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Volumn 50, Issue 3, 2013, Pages 514-523

New routes to therapy for spinal and bulbar muscular atrophy

Author keywords

androgen receptor; Polyglutamine disease; Spinal and bulbar muscular atrophy

Indexed keywords

ANDROGEN; GONADORELIN; GROWTH FACTOR; HEAT SHOCK PROTEIN; HISTONE DEACETYLASE 6; LUTEINIZING HORMONE; MICRORNA; NARATRIPTAN; NEUROTROPHIN; POLYGLUTAMINE; VASCULOTROPIN;

EID: 84878925743     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-9978-7     Document Type: Article
Times cited : (15)

References (87)
  • 1
    • 34248327285 scopus 로고    scopus 로고
    • CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model
    • 17494697 10.1523/JNEUROSCI.1242-07.2007 1:CAS:528:DC%2BD2sXmtVWrs7c%3D
    • Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G (2007) CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model. J Neurosci 27:5115-5126
    • (2007) J Neurosci , vol.27 , pp. 5115-5126
    • Adachi, H.1    Waza, M.2    Tokui, K.3    Katsuno, M.4    Minamiyama, M.5    Tanaka, F.6    Doyu, M.7    Sobue, G.8
  • 2
    • 0037444446 scopus 로고    scopus 로고
    • Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein
    • 12657679 1:CAS:528:DC%2BD3sXlsV2qtr0%3D
    • Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G (2003) Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci 23:2203-2211
    • (2003) J Neurosci , vol.23 , pp. 2203-2211
    • Adachi, H.1    Katsuno, M.2    Minamiyama, M.3    Sang, C.4    Pagoulatos, G.5    Angelidis, C.6    Kusakabe, M.7    Yoshiki, A.8    Kobayashi, Y.9    Doyu, M.10    Sobue, G.11
  • 5
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • 15483602 10.1038/nature02998 1:CAS:528:DC%2BD2cXotl2ktrc%3D
    • Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S (2004) Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431:805-810
    • (2004) Nature , vol.431 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 6
    • 0036501074 scopus 로고    scopus 로고
    • Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy
    • 11875046 10.1093/hmg/11.5.515 1:CAS:528:DC%2BD38XitlWisbg%3D
    • Bailey CK, Andriola IF, Kampinga HH, Merry DE (2002) Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy. Hum Mol Genet 11:515-523
    • (2002) Hum Mol Genet , vol.11 , pp. 515-523
    • Bailey, C.K.1    Andriola, I.F.2    Kampinga, H.H.3    Merry, D.E.4
  • 7
    • 62549084738 scopus 로고    scopus 로고
    • Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy
    • 19259967 10.1002/ana.21540 1:CAS:528:DC%2BD1MXktVynur4%3D
    • Banno H et al (2009) Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy. Ann Neurol 65:140-150
    • (2009) Ann Neurol , vol.65 , pp. 140-150
    • Banno, H.1
  • 8
    • 0035504324 scopus 로고    scopus 로고
    • Cytochrome c oxidase subunit Vb interacts with human androgen receptor: A potential mechanism for neurotoxicity in spinobulbar muscular atrophy
    • 11719263 10.1016/S0361-9230(01)00583-4 1:CAS:528:DC%2BD3MXosFOjsrg%3D
    • Beauchemin AM, Gottlieb B, Beitel LK, Elhaji YA, Pinsky L, Trifiro MA (2001) Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. Brain Res Bull 56:285-297
    • (2001) Brain Res Bull , vol.56 , pp. 285-297
    • Beauchemin, A.M.1    Gottlieb, B.2    Beitel, L.K.3    Elhaji, Y.A.4    Pinsky, L.5    Trifiro, M.A.6
  • 10
    • 0037081772 scopus 로고    scopus 로고
    • Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference
    • 11809726 10.1093/hmg/11.2.175 1:CAS:528:DC%2BD38XhtlKms7o%3D
    • Caplen NJ, Taylor JP, Statham VS, Tanaka F, Fire A, Morgan RA (2002) Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference. Hum Mol Genet 11:175-184
