A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe)

Food and Function

Volumn 4, Issue 6, 2013, Pages 845-855

  Haniadka, Raghavendra ^a   Saldanha, Elroy ^b   Sunita, Venkatesh ^a   Palatty, Princy L ^b   Fayad, Raja ^c   Baliga, Manjeshwar Shrinath ^a  

^a FATHER MULLER MEDICAL COLLEGE   (India)

^b Father Muller Medical College   (India)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; DERMATOLOGY; DISEASES; DRUG PRODUCTS;

FREE RADICAL SCAVENGING; INFECTIOUS DISEASE; INHIBITION OF LIPID PEROXIDATION; LABORATORY ANIMALS; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; SCIENTIFIC STUDIES; TRADITIONAL SYSTEMS; ZINGIBER OFFICINALE;

FOOD ADDITIVES;

ANIMALIA; HELICOBACTER PYLORI; ZINGIBER OFFICINALE; ZINGIBERACEAE;

ANTIEMETIC AGENT; PLANT EXTRACT;

ANIMAL; CHEMISTRY; DRUG EFFECTS; GASTRIC DILATATION; GINGER; HUMAN; STOMACH;

ANIMALS; ANTIEMETICS; GASTRIC DILATATION; GINGER; HUMANS; PLANT EXTRACTS; STOMACH;

EID: 84878721480     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c3fo30337c     Document Type: Review

References (96)

