-
1
-
-
0026598851
-
Small intestinal cytochromes P450
-
Kaminsky, L. S. and Fasco, M. J.: Small intestinal cytochromes P450. Crit. Rev. Toxicol., 21: 407-422 (1991).
-
(1991)
Crit. Rev. Toxicol
, vol.21
, pp. 407-422
-
-
Kaminsky, L.S.1
Fasco, M.J.2
-
2
-
-
0033009998
-
Is the role of the small intestine in first-pass metabolism overemphasized?
-
Lin, J. H., Chiba, M. and Baillie, T. A.: Is the role of the small intestine in first-pass metabolism overemphasized? Pharmacol. Rev., 51: 135-158 (1999).
-
(1999)
Pharmacol. Rev
, vol.51
, pp. 135-158
-
-
Lin, J.H.1
Chiba, M.2
Baillie, T.A.3
-
3
-
-
0036093847
-
The mucosa of the small intestine: How clinically relevant as an organ of drug metabolism?
-
Doherty, M. M. and Charman, W. N.: The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin. Pharmacokinet., 41: 235-253 (2002).
-
(2002)
Clin. Pharmacokinet
, vol.41
, pp. 235-253
-
-
Doherty, M.M.1
Charman, W.N.2
-
4
-
-
0037478407
-
Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts
-
Ding, X. and Kaminsky, L. S.: Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu. Rev. Pharmacol. Toxicol., 43: 149-173 (2003).
-
(2003)
Annu. Rev. Pharmacol. Toxicol
, vol.43
, pp. 149-173
-
-
Ding, X.1
Kaminsky, L.S.2
-
5
-
-
0031445547
-
Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
-
Paine, M. F., Khalighi, M., Fisher, J. M., Shen, D. D., Kunze, K. L., Marsh, C. L., Perkins, J. D. and Thummel, K. E.: Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J. Pharmacol. Exp. Ther., 283: 1552-1562 (1997).
-
(1997)
J. Pharmacol. Exp. Ther
, vol.283
, pp. 1552-1562
-
-
Paine, M.F.1
Khalighi, M.2
Fisher, J.M.3
Shen, D.D.4
Kunze, K.L.5
Marsh, C.L.6
Perkins, J.D.7
Thummel, K.E.8
-
6
-
-
0034680792
-
Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
-
Strassburg, C. P., Kneip, S., Topp, J., Obermayer-Straub, P., Barut, A., Tukey, R. H. and Manns, M. P.: Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J. Biol. Chem., 275: 36164-36171 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 36164-36171
-
-
Strassburg, C.P.1
Kneip, S.2
Topp, J.3
Obermayer-Straub, P.4
Barut, A.5
Tukey, R.H.6
Manns, M.P.7
-
7
-
-
0033022765
-
Characterization of human small intestinal cytochromes P-450
-
Zhang, Q. Y., Dunbar, D., Ostrowska, A., Zeisloft, S., Yang, J. and Kaminsky, L. S.: Characterization of human small intestinal cytochromes P-450. Drug. Metab. Dispos., 27: 804-809 (1999).
-
(1999)
Drug. Metab. Dispos
, vol.27
, pp. 804-809
-
-
Zhang, Q.Y.1
Dunbar, D.2
Ostrowska, A.3
Zeisloft, S.4
Yang, J.5
Kaminsky, L.S.6
-
8
-
-
0027404182
-
Rat small intestinal cytochromes P450 probed by warfarin metabolism
-
Fasco,M. J., Silkworth, J. B., Dunbar, D. A. and Kaminsky, L. S.: Rat small intestinal cytochromes P450 probed by warfarin metabolism. Mol. Pharmacol., 43: 226-233 (1993).
-
(1993)
Mol. Pharmacol
, vol.43
, pp. 226-233
-
-
Fasco, M.J.1
Silkworth, J.B.2
Dunbar, D.A.3
Kaminsky, L.S.4
-
9
-
-
9044236908
-
Characterization of rat small intestinal cytochrome P450 composition and inducibility
-
Zhang, Q. Y., Wikoff, J., Dunbar, D. and Kaminsky, L.: Characterization of rat small intestinal cytochrome P450 composition and inducibility. Drug. Metab. Dispos., 24: 322-328 (1996).
