Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes

Endocrinology

Volumn 148, Issue 12, 2007, Pages 5991-5997

  Araújo, Eliana P ^a   De Souza, Cláudio T ^a   Ueno, Mirian ^a   Cintra, Dennys E ^a   Bertolo, Manoel B ^a   Carvalheira, José B ^a   Saad, Mário J ^a   Velloso, Lício A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INFLIXIMAB; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PROTEIN KINASE B; PROTEIN SERINE KINASE; SERINE; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HYPERINSULINEMIC EUGLYCEMIC CLAMP; HYPOTHALAMUS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID DIET; LIVER; MALE; MOUSE; MUSCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SWISS WEBSTER MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOSE TISSUE; ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIETARY FATS; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPOTHALAMUS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEPTIN; LIVER; MALE; MICE; MUSCLE, SKELETAL; OBESITY; PHOSPHORYLATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 36348981083     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0132     Document Type: Article

References (38)

1. Permutt MA, Wasson J, Cox N 2005 Genetic epidemiology of diabetes. J Clin Invest 115:1431-1439
2. Grundy SM 2004 Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 89:2595-2600
3. Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867
4. Tilg H, Moschen AR 2006 Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6:772-783
5. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM 1996 IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science 271:665-668
6. Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91
7. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS 2002 A central role for JNK in obesity and insulin resistance. Nature 420:333-336
8. Shoelson SE, Lee J, Yuan M 2003 Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27(Suppl 3):S49-S52
9. Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM 1996 Tumor necrosis factor (TNF)-α inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem 271:13018-13022
10. De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, Saad MJ, Velloso LA 2005 Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146:4192-4199
11. Moraes JC, Amaral ME, Picardi PK, Calegari VC, Romanatto T, Bermudez-Echeverry M, Chiavegatto S, Saad MJ, Velloso LA 2006 Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-α on hypothalamic insulin-dependent inhibition of food intake. FEBS Lett 580:4625-4631
12. Scott DL, Kingsley GH 2006 Tumor necrosis factor inhibitors for rheumatoid arthritis. N Engl J Med 355:704-712
13. Chang JT, Lichtenstein GR 2006 Drug insight: antagonists of tumor-necrosis factor-α in the treatment of inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol 3:220-228
14. Yazdani-Biuki B, Stelzl H, Brezinschek HP, Hermann J, Mueller T, Krippl P, Graninger W, Wascher TC 2004 Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-α antibody infliximab. Eur J Clin Invest 34:641-642
15. Gonzalez-Gay MA, De Matias JM, Gonzalez-Juanatey C, Garcia-Porrua C, Sanchez-Andrade A, Martin J, Llorca J 2006 Anti-tumor necrosis factor-α blockade improves insulin resistance in patients with rheumatoid arthritis. Clin Exp Rheumatol 24:83-86
16. Yazdani-Biuki B, Mueller T, Brezinschek HP, Hermann J, Graninger W, Wascher TC 2006 Relapse of diabetes after interruption of chronic administration of anti-tumor necrosis factor-α antibody infliximab: a case observation. Diabetes Care 29:1712-1713
17. Trinder P 1969 Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 22:158-161
18. Scott AM, Atwater I, Rojas E 1981 A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia 21:470-475
19. Bonora E, Manicardi V, Zavaroni I, Coscelli C, Butturini U 1987 Relationships between insulin secretion, insulin metabolism and insulin resistance in mild glucose intolerance. Diabetes Metab 13:116-121
20. Prada PO, Pauli JR, Ropelle ER, Zecchin HG, Carvalheira JB, Velloso LA, Saad MJ 2006 Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats. FEBS Lett 580:4889-4894
21. Velloso LA, Kampe O, Hallberg A, Christmanson L, Betsholtz C, Karlsson FA 1993 Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. J Clin Invest 91:2084-2090
22. De Souza CT, Araujo EP, Prada PO, Saad MJ, Boschero AC, Velloso LA 2005 Short-term inhibition of peroxisome proliferator-activated receptor-γ coactivator-1α expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice. Diabetologia 48:1860-1871
23. Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, Corezola do Amaral ME, Hoer NF, Boschero AC, Saad MJ 2005 Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 146:1576-1587
24. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS 2000 Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105:1827-1832
25. Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, Azambuja MI, Tracy RP, Heiss G 1999 Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 353:1649-1652
26. Araujo EP, De Souza CT, Gasparetti AL, Ueno M, Boschero AC, Saad MJ, Velloso LA 2005 Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity. Endocrinology 146:1428-1437
27. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y 1997 A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 272:29911-29918
28. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS 2004 Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10:734-738
29. Larter CZ, Farrell GC 2006 Insulin resistance, adiponectin, cytokines in NASH: which is the best target to treat? J Hepatol 44:253-261
30. Browning JD, Horton JD 2004 Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114:147-152
31. Rossmeisl M, Rim JS, Koza RA, Kozak LP 2003 Variation in type 2 diabetes-related traits in mouse strains susceptible to diet-induced obesity. Diabetes 52:1958-1966
32. Pitombo C, Araujo EP, De Souza CT, Pareja JC, Geloneze B, Velloso LA 2006 Amelioration of diet-induced diabetes mellitus by removal of visceral fat. J Endocrinol 191:699-706
33. Mastroianni A, Minutilli E, Mussi A, Bordignon V, Trento E, D'Agosto G, Cordiali-Fei P, Berardesca E 2005 Cytokine profiles during infliximab monotherapy in psoriatic arthritis. Br J Dermatol 153:531-536
34. Charles P, Elliott MJ, Davis D, Potter A, Kalden JR, Antoni C, Breedveld FC, Smolen JS, Eberl G, deWoody K, Feldmann M, Maini RN 1999 Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-α therapy in rheumatoid arthritis. J Immunol 163:1521-1528
35. Feldmann M, Maini RN 2001 Anti-TNFα therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 19:163-196
36. Williams RO, Feldmann M, Maini RN 1992 Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 89:9784-9788
37. Piguet PF, Grau GE, Vesin C, Loetscher H, Gentz R, Lesslauer W 1992 Evolution of collagen arthritis in mice is arrested by treatment with antitumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor. Immunology 77:510-514
38. Carvalheira JB, Siloto RM, Ignacchitti I, Brenelli SL, Carvalho CR, Leite A, Velloso LA, Gontijo JA, Saad MJ 2001 Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS Lett 500:119-124