1. L. R. Johnson, Physiology of the Gastrointestinal Tract, Elsevier Academic Press, 2006
2. R. Gadekar P. K. Singour P. K. Chaurasiya R. S. Pawar U. K. Patil A potential of some medicinal plants as an antiulcer agents Pharmacogn. Rev. 2010 4 136 148
3. P. A. Vasala, Ginger, in Handbook of Herbs and Spices, ed., K. V. Peter, 2004, vol. 1
4. S. Chrubasik M. H. Pittler B. D. Roufogalis Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles Phytomedicine 2005 12 684 701
5. B. H. Ali G. Blunden M. O. Tanira A. Nemmar Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research Food Chem. Toxicol. 2008 46 409 420
6. V. S. Govindarajan Ginger-chemistry, technology, and quality evaluation: part 1 Crit. Rev. Food Sci. Nutr. 1982 17 1 96
7. V. S. Govindarajan Ginger-chemistry, technology, and quality evaluation: part 2 Crit. Rev. Food Sci. Nutr. 1982 17 189 258
8. T. Yoshikawa Y. Naito A. Kishi T. Tomii T. Kaneko S. Iinuma H. Ichikawa M. Yasuda S. Takahashi M. Kondo Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats Gut 1993 34 732 737
9. S. Lohsiriwat M. Rukkiat R. Chaikomin S. Leelakusolvong Effect of ginger on lower esophageal sphincter pressure J. Med. Assoc. Thailand 2010 93 366 372
10. M. L. Hu C. K. Rayner K. L. Wu S. K. Chuah W. C. Tai Y. P. Chou Y. C. Chiu K. W. Chiu T. H. Hu Effect of ginger on gastric motility and symptoms of functional dyspepsia World J. Gastroenterol. 2011 17 105 110
11. N. Yoshida H. Omoya T. Ito DAT-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog J. Pharmacol. Exp. Ther. 1992 260 1159 1165
12. S. S. Sharma Y. K. Gupta Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale) J. Ethnopharmacol. 1998 62 49 55
13. Y. K. Gupta M. Sharma Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale) Methods Find. Exp. Clin. Pharmacol. 2001 23 501 503
14. B. J. Pleuvrya Physiology and pharmacology of nausea and vomiting Anaesth. Intensive Care Med. 2006 7 473 477
15. W. Fischer-Rasmussen S. K. Kjaer C. Dahl U. Asping Ginger treatment of hyperemesis gravidarum Eur. J. Obstet. Gynecol. Reprod. Biol. 1991 38 19 24
16. T. Vutyavanich T. Kraisarin R. Ruangsri Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial Obstet. Gynecol. 2001 97 577 582
17. K. E. Willetts A. Ekangaki J. A. Eden Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial Aust. N. Z. J. Obstet. Gynaecol. 2003 43 139 144
18. C. Smith C. Crowther K. Willson N. Hotham V. McMillian A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy Obstet. Gynecol. 2004 103 639 645
19. J. Ensiyeh M. A. Sakineh Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial Midwifery 2009 25 649 653
20. G. Portnoi A. Chng Lu L. Karimi-Tabesh G. Koren M. P. Tan R. N. Einarson Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy Am. J. Obstet. Gynecol. 2003 189 1374 1377
21. D. Pongrojpaw C. Chiamchanya The efficacy of ginger in prevention of post-operative nausea and vomiting after outpatient gynecological laparoscopy J. Med. Assoc. Thailand 2003 86 244 250
22. S. Apariman S. Ratchanon B. Wiriyasirivej Effectiveness of ginger for prevention of nausea and vomiting after gynecological laparoscopy J. Med. Assoc. Thailand 2006 89 2003 2009
23. A. Tavlan S. Tuncer A. Erol R. Reisli G. Aysolmaz S. Otelcioglu Prevention of postoperative nausea and vomiting after thyroidectomy: combined antiemetic treatment with dexamethasone and ginger versus dexamethasone alone Clin. Drug Invest. 2006 26 209 214
24. D. S. Qian Z. S. Liu Pharmacologic studies of antimotion sickness actions of ginger Zhongguo Zhongxiyi Jiehe Zazhi 1992 12 2 95 98
25. D. Mowrey Motion sickness, ginger, and psychophysics Lancet 1982 319 655 657
26. H. C. Lien W. M. Sun Y. H. Chen H. Kim W. Hasler C. Owyang Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection Am. J. Physiol.: Gastrointest. Liver Physiol 2003 284 G481 G489
27. J. J. Stewart M. J. Wood C. D. Wood M. E. Mims Effects of ginger on motion sickness susceptibility and gastric function Pharmacology 1991 42 111 120
28. A. Groslashntvedab T. Braskab J. Kambskardac E. Hentzerad Ginger root against seasickness: a controlled trial on the open sea Acta Oto-Laryngol. 1988 105 1-2 45 49
29. A. Grøntved T. Brask J. Kambskard E. Hentzer Ginger root against seasickness: a controlled trial on the open sea Acta Oto-Laryngol. 1988 105 1-2 45 49
30. A. Sharma A. Haksar R. Chawla R. Kumar R. Arora S. Singh J. Prasad F. Islam M. P. Arora R. Kumar Sharma Zingiber officinale Rosc. modulates gamma radiation-induced conditioned taste aversion Pharmacol., Biochem. Behav. 2005 81 864 870
31. A. Haksar A. Sharma R. Chawla R. Kumar R. Arora S. Singh J. Prasad M. Gupta R. P. Tripathi M. P. Arora F. Islam R. K. Sharma Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner Pharmacol., Biochem. Behav. 2006 84 179 188
32. S. S. Sharma V. Kochupillai S. K. Gupta S. D. Seth Y. K. Gupta Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs J. Ethnopharmacol. 1997 57 93 96
33. Q. H. Qian W. Yue W. H. Chen Z. H. Yang Z. T. Liu Y. X. Wang Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink China Med. J. 2010 123 478 484
34. H. Abdel-Aziz T. Windeck M. Ploch E. J. Verspohl Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum Eur. J. Pharmacol. 2006 530 136 143
