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Volumn 23, Issue SUPPL. 3, 1997, Pages 16-24

Is leptin the link between obesity and insulin resistance?

(1)  Girard, J a  

a CNRS   (France)

Author keywords

Diabetes; Energy balance; Food intake; Insulin; Insulin resistance; Leptin; Obesity

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CYCLIC AMP; GLUCOCORTICOID; INSULIN; LEPTIN; LONG CHAIN FATTY ACID; RECOMBINANT PROTEIN; THIAZOLIDINE DERIVATIVE;

EID: 0030821976     PISSN: 03381684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (81)

References (105)
  • 2
    • 0001506303 scopus 로고
    • Insulin resistance in non-insulin-dependent diabetes mellitus
    • Olefsky JM. Insulin resistance in non-insulin-dependent diabetes mellitus. Current Opinion Endocrinol Diabetes, 1995, 2, 290-299.
    • (1995) Current Opinion Endocrinol Diabetes , vol.2 , pp. 290-299
    • Olefsky, J.M.1
  • 3
    • 0029034239 scopus 로고
    • Rôle des acides gras libres dans l'insulino-résistance au cours du diabète non-insulino-dépendant
    • Girard J Rôle des acides gras libres dans l'insulino-résistance au cours du diabète non-insulino-dépendant. Diab Metub, 1995, 21, 79-88.
    • (1995) Diab Metub , vol.21 , pp. 79-88
    • Girard, J.1
  • 4
    • 0007970034 scopus 로고
    • Non-esterified fatty acids in non-insulin-dependent diabetes: A critical update
    • Perriello G, Mitrakou A, Gumbiner B, Gerich JE. Non-esterified fatty acids in non-insulin-dependent diabetes: A critical update. Diabetes Annual, 1995, 9, 91-106.
    • (1995) Diabetes Annual , vol.9 , pp. 91-106
    • Perriello, G.1    Mitrakou, A.2    Gumbiner, B.3    Gerich, J.E.4
  • 5
    • 0029886961 scopus 로고    scopus 로고
    • Interactions between glucose and FFA metabolism in man
    • Saloranta C, Groop L. Interactions between glucose and FFA metabolism in man. Diabetes/Metabolism Rev, 1996, 12, 15-36.
    • (1996) Diabetes/Metabolism Rev , vol.12 , pp. 15-36
    • Saloranta, C.1    Groop, L.2
  • 6
    • 0026468362 scopus 로고
    • What if Minkowski Had Been Ageusic ? An Alternative Angle on Diabetes
    • McGarry JD. What if Minkowski Had Been Ageusic ? An Alternative Angle on Diabetes. Science, 1992, 258, 766-770.
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 7
    • 0028339336 scopus 로고
    • Disordered metabolism in diabetes: Have we under-emphasized the fat component ?
    • McGarry JD. Disordered metabolism in diabetes: have we under-emphasized the fat component ? J Cell Biochem. 1994, 55 Suppl, 29-38.
    • (1994) J Cell Biochem. , vol.55 , Issue.SUPPL. , pp. 29-38
    • McGarry, J.D.1
  • 9
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in dietinduced thermogenesis
    • Rothwell NJ, Stock MJ. A role for brown adipose tissue in dietinduced thermogenesis. Nature, 1979, 281, 31-35.
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 10
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev, 1984, 64, 1-63.
    • (1984) Physiol Rev , vol.64 , pp. 1-63
    • Nicholls, D.G.1    Locke, R.M.2
  • 11
    • 0027731309 scopus 로고
    • Development of Obesity in Transgenic Mice after Genetic Ablation of Brown Adipose Tissue
    • Lowell BB, Susulic VS, Hamann A, et al. Development of Obesity in Transgenic Mice After Genetic Ablation of Brown Adipose Tissue. Nature. 1993, 366, 740-742.
    • (1993) Nature , vol.366 , pp. 740-742
    • Lowell, B.B.1    Susulic, V.S.2    Hamann, A.3
  • 12
    • 0018756428 scopus 로고
    • Hypothalamic and genetic obesity animals: An autonomic and endocrine hypothesis
    • Bray G, York D. Hypothalamic and genetic obesity animals: an autonomic and endocrine hypothesis. Physiol Rev, 1979, 59, 719-809.
