Drug treatment of HIV-related opportunistic infections

Drugs

Volumn 53, Issue 1, 1997, Pages 40-73

  Klepser, Michael E ^a   Klepser, Teresa B ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMPHOTERICIN B; ATOVAQUONE; CLARITHROMYCIN; CLINDAMYCIN; CORTICOSTEROID; COTRIMOXAZOLE; DAPSONE; ETHAMBUTOL; FLUCYTOSINE; FOLINATE CALCIUM; FOLINIC ACID; FOSCARNET; GANCICLOVIR; ISONIAZID; ITRACONAZOLE; KETOCONAZOLE; PENTAMIDINE; PYRAZINAMIDE; PYRIMETHAMINE; RECOMBINANT ALPHA2A INTERFERON; RIFABUTIN; RIFAMPICIN; SULFADIAZINE; THIOACETAZONE; TRIMETHOPRIM; TRIMETREXATE; TUBERCULOSTATIC AGENT; UNINDEXED DRUG; VALACICLOVIR;

BLOOD TOXICITY; CANDIDIASIS; CLINICAL TRIAL; COCCIDIOIDOMYCOSIS; COCCIDIOSIS; CRYPTOCOCCOSIS; CYTOMEGALOVIRUS INFECTION; DRUG TOXICITY; GASTROINTESTINAL TOXICITY; HERPES SIMPLEX; HERPES ZOSTER; HISTOPLASMOSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; INTRAVITREAL DRUG ADMINISTRATION; KAPOSI SARCOMA; LIVER TOXICITY; MYCOBACTERIOSIS; NAUSEA; NEPHROTOXICITY; NEUROTOXICITY; OPPORTUNISTIC INFECTION; OPTIC NERVE DISEASE; ORAL DRUG ADMINISTRATION; OTOTOXICITY; PNEUMOCYSTIS PNEUMONIA; REVIEW; SIDE EFFECT; SKIN DISEASE; TOPICAL DRUG ADMINISTRATION; TOXOPLASMOSIS; TUBERCULOSIS;

CYTOMEGALOVIRUS; HERPES; HERPES ZOSTER; HUMAN IMMUNODEFICIENCY VIRUS; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM AVIUM COMPLEX; MYCOBACTERIUM TUBERCULOSIS; PNEUMOCYSTIS CARINII; SIMPLEXVIRUS;

EID: 0031037171     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199753010-00004     Document Type: Review

References (178)

1. Farizo KM, Buehler JW, Chamberland MK, at al. Spectrum of disease in persons with human immunodeficiency virus infection in the United States. JAMA 1992 Apr 1; 267(13): 1798-805
2. Kaplan JE, Masur H, Holmes KK, et al. USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: introduction. Clin Infect Dis 1995 Aug; 21 Suppl. 1: S1-11
3. Pneumocystis pneumonia - Los Angeles. MMWR Morb Mortal Wkly Rep 1981; 30: 250-2
4. Selik RM, Chu SY, Ward JW. Trends in infectious diseases and cancers among persons dying of HIV infection in the United States from 1987 to 1992. Ann Intern Med 1995 Dec 15; 123 (12): 933-6
5. Sattler FR, Cowan R, Nielsen DM, et al. Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a prospective, noncrossover study. Ann Intern Med 1988 Aug 15; 109: 280-7
6. Klein NC, Duncanson FP, Lenox TH, et al. Trimethoprim-sulfamethoxazole versus pentamidine for Pneumocystis carinii pneumonia in AIDS patients: results of a large prospective randomized treatment trial. AIDS 1992 Mar; 6 (3): 301-5
7. Medina I, Mills J, Leoung G, et al. Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone. N Engl J Med 1990 Sep 20; 323 (12): 776-82
8. Hughes W, Leoung G, Kramer F, et al. Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS. N Engl J Med 1993 May 27; 328 (21): 1521-7
9. Dohn MN, Weinberg WG, Torres RA, et al. Oral atovaquone compared with intravenous pentamidine for Pneumocystis carinii pneumonia in patients with AIDS. Ann Intern Med 1994 Aug 1; 121 (3): 174-180
10. Toma E, Fournier S, Dumont M, et al. Clindamycin/primaquine versus trimethoprim-sulfamethoxazole as primary therapy for Pneumocystis carinii pneumonia in AIDS: a randomized, double blind pilot trial. Clin Infect Dis 1993 Aug; 17 (2): 178-84
11. Sattler FR, Frame P, Davis R, et al. Trimetrexate with leucovorin versus trimethoprim-sulfamethoxazole for moderate to severe episodes of Pneumocystis carinii pneumonia in patients with AIDS: a prospective, controlled multicenter investigation of the AIDS Clinical Trials Group Protocol 029/031. J Infect Dis 1994 Jul; 170 (1): 165-72
12. Falloon J, Kovacs J, Hughes W, et al. A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrone. N Engl J Med 1991 Nov 28; 325 (22): 1534-8
13. Black JR, Feinberg J, Murphy RL, et al. Clindamycin and primaquine therapy for mild-to-moderate episodes of Pneumocystis carinii pneumonia in patients with AIDS: AIDS Clinical Trials Group 044. Clin Infect Dis 1994 Jun; 18 (6): 905-13
14. Toma E. Clindamycin/primaquine for treatment of Pneumocystis carinii pneumonia in AIDS. Eur J Clin Microbiol Infect Dis 1991 Mar; 10 (3): 210-3
15. Chin TW, Vanderbroucke A, Foy IW. Pharmacokinetics of trimethoprim-sulfamethoxazole in critically-ill and non-critically ill AIDS patients. Antimicrob Agents Chemother 1995 Jun; 39 (1): 28-33
