Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation

Experimental Neurology

Volumn 220, Issue 1, 2009, Pages 82-89

  Carloni, Silvia ^a   Girelli, Silvia ^a   Buonocore, Giuseppe ^b   Longini, Mariangela ^b   Balduini, Walter ^a  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Akt; CREB; Hypoxia ischemia; Neonate; Neurodegeneration; Neuroprotection; Statins

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PROTEIN KINASE B; SIMVASTATIN; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; LOW DRUG DOSE; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SINGLE DRUG DOSE;

AGE FACTORS; AGING; ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN INFARCTION; CAROTID STENOSIS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENZYME ACTIVATION; ENZYME INHIBITORS; HYPOXIA-ISCHEMIA, BRAIN; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; UP-REGULATION;

EID: 70349742221     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.07.026     Document Type: Article

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