Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion

Food Chemistry

Volumn 138, Issue 1, 2013, Pages 663-670

  Yang, Eun Ju ^a   Lim, Sun Ha ^b   Song, Kyung Sik ^a   Han, Hyung Soo ^c   Lee, Jongwon ^b  

^a Kyungpook National University   (South Korea)

^b Catholic University of Daegu   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

Aurantii Immatri Pericarpium; Cerebral infarction; Ischemia reperfusion; Nobiletin; Tangeretin

Indexed keywords

AURANTII IMMATRI PERICARPIUM; CEREBRAL INFARCTION; ISCHEMIA REPERFUSION; NOBILETIN; TANGERETIN;

CELL DEATH; DICHLOROMETHANE; ETHANOL;

BRAIN;

3,3',4',5,6,7,8 HEPTAMETHOXYFLAVONE; ACETIC ACID ETHYL ESTER; ALCOHOL; BUTANOL; DICHLOROMETHANE; HY 5356; NATSUDAIDAIN; NEUROPROTECTIVE AGENT; NOBILETIN; TANGERETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AURANTII IMMATRI PERICARPIUM; BRAIN INJURY; BRAIN ISCHEMIA; CARCINOMA CELL; CELL FRACTIONATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG IDENTIFICATION; DRUG SCREENING; HUMAN; HUMAN CELL; HYPOXIA; LIVER CELL CARCINOMA; MALE; MEDICINAL PLANT; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CITRUS; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; FLAVONES; FRUIT; HEP G2 CELLS; HUMANS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

RATTUS;

EID: 84870704926     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.09.137     Document Type: Article

References (30)

