Protein-ligand interactions: Thermodynamic effects associated with increasing nonpolar surface area

Journal of the American Chemical Society

Volumn 133, Issue 46, 2011, Pages 18518-18521

  Myslinski, James M ^a   DeLorbe, John E ^a   Clements, John H ^a   Martin, Stephen F ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; BINDING ENTHALPIES; BINDING FREE ENERGY; COMPLEX FORMATIONS; CRYSTALLOGRAPHIC ANALYSIS; HYDROPHOBIC EFFECT; LIGAND DESIGN; METHYLENE GROUPS; NONPOLAR SURFACE AREA; POSITIVE CORRELATIONS; PROTEIN-LIGAND INTERACTIONS; RING SIZES; SEVEN-MEMBERED RINGS; SH2 DOMAIN; SIX-MEMBERED RINGS; STRUCTURE AND ENERGETICS; THERMODYNAMIC EFFECT; THERMODYNAMIC PARAMETER; TRI-PEPTIDES; VAN DER WAALS CONTACTS; WATER MOLECULE;

AMINO ACIDS; ENTHALPY; ENTROPY; HYDROPHOBICITY; LIGANDS; PROTEINS; VAN DER WAALS FORCES;

BINDING ENERGY;

ALIPHATIC COMPOUND; AMINO ACID; LIGAND; PROTEIN; WATER;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; COMPLEX FORMATION; CRYSTALLOGRAPHY; ENTHALPY; ENTROPY; HYDROPHOBICITY; MOLECULAR INTERACTION; REACTION ANALYSIS; STRUCTURE ANALYSIS; SURFACE PROPERTY; THERMODYNAMICS;

CRYSTALLOGRAPHY, X-RAY; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEINS; SURFACE PROPERTIES; THERMODYNAMICS;

EID: 83055165964     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2068752     Document Type: Article

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