Adipokines and hepatic insulin resistance

Journal of Diabetes Research

Volumn 2013, Issue , 2013, Pages

  Li, Yu ^a   Ding, Lin ^a   Hassan, Waseem ^a,b   Abdelkader, Daoud ^a   Shang, Jing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; INSULIN; INTERLEUKIN 6; LEPTIN; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ADIPOCYTE; ENDOCRINE CELL; FIBROBLAST; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; LIVER; METABOLISM; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADIPOKINES; ANIMALS; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; LIVER; OBESITY;

EID: 84878741071     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2013/170532     Document Type: Review

References (100)

1. Saltiel A. R., The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. Journal of Clinical Investigation 2000 106 2 163 164 (Pubitemid 30483116)
2. Matthaei S., Stumvoll M., Kellerer M., Haring H. U., Pathophysiology and pharmacological treatment of insulin resistance. Endocrine Reviews 2000 21 6 585 561
3. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Journal of Clinical Investigation 2006 116 7 1784 1792 2-s2.0-33745834319 10.1172/JCI29126 (Pubitemid 44033298)
4. Tilg H., Moschen A. R., Inflammatory mechanisms in the regulation of insulin resistance. Molecular Medicine 2008 14 3-4 222 231 2-s2.0-41649093318 10.2119/2007-00119.Tilg (Pubitemid 351481853)
5. Marra F., Bertolani C., Adipokines in liver diseases. Hepatology 2009 50 3 957 969 2-s2.0-70349238777 10.1002/hep.23046
6. Hotamisligil G. S., Inflammation and metabolic disorders. Nature 2006 444 7121 860 867 2-s2.0-33845866857 10.1038/nature05485 (Pubitemid 46024993)
7. Rabe K., Lehrke M., Parhofer K. G., Adipokines and insulin resistance. Molecular Medicine 2008 14 11 741 751
8. Antuna-Puente B., Feve B., Fellahi S., Bastard J. P., Adipokines: the missing link between insulin resistance and obesity. Diabetes and Metabolism 2008 34 1 2 11 2-s2.0-39149143637 10.1016/j.diabet.2007.09.004
9. Scherer P. E., Williams S., Fogliano M., Baldini G., Lodish H. F., A novel serum protein similar to C1q, produced exclusively in adipocytes. Journal of Biological Chemistry 1995 270 45 26746 26749 2-s2.0-0028787490 10.1074/jbc.270.45.26746
10. Díez J. J., Iglesias P., The role of the novel adipocyte-derived hormone adiponectin in human disease. European Journal of Endocrinology 2003 148 3 293 300 2-s2.0-0037356826 10.1530/eje.0.1480293 (Pubitemid 36410714)
11. Saito K., Tobe T., Minoshima S., Asakawa S., Sumiya J., Yoda M., Nakano Y., Shimizu N., Tomita M., Organization of the gene for gelatin-binding protein (GBP28). Gene 1999 229 1-2 67 73 2-s2.0-0033580457 10.1016/S0378-1119(99)00041-4 (Pubitemid 29148308)
12. Ouchi N., Kihara S., Arita Y., Maeda K., Kuriyama H., Okamoto Y., Hotta K., Nishida M., Takahashi M., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y., Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999 100 25 2473 2476 2-s2.0-0033613545 (Pubitemid 30005109)
13. Vasseur F., Meyre D., Froguel P., Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert Reviews in Molecular Medicine 2006 8 27 1 12 2-s2.0-33751209234 10.1017/S1462399406000147 (Pubitemid 44782612)
14. Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K., cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochemical and Biophysical Research Communications 1996 221 2 286 289 2-s2.0-0029980285 10.1006/bbrc.1996.0587 (Pubitemid 26136463)