    • (1979) Physiol Rev , vol.59 , pp. 719-809
    • Bray, G.1    York, D.2
  • 13
    • 0026518215 scopus 로고
    • Tackling a weighty problem
    • Friedman JM, Leibel RL. Tackling a weighty problem. Cell. 1992, 69, 217-220.
    • (1992) Cell , vol.69 , pp. 217-220
    • Friedman, J.M.1    Leibel, R.L.2
  • 14
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
    • Fleury C, Neverova M, Collins S, et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genetics, 1997.
    • (1997) Nature Genetics
    • Fleury, C.1    Neverova, M.2    Collins, S.3
  • 16
    • 0029020677 scopus 로고
    • Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
    • Considine RV, Considine EL, Williams CJ, et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest, 1995, 95, 2986-2988.
    • (1995) J Clin Invest , vol.95 , pp. 2986-2988
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3
  • 17
    • 0029086176 scopus 로고
    • Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats
    • Ogawa Y, Masuzaki H, Isse N, et al. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest, 1995, 96, 1647-1652.
    • (1995) J Clin Invest , vol.96 , pp. 1647-1652
    • Ogawa, Y.1    Masuzaki, H.2    Isse, N.3
  • 18
    • 0028863211 scopus 로고
    • Structural organization and chromosomal assignment of the human obese gene
    • Isse N, Ogawa Y, Tamura N, et al. Structural organization and chromosomal assignment of the human obese gene. J Biol Chem, 1995, 270, 27728-27733.
    • (1995) J Biol Chem , vol.270 , pp. 27728-27733
    • Isse, N.1    Ogawa, Y.2    Tamura, N.3
  • 19
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 1995, 269, 543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 20
    • 0029033031 scopus 로고
    • Cloning of rat obese cDNA and its expression in obese rats
    • Murakami T, Shima K. Cloning of rat obese cDNA and its expression in obese rats. Biochem Biophys Res Comm, 1995, 209, 944-952.
    • (1995) Biochem Biophys Res Comm , vol.209 , pp. 944-952
    • Murakami, T.1    Shima, K.2
  • 21
    • 0029118124 scopus 로고
    • Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus
    • Maffei M, Fei H, Lee GH, et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA, 1995, 92, 6957-6960.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6957-6960
    • Maffei, M.1    Fei, H.2    Lee, G.H.3
  • 22
    • 0029102059 scopus 로고
    • Modulation of obese gene expression in rat brown and while adipose tissues
    • Moinat M, Deng CJ, Muzzin P, et al. Modulation of obese gene expression in rat brown and while adipose tissues. FEBS Lett, 1995, 373, 131-134.
    • (1995) FEBS Lett , vol.373 , pp. 131-134
    • Moinat, M.1    Deng, C.J.2    Muzzin, P.3
  • 23
    • 0029166158 scopus 로고
    • Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice
    • Trayhurn P, Thomas MEA, Duncan JS, Rayner DV. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett, 1995, 368, 488-490.
    • (1995) FEBS Lett , vol.368 , pp. 488-490
    • Trayhurn, P.1    Thomas, M.E.A.2    Duncan, J.S.3    Rayner, D.V.4
  • 24
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice : Evidence for diet-induced resistance to leptin action
    • Frcderich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice : Evidence for diet-induced resistance to leptin action. Nature Medicine, 1995, 1, 1311-1314.
    • (1995) Nature Medicine , vol.1 , pp. 1311-1314
    • Frcderich, R.C.1    Hamann, A.2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 25
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine, 1995, 1, 1155-1161.
    • (1995) Nature Medicine , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 26
    • 0030601101 scopus 로고    scopus 로고
    • Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA
    • Hardie LJ, Rayner DV, Holmes S, Trayhurn P. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Comm, 1996, 223, 660-665.
