Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases

Journal of Medicinal Chemistry

Volumn 55, Issue 14, 2012, Pages 6639-6643

  Rose, Nathan R ^a,b   Woon, Esther C Y ^b,d   Tumber, Anthony ^a   Walport, Louise J ^b   Chowdhury, Rasheduzzaman ^b   Li, Xuan Shirley ^a   King, Oliver N F ^b   Lejeune, Clarisse ^a,b   Ng, Stanley S ^a   Krojer, Tobias ^a   Chan, Mun Chiang ^b   Rydzik, Anna M ^b   Hopkinson, Richard J ^b   Che, Ka Hing ^a   Daniel, Michelle ^a   Strain Damerell, Claire ^a   Gileadi, Carina ^a   Kochan, Grazyna ^a   Leung, Ivanhoe K H ^b   Dunford, James ^a   Yeoh, Kar Kheng ^c   Ratcliffe, Peter J ^c   Burgess Brown, Nicola ^a   Von Delft, Frank ^a   Muller, Susanne ^a   Marsden, Brian ^a   Brennan, Paul E ^a   McDonough, Michael A ^b   Oppermann, Udo ^a   Klose, Robert J ^a   Schofield, Christopher J ^b   Kawamura, Akane ^b   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DAMINOZIDE; ENZYME INHIBITOR; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE INHIBITOR; PROTEIN KDM2; PROTEIN KDM7; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLOGRAPHY; DEMETHYLATION; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; HUMAN;

ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MODELS, MOLECULAR; PLANT GROWTH REGULATORS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; SUCCINATES;

EID: 84864199553     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300677j     Document Type: Article

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