    • (2002) Hum Mol Genet , vol.11 , pp. 175-184
    • Caplen, N.J.1    Taylor, J.P.2    Statham, V.S.3    Tanaka, F.4    Fire, A.5    Morgan, R.A.6
  • 11
    • 84855902779 scopus 로고    scopus 로고
    • Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy
    • 21954065 10.1242/dmm.007849
    • Chevalier-Larsen ES, Merry DE (2011) Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy. Dis Model Mech 5:141-145
    • (2011) Dis Model Mech , vol.5 , pp. 141-145
    • Chevalier-Larsen, E.S.1    Merry, D.E.2
  • 12
    • 2442719008 scopus 로고    scopus 로고
    • Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy
    • 15152038 10.1523/JNEUROSCI.0808-04.2004 1:CAS:528:DC%2BD2cXks1yrsrs%3D
    • Chevalier-Larsen ES, O'Brien CJ, Wang H, Jenkins SC, Holder L, Lieberman AP, Merry DE (2004) Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy. J Neurosci 24:4778-4786
    • (2004) J Neurosci , vol.24 , pp. 4778-4786
    • Chevalier-Larsen, E.S.1    O'Brien, C.J.2    Wang, H.3    Jenkins, S.C.4    Holder, L.5    Lieberman, A.P.6    Merry, D.E.7
  • 13
    • 27644525713 scopus 로고    scopus 로고
    • Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF
    • 16285929 10.1016/j.molcel.2005.09.002 1:CAS:528:DC%2BD2MXht1KqsrjP
    • Cho DH, Thienes CP, Mahoney SE, Analau E, Filippova GN, Tapscott SJ (2005) Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF. Mol Cell 20:483-489
    • (2005) Mol Cell , vol.20 , pp. 483-489
    • Cho, D.H.1    Thienes, C.P.2    Mahoney, S.E.3    Analau, E.4    Filippova, G.N.5    Tapscott, S.J.6
  • 14
    • 77957665681 scopus 로고    scopus 로고
    • A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases
    • 20699640 10.4161/auto.6.7.13042
    • Crippa V, Carra S, Rusmini P, Sau D, Bolzoni E, Bendotti C, De Biasi S, Poletti A (2010a) A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases. Autophagy 6:958-960
    • (2010) Autophagy , vol.6 , pp. 958-960
    • Crippa, V.1    Carra, S.2    Rusmini, P.3    Sau, D.4    Bolzoni, E.5    Bendotti, C.6    De Biasi, S.7    Poletti, A.8
  • 18
    • 0030023666 scopus 로고    scopus 로고
    • Testosterone therapy and the pathogenesis of Kennedy's disease (X-linked bulbospinal muscular atrophy)
    • 8867072 10.1016/0022-510X(95)00285-A 1:CAS:528:DyaK28XitlKnsr8%3D
    • Goldenberg JN, Bradley WG (1996) Testosterone therapy and the pathogenesis of Kennedy's disease (X-linked bulbospinal muscular atrophy). J Neurol Sci 135:158-161
    • (1996) J Neurol Sci , vol.135 , pp. 158-161
    • Goldenberg, J.N.1    Bradley, W.G.2
  • 19
    • 0030038266 scopus 로고    scopus 로고
    • Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa
    • 8690199 10.1053/gast.1996.v111.pm8690199 1:CAS:528:DyaK28XkvFOnsLg%3D
    • Hirakawa T, Rokutan K, Nikawa T, Kishi K (1996) Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 111:345-357
    • (1996) Gastroenterology , vol.111 , pp. 345-357
    • Hirakawa, T.1    Rokutan, K.2    Nikawa, T.3    Kishi, K.4
  • 21
    • 0042591262 scopus 로고    scopus 로고
    • Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity
    • 12714591 10.1074/jbc.M302975200 1:CAS:528:DC%2BD3sXltVSlt74%3D
    • Ishihara K, Yamagishi N, Saito Y, Adachi H, Kobayashi Y, Sobue G, Ohtsuka K, Hatayama T (2003) Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity. J Biol Chem 278:25143-25150
    • (2003) J Biol Chem , vol.278 , pp. 25143-25150
    • Ishihara, K.1    Yamagishi, N.2    Saito, Y.3    Adachi, H.4    Kobayashi, Y.5    Sobue, G.6    Ohtsuka, K.7    Hatayama, T.8
  • 22
  • 24
    • 77955883056 scopus 로고    scopus 로고
    • Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA)
    • 20687495 10.1007/978-1-4419-6448-9-6 1:CAS:528:DC%2BC3cXhs1WlsLnL
    • Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G (2010a) Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA). Adv Exp Med Biol 685:64-74
    • (2010) Adv Exp Med Biol , vol.685 , pp. 64-74
    • Katsuno, M.1    Banno, H.2    Suzuki, K.3    Adachi, H.4    Tanaka, F.5    Sobue, G.6
  • 25
    • 0038714285 scopus 로고    scopus 로고
    • Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy
    • 12754502 10.1038/nm878 1:CAS:528:DC%2BD3sXktFOnu7s%3D
    • Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, Sobue G (2003) Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat Med 9:768-773
    • (2003) Nat Med , vol.9 , pp. 768-773
    • Katsuno, M.1    Adachi, H.2    Doyu, M.3    Minamiyama, M.4    Sang, C.5    Kobayashi, Y.6    Inukai, A.7    Sobue, G.8
  • 26
    • 28044469532 scopus 로고    scopus 로고
    • Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease
    • 16260738 10.1073/pnas.0506249102 1:CAS:528:DC%2BD2MXht1KgsL3L
    • Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G (2005) Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci U S A 102:16801-16806
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16801-16806
    • Katsuno, M.1    Sang, C.2    Adachi, H.3    Minamiyama, M.4    Waza, M.5    Tanaka, F.6    Doyu, M.7    Sobue, G.8
  • 27
    • 33746077664 scopus 로고    scopus 로고
    • Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA)
    • 16513111 10.1016/j.expneurol.2006.01.021 1:CAS:528:DC%2BD28XntlGjsr0%3D
    • Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G (2006) Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA). Exp Neurol 200:8-18
    • (2006) Exp Neurol , vol.200 , pp. 8-18
    • Katsuno, M.1    Adachi, H.2    Waza, M.3    Banno, H.4    Suzuki, K.5    Tanaka, F.6    Doyu, M.7    Sobue, G.8
  • 28
    • 18644379256 scopus 로고    scopus 로고
    • Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
    • 12372280 10.1016/S0896-6273(02)00834-6 1:CAS:528:DC%2BD38XntFSjtbg%3D
    • Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi Y, Doyu M, Sobue G (2002) Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron 35:843-854
    • (2002) Neuron , vol.35 , pp. 843-854
    • Katsuno, M.1    Adachi, H.2    Kume, A.3    Li, M.4    Nakagomi, Y.5    Niwa, H.6    Sang, C.7    Kobayashi, Y.8    Doyu, M.9    Sobue, G.10
  • 29
    • 77955662063 scopus 로고    scopus 로고
    • Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): A multicentre, randomised, double-blind, placebo-controlled trial
    • 20691641 10.1016/S1474-4422(10)70182-4 1:CAS:528:DC%2BC3cXhtVersbbJ
    • Katsuno M et al (2010b) Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol 9:875-884
    • (2010) Lancet Neurol , vol.9 , pp. 875-884
    • Katsuno, M.1
  • 30
    • 2542449055 scopus 로고
    • A family of progressive bulbar palsy
    • Kawahara H (1897) A family of progressive bulbar palsy. Aichi Med J 16:3-4
    • (1897) Aichi Med J , vol.16 , pp. 3-4
    • Kawahara, H.1
  • 31
    • 0014310582 scopus 로고
    • Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait
    • 4233749 10.1212/WNL.18.7.671 1:STN:280:DyaF1czpslSrtQ%3D%3D
    • Kennedy WR, Alter M, Sung JH (1968) Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait. Neurology 18:671-680
    • (1968) Neurology , vol.18 , pp. 671-680
    • Kennedy, W.R.1    Alter, M.2    Sung, J.H.3
  • 33
    • 37749026167 scopus 로고    scopus 로고
    • Administration of testosterone results in reversible deterioration in Kennedy's disease
    • 17056629 10.1136/jnnp.2006.101899 1:STN:280:DC%2BD2sjktVehuw%3D%3D
    • Kinirons P, Rouleau GA (2008) Administration of testosterone results in reversible deterioration in Kennedy's disease. J Neurol Neurosurg Psychiatry 79:106-107