15. Lara-Castro C., Fu Y., Chung B. H., Garvey W. T., Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease. Current Opinion in Lipidology 2007 18 3 263 270 2-s2.0-34248350766 10.1097/MOL.0b013e32814a645f (Pubitemid 46743049)
16. Chen J., Tan B., Karteris E., Zervou S., Digby J., Hillhouse E. W., Vatish M., Randeva H. S., Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia 2006 49 6 1292 1302 2-s2.0-33646494846 10.1007/s00125-006-0194-7
17. Arita Y., Kihara S., Ouchi N., Takahashi M., Maeda K., Miyagawa J. I., Hotta K., Shimomura I., Nakamura T., Miyaoka K., Kuriyama H., Nishida M., Yamashita S., Okubo K., Matsubara K., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y., Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 1999 257 1 79 83 2-s2.0-0033515761 10.1006/bbrc.1999.0255 (Pubitemid 29299050)
18. Woo Y. C., Tso A. W., Xu A., Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction. PLoS One 2012 7 5 1 8
19. Simpson F., Whitehead J. P., Adiponectin-It's all about the modifications. International Journal of Biochemistry and Cell Biology 2010 42 6 785 788 2-s2.0-77953806826 10.1016/j.biocel.2009.12.021
20. Wong G. W., Krawczyk S. A., Kitidis-Mitrokostas C., Ge G., Spooner E., Hug C., Gimeno R., Lodish H. F., Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB Journal 2009 23 1 241 258 2-s2.0-58249117645 10.1096/fj.08-114991
21. Yamauchi T., Kamon J., Ito Y., Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003 423 6941 762 769 (Pubitemid 36735700)
22. Antuna-Puente B., Feve B., Fellahi S., Bastard J. P., Adipokines: the missing link between insulin resistance and obesity. Diabetes and Metabolism 2008 34 1 2 11 2-s2.0-39149143637 10.1016/j.diabet.2007.09.004
23. Matsuzawa Y., Adiponectin: a key player in obesity related disorders. Current Pharmaceutical Design 2010 16 17 1896 1901 2-s2.0-77953508725 10.2174/138161210791208893
24. Ukkola O., Santaniemi M., Adiponectin: a link between excess adiposity and associated comorbidities? Journal of Molecular Medicine 2002 80 11 696 702 2-s2.0-0036432925 10.1007/s00109-002-0378-7 (Pubitemid 35352035)
25. Díez J. J., Iglesias P., The role of the novel adipocyte-derived hormone adiponectin in human disease. European Journal of Endocrinology 2003 148 3 293 300 (Pubitemid 36410714)
26. Renaldi O., Pramono B., Sinorita H., Purnomo L. B., Asdie R. H., Asdie A. H., Hypoadiponectinemia: a risk factor for metabolic syndrome. Acta medica Indonesiana 2009 41 1 20 24 2-s2.0-77952515176
27. Dadson K., Liu Y., Sweeney G., Adiponectin action: a combination of endocrine and autocrine/paracrine effects. Frontiers in Endocrinology 2011 2 62 1 14
28. Berg A. H., Combs T. P., Du X., Brownlee M., Scherer P. E., The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine 2001 7 8 947 953 2-s2.0-0034881391 10.1038/90992 (Pubitemid 32756433)
29. Xie L., Boyle D., Sanford D., Scherer P. E., Pessin J. E., Mora S., Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles. Journal of Biological Chemistry 2006 281 11 7253 7259 2-s2.0-33646349753 10.1074/jbc.M511313200 (Pubitemid 43847493)
30. Vrachnis N., Belitsos P., Sifakis S., Role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus. International Journal of Endocrinology 2012 2012 12 549748
