Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 1, 2003, Pages 59-67

  Rosowsky, Andre ^a   Chen, Han ^a   Fu, Hongning ^a   Queener, Sherry F ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 (3',4',5' TRIMETHOXYBENZYL) 7H PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [2 (3',4',5' TRIMETHOXYPHENYL)ETHYL] 7H PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 (2' CHLOROBENZYL)PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 (2',5' DIMETHOXYBENZYL)PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 (3',4' DIMETHOXYBENZYL)PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 (3',5' DIMETHOXYBENZYL)PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 (4' FLUOROBENZYL)PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINOPYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINOPYRROLO[2,3 D]PYRIMIDINE; BASE; DIHYDROFOLATE REDUCTASE; ENZYME; ENZYME INHIBITOR; HALIDE; LIVER ENZYME; PALLADIUM; PIRITREXIM; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; IMMUNE DEFICIENCY; LIPOPHILICITY; MYCOBACTERIUM AVIUM; NONHUMAN; OPPORTUNISTIC INFECTION; PNEUMOCYSTIS CARINII; POLYMERIZATION; STRUCTURE ANALYSIS; TOXOPLASMA GONDII;

ANIMALS; FOLIC ACID ANTAGONISTS; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA; LIVER; MYCOBACTERIUM AVIUM; PNEUMOCYSTIS; PYRIMIDINES; RATS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TUMOR CELLS, CULTURED;

MYCOBACTERIUM; MYCOBACTERIUM AVIUM; PNEUMOCYSTIS CARINII; TOXOPLASMA GONDII;

EID: 0037413349     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00325-5     Document Type: Article

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