-
(1996)
Drug. Metab. Dispos
, vol.24
, pp. 322-328
-
-
Zhang, Q.Y.1
Wikoff, J.2
Dunbar, D.3
Kaminsky, L.4
-
10
-
-
0031882863
-
Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Importance of CYP2D1 and CYP2D2
-
Yamamoto, Y., Tasaki, T., Nakamura, A., Iwata, H., Kazusaka, A., Gonzalez, F. J. and Fujita, S.: Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2. Pharmacogenetics, 8: 73-82 (1998).
-
(1998)
Pharmacogenetics
, vol.8
, pp. 73-82
-
-
Yamamoto, Y.1
Tasaki, T.2
Nakamura, A.3
Iwata, H.4
Kazusaka, A.5
Gonzalez, F.J.6
Fujita, S.7
-
11
-
-
0022362531
-
Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat
-
Kahn, G. C., Rubenfield, M., Davies, D. S., Murray, S. and Boobis, A. R.: Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat. Drug. Metab. Dispos., 13: 510-516 (1985).
-
(1985)
Drug. Metab. Dispos
, vol.13
, pp. 510-516
-
-
Kahn, G.C.1
Rubenfield, M.2
Davies, D.S.3
Murray, S.4
Boobis, A.R.5
-
12
-
-
0026053039
-
Impairment of bunitrolol 4-hydroxylase activity in liver microsomes of dark agouti rats
-
Suzuki, T., Narimatsu, S., Fujita, S., Masubuchi, Y. and Umeda, S.: Impairment of bunitrolol 4-hydroxylase activity in liver microsomes of dark agouti rats. Biochem. Pharmacol., 42: 2241-2244 (1991).
-
(1991)
Biochem. Pharmacol
, vol.42
, pp. 2241-2244
-
-
Suzuki, T.1
Narimatsu, S.2
Fujita, S.3
Masubuchi, Y.4
Umeda, S.5
-
13
-
-
0029116307
-
Cytochrome P450 isozymes involved in aromatic hydroxylation and side-chain N-desisopropylation of alprenolol in rat liver microsomes
-
Narimatsu, S., Tachibana, M., Masubuchi, Y., Imaoka, S., Funae, Y. and Suzuki, T.: Cytochrome P450 isozymes involved in aromatic hydroxylation and side-chain N-desisopropylation of alprenolol in rat liver microsomes. Biol. Pharm. Bull., 18: 1060-1065 (1995).
-
(1995)
Biol. Pharm. Bull
, vol.18
, pp. 1060-1065
-
-
Narimatsu, S.1
Tachibana, M.2
Masubuchi, Y.3
Imaoka, S.4
Funae, Y.5
Suzuki, T.6
-
14
-
-
0028273879
-
An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: Relevance to its use as a model of the CYP2D6 poor metaboliser phenotype
-
Barham, H. M., Lennard, M. S. and Tucker, G. T.: An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: relevance to its use as a model of the CYP2D6 poor metaboliser phenotype. Biochem. Pharmacol., 47: 1295-1307 (1994).
-
(1994)
Biochem. Pharmacol
, vol.47
, pp. 1295-1307
-
-
Barham, H.M.1
Lennard, M.S.2
Tucker, G.T.3
-
15
-
-
4143125870
-
Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats
-
Saito, K., Sakai, N., Kim, H. S., Ishizuka, M., Kazusaka, A. and Fujita, S.: Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats. Drug Metab. Dispos., 32: 959-965 (2004).
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 959-965
-
-
Saito, K.1
Sakai, N.2
Kim, H.S.3
Ishizuka, M.4
Kazusaka, A.5
Fujita, S.6
-
16
-
-
0026775116
-
Bioanalytical applications of tandem mass spectrometry in the in vitro metabolism of the anticholinergic drug cimetropium bromide to detect differences in species metabolism
-
Kajbaf, M., Jahanshahi, M., Lamb, J. H., Gorrod, J. W. and Naylor, S.: Bioanalytical applications of tandem mass spectrometry in the in vitro metabolism of the anticholinergic drug cimetropium bromide to detect differences in species metabolism. Xenobiotica., 22: 641-655 (1992).
-
(1992)
Xenobiotica
, vol.22
, pp. 641-655
-
-
Kajbaf, M.1
Jahanshahi, M.2
Lamb, J.H.3
Gorrod, J.W.4
Naylor, S.5
-
17
-
-
0025816568
-
Sex and age-related differences in aminopyrine N-demethylase activity in DA- and Wistarstrain rat liver microsomes. Effect of ovariectomy.
