Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes

Biochemistry

Volumn 48, Issue 8, 2009, Pages 1702-1711

  Cody, Vivian ^a,b   Pace, Jim ^a   Makin, Jennifer ^a   Piraino, Jennifer ^a   Queener, Sherry F ^c   Rosowsky, Andre ^d  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c INDIANA UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; ACTIVE SITES; BINDING INTERACTIONS; CAUSATIVE AGENTS; CONFORMATIONAL CHANGES; CRYSTAL STRUCTURE DETERMINATIONS; DATA SUPPORTS; DIHYDROFOLATE REDUCTASE; DOUBLE MUTANTS; HUMAN ENZYMES; INHIBITION CONSTANTS; KINETIC ANALYSIS; MUTANT ENZYMES; MUTANT PROTEINS; PATHOGENIC ORGANISMS; SELECTIVE INHIBITORS; SINGLE MUTANTS; STRUCTURAL DATUM; TERNARY COMPLEXES; TRIMETHOPRIM; WILD TYPES;

AMINES; AMINO ACIDS; BINDING ENERGY; CRYSTAL STRUCTURE; ENZYMES; ORGANIC ACIDS;

ENZYME INHIBITION;

AMINO ACID; DIHYDROFOLATE REDUCTASE; METHOTREXATE; MUTANT PROTEIN; TRIMETHOPRIM;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HYPOTHESIS; MUTAGENESIS; MUTANT; NONHUMAN; PATHOGENESIS; PNEUMOCYSTIS JIROVECI; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; WILD TYPE;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; COENZYMES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PNEUMOCYSTIS JIROVECII; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE;

PNEUMOCYSTIS CARINII; PNEUMOCYSTIS JIROVECII;

EID: 64349092862     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801960h     Document Type: Article

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