1. J.H. Baek, J.E. Jang, C.M. Kang, H.Y. Chung, N.D. Kim, and K.W. Kim Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis Oncogene 19 2000 4621 4631
2. S.T. Chen, H.L. Chu, C.C. Chyau, C.C. Chu, and P.D. Duh Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress Food Chemistry 135 2012 2119 2127
3. P. Deb, S. Sharma, and K.M. Hassan Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis Pathophysiology 17 2010 197 218
4. U. Dirnagl, R.P. Simon, and J.M. Hallenbeck Ischemic tolerance and endogenous neuroprotection Trends in Neurosciences 26 2003 248 254
5. I. Ferrer Apoptosis: Future targets for neuroprotective strategies Cerebrovascular Diseases 21 suppl 2 2006 9 20
6. L.B. Goldstein Acute ischemic stroke treatment in 2007 Circulation 116 2007 1504 1514
7. H.S. Han, Y. Qiao, M. Karabiyikoglu, R.G. Giffard, and M.A. Yenari Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation The Journal of Neuroscience 22 2002 3921 3928
8. H.S. Han, J.S. Choi, Y.J. Kim, S.H. Lim, H.K. Lee, J.H. Jang, Y.S. Moon, and J.W. Lee Protective effect of Triticum aestivum L. extract and its components, starch, in rat focal cerebral ischemia Current Topics in Nutraceutical Research 6 2008 44 51
9. H.S. Han, and J.W. Lee Attenuation of brain injury by water extract of goat's-beard (Aruncus dioicus) and its ethyl acetate fraction in a rat model of ischemia-reperfusion Journal of Food Science and Nutrition 16 2011 217 223
10. L. Hui, C.Y. Qin, G.Q. Han, H.W. Xu, M. Meng, and Z. Yang Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines World Journal of Gastroenterology 13 2007 1652 1658
11. S.P. Johnsen, K. Overvad, C. Stripp, A. Tjønneland, S.E. Husted, and H.T. Sørensen Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women The American Journal of Clinical Nutrition 78 2003 57 64
12. S. Kawaii, Y. Tomono, E. Katase, K. Ogawa, and M. Yano HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from Citrus juices Journal of Agricultural and Food Chemistry 47 1999 128 135
13. K.H. Kim, and J.W. Lee Methanol extract of Cassia mimosoides var. nomame and its ethyl acetate fraction attenuate brain damage by inhibition of apoptosis in a rat model of ischemia-reperfusion Journal of Food Science and Nutrition 15 2010 255 261
14. J.W. Lee, K.W. Kim, J.K. Lee, and S.J. Lee Therapeutic agent for ischemia which inhibits apoptosis under ischemic condition US Patent 6 2004 716 822
15. Y.T. Lee, M.J. Han, S.H. Lim, S.H. Park, H.S. Suh, J.B. Park, Y.I. Kim, and J.W. Lee Effect of antibiotics on the survival of human hepatocellular carcinoma cells under hypoxic conditions Journal of the Korean Surgical Society 71 2006 31 38
16. S.H. Lim, J.Y. Lee, S.H. Park, Y.H. Kim, H.S. Suh, J.B. Park, and J.W. Lee Effect of combination of anticancer agents and nitroimidazoles on the survival of human hepatocellular carcinoma cells under hypoxic conditions Journal of the Korean Surgical Society 76 2009 337 347
17. S.H. Lim, H.S. Han, J.H. Park, and J.W. Lee Methanol extract of peony root (Peonia lactiflora) and its ethyl acetate fraction attenuate heart and brain injury in a rat model of ischemia-reperfusion Journal of the Korean Society for Applied Biological Chemistry 54 2011 799 801
18. J.A. Menthey, and P. Bendele Anti-inflammtory activity of an orange peel polymethoxylated flavone, 3′,4′,3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays Journal of Agricultural and Food Chemistry 56 2008 9399 9403
19. J.A. Manthey, T.B. Cesar, E. Jackson, and S. Mertens-Talcott Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry Journal of Agricultural and Food Chemistry 59 2011 145 151
20. K. Overgaard, and P. Meden Citicoline-the first effective neuroprotectant to be combined with thrombolysis in acute ischemic stroke? Journal of the Neurological Sciences 247 2006 119 120
21. S.A. Padosch, and B.W. Bottiger Neuronal apoptosis following cerebral ischaemia: Pathophysiology and possible therapeutic implications Current Opinion in Anaesthesiology 16 2003 439 445
22. J.L. Saver Proposal for a universal definition of cerebral infarction Stroke 39 2008 3110 3115
23. A. Simonyi, Q. Wang, R.L. Miller, M. Yusof, P.B. Shelat, A.Y. Sun, and G.Y. Sun Polyphenols in cerebral ischemia: Novel targets for neuroprotection Molecular Neurobiology 31 2005 135 147
24. H. Takanaga, A. Ohnishi, S. Yamada, H. Matsuo, S. Morimoto, Y. Shoyama, H. Ohtani, and Y. Sawada Polymethoxylated flavones in orange juice are inhibitors of p-glycoprotein but not cytochrome P450 3A4 The Journal of Pharmacology and Experimental Therapeutics 293 2000 230 236
25. C. Wang, Y. Pan, G. Fan, Y. Chai, and Y. Wu Application of an efficient strategy based on MAE, HPLC-DAD-MS/MS and HSCCC for the rapid extraction, identification, separation and purification of flavonoids from Fructus Aurantii Immaturus Biomedical Chromatography 24 2010 235 244
26. B. Wu, K. Kulkarni, S. Basu, S. Zhang, and M. Hu First-pass metabolism via UDP-glucuronosyltransferase: A barrier to oral bioavailability of phenolics Journal of Pharmaceutical Sciences 100 2011 3655 3681
27. T. Yamada, S. Hayasake, Y. Shibata, T. Ojima, T. Saegusa, T. Gotoh, S. Ishikawa, Y. Nakamura, and K. Kayaba Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: The Jichi Medical School chohort study Journal of Epidemiology 21 2011 169 175
28. Y. Yamamoto, N. Shioda, F. Han, S. Moriguchi, A. Nakajima, A. Yokosuka, Y. Mimaki, Y. Sashida, T. Yamkuni, Y. Ohizumi, and K. Fukunaga Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation Brain Research 1295 2009 218 229
29. J. Yuan Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke Apoptosis 14 2009 469 477
30. L. Zhang, Z. Zuo, and G. Lin Intestinal and hepatic glucuronidation of flavonoids Molecular Pharmaceutics 4 2007 833 845