Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet

Journal of the Science of Food and Agriculture

Volumn 92, Issue 2, 2012, Pages 388-396

  Song, Yong Bum ^a   An, Yu Ri ^b   Kim, Seung Jun ^b,c   Park, Hye Won ^b,c   Jung, Jin Wook ^c   Kyung, Jong Soo ^a   Hwang, Seung Yong ^b,c   Kim, Young Sook ^a  

^a Korea Ginseng Corporation   (South Korea)

^b Hanyang University   (South Korea)

^c GenoCheck Co Ltd   (South Korea)

Author keywords

Anti obesity; High fat diet; Korean red ginseng extract; Microarray

Indexed keywords

ANTILIPEMIC AGENT; PLANT EXTRACT;

ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; DRUG EFFECT; FAT INTAKE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; LIPID METABOLISM; MALE; MICROARRAY ANALYSIS; MOUSE; PANAX; PHYSIOLOGY; WEIGHT REDUCTION;

ANIMALS; DIETARY FATS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS; PANAX; PLANT EXTRACTS; SPECIFIC PATHOGEN-FREE ORGANISMS; WEIGHT LOSS;

MUS; PANAX GINSENG;

EID: 83255194020     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.4589     Document Type: Article

References (25)

1. Li L, Yang G, Li Q, Tang Y Li K, High-fat and lipid-induced insulin resistance in rats: The comparison of glucose metabolism, plasma resistin and adiponectin levels. Ann Nutr Metab 50: 499-505 (2006).
2. Matri A, Martinez-Gonzalez MA Martinez JA, Nutrition interaction between genes and lifestyle factors on obesity. Proc Nutr Soc 67: 1-8 (2008).
3. Qi L Cho YA, Gene-environment interaction and obesity. Nutr Rev 66: 684-694 (2008).
4. Laclaustra M, Corella D Ordovas J, Metabolic syndrome pathophysiology: The role of adipose tissue. Nur Metab Cardiovasc Dis 17: 125-139 (2007).
5. Karu N, Reifen R Kerem Z, Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. J Agric Food Chem 55: 2824-2828 (2007).
6. Inoue M, Wu CZ, Dou DQ, Chen YH Ogihara Y, Lipoprotein lipase activation by red ginseng saponins in hyperlipidemia model animals. Phytomedicine 6: 257-265 (1999).
7. Kim JH, Kang SA, Han SM Shim I, Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng. Phytother Res 23: 78-85 (2009).
8. Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ Shim I, Effect of crude saponin on Korean red ginseng on high-fat diet-induced obesity in the rat. J Pharmacol 97: 124-131 (2005).
9. Hwang JT, Kim SH, Lee MS, Kim SH, Yang HJ, Kim MJ, et al, Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. Biochem Biophys Res Commun 364: 1002-1008 (2007).
10. Hwang JT, Lee MS, Kim HJ, Sung MJ, Kim HY, Kim MS, et al, Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Phytother Res 23: 262-266 (2009).
11. Park HW, Kim SJ, An YR, Kim JS, Yu SY, Oh MJ, et al, Gene expression profiling of HepG2 cells treated with endocrine disrupting chemicals using the HazChem human array V3. Mol Cell Toxicol 6: 57-63 (2010).
12. Kim JS, Kim SJ, Lee SY, Han J, An YR, Kim AR, et al, Array2GO: a simple web-based tool to search gene ontology for analysis of multi genes expression. Biochip J 4: 320-335 (2010).
13. Ong YC Yong EL, Panax (ginseng)-panacea or placebo? Molecular and cellular basis of its pharmacological activity. Ann Acad Med Singapore 29: 42-46 (2009).
14. Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH Yue KK, Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol 550: 173-179 (2006).
15. Han GC, Ko SK, Sung JH Chung SH, Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. J Agric Food Chem 55: 10641-10648 (2007).
16. Lim S, Yoon JW, Choi SH, Cho BJ, Kim JT, et al, Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model. Metabolism 58: 8-15 (2009).
17. Morrison CD, Huypens P, Stewart LK Gettys TW, Implication of crosstalk between leptin and insulin signaling during the development of diet-induced obesity Biochim Biophys Acta 1972: 409-416 (2009).
18. Díez JJ Iglesias P, The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 148: 293-300 (2003).
19. Lopez IP, Marti A, Milagro FI, Zulet Md Mde L, Moreno-Aliaga MJ, Martinez JA, et al, DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats. Obes Res 11: 188-194 (2003).
20. Ferrante Jr AW, Thearle M, Liao T Leibel RL, Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. Diabetes 50: 2268-2278 (2001).
21. Kim S, Sohn I, Ahn JI, Lee KH, Lee YS Lee YS, Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model. Gene 340: 99-109 (2004).
22. Assmann G Seedorf U, Acid lipase deficiency: Wolman disease and cholesteryl ester storage. In Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. McGraw Hilll Inc., New Youk, 2563-2587 (1998).
23. Vahouny GV Treadwell CR. Absolute requirement for free sterol for absorption by rat intestinal mucosa. Proc Soc Exp Biol Med 116: 496-498 (1964).
24. Du H, Witte DP Grabowski GA, Tissue and cellular specific expression of murine lysosomal acid lipase mRNA and protein. J Lipid Res 37: 937-949 (1996).
25. Masuo K, Straznicky NE, Lambert GW, Katsuya T, Sugimoto K, Rakugi H, et al, Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population. Hypertens Res 31: 1093-1100 (2008).