Body distribution of poly-DL-lactide-poly(ethylene glycol) microspheres with entrapped Leptospira interrogans antigens following intravenous and oral administration of guinea-pigs

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 7, 2000, Pages 763-770

  Li, Xiaohong ^a   Zhang, Yanhua ^b   Yan, Ronghua ^b   Zhang, Min ^b   Yuan, Minglong ^a   Deng, Xianmo ^a   Huang, Zhitang ^c  

^a CHENGDU INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b SICHUAN UNIVERSITY   (China)

^c INSTITUTE OF CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; MICROSPHERE I 125; POLYETHYLENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG RELEASE; DRUG TISSUE LEVEL; DRUG UPTAKE; ENCAPSULATION; GUINEA PIG; RADIOACTIVITY; SCANNING ELECTRON MICROSCOPY; SCINTILLATION COUNTING; SPLEEN;

EID: 0033942495     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774615     Document Type: Article

References (18)

1. Alpar, H. O., Field, W. N., Hyde, R., Lewis, D. A. (1989) The transport of microspheres from the gastrointestinal tract to inflammatory air pouches in the rat. J. Pharm. Pharmcol. 41: 194-196
2. Bitz, C., Doelker, E. (1996) Influence of preparation method on residual solvents in biodegradable microspheres. Int. J. Pharm. 131: 171-181
3. Cleland, J. L., Barron, L., Berman, P. W., Daugherty, A., Gregory, T., Linn, A., Vennari, J., Wrin, T., Panell, M. F. (1996) Development of a single-shot subunit vaccine for HIV. J. Pharm. Sci. 85: 1346-1349
4. Cohen, S., Yoshioka, T., Lucarelli, M., Huang, L. H., Langer, R. (1991) Controlled delivery system for proteins based on poly(lactic/glycolic acid) microspheres. Pharm. Res. 8: 713-720
5. Damge, C., Aprahamian, M., Marchais, H., Benoit, J. P., Pinget, M. (1996) Intestinal absorption of PLGA microspheres in the rat. J. Anat. 189: 491-501
6. Deng, X. M., Xiong, C. D., Cheng, L. M. (1990) Synthesis and characterization of block copolymer from lactide and polyethylene glycol. J. Polym. Sci. Polym. Lett. 28: 411-416
7. Deng, X. M., Li, X. H., Yuan, M. L., Li, X. W., Xiong, C. D., Huang, Z. T., Jia, W. X. (1999a) Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application as matrix of microspheres containing vibrio cholera antigens. Chinese J. Polym. Sci. 17: 1-6
8. Deng, X. M., Li, X. H., Yuan, M. L., Xiong, C. D., Huang, Z. T., Jia, W. X., Zhang, Y. H. (1999b) Optimization of preparative conditions for poly-DL-lactide-poly(ethylene glycol) microspheres with entrapped Vibrio Cholera antigens. J. Control. Rel. 58: 123-131
9. Ebel, J. P. (1990) A method for quantifying particle absorption from the small intestine of the animal. Pharm. Res. 7: 848-851
10. Eldridge, J. H., Hammond, C. J., Meulbroek, J. A., Staas, J. K., Gilley, R. M., Tice, T. R. (1990) Controlled vaccine release in the gut-associated lymphoid tissues. 1. Orally administered biodegradable microspheres target the paper's patches. J. Control. Rel. 11: 205-214
11. 131T-labeled human growth hermone of high specific radioactivity. Biochem. J. 89: 114-119
12. Jani, P. U., Halber, G. W., Langridge, J., Florence, A. T. (1990) Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmcol. 42: 821-826
13. Jia, W. X., Zhang, W. B., Li, X. W., Deng, X. M. (1997) Experimental study on administration of microencapsulated Vibrio cholera vaccine. Chin. J. Microbiol. Immunology 17: 342-347
14. Li, X. H., Yuan, M. L., Xiong, C. D., Deng, X. M., Huang, Z. T. (1999a) Preparation of poly-DL-lactide-poly(ethylene glycol) microspheres encapsulating human serum albumin. Acta Polymeric Sinica 2: 156-161
15. Li, X. H., Deng, X. M., Yuan, M. L., Xiong, C. D., Huang, Z. T. (1999b) Investigation on process parameters involved in preparation of poly-DL-lactide-poly(ethylene glycol) microspheres containing Leptospira Interrogans antigens. Int. J. Pharm. 178: 245-255
16. O'Hagan, D. T. (1996) The intestinal uptake of particles and the implication for drug and antigen delivery. J. Anat. 189: 477-482
17. Singh, M., Li, X. M., McGee, J. P., Zamb, T., Koff, W., (1997) Controlled release microspheres as a single dose hepatitis B vaccine: evaluation of immunogenicity in animals. Vaccine 151: 475-481
18. Uchida, T., Goto, S., Foster, T. P. (1994) Particle size studies for subcutaneous delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation. J. Pharm. Pharmacol. 46: 556-560