Expression of GDNF and GDNFR-α mRNAs in muscles of patients with motor neuron diseases

Neurochemical Research

Volumn 24, Issue 6, 1999, Pages 785-790

  Yamamoto, Masahiko ^a   Mitsuma, Norimasa ^a   Inukai, Akira ^a   Ito, Yasuhiro ^a   Li, Mei ^a,b   Mitsuma, Terunori ^b   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

GDNF; GDNFR ; In situ hybridization; Motor neuron disease; MRNA; Muscle

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR ALPHA; GROWTH FACTOR RECEPTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONTROLLED STUDY; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; KENNEDY DISEASE; MOTONEURON; MOTOR NEURON DISEASE; MUSCLE BIOPSY; NERVE CELL DEGENERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOLEMMA;

EID: 0033042288     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020739831778     Document Type: Article

References (24)

1. Beck, K. D., Valverde, J., Alexi, T., Poulsen K., Moffat, B., Vandlen, R. A., Rosenthal, A., and Heftl, F. 1995. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373:339-341.
2. Henderson, C. E., Phillips, H. S., Pollock, R. A., Davies, A. M., Lemeulle, C., Armanini, M., Simpson, L. C., Moffet, B., Vandlen, R. A., Koliatsos, V. E., and Rosenthal, A. 1994. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266:1062-1064.
3. Lin, L. F. H., Doherty, D. H., Lile, J. D., Bektesh, S., and Collins, F. 1993. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132.
4. Trupp, M., Ryden, M., Jornvall, H., Funakoshi, H., Timmusk, T., Arenas, E., and Ibanez, C. F. 1995. Peripheral expression and biological avtivities of GDNF, new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol. 130: 137-148.
5. Durbec, P., Marcos-Gutierrez, C. V., Kilkenny, C., Grigoriou, M., Wartiowaarra, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M., Sariola, H., and Pachnis, V. 1996. GDNF signaling through the Ret receptor tyrosine kinase. Nature 381:789-793.
6. Jing, S. Q., Wen, D. Z., Yu, Y. B., Holst, P. L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R., Louis, J. C., Hu, S., Altrock, B. W., and Fox, G. M. 1996. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF. Cell 85:1113-1124.
7. Treanor, J. J. S., Goodman, L., Desauvage, F., Stone, D. M., Poulsen, K. T., Beck, C. D., Gray, C., Armanini, M. P., Pollock, R. A., Hefti, F., Phillips, H. S., Goddard, A., Moore, M. W., Bujbello, A., Davies, A. M., Asai, N., Takahashi, M., Vandlen, R., Henderson, C. E., and Rosenthal, A. 1996. Characterization of a multicomponent receptor for GDNF. Nature 382:80-83.
8. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A. S., Sieber, B. A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U., Sariola, H., Saarma, M., and Ibanez, C. F. 1996. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381:785-789.
9. Trupp, M., Belluardo, N., Funakoshi, H., and Ibanez, C. F. 1997. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-α indicates multiple mechanisms of trophic actions in the adult rat PNS. J. Neurosci. 17:3554-3567.
10. Nguyen, Q. T., Parsadanian, A. S., Snider, W. D., and Lichtman, J. W. 1998. Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscles. Science 279: 1725-1729.
11. Oppenheim, R. W., Houenou, L. J., Johnson, J. E., Lin, L. F. H., Li, L., Lo, A. C., Newsome, A. L., Prevette, D. M., and Wang, S. 1995. Developing motor neurons rescued from programmed and axotomy-inducd cell death by GDNF. Nature 373:344-346.
12. Lie, D. C., and Weis, J. 1998. GDNF expression is increased in denervated human skeletal muscle. Neurosci. Lett. 250:87-90.
13. Springer, J. E., Seeburger, J. L., He, J., Gabrea, A., Blankenhorn, E. P., and Bergman, L. W. 1995. cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle. Exp. Neurol. 131:47-52.
14. World Federation of Neurology Research Group on Neuromuscular Diseases. 1994. El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. J. Neurol. Sci. 124:96-107 (Suppl).
15. Tanaka, F., Doyu, M., Ito, Y., Matsumoto, M., Mitsuma, T., Abe, K., Aoki, M., Itoyama, Y., Fischbeck, K. H., and Sobue, G. 1996. Founder effect in spinal and bulbar muscular atrophy (SBMA). Hum. Mol. Genet. 5:1253-1257.
16. Chomczynski, P., and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
17. NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem. Res. 21:929-938.
18. Ito, Y., Yamamoto, M., Li, M., Doyu, M., Tanaka, F., Mitsuma, T., and Sobue, G. 1998. Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα, LIFRβ, IL-6α and gp130) in injured peripheral nerves. Brain Res. 793:321-327.
19. Yamamoto, M., Sobue, G., Yamamoto, K., Terao, S., and Mitsuma, T. 1996. Expression of glial cell line-derived neurotrophic factor mRNA in the spinal cord and muscle in amyotrophic lateral sclerosis Neurosci. Lett. 204:117-120.
20. Naveilhan, P., Elshamy, W. M., and Ernfors, P. 1997. Differential regulation of mRNAs for GDNF and its receptor Ret and GDNFR alpha after sciatic nerve lesion in the mouse. Eur. J. Neurosci. 9:1450-1460.
21. Yamamoto, M., Mitsuma, N., Ito, Y., Hattori, N., Nagamatsu, M., Li, M., Mitsuma, T., and Sobue, G. 1998. Expression of GDNF and GDNFR-α mRNAs in human peripheral neuropathies. Brain Res. 809:175-181.
22. Mitsuma, N., Yamamoto, M., Li, M., Ito, Y., Mitsuma, T., Mutoh, T., Takahashi, M., and Sobue, G. Expression of GDNF receptor (RET and GDNFR-α) mRNAs in the spinal cord of patients with amyotrophic lateral sclerosis. Brain Res. (in press)
23. Molliver, D. C., Wright, D. E., Leitner, M. L., Parsadanian, A. Sh., Doster, K., Wen, D., Yan, Q., and Snider, W. D. 1997. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron 19:849-861.
24. Yan, Q., Matheson, C., and Lopez, O. T. 1995. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373:341-344.