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 106-107
    • Kinirons, P.1    Rouleau, G.A.2
  • 34
    • 0034708793 scopus 로고    scopus 로고
    • Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract
    • 10722721 10.1074/jbc.275.12.8772 1:CAS:528:DC%2BD3cXit1emsL0%3D
    • Kobayashi Y, Kume A, Li M, Doyu M, Hata M, Ohtsuka K, Sobue G (2000) Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 275:8772-8778
    • (2000) J Biol Chem , vol.275 , pp. 8772-8778
    • Kobayashi, Y.1    Kume, A.2    Li, M.3    Doyu, M.4    Hata, M.5    Ohtsuka, K.6    Sobue, G.7
  • 35
    • 0025800526 scopus 로고
    • Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
    • 2062380 10.1038/352077a0
    • La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH (1991) Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352:77-79
    • (1991) Nature , vol.352 , pp. 77-79
    • La Spada, A.R.1    Wilson, E.M.2    Lubahn, D.B.3    Harding, A.E.4    Fischbeck, K.H.5
  • 36
    • 0037101834 scopus 로고    scopus 로고
    • Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor
    • 12165558 10.1093/hmg/11.17.1967 1:CAS:528:DC%2BD38Xms1Gnurc%3D
    • Lieberman AP, Harmison G, Strand AD, Olson JM, Fischbeck KH (2002) Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor. Hum Mol Genet 11:1967-1976
    • (2002) Hum Mol Genet , vol.11 , pp. 1967-1976
    • Lieberman, A.P.1    Harmison, G.2    Strand, A.D.3    Olson, J.M.4    Fischbeck, K.H.5
  • 37
    • 42049086100 scopus 로고    scopus 로고
    • Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
    • 18337722 10.1038/nature06731 1:CAS:528:DC%2BD1cXksFSju7Y%3D
    • Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, Zoghbi HY (2008) Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature 452:713-718
    • (2008) Nature , vol.452 , pp. 713-718
    • Lim, J.1    Crespo-Barreto, J.2    Jafar-Nejad, P.3    Bowman, A.B.4    Richman, R.5    Hill, D.E.6    Orr, H.T.7    Zoghbi, H.Y.8
  • 39
    • 2942733520 scopus 로고    scopus 로고
    • Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
    • 15102712 10.1093/hmg/ddh131 1:CAS:528:DC%2BD2cXktVWgs78%3D
    • Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G (2004) Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet 13:1183-1192
    • (2004) Hum Mol Genet , vol.13 , pp. 1183-1192
    • Minamiyama, M.1    Katsuno, M.2    Adachi, H.3    Waza, M.4    Sang, C.5    Kobayashi, Y.6    Tanaka, F.7    Doyu, M.8    Inukai, A.9    Sobue, G.10
  • 42
    • 77958530066 scopus 로고    scopus 로고
    • Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy
    • 20886071 10.1371/journal.pone.0012922
    • Mo K, Razak Z, Rao P, Yu Z, Adachi H, Katsuno M, Sobue G, Lieberman AP, Westwood JT, Monks DA (2010) Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy. PLoS One 5:e12922
    • (2010) PLoS One , vol.5 , pp. 12922
    • Mo, K.1    Razak, Z.2    Rao, P.3    Yu, Z.4    Adachi, H.5    Katsuno, M.6    Sobue, G.7    Lieberman, A.P.8    Westwood, J.T.9    Monks, D.A.10
  • 44
    • 73449118922 scopus 로고    scopus 로고
    • Autophagy and access: Understanding the role of androgen receptor subcellular localization in SBMA
    • 19770590 10.4161/auto.5.8.9726 1:CAS:528:DC%2BC3cXkvVeitL0%3D
    • Montie HL, Merry DE (2009) Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA. Autophagy 5:1194-1197
    • (2009) Autophagy , vol.5 , pp. 1194-1197
    • Montie, H.L.1    Merry, D.E.2
  • 45
    • 65549163327 scopus 로고    scopus 로고
    • Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy
    • 19279159 10.1093/hmg/ddp115 1:CAS:528:DC%2BD1MXlslWqtro%3D
    • Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE (2009) Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet 18:1937-1950
    • (2009) Hum Mol Genet , vol.18 , pp. 1937-1950
    • Montie, H.L.1    Cho, M.S.2    Holder, L.3    Liu, Y.4    Tsvetkov, A.S.5    Finkbeiner, S.6    Merry, D.E.7
  • 46
    • 57049117002 scopus 로고    scopus 로고
    • CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins
    • 18784277 10.1093/hmg/ddn296 1:CAS:528:DC%2BD1cXhsVeqsr%2FF
    • Morishima Y, Wang AM, Yu Z, Pratt WB, Osawa Y, Lieberman AP (2008) CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum Mol Genet 17:3942-3952
    • (2008) Hum Mol Genet , vol.17 , pp. 3942-3952
    • Morishima, Y.1    Wang, A.M.2    Yu, Z.3    Pratt, W.B.4    Osawa, Y.5    Lieberman, A.P.6
  • 48
    • 77957011660 scopus 로고    scopus 로고
    • Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
    • 20869592 10.1016/j.neuron.2010.08.034 1:CAS:528:DC%2BC3cXht1Wisr3J
    • Nedelsky NB, Pennuto M, Smith RB, Palazzolo I, Moore J, Nie Z, Neale G, Taylor JP (2010) Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron 67:936-952
    • (2010) Neuron , vol.67 , pp. 936-952
    • Nedelsky, N.B.1    Pennuto, M.2    Smith, R.B.3    Palazzolo, I.4    Moore, J.5    Nie, Z.6    Neale, G.7    Taylor, J.P.8
  • 50
    • 78149243700 scopus 로고    scopus 로고
    • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy
    • 20826791 10.1074/jbc.M110.146845 1:CAS:528:DC%2BC3cXhtlyntLjF
    • Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE (2010) An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. J Biol Chem 285:35567-35577
    • (2010) J Biol Chem , vol.285 , pp. 35567-35577
    • Orr, C.R.1    Montie, H.L.2    Liu, Y.3    Bolzoni, E.4    Jenkins, S.C.5    Wilson, E.M.6    Joseph, J.D.7    McDonnell, D.P.8    Merry, D.E.9
  • 51
    • 34547692622 scopus 로고    scopus 로고
    • Trinucleotide repeat disorders
    • 17417937 10.1146/annurev.neuro.29.051605.113042 1:CAS:528: DC%2BD2sXptFKnu70%3D
    • Orr HT, Zoghbi HY (2007) Trinucleotide repeat disorders. Annu Rev Neurosci 30:575-621
    • (2007) Annu Rev Neurosci , vol.30 , pp. 575-621
    • Orr, H.T.1    Zoghbi, H.Y.2
  • 53
    • 77953648932 scopus 로고    scopus 로고
    • B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy
    • 20336775 10.1002/jnr.22389 1:CAS:528:DC%2BC3cXnsVWitLY%3D
    • Palazzolo I, Nedelsky NB, Askew CE, Harmison GG, Kasantsev AG, Taylor JP, Fischbeck KH, Pennuto M (2010) B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy. J Neurosci Res 88:2207-2216
    • (2010) J Neurosci Res , vol.88 , pp. 2207-2216
    • Palazzolo, I.1    Nedelsky, N.B.2    Askew, C.E.3    Harmison, G.G.4    Kasantsev, A.G.5    Taylor, J.P.6    Fischbeck, K.H.7    Pennuto, M.8
  • 56
    • 80053094971 scopus 로고    scopus 로고
    • Neurotoxic effects of androgens in spinal and bulbar muscular atrophy
    • 21745497 10.1016/j.yfrne.2011.06.003 1:CAS:528:DC%2BC3MXht1agu7%2FP
    • Parodi S, Pennuto M (2011) Neurotoxic effects of androgens in spinal and bulbar muscular atrophy. Front Neuroendocrinol 32:416-425
    • (2011) Front Neuroendocrinol , vol.32 , pp. 416-425
    • Parodi, S.1    Pennuto, M.2
  • 57
    • 85010862936 scopus 로고    scopus 로고
    • Pathogenesis of polyglutamine diseases
    • doi: 10.1002/9780470015902.a0021486
    • Pennuto M, Sambataro F (2010) Pathogenesis of polyglutamine diseases. Encycl Life Sci. doi: 10.1002/9780470015902.a0021486
    • (2010) Encycl Life Sci
    • Pennuto, M.1    Sambataro, F.2
  • 58
    • 0036716277 scopus 로고    scopus 로고
    • Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes
    • 12205033 1:CAS:528:DC%2BD38XntV2ku7g%3D