-
Garcia-Agundez, J. A. and Benitez, J.: Sex and age-related differences in aminopyrine N-demethylase activity in DA- and Wistarstrain rat liver microsomes. Effect of ovariectomy.: Xenobiotica., 21: 755-762 (1991).
-
(1991)
Xenobiotica
, vol.21
, pp. 755-762
-
-
Garcia-Agundez, J.A.1
Benitez, J.2
-
18
-
-
0023766459
-
Inter-individual variation in the mutagenic activation of 2-acetylaminofluorene by human liver in relation to animal metabolic models
-
Smith, A. J. and Chipman, J. K.: Inter-individual variation in the mutagenic activation of 2-acetylaminofluorene by human liver in relation to animal metabolic models. Mutagenesis., 3: 323-328 (1988).
-
(1988)
Mutagenesis
, vol.3
, pp. 323-328
-
-
Smith, A.J.1
Chipman, J.K.2
-
19
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterstrom, R. H., Perlmann, T. and Lehmann, J. M.: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell, 92: 73-82 (1998).
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
20
-
-
0031682988
-
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
-
Honkakoski, P., Zelko, I., Sueyoshi, T. and Negishi, M.: The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell Biol., 18: 5652-5658 (1998).
-
(1998)
Mol. Cell Biol
, vol.18
, pp. 5652-5658
-
-
Honkakoski, P.1
Zelko, I.2
Sueyoshi, T.3
Negishi, M.4
-
21
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
-
Waxman, D. J.: P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem. Biophys., 369: 11-23 (1999).
-
(1999)
Arch Biochem. Biophys
, vol.369
, pp. 11-23
-
-
Waxman, D.J.1
-
22
-
-
8344219885
-
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
-
Squires, E. J., Sueyoshi, T. and Negishi, M.: Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J. Biol. Chem., 279: 49307-49314 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 49307-49314
-
-
Squires, E.J.1
Sueyoshi, T.2
Negishi, M.3
-
23
-
-
0142210183
-
Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells
-
Kobayashi, K., Sueyoshi, T., Inoue, K., Moore, R. and Negishi, M.: Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol. Pharmacol., 64: 1069-1075 (2003).
-
(2003)
Mol. Pharmacol
, vol.64
, pp. 1069-1075
-
-
Kobayashi, K.1
Sueyoshi, T.2
Inoue, K.3
Moore, R.4
Negishi, M.5
-
24
-
-
0035253128
-
Retinoid X receptor and its partners in the nuclear receptor family
-
Rastinejad, F.: Retinoid X receptor and its partners in the nuclear receptor family. Curr. Opin. Struct. Biol., 11: 33-38 (2001).
-
(2001)
Curr. Opin. Struct. Biol
, vol.11
, pp. 33-38
-
-
Rastinejad, F.1
-
25
-
-
0346156024
-
PPAR-alpha agonist-induced rodent tumors: Modes of action and human relevance
-
Klaunig, J. E., Babich, M. A., Baetcke, K. P., Cook, J. C., Corton, J. C., David, R. M., DeLuca, J. G., Lai, D. Y., McKee, R. H., Peters, J. M., Roberts, R. A. and Fenner-Crisp, P. A.: PPAR-alpha agonist-induced rodent tumors: modes of action and human relevance. Crit. Rev. Toxicol., 33: 655-780 (2003).
-
(2003)
Crit. Rev. Toxicol
, vol.33
, pp. 655-780
-
-
Klaunig, J.E.1
Babich, M.A.2
Baetcke, K.P.3
Cook, J.C.4
Corton, J.C.5
David, R.M.6
DeLuca, J.G.7
Lai, D.Y.8
McKee, R.H.9
Peters, J.M.10
Roberts, R.A.11
Fenner-Crisp, P.A.12
-
26
-
-
2642510760
-
Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
-
Nebert, D. W., Dalton, T. P., Okey, A. B. and Gonzalez, F. J.: Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J. Biol. Chem., 279: 23847-23850 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 23847-23850
-
-
Nebert, D.W.1
Dalton, T.P.2
Okey, A.B.3
Gonzalez, F.J.4
-
27
-
-
0028029165
-
A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4
-
Chen, D., Lepar, G. and Kemper, B.: A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. J Biol Chem., 18: 5420-5427 (1994).
