Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; Application of buchwald-hartwig aminations of heterocycles

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4422-4441

  Gangjee, Aleem ^a   Namjoshi, Ojas A ^a   Raghavan, Sudhir ^a   Queener, Sherry F ^b   Kisliuk, Roy L ^c   Cody, Vivian ^d  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TUFTS UNIVERSITY   (United States)

^d HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 BROMO PYRIDO[2,3 D]PYRIMIDINE; ANILINE DERIVATIVE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CROSS COUPLING REACTION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR MODEL; PNEUMOCYSTIS JIROVECI;

AMINATION; ANILINE COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FOLIC ACID ANTAGONISTS; HUMANS; MODELS, MOLECULAR; MYCOBACTERIUM AVIUM; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS JIROVECII; PYRIDINES; PYRIMIDINES; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84879051542     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400086g     Document Type: Article

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