The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke

Brain Research Bulletin

Volumn 82, Issue 3-4, 2010, Pages 228-233

  Liu, Lingling ^a   Zhang, Xiangjian ^a   Wang, Lina ^a   Yang, Rui ^a   Cui, Lili ^a   Li, Min ^a   Du, Wei ^a   Wang, Shan ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Brain derived neurotrophic factor; CAMP response element binding protein; Middle cerebral artery occlusion; Neuroprotection; Tanshinone IIA; Transducer of regulated CREB activity 1

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MEMBRANE PROTEIN; TANSHINONE IIA; TRANSDUCER OF REGULATED CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; ABIETANE DERIVATIVE; CRTC1 PROTEIN, RAT; HERBACEOUS AGENT; NEUROPROTECTIVE AGENT; PHENANTHRENE DERIVATIVE; TANSHINONE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETIC ASSOCIATION; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ACTIVE TRANSPORT; ANIMAL; CEREBROVASCULAR ACCIDENT; GENETICS; HUMAN; METABOLISM; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DRUGS, CHINESE HERBAL; HUMANS; MALE; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; STROKE; TRANSCRIPTION FACTORS; UP-REGULATION; DITERPENES, ABIETANE;

EID: 77953540227     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2010.04.005     Document Type: Article

References (35)

1. Altarejos J.Y., Goebel N., Conkright M.D., Inoue H., Xie J.X., Arias C.M., Sawchenko P.E., Montminy M. The creb1 coactivator crtc1 is required for energy balance and fertility. Nat. Med. 2008, 14(10):1112-1117.
2. Bittinger M.A., McWhinnie E., Meltzer J., Iourgenko V., Latario B., Liu X., Cen C.H., Song C., Garza D., Labow M. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr. Biol. 2004, 14(23):156-161.
3. Blanquet P.R., Mariani J., Fournier B. Identification of a biphasic signaling pathway involved in ischemic resistance of the hippocampal dentate gyrus. Exp. Neurol. 2006, 202(2):357-372.
4. Cao E.H., Liu X.Q., Wang J.J., Xu N.F. Effect of natural antioxidant Tanshinone II-A on DNA damage by lipid peroxidation in liver cells. Free Radic. Biol. Med. 1996, 20(6):801-806.
5. Cardinaux J.R., Notis J.C., Zhang Q., Vo N., Craig J.C., Fass D.M., Brennan R.G., Goodman R.H. Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. Mol. Cell Biol. 2000, 20(5):1546-1552.
6. Conkright M.D., Canettieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J.B., Montminy M. TORCs: transducers of regulatedn CREB activity. Mol. Cell 2003, 12(2):413-423.
7. Deng J., Zhang X.L., Wang J.W., Teng L.L., Ge J., Takemori H., Xiong Z.Q., Zhou Y. Expression and regulated nuclear transport of transducers of regulation CREB 1 in retinal ganglion cells. Neuroscience 2009, 159:1023-1031.
8. †. Phytother. Res. 2009, 23(5):608-613.
9. Fan G.W., Gao X.M., Wang H., Zhu Y., Zhang J., Hu L.M., Su Y.F., Kang L.Y., Zhang B.L. The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS. J. Steroid Biochem. Mol. Biol. 2009, 113:275-280.
10. Ferrer J., Krupinski E., Goutan E., Martí S., Ambrosio E., Arenas Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat. Acta Neuropathol. 2001, 101(3):229-238.
11. Gao J., Yang G., Pi R., Li R., Wang P., Zhang H., Le K., Chen S., Liu P. Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis. Transl. Res. 2008, 151(2):79-87.
12. Hatashita S., Hoff J.T., Salamat S.M. Ischemic brain edema and the osomotic gradient between blood and brain. J. Cereb. Blood Flow Metab. 1988, 8(4):552-559.
13. Hietakangas V., Cohen S.M. TORCing up metabolic control in the brain. Cell Metab. 2008, 7(5):357-358.
14. Hu B.R., Fux C.M., Martone M.E., Zivin J.A., Ellisman M.H. Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factors following transient cerebral ischemia in rat brain. Neuroscience 1999, 89:437-452.
15. Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J.M., Orth A.P., Miraglia L., Meltzer J., Garza D., Chirn G.W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F.P., Zhu J., Song C., Labow M.A. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100(21):12147-12152.
16. Kim H.H, Kim J.H., Kwak H.B., Huang H., Han S.H., Ha H., Lee S.W., Woo E.R., Lee Z.H. Inhibition of osteoclast differentiation and bone resorption by Tanshinone IIA isolated from Salvia Miltiorrhiza Bunge. Biochem. Pharmacol. 2004, 67(9):1647-1656.
17. Kitagawa K. CREB and cAMP response element-mediated gene expression in the ischemic brain. FEBS J. 2007, 274(13):3210-3217.
18. Kovacs K.A., Steullet P., Steinmann M., Do K.Q., Magistretti P.J., Halfon O., Cardinaux J.R. TORC1 is a calciumand cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc. Natl. Acad. Sci. U.S.A. 2007, 104(11):4700-4705.
19. Lam B.Y., Lo A.C., Sun X., Luo H.W., Chung S.K., Sucher N.J. Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice. Phytomedicine 2003, 10(4):286-291.
20. Lee B., Butcher G.Q., Hoyt K.R., Impey S., Obrietan K. Activity dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133. J. Neurosci. 2005, 25(5):1137-1148.
21. Li S., Zhang C., Takemori H., Zhou Y., Xiong Z.Q. TORC1 regulates activity dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. J. Neurosci. 2009, 29(8):2334-2343.
22. Liu Y., Zhang X.J., Yang C.H., Fan H.G. Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-κB expression. Brain Res. 2009, 1268:174-180.
23. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20(1):84-91.
24. Lonze B.E., Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35(4):605-623.
25. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2001, 2(8):599-609.
26. Schäbitz W.K., Schwab S., Spranger M., Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 1997, 17(5):500-506.
27. Screaton R.A., Conkright M.D., Katoh Y., Best J.L., Canettieri G., Jeffries S., Guzman E., Niessen S., Yates J.R., Takemori H., Okamoto M., Montminy M. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 2004, 119(1):61-74.
28. Tanaka K., Nagata E., Suzuki S., Dembo T., Nogawa S., Fukuuchi Y. Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia in rats. Brain Res. 1999, 818(2):520-526.
29. Wu H., Zhou Y., Xiong Z.Q. Transducer of regulated CREB and late phase long-term synaptic potentiation. FEBS J. 2007, 274(13):3218-3223.
30. Xu W., Yang J., Wu L.M. Cardioprotective effects of Tanshinone IIA on myocardial ischemia injury in rats. Pharmazie 2009, 64(5):332-336.
31. Yamashita K., Wiessner C., Lindholm B., Thoenen H., Hossman K.A. Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat. Metab. Brain Dis. 1997, 12(4):271-280.
32. Yang R., Liu A., Ma X., Li L., Su D., Liu J. Sodium Tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation. J. Cardiovasc. Pharmacol. 2008, 51(4):396-401.
33. Yang C.H., Zhang X.J., Fan H.G., Liu Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res. 2009, 1282:133-141.
34. Zhou Y., Wu H., Li S., Chen Q., Cheng X.W., Zheng J., Takemori H., Xiong Z.Q. Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS ONE 2006, 1:e16.
35. Zhou L., Zuo Z., Chow M.S.S. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmacol. 2005, 45:1345-1359.