    • (1996) Biochem Biophys Res Comm , vol.223 , pp. 660-665
    • Hardie, L.J.1    Rayner, D.V.2    Holmes, S.3    Trayhurn, P.4
  • 27
    • 0029131574 scopus 로고
    • Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
    • Frederich RC, Lollmann B, Hamann A, et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity, J Clin Invest, 1995, 96, 1658-1663.
    • (1995) J Clin Invest , vol.96 , pp. 1658-1663
    • Frederich, R.C.1    Lollmann, B.2    Hamann, A.3
  • 28
    • 0029983180 scopus 로고    scopus 로고
    • Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity
    • Mizuno TM, Bergen H, Funabashi T, et al. Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci USA, 1996, 93, 3434-3438.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3434-3438
    • Mizuno, T.M.1    Bergen, H.2    Funabashi, T.3
  • 29
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Medicine, 1995, 1, 950-953.
    • (1995) Nature Medicine , vol.1 , pp. 950-953
    • Lonnqvist, F.1    Arner, P.2    Nordfors, L.3    Schalling, M.4
  • 30
    • 0029083859 scopus 로고
    • Increased obese gene mRNA in omental fat cells from massively obese humans
    • Hamilton BS, Paglia D, Kwan AYM, Deitel M. Increased obese gene mRNA in omental fat cells from massively obese humans. Nature Medicine, 1995, 1, 953-956.
    • (1995) Nature Medicine , vol.1 , pp. 953-956
    • Hamilton, B.S.1    Paglia, D.2    Kwan, A.Y.M.3    Deitel, M.4
  • 31
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive leptin concentrations in normal weight and obese humans
    • Considinc RV, Sinha MK, Heiman ML, et al. Serum immunoreactive leptin concentrations in normal weight and obese humans. New England J Med, 1996, 334, 292-295.
    • (1996) New England J Med , vol.334 , pp. 292-295
    • Considinc, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 32
    • 0029893230 scopus 로고    scopus 로고
    • Mutation screening and identification of a sequence variation in the human OB gene coding region
    • Considine RV, Considine EL, Williams CJ, et al. Mutation screening and identification of a sequence variation in the human OB gene coding region. Biochem Biophys Res Comm, 1996, 220, 735-739.
    • (1996) Biochem Biophys Res Comm , vol.220 , pp. 735-739
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3
  • 33
    • 0028297731 scopus 로고
    • Appetite and the regulation of body composition
    • Weigle DS. Appetite and the regulation of body composition. FASER J, 1994, 8, 302-310.
    • (1994) FASER J , vol.8 , pp. 302-310
    • Weigle, D.S.1
  • 36
    • 0029157428 scopus 로고
    • Insulin mediates the transient increase in ob gene expression after food intake
    • Saladin R, De Vos P, Guerre-Millo M. et al. Insulin mediates the transient increase in ob gene expression after food intake. Nature, 1995, 377, 527-529.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 37
    • 0029092010 scopus 로고
    • Diet- And diabetes-induced changes of ob gene expression in rat adipose tissue
    • Becker DJ, Ongemba LN, Brichard V, Henquin JC, Brichard SM. Diet- and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Lett, 1995, 371, 324-328.
    • (1995) FEBS Lett , vol.371 , pp. 324-328
    • Becker, D.J.1    Ongemba, L.N.2    Brichard, V.3    Henquin, J.C.4    Brichard, S.M.5
  • 38
    • 0029078449 scopus 로고
    • Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
    • MacDougald OA, Hwang CS, Fan HY, Lane MD. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA. 1995, 92, 9034-9037.
    • (1995) Proc Natl Acad Sci USA. , vol.92 , pp. 9034-9037
    • MacDougald, O.A.1    Hwang, C.S.2    Fan, H.Y.3    Lane, M.D.4
  • 40
    • 0029942497 scopus 로고    scopus 로고
    • Pharmacologic manipulation of ob expression in a dietary model of obesity
    • Collins S, Surwit RS. Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem. 1996, 271, 9437-9440.
    • (1996) J Biol Chem. , vol.271 , pp. 9437-9440
    • Collins, S.1    Surwit, R.S.2
  • 41
    • 0028821861 scopus 로고
    • The ob gene and insulin: A relationship leading to clues to the understanding of obesity
    • Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B. The ob gene and insulin: A relationship leading to clues to the understanding of obesity. Diabetes. 1995, 44, 1467-1470.
