Liver X receptor agonists ameliorate TNFα-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression

Diabetologia

Volumn 49, Issue 12, 2006, Pages 3038-3048

  Fernandez Veledo S ^a   Nieto Vazquez, I ^a   Rondinone, C M ^b,c   Lorenzo, M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b ABBOTT LABORATORIES   (United States)

^c Metabolic Diseases   (United States)

Author keywords

Brown adipocytes; Glucose uptake; Insulin resistance; LXR; NR1HR; PTP1B; PTPN1; SLC2A4; TNF

Indexed keywords

22 HYDROXYCHOLESTEROL; GLUCOSE; GLUCOSE TRANSPORTER 4; GW 3965; HORMONE RECEPTOR STIMULATING AGENT; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LIVER X RECEPTOR STIMULATING AGENT; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C ZETA; PROTEIN TYROSINE PHOSPHATASE 1B; SODIUM PROTON EXCHANGE PROTEIN 2; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; CYTOLYSIS; DRUG ACTIVITY; ENZYME ACTIVATION; FETUS; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; GLUCOSE TRANSPORT; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; WILD TYPE;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL TRANSPORT; DNA-BINDING PROTEINS; FETUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; INSULIN RESISTANCE; MICE; MICE, KNOCKOUT; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750900770     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0472-4     Document Type: Article

References (48)

1. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383:728-731
2. Schultz JR, Tu H, Luk A et al (2000) Role of LXRs in control of lipogenesis. Genes Dev 14:2831-2838
3. Li AC, Binder CJ, Gutierrez A et al (2004) Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest 114:1564-1576
4. Steffensen KR, Gustafsson JA (2004) Putative metabolic effects of the liver X receptor (LXR). Diabetes 53(Suppl 1):S36-S42
5. Tontonoz P, Mangelsdorf DJ (2003) Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 17:985-993
6. Cao G, Liang Y, Broderick CL et al (2003) Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem 278:1131-1136
7. Efanov AM, Sewing S, Bokvist K, Gromada J (2004) Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells. Diabetes 53 (Suppl 3):S75-S78
8. Laffitte BA, Chao LC, Li J et al (2003) Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA 100:5419-5424
9. Steffensen KR, Nilsson M, Schuster GU, Stulnig TM, Dahlman-Wright K, Gustafsson JA (2003) Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively. Biochem Biophys Res Commun 310:589-593
10. Chawla A, Boisvert WA, Lee CH et al (2001) A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 7:161-171
11. Soukas A, Socci ND, Saatkamp BD, Novelli S, Friedman JM (2001) Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem 276:34167-34174
12. Juvet LK, Andresen SM, Schuster GU et al (2003) On the role of liver X receptors in lipid accumulation in adipocytes. Mol Endocrinol 17:172-182
13. Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI (2003) Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J Biol Chem 278:48283-48291
14. Valverde AM, Benito M, Lorenzo M (2005) The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance. Acta Physiol Scand 183:59-73
15. Hernandez R, Teruel T, Lorenzo M (2001) Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. FEBS Lett 494:225-231
16. Lorenzo M, Teruel T, Hernandez R, Kayali AG, Webster NJ (2002) PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes. Exp Cell Res 278:146-157
17. Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B (2001) Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 142:4195-4202
18. Teruel T, Hernandez R, Rial E, Martin-Hidalgo A, Lorenzo M (2005) Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats. Diabetologia 48:1180-1188
19. Hernandez R, Teruel T, Lorenzo M (2003) Rosiglitazone produces insulin sensitisation by increasing expression of the insulin receptor and its tyrosine kinase activity in brown adipocytes. Diabetologia 46:1618-1628
20. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
21. Hotamisligil GS (1999) Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol Diabetes 107:119-125
22. Hernandez R, Teruel T, de Alvaro C, Lorenzo M (2004) Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases. Diabetologia 47:1615-1624
23. Teruel T, Hernandez R, Lorenzo M (2001) Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 50:2563-2571
24. Olefsky JM (2000) Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 106:467-472
25. Malinowski JM, Bolesta S (2000) Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin Ther 22:1151-1168
26. Fernandez-Veledo S, Hernandez R, Teruel T, Mas JA, Ros M, Lorenzo M (2006) Ceramide mediates TNF-alpha-induced insulin resistance on GLUT4 gene expression in brown adipocytes. Arch Physiol Biochem 112:13-22
27. Schluter A, Barbera MJ, Iglesias R, Giralt M, Villarroya F (2002) Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation. Biochem J 362:61-69
28. Albers M, Blume B, Schlueter T et al (2006) A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. J Biol Chem 281:4920-4930
29. Kamei Y, Kawada T, Mizukami J, Sugimoto E (1994) The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha. Life Sci 55:L307-L312
30. Xue JC, Schwarz EJ, Chawla A, Lazar MA (1996) Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgamma. Mol Cell Biol 16:1567-1575
31. Wali RK, Kong J, Sitrin MD, Bissonnette M, Li YC (2003) Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts. J Cell Biochem 88:794-801
32. Grefhorst A, van Dijk TH, Hammer A et al (2005) Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice. Am J Physiol Endocrinol Metab 289:E829-E838
33. Cozzone D, Debard C, Dif N et al (2006) Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells. Diabetologia 49:990-999
34. Giannini S, Serio M, Galli A (2004) Pleiotropic effects of thiazolidinediones: taking a look beyond antidiabetic activity. J Endocrinol Invest 27:982-991
35. Leibowitz MD, Ardecky RJ, Boehm MF et al (2006) Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 147:1044-1053
36. Walcher D, Kummel A, Kehrle B et al (2006) LXR activation reduces proinflammatory cytokine expression in human CD4-positive lymphocytes. Arterioscler Thromb Vasc Biol 26:1022-1028
37. Bruemmer D, Law RE (2005) Liver x receptors: potential novel targets in cardiovascular diseases. Curr Drug Targets Cardiovasc Haematol Disord 5:533-540
38. Ahmad F, Goldstein BJ (1997) Effect of tumor necrosis factor-alpha on the phosphorylation of tyrosine kinase receptors is associated with dynamic alterations in specific protein-tyrosine phosphatases. J Cell Biochem 64:117-127
39. Kroder G, Bossenmaier B, Kellerer M et al (1996) Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling. J Clin Invest 97:1471-1477
40. Ozes ON, Akca H, Mayo LD et al (2001) A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA 98:4640-4645
41. Cheung AT, Wang J, Ree D, Kolls JK, Bryer-Ash M (2000) Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase. Diabetes 49:810-819
42. Zinker BA, Rondinone CM, Trevillyan JM et al (2002) PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Proc Natl Acad Sci USA 99:11357-11362
43. Gum RJ, Gaede LL, Koterski SL et al (2003) Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes 52:21-28
44. Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P (2003) Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem 278:10443-10449
45. Fukada T, Tonks NK (2003) Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling. EMBO J 22:479-493
46. Frederiksen KS, Wulf EM, Wassermann K, Sauerberg P, Fleckner J (2003) Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists. J Mol Endocrinol 30:317-329
47. Shao J, Gao Y, Yuan Z (1998) [Free fatty acids promoting PTP1B expression in rat skeletal muscle and hepatic cells]. Zhonghua Yi Xue Za Zhi 78:753-755
48. Wu Y, Ouyang JP, Wu K, Wang SS, Wen CY, Xia ZY (2005) Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats. Br J Pharmacol 146:234-243