    • Piccioni F, Pinton P, Simeoni S, Pozzi P, Fascio U, Vismara G, Martini L, Rizzuto R, Poletti A (2002) Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes. FASEB J 16:1418-1420
    • (2002) FASEB J , vol.16 , pp. 1418-1420
    • Piccioni, F.1    Pinton, P.2    Simeoni, S.3    Pozzi, P.4    Fascio, U.5    Vismara, G.6    Martini, L.7    Rizzuto, R.8    Poletti, A.9
  • 59
    • 2942588983 scopus 로고    scopus 로고
    • The polyglutamine tract of androgen receptor: From functions to dysfunctions in motor neurons
    • 15183036 10.1016/j.yfrne.2004.03.001 1:CAS:528:DC%2BD2cXks1elurk%3D
    • Poletti A (2004) The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons. Front Neuroendocrinol 25:1-26
    • (2004) Front Neuroendocrinol , vol.25 , pp. 1-26
    • Poletti, A.1
  • 62
    • 77951234323 scopus 로고    scopus 로고
    • Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases
    • 20147746 10.1074/jbc.R109.072181 1:CAS:528:DC%2BC3cXktFGlsrg%3D
    • Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC (2010) Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem 285:11061-11067
    • (2010) J Biol Chem , vol.285 , pp. 11061-11067
    • Renna, M.1    Jimenez-Sanchez, M.2    Sarkar, S.3    Rubinsztein, D.C.4
  • 63
    • 84869127465 scopus 로고    scopus 로고
    • IGF-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy
    • 22952056 10.2119/molmed.2012.00271 1:CAS:528:DC%2BC38XhvVOisb3I
    • Rinaldi C, Bott LC, Chen KL, Harmison GG, Katsuno M, Sobue G, Pennuto M, Fischbeck KH (2012) IGF-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy. Mol Med 18:1261-1268
    • (2012) Mol Med , vol.18 , pp. 1261-1268
    • Rinaldi, C.1    Bott, L.C.2    Chen, K.L.3    Harmison, G.G.4    Katsuno, M.5    Sobue, G.6    Pennuto, M.7    Fischbeck, K.H.8
  • 64
    • 0037243169 scopus 로고    scopus 로고
    • Molecular chaperone inducers in medicine and diseases
    • 12617033 10.1254/fpj.121.15 1:CAS:528:DC%2BD3sXlvVyksA%3D%3D
    • Rokutan K (2003) Molecular chaperone inducers in medicine and diseases. Nihon Yakurigaku Zasshi 121:15-20
    • (2003) Nihon Yakurigaku Zasshi , vol.121 , pp. 15-20
    • Rokutan, K.1
  • 65
    • 0024598830 scopus 로고
    • Quantitative distribution of nuclear androgen receptors in microdissected areas of the rat brain
    • 2725839 10.1159/000125151 1:CAS:528:DyaL1MXktVWjtro%3D
    • Roselli CE, Handa RJ, Resko JA (1989) Quantitative distribution of nuclear androgen receptors in microdissected areas of the rat brain. Neuroendocrinology 49:449-453
    • (1989) Neuroendocrinology , vol.49 , pp. 449-453
    • Roselli, C.E.1    Handa, R.J.2    Resko, J.A.3
  • 66
    • 78349310900 scopus 로고    scopus 로고
    • Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy
    • 20621188 10.1016/j.nbd.2010.06.016 1:CAS:528:DC%2BC3cXhtFCku7fF
    • Rusmini P, Bolzoni E, Crippa V, Onesto E, Sau D, Galbiati M, Piccolella M, Poletti A (2010) Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy. Neurobiol Dis 40:361-369
    • (2010) Neurobiol Dis , vol.40 , pp. 361-369
    • Rusmini, P.1    Bolzoni, E.2    Crippa, V.3    Onesto, E.4    Sau, D.5    Galbiati, M.6    Piccolella, M.7    Poletti, A.8
  • 67
    • 78349309239 scopus 로고    scopus 로고
    • 17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy
    • 20816782 10.1016/j.nbd.2010.08.023 1:CAS:528:DC%2BC3cXhsVWqsLfM
    • Rusmini P, Simonini F, Crippa V, Bolzoni E, Onesto E, Cagnin M, Sau D, Ferri N, Poletti A (2011) 17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy. Neurobiol Dis 41:83-95
    • (2011) Neurobiol Dis , vol.41 , pp. 83-95
    • Rusmini, P.1    Simonini, F.2    Crippa, V.3    Bolzoni, E.4    Onesto, E.5    Cagnin, M.6    Sau, D.7    Ferri, N.8    Poletti, A.9