-
(1994)
J Biol Chem
, vol.18
, pp. 5420-5427
-
-
Chen, D.1
Lepar, G.2
Kemper, B.3
-
28
-
-
0037450505
-
Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors
-
Akiyama, T. E. and Gonzalez, F. J.: Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim. Biophys. Acta., 1619: 223-234 (2003).
-
(2003)
Biochim. Biophys. Acta
, vol.1619
, pp. 223-234
-
-
Akiyama, T.E.1
Gonzalez, F.J.2
-
29
-
-
27244445072
-
Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age
-
Peng, F. C., Jian, W. C. and Edwards, R. J.: Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age. J. Toxicol. Environ. Health A., 12: 1871-1888 (2005).
-
(2005)
J. Toxicol. Environ. Health A
, vol.12
, pp. 1871-1888
-
-
Peng, F.C.1
Jian, W.C.2
Edwards, R.J.3
-
30
-
-
14344255557
-
Pharmacokinetics and metabolism of metoprolol and propranolol in the female DA and female Wistar rat: The female DA rat is not always an animal model for poor metabolizers of CYP2D6
-
Komura, H. and Iwaki, M.: Pharmacokinetics and metabolism of metoprolol and propranolol in the female DA and female Wistar rat: the female DA rat is not always an animal model for poor metabolizers of CYP2D6. J. Pharm. Sci., 94: 397-408 (2005).
-
(2005)
J. Pharm. Sci
, vol.94
, pp. 397-408
-
-
Komura, H.1
Iwaki, M.2
-
31
-
-
85015584860
-
Species difference in nisoldipine oxidation activity in the small intestine
-
Komura, H., Yasuda, M., Yoshida, N. H. and Sugiyama, Y.: Species difference in nisoldipine oxidation activity in the small intestine. Drug Metab. Pharmacokin., 17: 427-436 (2002).
-
(2002)
Drug Metab. Pharmacokin
, vol.17
, pp. 427-436
-
-
Komura, H.1
Yasuda, M.2
Yoshida, N.H.3
Sugiyama, Y.4
-
32
-
-
2442650220
-
Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat
-
Matsubara, T., Kim, H. J., Miyata, M., Shimada, M., Nagata, K. and Yamazoe, Y.: Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat. J. Pharmacol. Exp. Ther., 309: 1282-1290 (2004).
-
(2004)
J. Pharmacol. Exp. Ther
, vol.309
, pp. 1282-1290
-
-
Matsubara, T.1
Kim, H.J.2
Miyata, M.3
Shimada, M.4
Nagata, K.5
Yamazoe, Y.6
-
33
-
-
4143125870
-
Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats
-
Saito, K., Sakai, N., Kim, H. S., Ishizuka, M., Kazusaka, A. and Fujita, S.: Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats. Drug Metab Dispos., 32: 959-965 (2004).
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 959-965
-
-
Saito, K.1
Sakai, N.2
Kim, H.S.3
Ishizuka, M.4
Kazusaka, A.5
Fujita, S.6
-
34
-
-
0029125346
-
Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats
-
Masubuchi, Y., Takahashii, C., Fujio, N., Horie, T., Suzuki, T., Imaoka, S., Funae, Y. and Narimatsu, S.: Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats. Drug Metab. Dispos., 23: 999-1003 (1995).
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 999-1003
-
-
Masubuchi, Y.1
Takahashii, C.2
Fujio, N.3
Horie, T.4
Suzuki, T.5
Imaoka, S.6
Funae, Y.7
Narimatsu, S.8
-
35
-
-
0019492928
-
Animal modelling of human polymorphic drug oxidation-the metabolism of debrisoquine and phenacetin in rat inbred strains
-
Al-Dabbagh, S. G., Idle, J. R. and Smith, R. L.: Animal modelling of human polymorphic drug oxidation-the metabolism of debrisoquine and phenacetin in rat inbred strains. J. Pharm. Pharmacol., 33: 161-164 (1981).
-
(1981)
J. Pharm. Pharmacol
, vol.33
, pp. 161-164
-
-
Al-Dabbagh, S.G.1
Idle, J.R.2
Smith, R.L.3
-
36
-
-
0028326875
-
Urinary excretion of amphetamine and 4′-hydroxyamphetamine by Sprague Dawley and dark Agouti rats
-
Law, M. Y. and Moody, D. E.: Urinary excretion of amphetamine and 4′-hydroxyamphetamine by Sprague Dawley and dark Agouti rats. Life Sci., 54: 1073-1079 (1994).