16. Klepser ME, Zhu Z, Nicolau DP, et al. Characterization of oral absorption for trimethoprim-sulfamethoxazole (160mg/ 800mg) in patients with AIDS. Pharmacotherapy 1996 July-Aug; 16 (4): 656-62
17. Bozzette SA, Sattler FR, Chiu J, et al. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. N Engl J Med 1990 Nov 22; 323 (21): 1451-7
18. Gagnon S, Boota AM, Fischl MA, et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a double-blind, placebo-controlled trial. N Engl J Med 1990 Nov 22; 323(21): 1444-50
19. Montaner JSG, Lawson LM, Levitt N, et al. Corticosteroids prevent early deterioration in patients with moderately severe Pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome (AIDS). Ann Inlern Med 1990 Jul 1; 113 (1): 14-20
20. National Institutes of Health-University of California Expert Panel for Corticosteroids as Adjunctive Therapy for Pneumocystis Pneumonia. Consensus statement on the use of corticosteroids as adjunctive therapy for Pneumocystis pneumonia in the acquired immunodeficiency syndrome. N Engl J Med 1990 Nov 22; 323 (21): 1500-4
21. Schneider MME, Hoepelman AIM, Schattenkerk JKME, et al. A control led trial of aerosolized pentamidine or trimethoprimsulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection. N Engl J Med 1992 Dec 24; 327 (26): 1836-41
22. Hardy WD, Feinberg J, Finkelstein DM, et al. A controlled trial of trimethoprim-sulfamethoxazole or aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome: AIDS clinical trials group protocol 021. N Engl J Med 1992 Dec 24; 327 (26): 1842-8
23. Bozzette SA, Kinkelstein DM, Spector SA, et al. A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. N Engl J Med 1995 Mar 16; 332 (11): 693-9
24. Blum RN, Miller LA, Gaggini LC, et al. Comparative trial of dapsone versus trimethoprim/sulfamethoxazole for primary prophylaxis of Pneumocystis carinii pneumonia. J Acquir Immune Defic Syndr 1992 Apr; 5 (4): 341-7
25. Mallolas J, Zamora L, Gatell JM, et al. Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine. AIDS 1993 Jan; 7 (1): 59-64
26. Salmon-Ceron D, Fontbonne A, Saba J, et al. Lower survival in AIDS patients receiving dapsone compared with aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia. J Infect Dis 1995 Sep; 172 (3): 656-64
27. Slavin MA, Hoy JF, Stewart K, et al. Oral dapsone versus nebulized pentamidine for Pneumocystis carinii pneumonia prophylaxis: an open randomized prospective trial to assess efficacy and haematological toxicity. AIDS 1992 Oct; 6 (10): 1169-74
28. Podzamezer D, Salazar A, Jimenez J, et al. Intermittent trimethoprim-sulfamethoxazole compared with dapsone-pyrimethamine for the simultaneous primary prophylaxis of Pneumocystis pneumonia and toxoplasmosis in patients infected with HIV. Ann Intern Med 1995 May 15; 122 (10): 755-61
29. Dannemann B, McCutchan JA, Israelski D, et al. Treatment of toxoplasmic encephalitis in patients with AIDS: a randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. Ann Intern Med 1992 Jan 1; 116 (1): 33-43
30. Ruf B, Pohle HD. Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system. Eur J Clin Microbiol Infect Dis 1991 Mar; 10 (3): 183-6
31. Canessa A, Del Bono V, De Leo P et al. Cotrimoxazole therapy of Toxoplasma gondii encephalitis in AIDS patients. Eur J Clin Microbiol Infect Dis 1992 Feb; 11 (2): 125-30
32. Lacassin F, Schaffo D, Perronne C, et al. Clarithromycin-minocycline combination as salvage therapy for toxoplasmosis in patients infected with human immunodeficiency virus. Antimicrob Agents Chemother 1995 Jan; 39 (1): 276-7
33. Masur H, Polis MA, Tuazon CU, et al. Salvage trial of trimetrexate-leucovorin for the treatment of cerebral toxoplasmosis in patients with AIDS. J Infect Dis 1993 Jun; 167 (6): 1422-6
34. Kovacs JA, NIAID-Clinical Center Intramural AIDS Program. Efficacy of atovaquone in treatment of toxoplasmosis in patients with AIDS. Lancet 1992 Sep 12; 340 (8820): 637-8
35. Pedrol E, Gonzalez-Clemente JM, Gatell JM, et al. Central nervous system toxoplasmosis in AIDS patients: efficacy of an intermittent maintenance therapy. AIDS 1990 Jun; 4 (6): 511-7
36. de Gans J, Portegies P, Reiss P, et al. Pyrimethamine alone as maintenance therapy for central nervous system toxoplasmosis in 38 patients with AIDS. J Acquir Immune Defic Syndr 1992 Feb; 5 (2): 137-41
37. Leport C, Tournerie C, Raguin G, et al. Long-term follow-up of patients with AIDS on maintenance therapy for toxoplasmosis. Eur J Clin Microbiol Infect Dis 1991 Mar; 10 (3): 191-3
