Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: Synthesis and biological activities of 2,4- diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines

Journal of Medicinal Chemistry

Volumn 42, Issue 13, 1999, Pages 2447-2455

  Gangjee, Aleem ^a   Adair, Ona ^a   Queener, Sherry F ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PNEUMOCYSTIS CARINII; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII;

ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; MICE; MICE, INBRED ICR; PNEUMOCYSTIS; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TUMOR CELLS, CULTURED;

EID: 0033168020     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990079m     Document Type: Article

References (36)

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36. We thank the Developmental Therapeutics Program of the NCI for performing the in vitro anticancer evaluation.