2,4-Diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1438-1446

  Gangjee, Aleem ^a   Vasudevan, Anil ^a   Queener, Sherry F ^b   Kisliuk, Roy L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 [N (1 NAPHTHYLMETHYLENE)AMINO]PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 [N (2,5 DIMETHOXYBENZYL) N METHYLAMINO]PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 [N METHYL N (3,4,5 TRIMETHOXYBENZYL)AMINO]PYRIDO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 6 NITROPYRIDO[2,3 D]PYRIMIDINE; 2,4,6 TRIAMINOPYRIDO[2,3 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; ANTIPROTOZOAL AGENT; FOLIC ACID ANTAGONIST; UNCLASSIFIED DRUG;

AMINATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; LACTOBACILLUS CASEI; METHYLATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PNEUMOCYSTIS CARINII; RAT; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; FOLIC ACID ANTAGONISTS; HUMANS; LIVER; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; PNEUMOCYSTIS; PYRIMIDINES; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA;

EID: 0029990447     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950786p     Document Type: Article

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33. We thank the Developmental Therapeutics Program of the National Cancer Institute for performing the in vitro anticancer evaluation.