38. Carr A, Tindall B, Brew BJ, et al. Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS. Ann Intern Med 1992 Jul 15; 117 (2): 106-11
39. Girard PM, Landman R, Gaudebout C, et al. Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. N Engl J Med 1993 May 27; 328 (21): 1514-20
40. Torres RA, Barr M, Thorn M, et al. Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. Am J Med 1993 Dec; 95 (6): 573-83
41. Dismukes WE, Cloud G, Gallis HA, et al. Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks. N Engl J Med 1987 Aug 6; 317 (6): 334-41
42. de Lalla F, Pellizzer G, Vaglia A, et al. Amphotericin B as primary therapy for cryptococcosis in patients with AIDS: reliability of relatively high doses administered over a relatively short period. Clin Infect Dis 1995 Feb; 20 (2): 263-6
43. Saag MS, Powderly WG, Cloud GA, et al. Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. N Engl J Med 1992 Jan 9; 326 (2): 83-9
44. Larsen RA, Leal MAE, Chan LS. Fluconazole compared with amphotericin B plus flucytosine for cryptococcal meningitis in AIDS. Ann Intern Med 1990 Aug 1; 113 (3): 183-7
45. de Gans J, Portegies P, Tiessens G, et al. Itraconazole compared with amphotericin B plus flucytosine in AIDS patients with cryptococcal meningitis. AIDS 1992 Feb; 6 (2): 185-90
46. Larsen RA, Bozzette SA, Jones BE, et al. Fluconazole combined with flucytosine for treatment of cryptococcal meningitis in patients with AIDS. Cli Infect Dis 1994 Oct; 19 (4): 741-5
47. Powderly WG, Saag MS, Cloud GA, et al. A controlled trial of fluconazole or amphotericin B to prevent relapse of cryptococcal meningitis in patients with the acquired immunodeficiency syndrome. N Engl J Med 1992 Mar 19; 326 (12): 793-8
48. Bozzette SA, Larsen RA, Chiu J, et al. A placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. N Engl J Med 1991 Feb 28; 324 (9): 580-4
49. Nelson MR, Fisher M, Cartledge J, et al. The role of azoles in the treatment and prophylaxis of cryptococcal disease in HIV infection. AIDS 1994 May; 8 (5): 651-4
50. Klepser ME, Wolfe EJ, Pfaller MA. Characterization of the fungicidal dynamics of fluconazole and amphotericin B against Cryptococcus neoformans [abstract no. 77]. In: Program and Abstracts, 34th Infectious Diseases Society of America. New Orleans (LA): Infectious Diseases Society of America, 1996
51. Wheat LJ, Connolly-Stringfield PA, Baker RL, et al. Disseminated histoplasmosis in the acquired immune deficiency syndrome: clinical findings, diagnosis and treatment, and review of the literature. Medicine 1990 Nov; 69 (6): 361-74
52. Johnson PC, Hamill RJ, Sarosi GA. Clinical review: progressive disseminated histoplasmosis in the AIDS patient. Semin Respir Infect 1989 Jun; 4 (2): 139-46
53. McKinsey DS, Gupta MR, Riddler SA, et al. Long-term amphotericin B therapy for disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1989 Oct 15; 111 (8): 655-9
54. Dismukes WE, Bradsher RW, Cloud GC, et al. Itraconazole therapy for blastomycosis and histoplasmosis. Am J Med 1992 Nov; 93 (5): 489-97
55. Negroni R, Taborda A, Robies AM, et al. Itraconazole in the treatment of histoplasmosis associated with AIDS. Mycoses 1992 Nov-Dec; 35 (11-12): 281-7
56. Wheat J, Hafner R, Korzun AH, et al. Itraconazole treatment of disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome. Am J Med 1995 Apr; 98 (4): 336-42
57. Morris S, Wheat J, McKinsey D, et al. Prevention of relapse of histoplasmosis with fluconazole in patients with the acquired immunodeficiency syndrome. Am J Med 1994 Jun; 96 (6): 504-8
58. Wheat J, Hafner R, Wulfsohn M, et al. Prevention of relapse of histoplasmosis with itraconazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1993 Apr 15; 118 (8): 610-6
59. Small PM, Scheeler GK Goodman PC, et al. Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection. N Engl J Med 1991 Jan 31; 324 (5): 289-94
60. Schürmann D, Bergmann F, Jautzke G, et al. Acute and long-term efficacy of antituberculous treatment in HIV-seropositive patients with tuberculosis: a study of 36 cases. J Infect 1993 Jan; 26 (1): 45-54
61. American Thoracic Society Treatment of tuberculosis and tuberculosis infection in adults and children. Am J Respir Crit Care Med 1994 May; 149 (5): 1359-74
62. Steele MA, Burk RF, DesPrez RM. Toxic hepatitis with isoniazid and rifampin, a meta-analysis. Chest 1991 Feb; 99 (2): 465-71