    • (1995) Diabetes , vol.44 , pp. 1467-1470
    • Cusin, I.1    Sainsbury, A.2    Doyle, P.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 42
    • 0030071310 scopus 로고    scopus 로고
    • Differential expression of ob mRNA in rat adipose tissues in response to insulin
    • Zheng DH, Jones JP, Usala SJ, Dohm DL. Differential expression of ob mRNA in rat adipose tissues in response to insulin. Biochem Biophys Res Comm, 1996, 218, 434-437.
    • (1996) Biochem Biophys Res Comm , vol.218 , pp. 434-437
    • Zheng, D.H.1    Jones, J.P.2    Usala, S.J.3    Dohm, D.L.4
  • 43
    • 0029813768 scopus 로고    scopus 로고
    • The beta(3)-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes
    • Gettys TW, Harkness PJ, Watson PM. The beta(3)-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinol, 1996, 137, 4054-4057.
    • (1996) Endocrinol , vol.137 , pp. 4054-4057
    • Gettys, T.W.1    Harkness, P.J.2    Watson, P.M.3
  • 44
    • 0030040740 scopus 로고    scopus 로고
    • Regulation of ob gene mRNA levels in cultured adipocytes
    • Rentsch J, Chiesi M. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett, 1996, 379, 55-59.
    • (1996) FEBS Lett , vol.379 , pp. 55-59
    • Rentsch, J.1    Chiesi, M.2
  • 45
    • 0030063976 scopus 로고    scopus 로고
    • Expression of ob gene in adipose cells. Regulation by insulin
    • Leroy P, Dessolin S, Villageois P, et al. Expression of ob gene in adipose cells. Regulation by insulin. J Biol Chem, 1996, 271, 2365-2368.
    • (1996) J Biol Chem , vol.271 , pp. 2365-2368
    • Leroy, P.1    Dessolin, S.2    Villageois, P.3
  • 46
    • 0030055611 scopus 로고    scopus 로고
    • The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue
    • Vidai H, AubŒuf D, Devos P, et al. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J Clin Invest, 1996, 98, 251-255.
    • (1996) J Clin Invest , vol.98 , pp. 251-255
    • Vidai, H.1    AubŒuf, D.2    Devos, P.3
  • 47
    • 0029853078 scopus 로고    scopus 로고
    • Acute insulin administration does not affect plasma leptin levels in lean or obese subjects
    • Muscelli E, Camastra S, Masoni A, et al. Acute insulin administration does not affect plasma leptin levels in lean or obese subjects. Ear J Clin Invest, 1996, 26, 940-943.
    • (1996) Ear J Clin Invest , vol.26 , pp. 940-943
    • Muscelli, E.1    Camastra, S.2    Masoni, A.3
  • 48
    • 0029665017 scopus 로고    scopus 로고
    • Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro
    • Kolaczynski JW, Nyee MR, Considine RV, et al. Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes, 1996, 45, 699-701.
    • (1996) Diabetes , vol.45 , pp. 699-701
    • Kolaczynski, J.W.1    Nyee, M.R.2    Considine, R.V.3
  • 49
    • 0029823153 scopus 로고    scopus 로고
    • Effects of Acute Hyperinsulinemia on Plasma Leptin Concentrations in Insulin-Sensitive and Insulin-Resistant Pima Indians
    • Pratley RE, Nicolson M, Bogardus C, Ravussin E. Effects of Acute Hyperinsulinemia on Plasma Leptin Concentrations in Insulin-Sensitive and Insulin-Resistant Pima Indians. J Clin Endocrinol Metab, 1996, 81, 4418-4421.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4418-4421
    • Pratley, R.E.1    Nicolson, M.2    Bogardus, C.3    Ravussin, E.4
  • 50
    • 0029829386 scopus 로고    scopus 로고
    • The Effects of Acute Hyperglycemia and Hyper-insulinemia on Plasma Leptin Levels: Its Relationship with Body Fat, Visceral Adiposity, and Age in Women
    • Ryan AS, Elahi D. The Effects of Acute Hyperglycemia and Hyper-insulinemia on Plasma Leptin Levels: Its Relationship with Body Fat, Visceral Adiposity, and Age in Women. J Clin Endocrinol Metab, 1996, 81, 4433-4438.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4433-4438
    • Ryan, A.S.1    Elahi, D.2
  • 51
    • 0029924714 scopus 로고    scopus 로고
    • Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM
    • Malmstrom R, Taskinen MR, Karonen SL, Yki-Jarvinen H. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia, 1996, 39, 993-996.
