Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting

Supportive Care in Cancer

Volumn 17, Issue 5, 2009, Pages 563-572

  Zick, Suzanna M ^a,c   Ruffin, MacK T ^a   Lee, Julia ^a   Normolle, Daniel P ^a   Siden, Rivka ^a   Alrawi, Sara ^a   Brenner, Dean E ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Apripetant; Chemotherapy induced nausea and vomiting; Ginger

Indexed keywords

ANTINEOPLASTIC AGENT; APREPITANT; CAPECITABINE; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOCETAXEL; DOLASETRON MESILATE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; GINGER EXTRACT; GINGEROL; GRANISTRON; IRINOTECAN; ONDANSETRON; OXALIPLATIN; PACLITAXEL; PALONOSETRON; PLACEBO; SEROTONIN 3 ANTAGONIST; SHOGAOL; TRASTUZUMAB; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; ANEMIA; ARTICLE; CHEMOTHERAPY; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERANCE; DYSPNEA; FATIGUE; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; LABORATORY TEST; LEUKOCYTE COUNT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEOPLASM; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; THROMBOCYTE COUNT; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADULT; AGED; ANTIEMETICS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GINGER; HUMANS; MALE; MIDDLE AGED; MORPHOLINES; NAUSEA; PREVALENCE; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; SEVERITY OF ILLNESS INDEX; VOMITING;

EID: 64449086682     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-008-0528-8     Document Type: Article

References (36)

1. R Aeschbach J Loliger BC Scott 1994 Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol Food Chem Toxicol 32 1 31 36
2. JD Baranowski 1985 High-performance liquid-chromatographic separation of pungency components of ginger J Chromatogr A 319 3 471 474
3. B Bloechl-Daum RR Deuson P Mavros M Hansen J Herrstedt 2006 Delayed nausea and vomiting continue to reduce patients' quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment J Clin Oncol 24 27 4472 4478
4. S Chrubasik MH Pittler BD Roufogalis 2005 Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles Phytomedicine 12 9 684 701
5. A Coates S Abraham SB Kaye 1983 On the receiving end-patient perception of the side-effects of cancer chemotherapy Eur J Cancer Clin Oncol 19 2 203 208
6. L Cohen CA de Moor P Eisenberg EE Ming H Hu 2007 Chemotherapy-induced nausea and vomiting: incidence and impact on patient quality of life at community oncology settings Support Care Cancer 15 5 497 503
7. GA Colditz JN Miller F Mosteller 1989 How study design affects outcomes in comparisons of therapy. I: Medical Stat Med 8 4 441 454
8. http://ctep.cancer.gov/forms/CTCAEv3.pdf. Accessed on March 25th 2008
9. PJ Devereaux BJ Manns WA Ghali 2001 Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials JAMA 285 15 2000 2003
10. R de Wit J Herrstedt B Rapoport 2003 Addition of the oral NK1 antagonist aprepitant to standard antiemetics provides protection against nausea and vomiting during multiple cycles of cisplatin-based chemotherapy J Clin Oncol 21 22 4105 4111
11. D Fergusson K Glass D Waring S Shapiro 2004 Turning a blind eye: the success of blinding reported in a random sample of randomized, placebo controlled trials BMJ 328 7437
12. P Feyer UR Kleeberg M Steingraber W Gunther M Behrens 2008 Frequency of side effects in outpatient cancer care and their influence on patient satisfaction-a prospective survey using the PASQOC(R) questionnaire Support Care Cancer 16 567 575
13. SM Grunberg RR Deuson P Mavros 2004 Incidence of chemotherapy-induced nausea and emesis after modern antiemetics Cancer 100 10 2261 2268
14. R Grzanna L Lindmark CG Frondoza 2005 Ginger-an herbal medicinal product with broad anti-inflammatory actions J Med Food 8 2 125 132
15. YK Gupta M Sharma 2001 Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale) Methods Find Exp Clin Pharmacol 23 9 501 503
16. DH Henry HN Viswanathan EP Elkin S Traina S Wade D Cella 2008 Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S Support Care Cancer 16 791 801
17. Hoffman D (1983) The new holistic herbal. Element Books Limited, Shaftesbury, Dorset
18. QR Huang M Iwamoto S Aoki N Tanaka K Tajima J Yamahara Y Takaishi M Yoshida T Tomimatsu Y Tamai 1991 Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger Chem Pharm Bull (Tokyo) 39 2 397 399
19. SD Jolad RC Lantz GJ Chen RB Bates BN Timmermann 2005 Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production Phytochemistry 66 13 1614 1635
20. SD Jolad RC Lantz AM Solyom GJ Chen RB Bates BN Timmermann 2004 Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production Phytochemistry 65 13 1937 1954
21. MG Kris PJ Hesketh MR Somerfield 2006 American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006 J Clin Oncol 24 18 2932 2947
22. TP Krishnakantha BR Lokesh 1993 Scavenging of superoxide anions by spice principles Indian J Biochem Biophys 30 2 133 134
23. RC Lantz GJ Chen M Sarihan AM Solyom SD Jolad BN Timmermann 2007 The effect of extracts from ginger rhizome on inflammatory mediator production Phytomedicine 14 2-3 123 128
24. S Manusirivithaya M Sripramote S Tangjitgamol 2004 Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin Int J Gynecol Cancer 14 6 1063 1069
25. Mills S, Bone K (2000) Principles and practice of phytotherapy. Churchill Livingstone, Oxford
26. GR Morrow 1992 A patient report measure for the quantification of chemotherapy induced nausea and emesis: psychometric properties of the Morrow assessment of nausea and emesis (MANE) Br J Cancer Suppl 19 S72 S74
27. Ody P (1993) The complete medicinal herbal. Dorling-Kindersley, New York
28. J Pace 1987 Oral ingestion of encapsulated ginger and reported self-care action for the relief of chemotherapy-associated N & E Dissertations Abstracts International 47 3297 B
29. Pecoraro A, Patel J, Guthrie T, Ndubisi B (1998) Efficacy of ginger as an adjunctive anti-emetic in acute chemotherapy-induced nausea and vomiting. ASHP Mid-Year Clinical Meeting, 429E
30. K Platel K Srinivasan 2000 Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats Nahrung 44 1 42 46
31. SS Sharma YK Gupta 1998 Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale) J Ethnopharmacol 62 1 49 55
32. C Shibata I Sasaki H Naito T Ueno S Matsuno 1999 The herbal medicine Dai-Kenchu-Tou stimulates upper gut motility through cholinergic and 5-hydroxytryptamine 3 receptors in conscious dogs Surgery 126 5 918 924
33. S Sontakke V Thawani MS Naik 2003 Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: a randomized, cross-over, double-blind study Indian J Pharmacol 35 32 36
34. YJ Surh E Lee JM Lee 1998 Chemoprotective properties of some pungent ingredients present in red pepper and ginger Mutat Res 402 1-2 259 267
35. J Yamahara QR Huang M Iwamoto G Kobayash H Matsuda H Fujimura 1989 Active components of ginger exhibiting anti-serotonergic action Phytother Res 3 70 71
36. J Yamahara QR Huang YH Li L Xu H Fujimura 1990 Gastrointestinal motility enhancing effect of ginger and its active constituents Chem Pharm Bull (Tokyo) 38 2 430 431