63. World Health Organization. Severe hypersensitivity reactions among HIV-seropositive patients with tuberculosis treated with thioacetazone. Wkly Epidemiol Record 1992; 67: 1-3
64. Barnes PF, Bloch AB, Davidson PT, et al. Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med 1991 Jun 6; 324 (23): 1644-50
65. Horsburgh CR, Havlik JA, Ellis DA, et al. Survival of patients with acquired immune deficiency syndrome and disseminated Mycobacterium avium complex infection with and without antimycobacterial chemotherapy. Am Rev Respir Dis 1991 Sep; 144 (3 Pt 1): 557-9
66. Chin DP, Reingold AL, Stone EN, et al. The impact of Mycobacterium avium complex bacteremia and its treatment on survival of AIDS patients-a prospective study. J Infect Dis 1994 Sep; 170 (3): 578-84
67. Kerlikowske KM, Katz MH, Chan AK, et al. Antimycobacterial therapy for disseminated Mycobacterium avium complex infection in patients with acquired immunodeficiency syndrome. Arch Intern Med 1992 Apr; 152 (4): 813-7
68. Olliaro P, Dautzenberg B. Control of the body burden of M. avium complex is associated with improved quality of life and prolonged survival of patients with AIDS: a prospective trial with rifabutin combined with isoniazid, clofazimine, ethambutol. J Chemother 1994 Jun; 6 (3): 189-96
69. Nightingale SD, Cameron DW, Gordin FM, et al. Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. N Engl J Med 1993 Sep 16; 329 (12): 828-33
70. Jacobson MA, Yajko D, Northfelt D, et al. Randomized, placebo-controlled trial of rifampin, ethambutol, and ciprofloxacin for AIDS patients with disseminated Mycobacterium avium complex infection. J Infect Dis 1993 Jul; 168 (1): 112-9
71. Shafran SD, Singer J, Zarowny DP, et al. A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin. N Engl J Med 1996 Aug 8; 335 (6): 377-83
72. Kemper CA, Havlir D, Haghighat D, et al. The individual microbiologie effect of three antimycobacterial agents, clofazimine, ethambutol, and rifampin, on Mycobacterium avium complex bacteremia in patients with AIDS. J Infect Dis 1994 Jul; 170 (1): 157-64
73. Sullam PM, Gordin FM, Wynne BA, et al. Efficacy of rifabutin in the treatment of disseminated infection due to Mycobacterium avium complex. Clin Infect Dis 1994 Jul; 19 (1): 84-6
74. Chin J, Nussbaum J, Bozzette S, et al. Treatment of disseminated Mycobacterium avium complex infection in AIDS with amikacin, ethambutol, rifampin, and ciprofloxacin. Ann Intern Med 1990 Sep 1; 113 (5): 358-61
75. Kissinger P, Clark R, Morse A, et al. Comparison of multiple drug therapy regimens for HIV-related disseminated Mycobacterium avium complex disease. J Acquir Immune Defic Syndr Hum Retrovirol 1995 Jun 1; 9 (2): 133-7
76. Baron FJ, Young LS. Amikacin, ethambutol, and rifampin for treatment of disseminated Mycobacterium avium-intracellulare infections in patients with acquired immune deficiency syndrome. Diagn Microbiol Infect Dis 1986 Sep; 5 (3): 215-20
77. Jorup-Rönström C, Julander I, Petrini B. Efficacy of triple drug regimen of amikacin, ethambutol and rifabutin in AIDS patients with symptomatic Mycobacterium avium complex infection. J Infect 1993 Jan; 26 (1): 67-70
78. Kemper CA, Meng TC, Nussbaum J, et al. Treatment of Mycobacterium avium complex bacteremia in AIDS with a four-drug oral regimen: rifampin, ethambutol, clofazimine, and ciprofloxacin. Ann Intern Med 1992 Mar 15; 116 (6): 466-72
79. Hoy J, Mijch A, Sandland M, et al. Quadruple-drug therapy for Mycobacterium avium-intracellulare bacteremia in AIDS patients. J Infect Dis 1990 Apr; 161 (4): 801-5
80. de Lalla F, Maserati R, Scarpellini P, et al. Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS. Antimicrob Agents Chemother 1992 Jul; 36 (7): 1567-9
81. Dautzenberg B, Marc TS, Meyohas MC, et al. Clarithromycin and other antimicrobial agents in the treatment of disseminated Mycobacterium avium infections in patients with acquired immunodeficiency syndrome. Arch Intern Med 1993 Feb 8; 153 (3): 368-72
82. Wallace RJ, Brown BA, Griffith DE, et al. Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. Am J Respir Crit Care Med 1994 May; 149 (5): 1335-41
83. Ruf B, Schürmann D, Mauch H, et al. Effectiveness of the macrolide clarithromycin in the treatment of Mycobacterium avium complex infection in HIV-infected patients. Infection 1992 Sep-Oct; 20 (5): 267-72
