Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy

Journal of Neuroscience

Volumn 24, Issue 20, 2004, Pages 4778-4786

  Chevalier Larsen, Erica S ^a   O'Brien, Christopher J ^a   Wang, Huiyi ^a   Jenkins, Shannon C ^a   Holder, Latia ^a   Lieberman, Andrew P ^b   Merry, Diane E ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Androgen; Animal model; Motor neuron; Neurodegeneration; Neurofilament; Polyglutamine; Testosterone; Transgenic

Indexed keywords

ANDROGEN RECEPTOR; POLYGLUTAMINE; TESTOSTERONE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATION; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; GENDER; HORMONAL THERAPY; KENNEDY DISEASE; MALE; MOTOR NEURON DISEASE; MOTOR PERFORMANCE; MOUSE; NERVE CELL; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; SYMPTOM; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CASTRATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HUMANS; LAMENESS, ANIMAL; MALE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MOTOR NEURONS; MUSCLE WEAKNESS; MUSCULAR DISORDERS, ATROPHIC; NEUROFILAMENT PROTEINS; PEPTIDES; PHOSPHORYLATION; RECEPTORS, ANDROGEN; RECOVERY OF FUNCTION; SEX FACTORS; SPINAL CORD; TREATMENT OUTCOME;

EID: 2442719008     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0808-04.2004     Document Type: Article

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