31. Gastaldelli A., Harrison S. A., Belfort-Aguilar R., Hardies L. J., Balas B., Schenker S., Cusi K., Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology 2009 50 4 1087 1093 2-s2.0-70350064027 10.1002/hep.23116
32. Baranova A., Gowder S. J., Schlauch K., Elariny H., Collantes R., Afendy A., Ong J. P., Goodman Z., Chandhoke V., Younossi Z. M., Gene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistance. Obesity Surgery 2006 16 9 1118 1125 2-s2.0-33748946404 10.1381/096089206778392149 (Pubitemid 44433145)
33. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B. B., Kadowaki T., Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 2002 8 11 1288 1295 2-s2.0-0036851817 10.1038/nm788 (Pubitemid 35373562)
34. Nawrocki A. R., Rajala M. W., Tomas E., Pajvani U. B., Saha A. K., Trumbauer M. E., Pang Z., Chen A. S., Ruderman N. B., Chen H., Rossetti L., Scherer P. E., Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists. Journal of Biological Chemistry 2006 281 5 2654 2660 2-s2.0-33646346627 10.1074/jbc.M505311200 (Pubitemid 43845727)
35. Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., Okada-Iwabu M., Kawamoto S., Kubota N., Kubota T., Ito Y., Kamon J., Tsuchida A., Kumagai K., Kozono H., Hada Y., Ogata H., Tokuyama K., Tsunoda M., Ide T., Murakami K., Awazawa M., Takamoto I., Froguel P., Hara K., Tobe K., Nagai R., Ueki K., Kadowaki T., Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 2007 13 3 332 339 2-s2.0-33847733103 10.1038/nm1557 (Pubitemid 46376688)
36. Liu Y., Michael M. D., Kash S., Bensch W. R., Monia B. P., Murray S. F., Otto K. A., Syed S. K., Bhanot S., Sloop K. W., Sullivan J. M., Reifel-Miller A., Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. Endocrinology 2007 148 2 683 692 2-s2.0-33846443694 10.1210/en.2006-0708 (Pubitemid 46143170)
37. Combs T. P., Pajvani U. B., Berg A. H., Lin Y., Jelicks L. A., Laplante M., Nawrocki A. R., Rajala M. W., Parlow A. F., Cheeseboro L., Ding Y. Y., Russell R. G., Lindemann D., Hartley A., Baker G. R. C., Obici S., Deshaies Y., Ludgate M., Rossetti L., Scherer P. E., A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004 145 1 367 383 2-s2.0-9144263120 10.1210/en.2003-1068 (Pubitemid 38094532)
38. Kim J. Y., van de Wall E., Laplante M., Obesity associated improvements in metabolic profile through expansion of adipose tissue. Journal of Clinical Investigation 2007 117 9 2621 2637 (Pubitemid 47494363)
39. Berg A. H., Combs T. P., Du X., Brownlee M., Scherer P. E., The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine 2001 7 8 947 953 2-s2.0-0034881391 10.1038/90992 (Pubitemid 32756433)
40. Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., Okada-Iwabu M., Kawamoto S., Kubota N., Kubota T., Ito Y., Kamon J., Tsuchida A., Kumagai K., Kozono H., Hada Y., Ogata H., Tokuyama K., Tsunoda M., Ide T., Murakami K., Awazawa M., Takamoto I., Froguel P., Hara K., Tobe K., Nagai R., Ueki K., Kadowaki T., Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 2007 13 3 332 339 2-s2.0-33847733103 10.1038/nm1557 (Pubitemid 46376688)
41. Awazawa M., Ueki K., Inabe K., Yamauchi T., Kubota N., Kaneko K., Kobayashi M., Iwane A., Sasako T., Okazaki Y., Ohsugi M., Takamoto I., Yamashita S., Asahara H., Akira S., Kasuga M., Kadowaki T., Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metabolism 2011 13 4 401 412 2-s2.0-79953765855 10.1016/j.cmet.2011.02.010
