Structure-based design and synthesis of lipophilic 2,4-diamino-6- substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents

Journal of Medicinal Chemistry

Volumn 41, Issue 18, 1998, Pages 3426-3434

  Gangjee, Aleem ^a   Vidwans, Anup P ^a   Vasudevan, Anil ^a,e   Queener, Sherry F ^b   Kisliuk, Roy L ^c   Cody, Vivian ^d   Li, Ruming ^d   Galitsky, Nikolai ^d   Luft, Joe R ^d   Pangborn, Walter ^d  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^e ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 [N (2',5' DIMETHOXYBENZYL) N METHYLAMINO]PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINOQUINAZOLINE DERIVATIVE; DIHYDROFOLATE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN TISSUE; NONHUMAN; PNEUMOCYSTIS CARINII; RAT; TOXOPLASMA GONDII;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HUMANS; LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NADP; PNEUMOCYSTIS; PYRIDINES; PYRIMIDINES; QUINAZOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TUMOR CELLS, CULTURED;

EID: 15144358589     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980081y     Document Type: Article

References (34)

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