Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii

Journal of Medicinal Chemistry

Volumn 40, Issue 7, 1997, Pages 1173-1177

  Gangjee, A ^a   Mavandadi, F ^a   Queener, S F ^a  

^a DUQUESNE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 [(2' NAPHTHYLTHIO)METHYL]PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [(2',5' DIMETHOXY N METHYLANILINO)METHYL]PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [[(3',4' DIMETHOXYPHENYL)THIO]METHYL]PYRROLO[2,3 D]PYRIMIDINE; ANTIPROTOZOAL AGENT; DIHYDROFOLATE REDUCTASE INHIBITOR; N [4 [N [(2,4 DIAMINOPYRROLO[2,3 D]PYRIMIDIN 5 YL)METHYL]METHYLAMINO]BENZOYL]GLUTAMIC ACID; UNCLASSIFIED DRUG; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; FOLIC ACID ANTAGONIST; PYRIMIDINE DERIVATIVE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; NONHUMAN; PNEUMOCYSTIS CARINII; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII; ANIMAL; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; LIVER; METHYLATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PNEUMOCYSTIS; RAT; TOXOPLASMA;

ANIMALS; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; PNEUMOCYSTIS; PYRIMIDINES; RATS; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA;

EID: 0030610833     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960717q     Document Type: Article

References (19)