42. Bermejo A. L., Botas P., Funahashi T., Adiponectin, hepatocellular dysfunction and insulin sensitivity. Clinical Endocrinology 2004 60 2 256 263 (Pubitemid 38200909)
43. Bajaj M., Suraamornkul S., Piper P., Hardies L. J., Glass L., Cersosimo E., Pratipanawatr T., Miyazaki Y., Defronzo R. A., Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients. Journal of Clinical Endocrinology and Metabolism 2004 89 1 200 206 2-s2.0-0842313004 10.1210/jc.2003-031315 (Pubitemid 38183882)
44. Lin E., Phillips L. S., Ziegler T. R., Schmotzer B., Wu K., Gu L. H., Khaitan L., Lynch S. A., Torres W. E., Smith C. D., Gletsu-Miller N., Increases in adiponectin predict improved liver, but not peripheral, insulin sensitivity in severely obese women during weight loss. Diabetes 2007 56 3 735 742 2-s2.0-33847415067 10.2337/db06-1161 (Pubitemid 46348478)
45. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. M., Positional cloning of the mouse obese gene and its human homologue. Nature 1994 372 6505 425 432 2-s2.0-0028139089 10.1038/372425a0 (Pubitemid 24365442)
46. Halaas J. L., Gajiwala K. S., Maffei M., Cohen S. L., Chait B. T., Rabinowitz D., Lallone R. L., Burley S. K., Friedman J. M., Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995 269 5223 543 546 2-s2.0-0029073613
47. Silha J. V., Krsek M., Skrha J. V., Sucharda P., Nyomba B. L. G., Murphy L. J., Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistence. European Journal of Endocrinology 2003 149 4 331 335 2-s2.0-0142216501 10.1530/eje.0.1490331 (Pubitemid 37304704)
48. Wang J., Obici S., Morgan K., Barzilai N., Feng Z., Rossetti L., Overfeeding rapidly induces leptin and insulin resistance. Diabetes 2001 50 12 2786 2791 2-s2.0-0035654626 (Pubitemid 33733130)
49. Zimmet P., Hodge A., Nicolson M., Staten M., De Courten M., Moore J., Morawiecki A., Lubina J., Collier G., Alberti G., Dowse G., Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross Sectional Study. British Medical Journal 1996 313 7063 965 969 2-s2.0-10544220841 (Pubitemid 26385521)
50. Kolaczynski J. W., Nyce M. R., Considine R. V., Boden G., Nolan J. J., Henry R., Mudaliar S. R., Olefsky J., Caro J. F., Acute and chronic effect of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 1996 45 5 699 701 2-s2.0-0029665017 (Pubitemid 26142812)
51. Gabriel M., Jinagouda S., Boyadjian R., Is leptin the link between obesity and insulin resistance? Diabetes & Metabolism 1997 45 3 16 24
52. Dagogo-Jack S., Fanelli C., Paramore D., Brothers J., Landt M., Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 1996 45 5 695 698 2-s2.0-0030012248 (Pubitemid 26142811)
53. Lichnovská R., Gwozdziewiczová S., Chlup R., Serum leptin in the development of insulin resistance and other disorders in the metabolic syndrome. Biomedical Papers of the Medical Faculty of the University Palacký Olomouc, Czechoslovakia 2005 149 1 119 126
54. Segal K. R., Landt M., Klein S., Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 1996 45 3 988 991 2-s2.0-0030013679 (Pubitemid 26225519)
55. Zimmet P. Z., Collins V. R., De Courten M. P., Hodge A. M., Collier G. R., Dowse G. K., Alberti K. G. M. M., Tuomilehto J., Hemraj F., Gareeboo H., Chitson P., Fareed D., Is there a relationship between leptin and insulin sensitivity independent of obesity? A population-based study in the Indian Ocean nation of Mauritius. International Journal of Obesity 1998 22 2 171 177 2-s2.0-3042715083 (Pubitemid 28058770)