84. Chaisson RE, Benson CA, Dube MP, et al. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease: a randomized, double-blind, dose-ranging study in patients with AIDS. Ann Intern Med 1994 Dec 15; 121 (12): 905-11
85. Havlir DV, DubJ MP, Sattler FR, et al. Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. N Engl J Med 1996 Aug 8; 335 (6): 392-8
86. Pierce M, Crampton S, Henry D, et al. A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome. N Engl J Med 1996 Aug 8; 335 (6): 384-91
87. Jabs DA, Green WR, Fox R, et al. Ocular manifestations of acquired immunodeficiency syndrome. Ophthalmology 1989 Jul; 96 (7): 1092-9
88. Dieterich DT, Poles MA, Lew EA, et al. Concurrent use of ganciclovir and foscarnet to treat cytomegalovirus infection in AIDS patients. J Infect Dis 1993 May; 167 (5): 1184-8
89. Studies of ocular complications of AIDS research group, in collaboration with the AIDS clinical trials group. Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis. N Engl J Med 1992 Jan 23; 326 (4): 213-20
90. Moyle G, Harman C, Mitchell S, et al. Foscarnet and ganciclovir in the treatment of CMV retinitis in AIDS patients: a randomized comparison. J Infect 1992 Jul; 25 (1): 21-7
91. Harb GE, Bacchetti P, Jacobson MA. Survival of patients with AIDS and cytomegalovirus disease treated with ganciclovir or foscarnet. AIDS 1991 Aug; 5 (8): 959-65
92. Polis MA, De Smet MA, Baird BF, et al. Increased survival of a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis who received sodium phosphonoformate (foscarnet). Am J Med 1993 Feb; 94 (2): 175-80
93. Fanning MM, Read SE, Benson M, et al. Foscarnet therapy of cytomegalovirus retinitis in AIDS. J Acquir Immune Defic Syndr 1990; 3 (5): 472-9
94. Palestine AG, Polis MA, De Smet MA, et al. A randomized. controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Intern Med 1991 Nov 1; 115 (9): 665-73
95. Katlama C, Dohin E, Caumes E, et al. Foscarnet induction therapy for cytomegalovirus retinitis in AIDS: comparison of twice-daily and three-times-daily regimens. J Acquir Immune Defic Syndr 1992; 5 Suppl. 1: S18-24
96. Jacobson MA, O'Donnell JJ, Brodie HR, et al. Randomized prospective trial of ganciclovir maintenance therapy for cytomegalovirus retinitis. J Med Virol 1988 Jul; 25 (3): 339-49
97. Spector SA, Wingeist T, Pollard RB, et al. A randomized, controlled study of intravenous ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS. J Infect Dis 1993 Sep; 168 (3): 557-63
98. Peters M, Schürmann D, Bergmann F, et al. Safety of alternating ganciclovir and foscarnet maintenance therapy in human immunodeficiency virus (HIV)-related cytomegalovirus infections: an open-labeled pilot study. Scand J Infect Dis 1994; 26 (1): 49-54
99. Jacobson MA, Kramer F, Bassiakos Y, et al. Randomized phase I trial of two different combination foscarnet and ganciclovir chronic maintenance therapy regimens for AIDS patients with cytomegalovirus retinitis: AIDS clinical trials group protocol 151. J Infect Dis 1994 Jul; 170 (1): 189-93
100. Drew WL, Ives D, Lalezari JP, et al. Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. N Engl J Med 1995 Sep 7; 333 (10): 615-20
101. Oral Ganciclovir European and Australian Cooperative Study Group. Intravenous versus oral ganciclovir: European/Australian comparative study of efficacy and safety in the prevention of cytomegalovirus retinitis recurrence in patients with AIDS. AIDS 1995 May; 9 (5): 471-7
102. Spector SA, McKinley GF, Lalezari JP, et al. Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. N Engl J Med 1996 Jun 6; 334 (23): 1491-7
103. Diaz-Llopis M, Chipont E, Sanches S, et al. Intravitreal foscarnet for cytomegalovirus retinitis in a patient with acquired immunodeficiency syndrome. Am J Ophthalmol 1992 Dec 15; 114 (6): 742-7
104. Anand R, Font RL, Fish RH, et al. Pathology of cytomegalovirus retinitis treated with sustained release intravitreal ganciclovir. Ophthalmology 1993 Jul; 100 (7): 1032-9
105. Anderson RD, Griffy KG, Jung D, et al. Ganciclovir absolute bioavailability and steady-state pharmacokinetics alter oral administration of two 3000-mg/d dosing regimens in human immunodeficiency virus- and cytomegalovirus-seropositive patients. Clin Ther 1995 May-Jun; 17 (3): 425-32
106. Stevens DA. Coccidioidomycosis. N Engl J Med 1995 Apr 20; 332 (16): 1077-82
107. Drutz DJ. Amphotericin B in the treatment of coccidioidomycosis. Drugs 1983 Oct; 26 (4): 337-46
