Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 46, 2005, Pages 16801-16806

  Katsuno, Masahisa ^a   Sang, Chen ^a   Adachi, Hiroaki ^a   Minamiyama, Makoto ^a   Waza, Masahiro ^a   Tanaka, Fumiaki ^a   Doyu, Manabu ^a   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Androgen receptor; Geranylgeranylacetone; Heat shock factor 1; Spinal and bulbar muscular atrophy

Indexed keywords

ANDROGEN RECEPTOR; ANTIULCER AGENT; CHAPERONE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 105; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; POLYGLUTAMINE; TEPRENONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BULBAR PARALYSIS; CELL DEATH; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; DRUG SAFETY; EMBRYO; EXON; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN LOCALIZATION; SPINAL MUSCULAR ATROPHY; STRESS; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; DITERPENES; HEAT-SHOCK PROTEINS; HUMANS; MICE; MOTOR NEURON DISEASE; PEPTIDES; RECEPTORS, ANDROGEN;

ANIMALIA; MUS MUSCULUS;

EID: 28044469532     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0506249102     Document Type: Article

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