35. S. Manusirivithaya M. Sripramote S. Tangjitgamol C. Sheanakul S. Leelahakorn T. Thavaramara K. Tangcharoenpanich Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin Int. J. Gynecol. Cancer 2004 14 1063 1069
36. S. Sontakke V. Thawani M. S. Naik Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: a randomized, cross-over, double blind study Indian J. Pharmacol. 2003 35 32 36
37. M. E. Levine M. Gillis S. Yanchis A. C. Voss R. M. Stern K. L. Koch Protein and ginger for the treatment of chemotherapy-induced delayed nausea and gastric dysrhythmia Neurogastroenterol. Motil. 2006 18 488
38. A. K. Pillai K. K. Sharma Y. K. Gupta S. Bakhshi Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy Pediatr. Blood Canc. 2011 56 234 238
39. Y. Panahi A. Saadat A. Sahebkar F. Hashemian M. Taghikhani E. Abolhasani Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial Int. Cancer Ther. 2012 11 204 211
40. J. L. Ryan C. E. Heckler J. A. Roscoe S. R. Dakhil J. Kirshner P. J. Flynn J. T. Hickok G. R. Morrow Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients Support Care Cancer 2012 20 1479 1489
41. S. M. Zick M. T. Ruffin J. Lee D. P. Normolle R. Siden S. Alrawi D. E. Brenner Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting Support Care Cancer 2009 17 563 572
42. Y. Fujii T. Matsura M. Kai H. Matsui H. Kawasaki K. Yamada Mitochondrial cytochrome c release and caspase-3-like protease activation during indomethacin-induced apoptosis in rat gastric mucosal cells Proc. Soc. Exp. Biol. Med. 2000 224 102 108
43. M. A. Al-Yahya S. Rafatullah J. S. Mossa A. M. Ageel N. S. Parmar M. Tariq Gastroprotective activity of ginger Zingiber officinale rosc., in albino rats Am. J. Chin. Med. 1989 17 51 56
44. C. V. Rao K. Sairam R. K. Goel Experimental evaluation of Bacopa monniera in rat gastric ulceration and secretion Indian J. Physiol. Pharmacol. 2000 44 35 41
45. M. Khushtar V. Kumar K. Javed U. Bhandari Protective effect of ginger oil on aspirin and pylorus ligation-induced gastric ulcer model in rats Indian J. Pharm. Sci. 2009 71 554 558
46. C. H. Cho C. W. Ogle S. Dai A study on the etiology of reserpine ulceration and the antiulcer action of solcoseryl in rat stomach J. Pharm. Pharmacol. 1985 37 823 825
47. S. Yusuf A. B. Adelaiye A. J. Nok D. A. Ameh E. O. Balogun Effect of acute bilateral adrenalectomy and reserpine on gastric mucus secretion and mucosal injury in pyloric ligated rats Afr. J. Biotechnol. 2008 7 3143 3148
48. K. Watanabe Some pharmacological factors involved in formation and deficiency delays gastric ulcer healing in rats Dig. Dis. Sci. 1966 40 1340 1344
49. H. Kitagawa M. Fujwara Y. Osumi Effect of Water immersion stress on blood flow in rats Gastroenterology 1979 77 298 302
50. K. Takeuchi M. Kajimura M. Kodaira S. Lin H. Hanai E. Kaneko Up-regulation of H2 receptor and adenylate cyclase in rabbit parietal cells during prolonged treatment with H2-receptor antagonists Dig. Dis. Sci. 1999 44 1703 1709
51. S. J. Konturek W. Obtulowicz N. Kwiecien E. Sito J. Oleksy B. Miszczuk-Jamska Effect of ranitidine, a new H2-antagonist, on gastric and pancreatic secretion in duodenal ulcer patients Dig. Dis. Sci. 1980 25 737 743
52. I. Szelenyi K. Brune Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats Dig. Dis. Sci. 1988 33 865 871
53. J. Yamahara M. Mochizuki H. Q. Rong H. Matsuda H. Fujimura The anti-ulcer effect in rats of ginger constituents J. Ethnopharmacol. 1988 23 2-3 299 304
54. S. M. Nanjundaiah H. N. Annaiah M. S. Dharmesh Gastroprotective effect of ginger rhizome (Zingiber officinale) extract: role of gallic acid and cinnamic acid in H+, K+-ATPase/H. Pylori inhibition and anti-oxidative mechanism J. Evidence-Based Complementary Altern. Med. 2009 249487
55. U. N. Prakash K. Srinivasan Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats Appl. Physiol., Nutr., Metab. 2010 35 134 141
56. G. Deliconstantinos V. Villiotou Gas phase oxidants of cigarette smoke increase nitric oxide synthase and xanthine oxidase activities of rabbit brain synaptosomes Neurochem. Res. 2000 25 769 774
57. B. Galunskam K. Marazova T. Yankova A. Popov P. Frangov I. Krushkov A. Dimassa Effect of paracetamol and proparacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats Pharmacol. Res. 2002 46 141 142
58. J. K. Ko C. C. Leung Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats J. Gastroenterol. Hepatol. 2010 25 1861 1868
59. IARC, Schistosomes, liver flukes and Helicobacter pylori, Iarc Scientific Publication No. 61, International Agency for Reseach on Cancer, Lyon, France, 1994, pp. 177-241
60. P. Patel S. Khulusi M. A. Mendall R. Lloyd R. Jazrawi J. D. Maxwell T. C. Northfield Prospective screening of dyspeptic patients by Helicobacter pylori serology Lancet 1995 346 1315 1318
61. G. B. Mahady S. L. Pendland G. S. Yun Z. Z. Lu A. Stoia Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori Anticancer Res. 2003 23 5A 3699 3702
62. A. Weseler H. K. Geiss R. Saller J. Reichling A novel colorimetric broth microdilution method to determine the minimum inhibitory concentration (MIC) of antibiotics and essential oils against Helicobacter pylori Pharmazie 2005 60 498 502