    • (1996) Diabetologia , vol.39 , pp. 993-996
    • Malmstrom, R.1    Taskinen, M.R.2    Karonen, S.L.3    Yki-Jarvinen, H.4
  • 52
    • 0029784397 scopus 로고    scopus 로고
    • Supra-physiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects
    • Utriainen U, Malmstrom R, Makimattila S, Yki-Jarvinen H. Supra-physiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes, 1996, 45, 1364-1366.
    • (1996) Diabetes , vol.45 , pp. 1364-1366
    • Utriainen, U.1    Malmstrom, R.2    Makimattila, S.3    Yki-Jarvinen, H.4
  • 53
    • 0029999753 scopus 로고    scopus 로고
    • Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents
    • Igel M, Kainulainen H, Brauers A, Becker W, Herberg L, Joost HG. Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents. Diabelologia, 1996, 39, 758-765.
    • (1996) Diabelologia , vol.39 , pp. 758-765
    • Igel, M.1    Kainulainen, H.2    Brauers, A.3    Becker, W.4    Herberg, L.5    Joost, H.G.6
  • 54
    • 0028826355 scopus 로고
    • Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system
    • Trayhum P, Duncan JS, Rayncr DV. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J, 1995, 311, 729-733.
    • (1995) Biochem J , vol.311 , pp. 729-733
    • Trayhum, P.1    Duncan, J.S.2    Rayncr, D.V.3
  • 55
    • 0030015246 scopus 로고    scopus 로고
    • Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice
    • Mantzoros CS, Qu DQ, Frederich RC, et al. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes, 1996, 45, 909-914.
    • (1996) Diabetes , vol.45 , pp. 909-914
    • Mantzoros, C.S.1    Qu, D.Q.2    Frederich, R.C.3
  • 56
    • 0029021599 scopus 로고
    • Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
    • De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem, 1995, 270, 15958-15961.
    • (1995) J Biol Chem , vol.270 , pp. 15958-15961
    • De Vos, P.1    Saladin, R.2    Auwerx, J.3    Staels, B.4
  • 57
    • 0029976448 scopus 로고    scopus 로고
    • Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP
    • Slicker LJ, Sloop KW, Surface PL, et al. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem, 1996, 271, 5301-5304.
    • (1996) J Biol Chem , vol.271 , pp. 5301-5304
    • Slicker, L.J.1    Sloop, K.W.2    Surface, P.L.3
  • 58
    • 0028972884 scopus 로고
    • Dexamethasone regulates obese gene expression in isolated rat adipocytes
    • Murakami T, Iida M, Shima K. Dexamethasone regulates obese gene expression in isolated rat adipocytes. Biochem Biophys Res Comm, 1995, 209, 1260-1267.
    • (1995) Biochem Biophys Res Comm , vol.209 , pp. 1260-1267
    • Murakami, T.1    Iida, M.2    Shima, K.3
  • 59
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter MA, Cullcn MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 1995, 269, 540-543.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullcn, M.J.2    Baker, M.B.3
  • 60
    • 0029962467 scopus 로고    scopus 로고
    • Correction of obesity and diabetes in genetically obese mice by leptin gene therapy
    • Muzzin P, Eisensmith RC, Copelend KC, Woo SLC. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Nail Acad Sci USA, 1996, 93, 14804-14808.