-
(1994)
Life Sci
, vol.54
, pp. 1073-1079
-
-
Law, M.Y.1
Moody, D.E.2
-
37
-
-
0034694148
-
Urinary excretion of 4-hydroxyamphetamine and amphetamine in male and female Sprague-Dawley and Dark Agouti rats following multiple doses of amphetamine
-
Law, M. Y. and Moody, D. E.: Urinary excretion of 4-hydroxyamphetamine and amphetamine in male and female Sprague-Dawley and Dark Agouti rats following multiple doses of amphetamine. Toxicol. Lett., 117: 139-144 (2000).
-
(2000)
Toxicol. Lett
, vol.117
, pp. 139-144
-
-
Law, M.Y.1
Moody, D.E.2
-
38
-
-
0023807422
-
In-vivo and in-vitro dextromethorphan metabolism in SD and DA rat. An animal model of the debrisoquine-type polymorphic oxidation in man
-
Zysset, T., Zeugin, T. and Kupfer, A.: In-vivo and in-vitro dextromethorphan metabolism in SD and DA rat. An animal model of the debrisoquine-type polymorphic oxidation in man. Biochem. Pharmacol., 37: 3155-3160 (1988).
-
(1988)
Biochem. Pharmacol
, vol.37
, pp. 3155-3160
-
-
Zysset, T.1
Zeugin, T.2
Kupfer, A.3
-
39
-
-
0024593661
-
Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism
-
Muralidharan, G., Midha, K. K., McKay, G., Hawes, E. M. and Inaba, T.: Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism. Xenobiotica, 19: 189-197 (1989).
-
(1989)
Xenobiotica
, vol.19
, pp. 189-197
-
-
Muralidharan, G.1
Midha, K.K.2
McKay, G.3
Hawes, E.M.4
Inaba, T.5
-
40
-
-
1642457236
-
Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes
-
Staack, R. F., Paul, L. D., Springer, D., Kraemer, T. and Maurer, H. H.: Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes. Biochem. Pharmacol., 67: 235-244 (2004).
-
(2004)
Biochem. Pharmacol
, vol.67
, pp. 235-244
-
-
Staack, R.F.1
Paul, L.D.2
Springer, D.3
Kraemer, T.4
Maurer, H.H.5
-
41
-
-
0032441462
-
Physiological and pathophysiological regulation of cytochrome P450
-
Morgan, E. T., Sewer, M. B., Iber, H., Gonzalez, F. J., Lee, Y. H., Tukey, R. H., Okino, S., Vu, T., Chen, Y. H., Sidhu, J. S. and Omiecinski, C. J.: Physiological and pathophysiological regulation of cytochrome P450. Drug Metab. Dispos., 26: 1232-1240 (1998).
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 1232-1240
-
-
Morgan, E.T.1
Sewer, M.B.2
Iber, H.3
Gonzalez, F.J.4
Lee, Y.H.5
Tukey, R.H.6
Okino, S.7
Vu, T.8
Chen, Y.H.9
Sidhu, J.S.10
Omiecinski, C.J.11
-
42
-
-
0029738490
-
First-pass metabolism of midazolam by the human intestine
-
Paine, M. F., Shen, D. D., Kunze, K. L., Perkins, J. D., Marsh, C. L., McVicar, J. P., Barr, D. M., Gillies, B. S. and Thummel, K. E.: First-pass metabolism of midazolam by the human intestine. Clin. Pharmacol. Ther., 60: 14-24 (1996).
-
(1996)
Clin. Pharmacol. Ther
, vol.60
, pp. 14-24
-
-
Paine, M.F.1
Shen, D.D.2
Kunze, K.L.3
Perkins, J.D.4
Marsh, C.L.5
McVicar, J.P.6
Barr, D.M.7
Gillies, B.S.8
Thummel, K.E.9
-
43
-
-
0030015297
-
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism
-
Thummel, K. E., O'Shea, D., Paine, M. F., Shen, D. D., Kunze, K. L., Perkins, J. D. and Wilkinson, G. R.: Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. Clin. Pharmacol. Ther., 59: 491-502 (1996).
