Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy

Pediatric Blood and Cancer

Volumn 56, Issue 2, 2011, Pages 234-238

  Pillai, Anu Kochanujan ^a   Sharma, Kamlesh K ^a   Gupta, Yogendra K ^a   Bakhshi, Sameer ^a,b  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b INSTITUTE ROTARY CANCER HOSPITAL   (India)

Author keywords

Chemotherapy; Children; Cisplatin; Ginger; Nausea; Oncology; Vomiting; Young adults

Indexed keywords

CISPLATIN; DEXAMETHASONE; DOXORUBICIN; GINGER EXTRACT; ONDANSETRON; PLACEBO;

ADD ON THERAPY; ADOLESCENT; ADULT; ARTICLE; BLEEDING; CANCER PATIENT; CHEMOTHERAPY INDUCED EMESIS; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; EDMONTON SYMPTOM ASSESSMENT SCALE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NATIONAL CANCER INSTITUTE CRITERIA; OSTEOSARCOMA; PLANT ROOT; POWDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RATING SCALE; TACHYCARDIA;

ADOLESCENT; ANTIEMETICS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE NEOPLASMS; CHILD; CISPLATIN; DEXAMETHASONE; DOUBLE-BLIND METHOD; DOXORUBICIN; FEMALE; GINGER; HUMANS; MALE; NAUSEA; ONDANSETRON; PHYTOTHERAPY; PLANT ROOTS; SARCOMA; VOMITING; YOUNG ADULT;

EID: 78650154702     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22778     Document Type: Article

References (19)

1. Sontakke S, Thawani V, Naik MS. Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study. Ind J Pharmacol 2003; 35: 32-36.
2. Quimby EL. The use of herbal therapies in pediatric oncology patients: Treating symptoms of cancer and side effects of standard therapies. J Ped Oncol Nurs 2007; 24: 35-40.
3. Zick SM, Ruffin MT, Lee J, et al. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Supp Care Cancer 2009; 17: 563-572.
4. Medappa N. Ginger: Its Role in Xenobiotic Metabolism [Online]. ICMR Bulletin In: ICMR Offset Press; 33(6): 57-63 [cited 2003 June]. Available from: .
5. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: Randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001; 97: 577-582.
6. Grøntved A, Brask T, Kambskard J, et al. Ginger root against seasickness: A controlled trial on the open sea. Acta Otolaryngol 1998; 105: 45-49.
7. Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, et al. The efficacy of ginger for the prevention of postoperative nausea and vomiting: A meta-analysis. Am J Obstet Gynecol 2006; 194: 95-99.
8. Jewell MD, Young G. Interventions: For nausea and vomiting in early pregnancy. In: The Cochrane Library [Online]. 2008 (Cochrane Review) Issue 4. Chichester, UK: John Wiley & Sons, Ltd [cited 2008 April].
9. Ryan JL, Heckler C, Dakhil SR, et al. Ginger for chemotherapy-related nausea in cancer patients: A URCC CCOP randomized, double-blind, placebo-controlled clinical trial of 644 cancer patients. J Clin Oncol 2009; 27: (suppl; abstr 9511).
10. Dudgeon DJ, Harlos M, Clinch JJ. The Edmonton Symptom Assessment Scale (ESAS) as an audit tool. J Palliat Care 1999; 15: 14-19.
11. Moro C, Brunelli C, Miccinesi G, et al. Edmonton symptom assessment scale: Italian validation in two palliative care settings. Support Care Cancer 2006; 14: 30-37.
12. Chang VT, Hwang SS, Feuerman M. Validation of the Edmonton Symptom Assessment Scale (ESAS) [abstract 68]. J Pain Sympt Manage 1999; 18: S19.
13. PDQ Supportive and Editorial Board. NCI Guidelines [Online]. 1999 July 23 [1999 December 19]; Available from: URL: .
14. Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: A systematic review of randomized controlled trials. Br J Anesthesia 2000; 84: 367-371.
15. Pace JC. Oral ingestion of encapsulated ginger and reported self care actions for the relief of chemotherapy associated nausea and vomiting. Dissertations Abstracts Int 1987; 47: 3297-B.
16. Levine ME, Gillis MG, Koch SY, et al. The effect of protein meals with ginger for the treatment of chemotherapy-induced delayed nausea. J Altern Complement Med 2008; 14: 545-551.
17. Sharma SS, Kochupillai V, Gupta SK, et al. Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs. J Ethnopharmacol 1997; N57: 93-96.
18. Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Int J Phytother Phytopharmacol 2005; 12: 684-702.
19. Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2005; 59: 425-432.