    • (1996) Proc Nail Acad Sci USA , vol.93 , pp. 14804-14808
    • Muzzin, P.1    Eisensmith, R.C.2    Copelend, K.C.3    Woo, S.L.C.4
  • 61
    • 0029048408 scopus 로고
    • Recombinant mouse ob protein : Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein : Evidence for a peripheral signal linking adiposity and central neural networks. Science, 1995, 269, 546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 62
    • 0029763177 scopus 로고    scopus 로고
    • The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals
    • Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, Jeanrenaud B. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes, 1996, 45, 1446-1451.
    • (1996) Diabetes , vol.45 , pp. 1446-1451
    • Cusin, I.1    Rohner-Jeanrenaud, F.2    Stricker-Krongrad, A.3    Jeanrenaud, B.4
  • 63
    • 0029908857 scopus 로고    scopus 로고
    • Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
    • Chen G, Koyama K, Yuan X, et al. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA, 1996, 93, 14795-14799.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14795-14799
    • Chen, G.1    Koyama, K.2    Yuan, X.3
  • 64
    • 0029939065 scopus 로고    scopus 로고
    • Decreased food intake does not completely account for adiposity reduction after ob protein infusion
    • Levin N, Nelson C, Gurney A, Vandlen R, De Sauvage F. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Nail Acad Sci USA, 1996, 93, 1726-1730.
    • (1996) Proc Nail Acad Sci USA , vol.93 , pp. 1726-1730
    • Levin, N.1    Nelson, C.2    Gurney, A.3    Vandlen, R.4    De Sauvage, F.5
  • 66
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia, 1973, 9, 294-298.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 67
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tanaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell, 1995, 83, 1263-1271.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tanaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 68
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor : Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H, Chartat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor : Identification of a mutation in the leptin receptor gene in db/db mice. Cell, 1996, 84, 491-495.
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Chartat, O.2    Tartaglia, L.A.3
  • 69
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor
    • Chua SC, Chung WK, Wupeng XS, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor. Science, 1996, 271, 994-996.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua, S.C.1    Chung, W.K.2    Wupeng, X.S.3
  • 70
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature, 1996, 379, 632-635.
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.H.1    Proenca, R.2    Montez, J.M.3
  • 72
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett, 1996, 387, 113-116.
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 73
    • 0029949063 scopus 로고    scopus 로고
    • Leptin activation in hypothalamus
    • Woods AJ, Stock MJ. Leptin activation in hypothalamus. Nature, 1996, 381, 745.
    • (1996) Nature , vol.381 , pp. 745
    • Woods, A.J.1    Stock, M.J.2
  • 74
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • Stephens TW, Basinski M, Bristow M, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature, 1995, 377, 530-532.
    • (1995) Nature , vol.377 , pp. 530-532
    • Stephens, T.W.1    Basinski, M.2    Bristow, M.3
  • 75
    • 0029946875 scopus 로고    scopus 로고
    • The central regulation of energy homoeostasis: Roles of neuropeptide Y and other brain peptides
    • Bing C, Wang Q, Pickavance L, Williams G. The central regulation of energy homoeostasis: Roles of neuropeptide Y and other brain peptides. Biochem Soc Transac, 1996, 24, 559-565.
    • (1996) Biochem Soc Transac , vol.24 , pp. 559-565
    • Bing, C.1    Wang, Q.2    Pickavance, L.3    Williams, G.4
  • 76
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz MW, Baskin DG, Bukowski TR, et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes, 1996, 45, 531-535.
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3
  • 77
    • 10244235259 scopus 로고    scopus 로고
    • Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior
    • Hu Y, Bloomquist BT, Cornfield LJ, et al. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem, 1996, 271, 26315-26319.
    • (1996) J Biol Chem , vol.271 , pp. 26315-26319
    • Hu, Y.1    Bloomquist, B.T.2    Cornfield, L.J.3
  • 78
    • 15844420659 scopus 로고    scopus 로고
    • A receptor subtype involved in neuropeptide-Y-induced food intake
    • Gerald C, Walker MW, Criscione L, et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature, 1996, 382, 168-171.
    • (1996) Nature , vol.382 , pp. 168-171
    • Gerald, C.1    Walker, M.W.2    Criscione, L.3
  • 79
    • 8044234377 scopus 로고    scopus 로고
    • Neuropeptide Y-Induced Feeding in the Rat Is Mediated by a Novel Receptor
    • O'Shca D, Morgan DGA, Meeran K, et al. Neuropeptide Y-Induced Feeding in the Rat Is Mediated by a Novel Receptor. Endocrinol. 1997, 138, 196-202.
