Binding of 2′-Amino-2′-Deoxycytidine-5′-Triphosphate to Norovirus Polymerase Induces Rearrangement of the Active Site

Journal of Molecular Biology

Volumn 390, Issue 1, 2009, Pages 10-16

  Zamyatkin, Dmitry F ^a   Parra, Francisco ^b   Machín, Ángeles ^b   Grochulski, Pawel ^c   Ng, Kenneth K S ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^c CANADIAN LIGHT SOURCE INC   (Canada)

Author keywords

antiviral; calicivirus; enzyme inhibitor; positive strand RNA virus; viral replication

Indexed keywords

2' AMINO 2' DEOXYCYTIDINE 5' TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; RNA POLYMERASE; UNCLASSIFIED DRUG; 2'-AMINO-2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE; CYTIDINE TRIPHOSPHATE; DRUG DERIVATIVE; ENZYME INHIBITOR; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; MOLECULAR MECHANICS; NONHUMAN; NOROVIRUS; PRIORITY JOURNAL; CHEMISTRY; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CALICIVIRIDAE; NOROVIRUS; RNA VIRUSES;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTIDINE TRIPHOSPHATE; ENZYME INHIBITORS; NOROVIRUS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA REPLICASE; VIRAL PROTEINS;

EID: 67349175999     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.04.069     Document Type: Article

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