56. Shimomura I., Hammer R. E., Ikemoto S., Brown M. S., Goldstein J. L., Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999 401 6748 73 76 2-s2.0-0033517284 10.1038/43448 (Pubitemid 29418444)
57. German J., Kim F., Schwartz G. J., Havel P. J., Rhodes C. J., Schwartz M. W., Morton G. J., Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology 2009 150 10 4502 4511 2-s2.0-70349337472 10.1210/en.2009-0445
58. Steppan C. M., Bailey S. T., Bhat S., Brown E. J., Banerjee R. R., Wright C. M., Patel H. R., Ahima R. S., Lazar M. A., The hormone resistin links obesity to diabetes. Nature 2001 409 6818 307 312 2-s2.0-0035905758 10.1038/35053000 (Pubitemid 32151228)
59. Steppan C. M., Brown E. J., Wright C. M., A family of tissue-specific resistin-like molecules. Proceedings of the National Academy of Sciences of the United States of America 2001 98 2 502 506 (Pubitemid 32105071)
60. Patel S. D., Rajala M. W., Rossetti L., Scherer P. E., Shapiro L., Disulfide-dependent multimeric assembly of Resistin family hormones. Science 2004 304 5674 1154 1158 2-s2.0-2442707674 10.1126/science.1093466 (Pubitemid 38661851)
61. Barnes K. M., Miner J. L., Role of resistin in insulin sensitivity in rodents and humans. Current Protein and Peptide Science 2009 10 1 96 107 2-s2.0-63849103057 10.2174/138920309787315239
62. Ghosh S., Singh A. K., Aruna B., Mukhopadhyay S., Ehtesham N. Z., The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications. Gene 2003 305 1 27 34 2-s2.0-0037434632 10.1016/S0378-1119(02)01213-1 (Pubitemid 36197863)
63. Muse E. D., Obici S., Bhanot S., Monia B. P., McKay R. A., Rajala M. W., Scherer P. E., Rossetti L., Role of resistin in diet-induced hepatic insulin resistance. Journal of Clinical Investigation 2004 114 2 232 239 2-s2.0-4043082182 10.1172/JCI200421270 (Pubitemid 39071628)
64. Zhou L., Sell H., Eckardt K., Yang Z., Eckel J., Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. FEBS Letters 2007 581 22 4303 4308 2-s2.0-34548124842 10.1016/j.febslet.2007.07.076 (Pubitemid 47301863)
65. Steppan C. M., Bailey S. T., Bhat S., Brown E. J., Banerjee R. R., Wright C. M., Patel H. R., Ahima R. S., Lazar M. A., The hormone resistin links obesity to diabetes. Nature 2001 409 6818 307 312 2-s2.0-0035905758 10.1038/35053000 (Pubitemid 32151228)
66. Kim K. H., Zhao L., Moon Y., Kang C., Sul H. S., Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America 2004 101 17 6780 6785 2-s2.0-2342643579 10.1073/pnas.0305905101 (Pubitemid 38586051)
67. Bastard J. P., Maachi M., Van Nhieu J. T., Jardel C., Bruckert E., Grimaldi A., Robert J. J., Capeau J., Hainque B., Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. Journal of Clinical Endocrinology and Metabolism 2002 87 5 2084 2089 2-s2.0-0036098188 10.1210/jc.87.5.2084 (Pubitemid 34521492)
68. Van S. J., Interleukin-6: an overview. Annual Review of Immunology 1990 8 253 278
69. Fried S. K., Bunkin D. A., Greenberg A. S., Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology and Metabolism 1998 83 3 847 850 2-s2.0-0031762908 10.1210/jc.83.3.847 (Pubitemid 28496456)
70. Mohamed-Ali V., Goodrick S., Rawesh A., Katz D. R., Miles J. M., Yudkin J. S., Klein S., Coppack S. W., Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor- α in vivo. Journal of Clinical Endocrinology and Metabolism 1997 82 12 4196 4200 2-s2.0-0030735542 (Pubitemid 27525539)