63. R. O'Mahony H. Al-Khtheeri D. Weerasekera N. Fernando D. Vaira J. Holton C. Basset Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori World J. Gastroenterol. 2005 11 7499 7507
64. M. N. Siddaraju S. M. Dharmesh Inhibition of gastric H+, K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale Mol. Nutr. Food Res. 2007 51 324 332
65. K. Gaus Y. Huang D. A. Israel S. L. Pendland B. A. Adeniyi G. B. Mahady Standardized ginger (Zingiber officinale) extract reduces bacterial load and suppresses acute and chronic inflammation in Mongolian gerbils infected with cagA Helicobacter pylori Pharm. Biol. 2009 47 92 98
66. S. Gonlachanvit Y. H. Chen W. L. Hasler W. M. Sun C. Owyang Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins J. Pharmacol. Exp. Ther. 2003 203 1098 1103
67. M. S. Baliga G. C. Jagetia S. K. Rao K. Babu Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study Nahrung 2003 47 261 264
68. G. Jagetia M. Baliga P. Venkatesh Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action Cancer Biother.Radiopharm. 2004 19 422 435
69. T. P. Krishnakantha B. R. Lokesh Scavenging of superoxide anions by spice principles Indian J. Biochem. Biophys. 1993 30 133 134
70. R. Aeschbach J. Löliger B. C. Scott A. Murcia J. Butler B. Halliwell O. I. Aruoma Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol Food Chem. Toxicol. 1994 32 31 36
71. S. G. Shin J. Y. Kim H. Y. Chung J. C. Jeong Zingerone as an antioxidant against peroxynitrite J. Agric. Food Chem. 2005 53 7617 7622
72. K. Ippoushi K. Azuma H. Ito H. Horie H. Higashio [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions Life Sci. 2003 73 3427 3437
73. S. Shobana K. A. Naidu Antioxidant activity of selected Indian spices Prostaglandins, Leukotrienes Essent. Fatty Acids 2000 62 107 110
74. W. Y. Chung Y. J. Jung Y. J. Surh S. S. Lee K. K. Park Antioxidative and antitumor promoting effects of [6]-paradol and its homologs Mutat. Res. 2001 496 199 206
75. A. C. Reddy B. R. Lokesh Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes Mol. Cell. Biochem. 1992 111 117 124
76. S. Gorelik M. Ligumsky R. Kohen J. Kanner A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products FASEB J. 2008 22 41 46
77. B. Halliwell Biochemistry of oxidative stress Biochem. Soc. Trans. 2007 35 1147 1150
78. T. P. Devasagayam J. C. Tilak K. K. Boloor K. S. Sane S. S. Ghaskadbi R. D. Lele Free radicals and antioxidants in human health: current status and future prospects J. Assoc. Phys. India 2004 52 794 804
79. A. T. Afshari A. Shirpoor A. Farshid R. Saadatian Y. Rasmi E. Saboory I. Behrooz The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats Food Chem. 2007 101 148 153
80. K. Mallikarjuna P. Sahitya Chetan K. Sathyavelu Reddy W. Rajendra Ethanol toxicity: rehabilitation of hepatic antioxidant defense system with dietary ginger Fitoterapia 2008 79 174 178
81. K. R. Shanmugam C. H. Ramakrishna K. Mallikarjuna K. S. Reddy Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats Indian J. Exp. Biol. 2010 48 143 149
82. H. S. El-Abhar L. N. Hammad H. S. Gawad Modulating effect of ginger extract on rats with ulcerative colitis J. Ethnopharmacol. 2008 13 367 372
83. F. Aktan S. Henness V. H. Tran C. C. Duke B. D. Roufogalis A. J. Ammit Gingerol metabolite and a synthetic analogue capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity Planta Med. 2006 72 727 734
84. K. C. Srivastava Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study Prostaglandins, Leukotrienes Med. 1984 13 227 235
85. R. Grzanna L. Lindmark C. G. Frondoza Ginger - an herbal medicinal product with broad anti-inflammatory actions J. Med. Food 2005 8 125 132
86. E. Tjendraputra V. H. Tran D. Liu-Brennan B. D. Roufogalis C. C. Duke Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells Bioorg. Chem. 2001 29 156 163
87. B. B. Aggarwal S. Shishodia Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning Ann. N. Y. Acad. Sci. 2004 1030 434 441
88. K. Polasa K. Nirmala Ginger: its role in xenobiotic metabolism ICMR Bulletin 2003 33 56 62
89. K. Nirmala T. Prasanna Krishna K. Polasa Modulation of xenobiotic metabolism in ginger (Zingiber officinale Roscoe) fed rats Int. J. Nutr. Metab. 2010 2 56 62
90. K. Sambaiah K. Srinivasan Influence of spices and spice principles on hepatic mixed function oxygenase system in rats Indian J. Biochem. Biophys. 1989 26 254 258
91. A. S. El-Sharaky A. A. Newairy M. A. Kamel S. M. Eweda Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats Food Chem. Toxicol. 2009 47 1584 1590
92. S. Banerjee R. Sharma R. K. Kale A. R. Rao Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver Nutr. Cancer 1994 21 263 269
93. M. N. Ghayur A. H. Khan A. H. Gilani Ginger facilitates cholinergic activity possibly due to blockade of muscarinic autoreceptors in rat stomach fundus Pak. J. Pharm. Sci. 2007 20 231 235
94. B. Halliwell Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch. Biochem. Biophys. 2008 476 107 112
95. S. Vertuani A. Angusti S. Manfredini The antioxidants and pro-antioxidants network: an overview Curr. Pharm. Des. 2004 10 1677 1694
96. A. S. El-Sharaky A. A. Newairy M. A. Kamel S. M. Eweda Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats Food Chem. Toxicol. 2009 47 1584 1590