. J Thromb Haemost 4: 2687-2694.
18. Relou IA, Hackeng CM, Akkerman JW, Malle E. 2003. Low-density lipoprotein and its effect on human blood platelets. Cell Mol Life Sci 60: 961-971.
19. Rittenhouse SE. 1984. Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP. Biochem J 222: 103-110.
20. 2) of phosphatidylinositol metabolism and arachidonic acid release in human platelets. J Clin Invest 70: 1216-1224.
21. Rittenhouse-Simmons S. 1979. Production of diglyceride from phosphatidylinositol in activated human platelets. J Clin Invest 63: 580-587.
22. Shanmuganayagam D, Warner TF, Krueger CG, Reed JD, Folts JD. 2007. Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits. Atherosclerosis 190: 135-142.
23. Siess W, Siegel FL, Lapetina EG. 1983. Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation. J Biol Chem 258: 11236-11242.
24. Son DJ, Cho MR, Jin YR et al. 2004. Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. Prostaglandins Leukot Essent Fatty Acids 71: 25-31.
25. Steinberg D. 2002. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med 8: 1211-1217.
26. Surya II, Mommersteeg M, Gorter G, Erkelens DW, Akkerman JW. 1991. Abnormal platelet functions in a patient with abetalipoproteinemia. Thromb Haemost 65: 306-311.
27. van Zanten GH, de Graaf S, Slootweg PJ et al. 1994. Increased platelet deposition on atherosclerotic coronary arteries. J Clin Invest 93: 615-632.
28. Warner MH, Hannun YA. 1991. Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion. Blood 78: 435-444.
29. Yu JY, Jin YR, Lee JJ et al. 2006. Antiplatelet and antithrombotic activities of Korean Red Ginseng. Arch Pharm Res 29: 898-903.
30. Yun YP, Do JH, Ko SR et al. 2001. Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation. J Ethnopharmacol 77: 259-264.