  • 69
    • 0037056302 scopus 로고    scopus 로고
    • Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women
    • 12221177 10.1212/WNL.59.5.770
    • Schmidt BJ, Greenberg CR, Allingham-Hawkins DJ, Spriggs EL (2002) Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women. Neurology 59:770-772
    • (2002) Neurology , vol.59 , pp. 770-772
    • Schmidt, B.J.1    Greenberg, C.R.2    Allingham-Hawkins, D.J.3    Spriggs, E.L.4
  • 70
    • 0025232316 scopus 로고
    • Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study
    • 2324335 10.1002/cne.902940107 1:CAS:528:DyaK3MXhslKltw%3D%3D
    • Simerly RB, Chang C, Muramatsu M, Swanson LW (1990) Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 294:76-95
    • (1990) J Comp Neurol , vol.294 , pp. 76-95
    • Simerly, R.B.1    Chang, C.2    Muramatsu, M.3    Swanson, L.W.4
  • 72
    • 12144286872 scopus 로고    scopus 로고
    • Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration
    • 15003169 10.1016/S0896-6273(04)00082-0 1:CAS:528:DC%2BD2cXisVKitLc%3D
    • Sopher BL, Thomas PS Jr, LaFevre-Bernt MA, Holm IE, Wilke SA, Ware CB, Jin LW, Libby RT, Ellerby LM, La Spada AR (2004) Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron 41:687-699
    • (2004) Neuron , vol.41 , pp. 687-699
    • Sopher, B.L.1    Thomas, Jr.P.S.2    Lafevre-Bernt, M.A.3    Holm, I.E.4    Wilke, S.A.5    Ware, C.B.6    Jin, L.W.7    Libby, R.T.8    Ellerby, L.M.9    La Spada, A.R.10
  • 74
    • 77950420275 scopus 로고    scopus 로고
    • Mitochondrial DNA damage in spinal and bulbar muscular atrophy patients and carriers
    • 20035733 10.1016/j.cca.2009.12.007 1:CAS:528:DC%2BC3cXktVShs7c%3D
    • Su S, Jou S, Cheng W, Lin T, Li J, Huang C, Lee Y, Soong B, Liu C (2010) Mitochondrial DNA damage in spinal and bulbar muscular atrophy patients and carriers. Clin Chim Acta 411:626-630
    • (2010) Clin Chim Acta , vol.411 , pp. 626-630
    • Su, S.1    Jou, S.2    Cheng, W.3    Lin, T.4    Li, J.5    Huang, C.6    Lee, Y.7    Soong, B.8    Liu, C.9
  • 75
    • 0038722748 scopus 로고    scopus 로고
    • Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein
    • 12815067 10.1101/gad.1087503 1:CAS:528:DC%2BD3sXkvFSisrg%3D
    • Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT (2003) Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev 17:1463-1468
    • (2003) Genes Dev , vol.17 , pp. 1463-1468
    • Taylor, J.P.1    Taye, A.A.2    Campbell, C.3    Kazemi-Esfarjani, P.4    Fischbeck, K.H.5    Min, K.T.6
  • 76
    • 33744770333 scopus 로고    scopus 로고
    • Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction
    • 16644868 10.1093/hmg/ddl110 1:CAS:528:DC%2BD28Xksl2hu7s%3D
    • Thomas M, Harrell JM, Morishima Y, Peng HM, Pratt WB, Lieberman AP (2006a) Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction. Hum Mol Genet 15:1876-1883
    • (2006) Hum Mol Genet , vol.15 , pp. 1876-1883
    • Thomas, M.1    Harrell, J.M.2    Morishima, Y.3    Peng, H.M.4    Pratt, W.B.5    Lieberman, A.P.6
  • 77
    • 33745592187 scopus 로고    scopus 로고
    • Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy
    • 16772330 10.1093/hmg/ddl148 1:CAS:528:DC%2BD28XmsVejtrk%3D
    • Thomas PS Jr, Fraley GS, Damian V, Woodke LB, Zapata F, Sopher BL, Plymate SR, La Spada AR (2006b) Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy. Hum Mol Genet 15:2225-2238
    • (2006) Hum Mol Genet , vol.15 , pp. 2225-2238
    • Thomas, Jr.P.S.1    Fraley, G.S.2    Damian, V.3    Woodke, L.B.4    Zapata, F.5    Sopher, B.L.6    Plymate, S.R.7    La Spada, A.R.8
  • 78
    • 60549084901 scopus 로고    scopus 로고
    • 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse
    • 19066230 1:CAS:528:DC%2BD1MXhvV2jtr0%3D
    • Tokui K, Adachi H, Waza M, Katsuno M, Minamiyama M, Doi H, Tanaka K, Hamazaki J, Murata S, Tanaka F, Sobue G (2009) 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse. Hum Mol Genet 18:898-910
    • (2009) Hum Mol Genet , vol.18 , pp. 898-910
    • Tokui, K.1    Adachi, H.2    Waza, M.3    Katsuno, M.4    Minamiyama, M.5    Doi, H.6    Tanaka, K.7    Hamazaki, J.8    Murata, S.9    Tanaka, F.10    Sobue, G.11
  • 79
    • 0037184933 scopus 로고    scopus 로고
    • Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy
    • 12388541 10.1074/jbc.M209466200 1:CAS:528:DC%2BD38Xps12ntbg%3D
    • Walcott JL, Merry DE (2002) Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy. J Biol Chem 277:50855-50859
    • (2002) J Biol Chem , vol.277 , pp. 50855-50859
    • Walcott, J.L.1    Merry, D.E.2
  • 80
    • 27144503120 scopus 로고    scopus 로고
    • 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
    • 16155577 10.1038/nm1298 1:CAS:528:DC%2BD2MXhtVOiu77I
    • Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G (2005) 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med 11:1088-1095
    • (2005) Nat Med , vol.11 , pp. 1088-1095
    • Waza, M.1    Adachi, H.2    Katsuno, M.3    Minamiyama, M.4    Sang, C.5    Tanaka, F.6    Inukai, A.7    Doyu, M.8    Sobue, G.9
  • 82
    • 0031753892 scopus 로고    scopus 로고
    • Heat shock preconditioning ameliorates liver injury following normothermic ischemia-reperfusion in steatotic rat livers
    • 9735239 10.1006/jsre.1998.5403 1:STN:280:DyaK1cvgvVSgtA%3D%3D
    • Yamagami K, Yamamoto Y, Kume M, Kimoto S, Yamamoto H, Ozaki N, Yamamoto M, Shimahara Y, Toyokuni S, Yamaoka Y (1998) Heat shock preconditioning ameliorates liver injury following normothermic ischemia-reperfusion in steatotic rat livers. J Surg Res 79:47-53
    • (1998) J Surg Res , vol.79 , pp. 47-53
    • Yamagami, K.1    Yamamoto, Y.2    Kume, M.3    Kimoto, S.4    Yamamoto, H.5    Ozaki, N.6    Yamamoto, M.7    Shimahara, Y.8    Toyokuni, S.9    Yamaoka, Y.10
  • 83
    • 0033042288 scopus 로고    scopus 로고
    • Expression of GDNF and GDNFR-alpha mRNAs in muscles of patients with motor neuron diseases
    • 10447463 10.1023/A:1020739831778 1:CAS:528:DyaK1MXjvVeqsLY%3D
    • Yamamoto M, Mitsuma N, Inukai A, Ito Y, Li M, Mitsuma T, Sobue G (1999) Expression of GDNF and GDNFR-alpha mRNAs in muscles of patients with motor neuron diseases. Neurochem Res 24:785-790
    • (1999) Neurochem Res , vol.24 , pp. 785-790
    • Yamamoto, M.1    Mitsuma, N.2    Inukai, A.3    Ito, Y.4    Li, M.5    Mitsuma, T.6    Sobue, G.7
  • 86
    • 33749442673 scopus 로고    scopus 로고
    • Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model
    • 16981011 1:CAS:528:DC%2BD28XhtVKgu7rL
    • Yu Z, Dadgar N, Albertelli M, Gruis K, Jordan C, Robins DM, Lieberman AP (2006) Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model. J Clin Invest 116:2663-2672
    • (2006) J Clin Invest , vol.116 , pp. 2663-2672
    • Yu, Z.1    Dadgar, N.2    Albertelli, M.3    Gruis, K.4    Jordan, C.5    Robins, D.M.6    Lieberman, A.P.7
  • 87
    • 80055089069 scopus 로고    scopus 로고
    • Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice
    • 22022281 10.1371/journal.pgen.1002321 1:CAS:528:DC%2BC3MXhsVWqsLfL
    • Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP (2011) Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. PLoS Genet 7:e1002321
    • (2011) PLoS Genet , vol.7 , pp. 1002321
    • Yu, Z.1    Wang, A.M.2    Adachi, H.3    Katsuno, M.4    Sobue, G.5    Yue, Z.6    Robins, D.M.7    Lieberman, A.P.8


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