Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF

Molecular Cell

Volumn 20, Issue 3, 2005, Pages 483-489

  Cho, Diane H ^a,b   Thienes, Cortlandt P ^a   Mahoney, Sarah E ^a   Analau, Erwin ^a   Filippova, Galina N ^a   Tapscott, Stephen J ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; HISTONE; LYSINE; NUCLEOTIDE;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; EUCHROMATIN; GENE LOCUS; GENETIC TRANSCRIPTION; HETEROCHROMATIN; HUMAN; HUMAN CELL; METHYLATION; MYOTONIC DYSTROPHY; NUCLEOSOME; NUCLEOTIDE REPEAT; WILD TYPE;

CELLS, CULTURED; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; FIBROBLASTS; HETEROCHROMATIN; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; INSULATOR ELEMENTS; METHYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; QUANTITATIVE TRAIT LOCI; REPRESSOR PROTEINS; RNA, ANTISENSE; TRANSCRIPTION, GENETIC; TRINUCLEOTIDE REPEATS;

EID: 27644525713     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.09.002     Document Type: Article

References (23)

1. D.A. Bergstrom, and S.J. Tapscott Molecular distinction between specification and differentiation in the myogenic basic helix-loop-helix transcription factor family Mol. Cell. Biol. 21 2001 2404 2412
2. E. Bernstein, and C.D. Allis RNA meets chromatin Genes Dev. 19 2005 1635 1655
3. Y.Q. Feng, J. Seibler, R. Alami, A. Eisen, K.A. Westerman, P. Leboulch, S. Fiering, and E.E. Bouhassira Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange J. Mol. Biol. 292 1999 779 785
4. G.N. Filippova, C.P. Thienes, B.H. Penn, D.H. Cho, Y.J. Hu, J.M. Moore, T.R. Klesert, V.V. Lobanenkov, and S.J. Tapscott CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus Nat. Genet. 28 2001 335 343
5. G.N. Filippova, M.K. Cheng, J.M. Moore, J.P. Truong, Y.J. Hu, D.K. Nguyen, K.D. Tsuchiya, and C.M. Disteche Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development Dev. Cell 8 2005 31 42
6. H. Jiang, A. Mankodi, M.S. Swanson, R.T. Moxley, and C.A. Thornton Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons Hum. Mol. Genet. 13 2004 3079 3088
7. R.N. Kanadia, K.A. Johnstone, A. Mankodi, C. Lungu, C.A. Thornton, D. Esson, A.M. Timmers, W.W. Hauswirth, and M.S. Swanson A muscleblind knockout model for myotonic dystrophy Science 302 2003 1978 1980
8. H. Kawasaki, and K. Taira Induction of DNA methylation and gene silencing by short interfering RNAs in human cells Nature 431 2004 211 217
9. T.R. Klesert, A.D. Otten, T.D. Bird, and S.J. Tapscott Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP Nat. Genet. 16 1997 402 406
10. T.R. Klesert, D.H. Cho, J.I. Clark, J. Maylie, J. Adelman, L. Snider, E.C. Yuen, P. Soriano, and S.J. Tapscott Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy Nat. Genet. 25 2000 105 109
11. R. Krahe, T. Ashizawa, C. Abbruzzese, E. Roeder, P. Carango, M. Giacanelli, V.L. Funanage, and M.J. Siciliano Effect of myotonic dystrophy trinucleotide repeat expansion on DMPK transcription and processing Genomics 28 1995 1 14
12. J. Ma, K.K. Hwang, H.J. Worman, J.C. Courvalin, and J.C. Eissenberg Expression and functional analysis of three isoforms of human heterochromatin-associated protein HP1 in Drosophila Chromosoma 109 2001 536 544
13. C. Maison, and G. Almouzni HP1 and the dynamics of heterochromatin maintenance Nat. Rev. Mol. Cell Biol. 5 2004 296 304
14. A. Mankodi, E. Logigian, L. Callahan, C. McClain, R. White, D. Henderson, M. Krym, and C.A. Thornton Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat Science 289 2000 1769 1773
15. K.V. Morris, S.W. Chan, S.E. Jacobsen, and D.J. Looney Small interfering RNA-induced transcriptional gene silencing in human cells Science 305 2004 1289 1292
16. A.D. Otten, and S.J. Tapscott Triplet repeat expansion in myotonic dystrophy alters the adjacent chromatin structure Proc. Natl. Acad. Sci. USA 92 1995 5465 5469
17. V. Pant, S. Kurukuti, E. Pugacheva, S. Shamsuddin, P. Mariano, R. Renkawitz, E. Klenova, V. Lobanenkov, and R. Ohlsson Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance Mol. Cell. Biol. 24 2004 3497 3504
18. A. Saveliev, C. Everett, T. Sharpe, Z. Webster, and R. Festenstein DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing Nature 422 2003 909 913
19. C.J. Schoenherr, J.M. Levorse, and S.M. Tilghman CTCF maintains differential methylation at the Igf2/H19 locus Nat. Genet. 33 2003 66 69
20. P. Steinbach, D. Glaser, W. Vogel, M. Wolf, and S. Schwemmle The DMPK gene of severely affected myotonic dystrophy patients is hypermethylated proximal to the largely expanded CTG repeat Am. J. Hum. Genet. 62 1998 278 285
21. C.A. Thornton, J.P. Wymer, Z. Simmons, C. McClain, and R.T. Moxley 3rd Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene Nat. Genet. 16 1997 407 409
22. C. Tufarelli, J.A. Stanley, D. Garrick, J.A. Sharpe, H. Ayyub, W.G. Wood, and D.R. Higgs Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease Nat. Genet. 34 2003 157 165
23. C.R. Vakoc, S.A. Mandat, B.A. Olenchock, and G.A. Blobel Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin Mol. Cell 19 2005 381 391