108. Galgiani JN, Stevens DA, Grayhill JR, et al. Ketoconazole therapy of progressive Coccidioidomycosis: comparison of 400-and 800-mg doses and observations at higher doses. Am J Med 1988 Mar; 84 (3): 603-10
109. DeFelice R, Galgiani JN, Camphell SC, et al. Ketoconazole treatment of nonprimary Coccidioidomycosis: evaluation of 60 patients during three years of study. Am J Med 1982 Apr; 72 (4): 681-7
110. Stevens DA, Stiller RL, Williams PL, et al. Experience with ketoconazole in three major manifestations of progressive Coccidioidomycosis. Am J Med 1983 Jan 24; 74 (1B): 58-63
111. Catanzaro A, Einstein H, Levine B, et al. Ketoconazole for treatment of disseminated Coccidioidomycosis. Ann Intern Med 1982 Apr; 96 (4): 436-40
112. Ross JB, Levine B, Catanzaro A, et al. Ketoconazole for treatment of chronic pulmonary Coccidioidomycosis. Ann Intern Med 1982 Apr; 96 (4): 440-3
113. Dismukes WE, Stamm AM, Graybill JR, et al. Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in 52 patients. Ann Intern Med 1983 Jan; 98 (1): 13-20
114. Welsh O, Gonzalez JG, Diaz M, et al. Therapeutic evaluation of ketoconazole in patients with Coccidioidomycosis. Rev Infect Dis 1980 Jul-Aug; 2 (4): 651-5
115. Tucker RM, Denning DW, Dupont B, et al. Itraconazole therapy for chronic coccidioidal meningitis. Ann Intern Med 1990 Jan 15; 112 (2): 108-12
116. Grayhill JR, Stevens DA, Galgiani JN, et al. Itraconazole treatment of Coccidioidomycosis. Am J Med 1990 Sep; 89 (3): 282-90
117. Tucker RM, Denning DW, Arathoon EG, et al. Itraconazole therapy for nonmeningeal Coccidioidomycosis: clinical and laboratory observations. J Am Acad Dermatol 1990 Sep; 23 (3 Pt 2): 593-601
118. Tucker RM, Galgiani JN, Denning DW, et al. Treatment of coccidioidal meningitis with fluconazole Rev Infect Dis 1990 Mar-Apr; 12 Suppl. 3: S380-9
119. DeHovitz JA, Pape JW, Boncy M, et al. Clinical manifestations and therapy of Isospora belli infection in patients with the acquired immunodeficiency syndrome. N Engl J Med 1986 Jul 10; 315 (2): 87-90
120. Pape JW, Verdier RI, Johnson WD. Treatment and prophylaxis of Isospora belli infection in patients with the acquired immunodeficiency syndrome. N Engl J Med 1989 Apr 20; 320 (16): 1044-7
121. Just-Nübling G, Gentschew G, Dohle M, et al. Fluconazole in the treatment of oropharyngeal candidosis in HIV-positive patients. Mycoses 1990 Sep-Oct; 33 (9-10): 435-40
122. Pons V, Greenspan D, Debruin M, et al. Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. J Acquir Immune Defic Syndr 1993 Dec; 6 (12): 1311-6
123. Chave JP, Francioli P, Hirschel B, et al. Single dose therapy for esophageal candidiasis [letter]. AIDS 1990 Oct; 4 (10): 1034-5
124. De Wit S, Goosens H, Clumeek N. Single-dose versus 7 days of fluconazole treatment for oral candidiasis in HIV-infected patients: a prospective, randomized pilot study [letter]. J Infect Dis 1993 Nov; 168 (5): 1332-3
125. Laine L, Dretler RH, Conteas CN, et al. Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. Ann Intern Med 1992 Oct 15; 117 (8): 655-60
126. Gil A, Lavilla P, Valencia E, et al. Safety and efficacy of fluconazole treatment for Candida oesophagitis in AIDS. Postgrad Med J 1991 Jun; 67 (788): 548-52
127. Agresti MG, de Bernardis F, Mondello F, et al. Clinical and mycological evaluation of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS patients. Eur J Epidemol 1994 Feb; 10 (1): 17-22
128. Parente F, Ardizzone S, Cernuschi M, et al. Prevention of symptomatic recurrences of esophageal candidiasis in AIDS patients after the first episode: a prospective open study. Am J Gastroenterol 1994 Mar; 89 (3): 416-20
129. Ruhnke M, Eigler A, Tennagen I, et al. Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection. J Clin Microbiol 1994 Sep; 32 (9): 2092-8
130. Newman SL, Flanigan TP, Fisher A, et al. Clinically significant mucosal candidiasis resistant to fluconazole treatment in patients with AIDS. Clin Infect Dis 1994 Oct; 19 (4): 684-6
131. Baily GG, Perry FM, Denning DW, et al. Fluconazole-resistant candidosis in an HIV cohort. AIDS 1994 Jun; 8 (6): 787-92
132. Podzamczer D, Bolao F, Clotet B, et al. Low-dose interferon alpha combined with zidovudine in patients with AIDS-associated Kaposi's sarcoma. J Intern Med 1993 Mar; 233 (3): 247-53
133. Rozenbaum W, Gharakhanian S, Navarette M, et al. Long-term follow-up of 120 patients with AIDS-related Kaposi's sarcoma treated with interferon alpha-2a. J Invest Dermatol 1990 Dec; 95 (6Suppl.): 161S-5S