71. Vicennati V., Vottero A., Friedman C., Papanicolaou D. A., Hormonal regulation of interleukin-6 production in human adipocytes. International Journal of Obesity 2002 26 7 905 911 2-s2.0-0036313811 10.1038/sj.ijo.0802035 (Pubitemid 34756171)
72. Senn J. J., Klover P. J., Nowak I. A., Mooney R. A., Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 2002 51 12 3391 3399 2-s2.0-0036894360 (Pubitemid 35403441)
73. Klover P. J., Zimmers T. A., Koniaris L. G., Mooney R. A., Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003 52 11 2784 2789 2-s2.0-0242268894 10.2337/diabetes.52.11.2784 (Pubitemid 37339708)
74. Carey A. L., Steinberg G. R., Macaulay S. L., Thomas W. G., Holmes A. G., Ramm G., Prelovsek O., Hohnen-Behrens C., Watt M. J., James D. E., Kemp B. E., Pedersen B. K., Febbraio M. A., Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 2006 55 10 2688 2697 2-s2.0-33750859187 10.2337/db05-1404 (Pubitemid 44923666)
75. Steensberg A., Fischer C. P., Sacchetti M., Keller C., Osada T., Schjerling P., van Hall G., Febbraio M. A., Pedersen B. K., Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. Journal of Physiology 2003 548 2 631 638 2-s2.0-0038745434 10.1113/jphysiol.2002.032938 (Pubitemid 36527483)
76. Senn J. J., Klover P. J., Nowak I. A., Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. Journal of Biological Chemistry 2003 278 16 13740 13746 (Pubitemid 36799910)
77. Borst S. E., The role of TNF- α in insulin resistance. Endocrine 2004 23 2-3 177 182
78. Gwozdziewiczova S., Lichnovska R., Yahia R. B., TNF α-in the development of insulin resistance and other disorders in metabolic syndrome. Biomedical Papers of the Medical Faculty of the University Palacký Olomouc, Czechoslovakia 2005 149 1 109 117
79. Araújo E. P., De Souza C. T., Ueno M., Infliximab restores glucose homeostasis in an animal model of diet induced obesity and diabetes. Endocrinology 2007 148 12 5991 5997 (Pubitemid 350146162)
80. Huvers F. C., Popa C., Netea M. G., Van Den Hoogen F. H. J., Tack C. J., Improved insulin sensitivity by anti-TNF α antibody treatment in patients with rheumatic diseases. Annals of the Rheumatic Diseases 2007 66 4 558 559 2-s2.0-34147167977 10.1136/ard.2006.062323 (Pubitemid 46580485)
81. Togashi N., Ura N., Higashiura K., Murakami H., Shimamoto K., Effect of TNF- α -converting enzyme inhibitor on insulin resistance in fructose-fed rats. Hypertension 2002 39 2 578 580 2-s2.0-0036175563 10.1161/hy0202.103290 (Pubitemid 34165186)
82. De Taeye B. M., Novitskaya T., McGuinness O. P., Gleaves L., Medda M., Covington J. W., Vaughan D. E., Macrophage TNF- α contributes to insulin resistance and hepatic steatosis in diet-induced obesity. American Journal of Physiology-Endocrinology and Metabolism 2007 293 3 E713 E725 2-s2.0-34548395788 10.1152/ajpendo.00194.2007 (Pubitemid 47358983)
83. Uysal K. T., Wiesbrock S. M., Marino M. W., Hotamisligil G. S., Protection from obesity-induced insulin resistance in mice lacking TNF- α function. Nature 1997 389 6651 610 614 2-s2.0-0030756346 10.1038/39335 (Pubitemid 27446179)
84. Swaroop J. J., Rajarajeswari D., Naidu J. N., Association of TNF- α with insulin resistance in type 2 diabetes mellitus. Indian Journal of Medical Research 2012 135 127 130
85. Bastuk T., Unsal A., Ulas T., Effects of rosiglitazone treatment on insulin resistance and TNF-alpha levels in patients with chronic kidney disease: A Prospective Study. European Review for Medical and Pharmacological Sciences 2012 16 11 1519 1524
