Synthesis and biological evaluation of nonclassical 2,4-diamino-5- methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases

Journal of Medicinal Chemistry

Volumn 40, Issue 4, 1997, Pages 479-485

  Gangjee, Aleem ^a   Vasudevan, Anil ^a   Queener, Sherry F ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 METHYLPYRIDO[2,3 D]PYRIMIDINE; DIHYDROFOLATE REDUCTASE INHIBITOR; EPIROPRIM; FOLINIC ACID; PIRITREXIM; PYRIMIDINE DERIVATIVE; TRIMETHOPRIM; TRIMETREXATE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; OPPORTUNISTIC INFECTION; PNEUMOCYSTIS CARINII; TOXOPLASMA GONDII;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANIMALS; FOLIC ACID ANTAGONISTS; HUMANS; LIVER; MICE; PNEUMOCYSTIS; PYRIMIDINES; RATS; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TRIMETREXATE;

EID: 0031059045     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960734f     Document Type: Article

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