134. 2a in the treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma. J Immunother 1991 Feb; 10 (1): 39-50
135. n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma. J Acquir Immune Defic Syndr 1991; 4 (1): 1-10
136. Volberding PA, Abrams DI, Conant M, et al. Vinblastine therapy for Kaposi's sarcoma in the acquired immunodeficiency syndrome. Ann Intern Med 1985 Sep; 103 (3): 335-8
137. Laubenstein LJ, Kriegel RL, Odajnk CM, et al. Treatment of endemic Kaposi's sarcoma with etoposide or a combination of doxorubicin, bleomycin, and vinblastine. J Clin Oncol 1984 Oct; 2 (10): 1115-20
138. Mintzer DM, Real FX, Jovino L, et al. Treatment of Kaposi's sarcoma and thrombocytopenia with vincristine in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1985 Feb; 102 (2): 200-2
139. Kaplan L, Abrams D, Volberding P. Treatment of Kaposi's sarcoma in acquired immunodeficiency syndrome with an alternating vincristine-vinblastine regimen. Cancer Treat Rep 1986 Sep; 70 (9): 1121-2
140. Gelmann EP, Longo D, Lane HC, et al. Combination chemotherapy of disseminated Kaposi's sarcoma in patients with the acquired immunodeficiency syndrome. Am J Med 1987 Mar; 82 (3): 456-62
141. Gill PS, Rarick M, Espina B, et al. Advanced AIDS-related Kaposi's sarcoma: results of pilot studies using combination chemotherapy (low-dose adriamycin, bleomycin, and vincristine). Cancer 1990 Mar 1; 65 (5): 1074-8
142. Gill P, Rarick M, Bernstein-Singer M. Treatment of advanced Kaposi's sarcoma using a combination of bleomycin and vincristine. Am J Oncol 1990; 13: 315-9
143. Harrison M, Tomlinson D, Stewart S. Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma. J Clin Oncol 1995 Apr; 13 (4): 914-20
144. Gil PS, Espina BM, Muggia E, et al. Phase I/II clinical and pharmacokinetic evaluation liposomal daunorubicin. J Clin Oncol 1995 Apr; 13 (4): 996-1003
145. Wagner D, Kern WV, Kern P. Liposomal doxorubicin in AIDS-related Kaposi's sarcoma: long-term experiences. Clin Invest 1994 Jun; 72 (6): 417-23
146. Paredes J, Kahn JO, Tong WP, et al. Weekly oral etoposide in patients with Kaposi's sarcoma associated with human immunodeficiency virus infection: a phase I multicenter trial of the AIDS clinical trials group. J Acquir Immune Defic Syndr 1995 Feb; 9 (2): 138-44
147. Bogner JR, Kronawitter U, Rolinski B, et al. Liposomal doxorubicin in the treatment of advanced AIDS-related Kaposi's sarcoma. J Acquir Immune Defic Syndr 1994 May; 7 (5): 463-8
148. Kalb RE, Grossman ME. Chronic perianal herpes simplex in inimunocompromised hosts. Am J Med 1986 Mar; 80 (3): 1486-90
149. Rompalo AM, Mertz GJ, Davis LG, et al. Oral acyclovir for treatment of first-episode herpes simplex virus proctitis. JAMA 1988 May 20; 259 (19): 2879-81
150. Straus SE, Seidlin M, Takiff H, et al. Oral acyclovir to suppress recurring herpes simplex virus infections in immunodeficient patients. Ann Intern Med 1984 Apr; 100 (4): 522-4
151. Conant MA. Prophylactic and suppressive treatment with acyclovir and the management of herpes in patients with acquired immunodeficiency syndrome. J Am Acad Dermatol 1988 Jan; 18 (1 Pt 2): 186-8
152. Whitley RJ, Alford CA, Hirsch MS, et al. Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med 1986 Jan 16; 314 (3): 144-9
153. Sköldenberg B, Alestig K, Burman L, et al. Acyclovir versus vidarabine in herpes simplex encephalitis: randomized multicenter study in consecutive Swedish patients. Lancet 1984 Sep 29; 11 (8405): 707-11
154. International Valaciclovir HSV Study Group, Smiley ML. Wellcome Foundation. Valaciclovir and acyclovir for the treatment of recurrent genital herpes simplex virus infections [abstract no. 1210]. In: Program and abstracts of the 33rd ICAAC. Washington. DC: American Society for Microbiology, 1993
155. Bacon TH, Schinazi RF. An overview of the further evaluation of peniciclovir against herpes simplex virus and varicella-zoster virus in cell culture highlighting contrasts with acyclovir. Antiviral Chem Chemother 1993; 4 Suppl. 1: 25-36
156. Erlich KS, Mills J, Chalis P, et al. Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. N Engl J Med 1989 Feb 2; 320 (5): 293-6
157. Chatis PA, Miller CH, Schrager, et al. Successful treatment with foscarnet of an acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with the acquired immunodeficiency syndrome. N Engl J Med 1989 Feb 2; 320 (5): 297-300