    • (1997) Endocrinol. , vol.138 , pp. 196-202
    • O'Shca, D.1    Morgan, D.G.A.2    Meeran, K.3
  • 80
    • 0029762615 scopus 로고    scopus 로고
    • Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
    • Mercer JG, Hoggard N, Williams LM, et al. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol, 1996, 8, 733-735.
    • (1996) J Neuroendocrinol , vol.8 , pp. 733-735
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3
  • 81
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by loss of the neuropeptide Y
    • Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by loss of the neuropeptide Y. Science, 1996, 274, 1704-1707.
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 82
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergiic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergiic neurons in feeding and the agouti obesity syndrome. Nature, 1997, 385, 165-168.
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 83
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor gene results in obesity in mice
    • Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor gene results in obesity in mice. Cell, 1997, 88, 131-141.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 84
    • 0031012588 scopus 로고    scopus 로고
    • The alphabet of weight control
    • Friedman JM. The alphabet of weight control. Nature, 1997, 385, 119-120.
    • (1997) Nature , vol.385 , pp. 119-120
    • Friedman, J.M.1
  • 85
    • 13344282056 scopus 로고    scopus 로고
    • A role for GLP-1 in the central regulation of feeding
    • Turton MD, O'Shea D, Gunn I, et al. A role for GLP-1 in the central regulation of feeding. Nature, 1996, 379, 69-72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 86
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the GLP-1 receptor gene
    • Scrocchi LA, Brown TJ, Maclusky N, et al. Glucose intolerance but normal satiety in mice with a null mutation in the GLP-1 receptor gene. Nature Medicine, 1996, 2, 1254-1258.
    • (1996) Nature Medicine , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    Maclusky, N.3
  • 87
    • 13344279395 scopus 로고    scopus 로고
    • A role for melaninconcentrating hormone in the central regulation of feeding behaviour
    • Qu D, Ludwig DS, Gammeltoft S, et al. A role for melaninconcentrating hormone in the central regulation of feeding behaviour. Nature, 1996, 380, 243-247.
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3
  • 88
    • 0031023301 scopus 로고    scopus 로고
    • Melanin-Concentrating Hormone Acutely Stimulates Feeding, but Chronic Administration Has No Effect on Body Weight
    • Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR. Melanin-Concentrating Hormone Acutely Stimulates Feeding, but Chronic Administration Has No Effect on Body Weight. Endocrinol, 1997, 138, 351-355.
    • (1997) Endocrinol , vol.138 , pp. 351-355
    • Rossi, M.1    Choi, S.J.2    O'Shea, D.3    Miyoshi, T.4    Ghatei, M.A.5    Bloom, S.R.6
  • 89
    • 0029932592 scopus 로고    scopus 로고
    • Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice
    • Lynn RB, Cao GY, Considine RV, Hyde TM, Caro JF. Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Comm, 1996, 219, 884-889.
    • (1996) Biochem Biophys Res Comm , vol.219 , pp. 884-889
    • Lynn, R.B.1    Cao, G.Y.2    Considine, R.V.3    Hyde, T.M.4    Caro, J.F.5
  • 90
    • 0029980118 scopus 로고    scopus 로고
    • Ob protein binds specifically to the choroid plexus of mice and rats
    • Devos R, Richards JG, Campfield LA, et al. Ob protein binds specifically to the choroid plexus of mice and rats. Proc Natl Acad Sci USA, 1996, 93, 5668-5673.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5668-5673
    • Devos, R.1    Richards, J.G.2    Campfield, L.A.3
  • 91
    • 0029986894 scopus 로고    scopus 로고
    • Localization of binding sites in the central nervous system for leptin (ob protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice
    • Malik KF, Young WS. Localization of binding sites in the central nervous system for leptin (ob protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinol, 1996, 137, 1497-1500.