86. Miles P. D. G., Romeo O. M., Higo K., Cohen A., Rafaat K., Olefsky J. M., TNF- α -induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 1997 46 11 1678 1683 2-s2.0-0030661983 (Pubitemid 27456397)
87. Rask-Madsen C., Domínguez H., Ihlemann N., Hermann T., Køber L., Torp-Pedersen C., Tumor necrosis factor- α inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 2003 108 15 1815 1821 2-s2.0-0142053963 10.1161/01.CIR.0000091406.72832.11 (Pubitemid 37296090)
88. Kirwan J. P., Hauguel-De Mouzon S., Lepercq J., Challier J. C., Huston-Presley L., Friedman J. E., Kalhan S. C., Catalano P. M., TNF- α is a predictor of insulin resistance in human pregnancy. Diabetes 2002 51 7 2207 2213 2-s2.0-0036307159 (Pubitemid 34729026)
89. Uysal K. T., Wiesbrock S. M., Marino M. W., Hotamisligil G. S., Protection from obesity-induced insulin resistance in mice lacking TNF- α function. Nature 1997 389 6651 610 614 2-s2.0-0030756346 10.1038/39335 (Pubitemid 27446179)
90. Bernstein L. E., Berry J., Kim S., Effects of etanercept in patients with the metabolic syndrome. Archives of Internal Medicine 2006 166 8 902 908
91. Dominguez H., Storgaard H., Rask M. C., Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. Journal of Value Resonance 2005 42 6 517 525 (Pubitemid 41527607)
92. Ofei F., Hurel S., Newkirk J., Sopwith M., Taylor R., Effects of an engineered human anti-TNF- α antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 1996 45 3 881 885 2-s2.0-0029906375 (Pubitemid 26225502)
93. Fernández-Veledo S., Nieto-Vazquez I., Rondinone C. M., Lorenzo M., Liver X receptor agonists ameliorate TNF α -induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression. Diabetologia 2006 49 12 3038 3048 2-s2.0-33750900770 10.1007/s00125-006-0472-4 (Pubitemid 44730308)
94. Hotamisligil G. S., Arner P., Caro J. F., Atkinson R. L., Spiegelman B. M., Increased adipose tissue expression of tumor necrosis factor- α in human obesity and insulin resistance. Journal of Clinical Investigation 1995 95 5 2409 2415 2-s2.0-0028931724
95. Wascher T. C., Lindeman J. H. N., Sourij H., Kooistra T., Pacini G., Roden M., Chronic TNF- α neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome. Molecular Medicine 2011 17 3-4 189 193 2-s2.0-79952856377 10.2119/molmed.2010.00221
96. Bastard J. P., Maachi M., Lagathu C., Kim M. J., Caron M., Vidal H., Capeau J., Feve B., Recent advances in the relationship between obesity, inflammation, and insulin resistance. European Cytokine Network 2006 17 1 4 12 2-s2.0-33745896155
97. Gual P., Le Marchand-Brustel Y., Tanti J. F., Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005 87 1 99 109 2-s2.0-14544271905 10.1016/j.biochi.2004.10.019 (Pubitemid 40298772)
98. Olivares-Reyes J. A., Arellano-Plancarte A., Castillo-Hernandez J. R., Angiotensin II and the development of insulin resistance: implications for diabetes. Molecular and Cellular Endocrinology 2009 302 2 128 139 2-s2.0-63149193315 10.1016/j.mce.2008.12.011
99. Tishinsky J. M., Robinson L. E., Dyck D. J., Insulin-sensitizing properties of adiponectin. Biochimie 2012 94 10 2131 2136
100. Buechler C., Wanninger J., Neumeier M., Adiponectin, a key adipokine in obesity related liver diseases. World Journal of Gastroenterology 2011 17 23 2801 2811 2-s2.0-79959672175 10.3748/wjg.v17.i23.2801