158. Safrin S, Crumpacker C, Chatis P, et al. A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. N Engl J Med 1991 Aug 22; 325 (8): 551-5
159. Safrin S, Assaykeen T, Follansbee S, et al. Foscarnet therapy for acyclovir-resistant mucocutaneous herpes simplex virus infection in 26 AIDS patients: preliminary data. J Infect Dis 1990 Jun; 161 (6): 1078-84
160. Erlich KS, Jacobson MA, Koehler JE, et al. Foscarnet therapy for severe acyclovir-resistant herpes simplex virus type-2 infections in patients with the acquired immunodeficiency syndrome (AIDS): an uncontrolled trial. Ann Intern Med 1989 May 1; 110 (9): 710-3
161. Engel JP, Englund JA, Fletcher CV, et al. Treatment of resistant herpes simplex virus with continuous-infusion acyclovir. JAMA 1990 Mar 23/30; 263 (12): 1662-4
162. Fletcher CV, Englund JA, Bean B, et al. Continuous infusion of high-dose acyclovir for serious herpes virus infections. Antimirob Agents Chemother 1989 Aug; 33 (8): 1375-8
163. Snoeck R, Andrei G, Gerard M, et al. Successful treatment of progressive mucocutaneous infection due to acyclovir and foscarnet-resistant herpes simplex virus with (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC). Clin Infect Dis 1994 Apr; 18 (4): 570-8
164. Lalezari JP, Drew WL, Glutzer E, et al. Treatment with intravenous (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)cytosine of acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with AIDS. J Infect Dis 1994 Sep; 170 (3): 570-2
165. Birch CJ, Tyssen DP, Tachedjian G, et al. Clinical effects and in vitro studies of trifluorothymidine combined with interferon-alpha for treatment of drug-resistant and -sensitive herpes simplex virus infections. J Infect Dis 1992 Jul; 166 (1): 108-12
166. Balfour HH, Benson C, Braun J, et al. Management of acyclovir-resistant herpes simplex and varicella-zoster virus infections. J Acquir Immune Defic Syndr 1994 Mar; 7 (3): 254-60
167. Kaplan MH, Sadick N, McNutt NS, et al. Dermatologic findings and manifestations of acquired immunodeficiency syndrome (AIDS). J Am Acad Dermatol 1987 Mar; 16 (3 Pt 1): 485-506
168. Cohen PR, Beltrani VP, Grossman ME. Disseminated herpes zoster in patients with human immunodeficiency virus infection. Am J Med 1988 Jun; 84 (6): 1076-80
169. Gilson IH, Barnett JH, Conant MA, et al. Disseminated ecthymatous herpes varicella-foster virus infection in patients with acquired immunodeficiency syndrome. J Am Acad Dermatol 1989 Apr; 20 (4): 637-42
170. Wood MJ, Johnson RW, McKendrick MW, et al. A randomized trial of acyclovir for 7 days or 21 days with and without prednisolone for treatment of acute herpes zoster. N Engl J Med 1994 Mar 31; 330 (13): 896-900
171. Linnemann CC, Biron KK, Hoppenjans, et al. Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy. AIDS 1990 Jun; 4 (6): 577-9
172. Safrin S, Berger TG, Gilson I, et al. Foscarnet therapy in five patients with AIDS and acyclovir-resistant varicella-zoster virus infection. Ann Intern Med 1991 Jul 1; 115 (1): 19-21
173. Smiley ML, International Valaciclovir Zoster Study Group. The efficacy and safely of valaciclovir for the treatment of herpes zoster [abstract no. 1203]. In: Program and abstracts of the 33rd ICAAC. Washington, DC: American Society for Microbiology, 1993
174. Tyring S, Barbarash RA, Nahlik JE, et al. Famciclovir for the treatment of acute herpes zoster: effects on acute diseuse and postherpatic neuralgia: a randomized, double-blind, placebo-controlled trial: Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med 1995 Jul 15; 123 (2): 89-96
175. Gheeraert P, Famciclovir Herpes Zoster Clinical Study Group. Efficacy and safety of famciclovir in the treatment of uncomplicated herpes zoster [abstract no. 1108]. In: Program and abstracts of the 33rd ICAAC. Washington, DC: American Society for Microbiology, 1993
176. Heidl M, Scholz H, Dorffel W, et al. Antiviral therapy of varicella-zoster virus infection in immunocompromised children-a prospective randomized sludy of acyclovir versus brivudin. Infection 1991 Nov-Dec; 19 (6): 401-5
177. Nimura M. A double-blind clinical study in patients with herpes zoster to establish YN-72 (Brovavir) dose. Adv Exper Med Bio 1990; 278: 267-75
178. Hiraoka A, Masaoka T, Nagai K, et al. Clinical effect of BV-araU on varicella-zoster virus infection in immunocompromised patients with haematological malignancies. J Antimicrob Chemother 1991 Mar; 27 (3): 361-7