    • (1996) Endocrinol , vol.137 , pp. 1497-1500
    • Malik, K.F.1    Young, W.S.2
  • 92
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks WA, Kastin AJ, Huang WT, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides, 1996, 17, 305-311.
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.T.3    Jaspan, J.B.4    Maness, L.M.5
  • 93
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-ftuioVserum leptin ratio in obesity : A possible mechanism for leptin resistance
    • Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal-ftuioVserum leptin ratio in obesity : A possible mechanism for leptin resistance. Lancet, 1996, 348, 159-161.
    • (1996) Lancet , vol.348 , pp. 159-161
    • Caro, J.F.1    Kolaczynski, J.W.2    Nyce, M.R.3
  • 94
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels : Relationship to plasma levels and to adiposity in humans
    • Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte DJ. Cerebrospinal fluid leptin levels : Relationship to plasma levels and to adiposity in humans. Nature Medicine, 1996, 2, 589-593.
    • (1996) Nature Medicine , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte, D.J.5
  • 95
    • 0029069145 scopus 로고
    • Transcriptional responses to polypetide ligands : The JAK-STAT pathway
    • Schindler C, Darnell JFJ. Transcriptional responses to polypetide ligands : the JAK-STAT pathway. Annu Rev Biochem, 1995, 64, 621-651.
    • (1995) Annu Rev Biochem , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell, J.F.J.2
  • 96
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H, Morella KK, White DW, et al The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA, 1996, 93, 8374-8378.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3
  • 98
    • 0029424575 scopus 로고
    • Appetite control: Does leptin lighten the problem of obesily ?
    • McGarry JD. Appetite control: Does leptin lighten the problem of obesily ? Current Biology, 1995, 5, 1342-1344.
    • (1995) Current Biology , vol.5 , pp. 1342-1344
    • McGarry, J.D.1
  • 99
    • 0027362079 scopus 로고
    • Chronic Intracerebroventricular Neuropeptide Y Administration to Normal Rats Mimics Hormonal and Metabolic Changes of Obesity
    • Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B. Chronic Intracerebroventricular Neuropeptide Y Administration to Normal Rats Mimics Hormonal and Metabolic Changes of Obesity. Endocrinol, 1993, 133, 1753-1758.
    • (1993) Endocrinol , vol.133 , pp. 1753-1758
    • Zarjevski, N.1    Cusin, I.2    Vettor, R.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 100
    • 85050956429 scopus 로고
    • Induction and reversibility of an obesity syndrome by intracere-broventricular neuropeptide Y administration to normal rats
    • Vettor R, Zarjevski N, Cusin I, Rohner-Jeanrenaud F, Jeanrenaud B. Induction and reversibility of an obesity syndrome by intracere-broventricular neuropeptide Y administration to normal rats. Diabetologia, 1994, 37, 1202-1208.
    • (1994) Diabetologia , vol.37 , pp. 1202-1208
    • Vettor, R.1    Zarjevski, N.2    Cusin, I.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 102
    • 15844410399 scopus 로고    scopus 로고
    • Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
    • Bai Y, Zhang S, Kim KS, Lee JK, Kim KH. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem, 1996, 271, 13939-13942.
    • (1996) J Biol Chem , vol.271 , pp. 13939-13942
    • Bai, Y.1    Zhang, S.2    Kim, K.S.3    Lee, J.K.4    Kim, K.H.5
  • 103
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science, 1996, 274, 1185-1188.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 104
    • 0029912832 scopus 로고    scopus 로고
    • Does leptin contribute to diabetes caused by obesity ?
    • Taylor S.I, Barr V, Reitman M. Does leptin contribute to diabetes caused by obesity ? Science, 1996, 274, 1151-1152.
    • (1996) Science , vol.274 , pp. 1151-1152
    • Taylor, S.I.1    Barr, V.2    Reitman, M.3
  • 105
    • 0028982829 scopus 로고
    • Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression
    • Sutherland C, O'Brien RM, Granncr DK. Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression. J Biol Chem, 1995, 270, 15501-15506.
    • (1995) J Biol Chem , vol.270 , pp. 15501-15506
    • Sutherland, C.1    O'Brien, R.M.2    Granncr, D.K.3


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