Correlating structure and energetics in protein-ligand interactions: Paradigms and paradoxes

Annual Review of Biochemistry

Volumn 82, Issue , 2013, Pages 267-293

  Martin, Stephen F ^a   Clements, John H ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Biomolecular recognition; Hydrophobic effects; Preorganization; Protein ligand interactions; Thermodynamics

Indexed keywords

BINDING PROTEIN; CARBONATE DEHYDRATASE II; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; LIPOCALIN; OLIDOPEPTIDE BINDING PROTEIN; OLIGOSACCHARIDE; PROTEIN SH2; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

ATOM; BINDING AFFINITY; CRYSTAL STRUCTURE; CYCLIZATION; DISPERSION; ENERGY TRANSFER; ENTHALPY; ENTROPY; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN LIGAND INTERACTION; PROTEIN STRUCTURE; REVIEW; SHIGELLA FLEXNERI; WATER STRUCTURE;

CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; THERMODYNAMICS;

EID: 84878914295     PISSN: 00664154     EISSN: 15454509     Source Type: Book Series    
DOI: 10.1146/annurev-biochem-060410-105819     Document Type: Review

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