-
(1996)
Clin. Pharmacol. Ther
, vol.59
, pp. 491-502
-
-
Thummel, K.E.1
O'Shea, D.2
Paine, M.F.3
Shen, D.D.4
Kunze, K.L.5
Perkins, J.D.6
Wilkinson, G.R.7
-
44
-
-
0028126571
-
Midazolam is metabolized by at least three different cytochrome P450 enzymes
-
Wandel, C., Bocker, R., Bohrer, H., Browne, A., Rugheimer, E. and Martin, E.: Midazolam is metabolized by at least three different cytochrome P450 enzymes. Br. J. Anaesth., 73: 658-661 (1994).
-
(1994)
Br. J. Anaesth
, vol.73
, pp. 658-661
-
-
Wandel, C.1
Bocker, R.2
Bohrer, H.3
Browne, A.4
Rugheimer, E.5
Martin, E.6
-
45
-
-
0029790347
-
Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450
-
Ghosal, A., Satoh, H., Thomas, P. E., Bush, E. and Moore, D.: Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450. Drug Metab. Dispos., 24: 940-947 (1996).
-
(1996)
Drug Metab. Dispos
, vol.24
, pp. 940-947
-
-
Ghosal, A.1
Satoh, H.2
Thomas, P.E.3
Bush, E.4
Moore, D.5
-
46
-
-
0033714947
-
Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level
-
Cotreau, M. M., von Moltke, L. L., Beinfeld, M. C. and Greenblatt, D. J.: Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level. J. Pharmacol. Toxicol. Methods, 43: 41-54 (2000).
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.43
, pp. 41-54
-
-
Cotreau, M.M.1
von Moltke, L.L.2
Beinfeld, M.C.3
Greenblatt, D.J.4
-
47
-
-
0141569628
-
Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug resistance 1 subfamily mRNAS in small intestine
-
Takara, K., Ohnishi, N., Horibe, S. and Yokoyama, T.: Expression profiles of drug-metabolizing enzyme CYP3A and drug efflux transporter multidrug resistance 1 subfamily mRNAS in small intestine. Drug Metab. Dispos., 31: 1235-1239 (2003).
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 1235-1239
-
-
Takara, K.1
Ohnishi, N.2
Horibe, S.3
Yokoyama, T.4
-
48
-
-
0038340961
-
The site-specific transport and metabolism of tacrolimus in rat small intestine
-
Tamura, S., Tokunaga, Y., Ibuki, R., Amidon, G. L., Sezaki, H. and Yamashita, S.: The site-specific transport and metabolism of tacrolimus in rat small intestine. J. Pharmacol. Exp. Ther., 306: 310-316 (2003).
-
(2003)
J. Pharmacol. Exp. Ther
, vol.306
, pp. 310-316
-
-
Tamura, S.1
Tokunaga, Y.2
Ibuki, R.3
Amidon, G.L.4
Sezaki, H.5
Yamashita, S.6
-
49
-
-
0033525886
-
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
-
Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P. and Negishi, M.: The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem., 274: 6043-6046 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 6043-6046
-
-
Sueyoshi, T.1
Kawamoto, T.2
Zelko, I.3
Honkakoski, P.4
Negishi, M.5
-
50
-
-
0036070955
-
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor
-
Goodwin, B., Hodgson, E., D'Costa, D. J., Robertson, G. R. and Liddle, C.: Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol. Pharmacol., 62: 359-365 (2002).
-
(2002)
Mol. Pharmacol
, vol.62
, pp. 359-365
-
-
Goodwin, B.1
Hodgson, E.2
D'Costa, D.J.3
Robertson, G.R.4
Liddle, C.5
-
51
-
-
0037016761
-
Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
-
Gerbal-Chaloin, S., Daujat, M., Pascussi, J. M., Pichard-Garcia, L., Vilarem, M. J. and Maurel, P.: Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. J. Biol. Chem., 277: 209-217 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 209-217
-
-
Gerbal-Chaloin, S.1
Daujat, M.2
Pascussi, J.M.3
Pichard-Garcia, L.4
Vilarem, M.J.5
Maurel, P.6
-
52
-
-
0034635529
-
The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/ 3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated transactivation
-
Kassam, A., Winrow, C. J., Fernandez-Rachubinski, F., Capone, J. P. and Rachubinski, R. A.: The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/ 3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated transactivation. J. Biol. Chem., 275: 4345-4350 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 4345-4350
-
-
Kassam, A.1
Winrow, C.J.2
Fernandez-Rachubinski, F.3
Capone, J.P.4
Rachubinski, R.A.5
|