The coming of age of our understanding of the enterohepatic circulation of bile salts

American Journal of Surgery

Volumn 185, Issue 2, 2003, Pages 168-172

  Redinger, Richard N ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Bile salt; Cholesterol homeostasis; Nuclear hormone receptors

Indexed keywords

ABC TRANSPORTER; BILE ACID; BILE SALT; BINDING PROTEIN; CHOLESTEROL; FARNESOID X RECEPTOR; HIGH DENSITY LIPOPROTEIN; HORMONE RECEPTOR; LIGAND; LIVER X RECEPTOR; OXYSTEROL; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; AUTOREGULATION; BILE ACID SYNTHESIS; CATABOLISM; ENTEROHEPATIC CIRCULATION; FEEDBACK SYSTEM; GENETIC REGULATION; HOMEOSTASIS; LIPID TRANSPORT; LIPOLYSIS; LIVER CELL; MOLECULAR BIOLOGY; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SMALL INTESTINE ABSORPTION;

EID: 0037307826     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9610(02)01212-6     Document Type: Review

References (30)

1. Repa J.J., Mangelsdorf D.J. Nuclear receptor regulation of cholesterol and bile acid metabolism. Curr Opin Biotechnol. 10:1999;557-563.
2. Carey M.C. The enterohepatic circulation. Arias I., Popper H., et al. The liver: biology and pathobiology. 1982;429-465 Raven Press, New York.
3. Hoffman A.F. Bile acids. Arias I.M., Buyer J.L., et al. Biology and pathophysiology. 1994;677-717 Raven Press, New York.
4. Hoffman A.F. Intestinal absorption of bile acids and biliary constituents: the intestinal components of the enterohepatic circulation and the integrated system. Johnson L.R. Physiology of the gastrointestinal tract. 1994;1845-1865 Raven Press, New York.
5. Brown M.S., Goldstein J.L. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA. 96:1999;11041-11048.
6. Repa J.J., Mangelsdorf D.J. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol. 16:2000;459-481.
7. Makishima M., Okamoto A.Y., Repa J.J., et al. Identification of a nuclear receptor for bile acids. Science. 284:1999;1362-1365.
8. Kern F. Bile salt malabsorption in regional ileitis, ileal resection and mannitol induced diarrhea. J Clin Invest. 47:1968;261.
9. Hoffman A.F. Enterohepatic circulation of bile acids. Shultz S.G., Forte J.G., Rainer B.B. Handbook of physiology. 1989;567-596 Oxford University Press, New York. Vol 3.
10. Thaysen E.H., Pedersen L. Idiopathic bile acid catharsis. Gut. 17:1976;965-970.
11. Small D.M., Dowling R.H., Redinger R.N. The enterohepatic circulation of bile salts. Arch Intern Med. 130:1972;552-573.
12. Russell D.W., Setchell K.D. Bile acid biosynthesis. Biochemistry. 31:1992;4737-4749.
13. Xie W., Radominska-Pandya A., Shi Y., et al. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA. 98:2001;3375-3380.
14. Sinal C.J., Tohkin M., Miyata M., et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 102:2000;731-744.
15. Schoonjans K., Brendel C., Mangelsdorf D., Auwerx J. Sterols and gene expression control of affluence . Biochim Biophys Acta. 1529:2000;114-125.
16. Lecureur V., Courtois A., Payen L., et al. Expression and regulation of hepatic drug and bile acid transporters. Toxicology. 153:2000;203-219.
17. Hofmann A.F., Small D.M. Detergent properties of bile salts correlation with physiological function . Annu Rev Med. 18:1967;333-376.
18. Wang X., Sato R., Brown M.S., et al. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77:1994;53-62.
19. Vallett S.M., Sanchez H.B., Rosenfeld J.M., Osborne T.F. A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J Biol Chem. 271:1996;12247-12253.
20. Russell D.W. Oxysterol biosynthetic enzymes. Biochim Biophys Acta. 1529:2000;126-135.
21. Lu T.T., Makishima M., Repa J.J., et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell. 6:2000;507-515.
22. Willy P.J., Umesono K., Ong E.S., et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9:1995;1033-1045.
23. Waxman D.J. P450 gene induction by structurally diverse xenochemicals central role of nuclear receptors CAR, PXR, and PPAR . Arch Biochem Biophys. 369:1999;11-23.
24. Tu H, Okamoto AY, Shan B. FXR, a bile acid receptor and biological sensor. Trends Cardiovasc Med. 10:2000;30-35.
25. Goodwin B., Jones S.A., Price R.R., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell. 6:2000;517-526.
26. Grober J., Zaghini I., Fujii H., et al. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J Biol Chem. 274:1999;29749-29754.
27. Urizar N.L., Dowhan D.H., Moore D.D. The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression. J Biol Chem. 275:2000;39313-39317.
28. Ananthanarayanan M., Balasubramanian N., Makishima M., et al. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem. 276:2001;28857-28865.
29. Repa J.J., Turley S.D., Lobaccaro J.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 289:2000;1524-1529.
30. Drobnik W., Lindenthal B., Lieser B., et al. ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism. Gastroenterology. 120:2001;1203-1211.