Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats

Indian Journal of Experimental Biology

Volumn 48, Issue 2, 2010, Pages 143-149

  Shanmugam, K R ^a   Ramakrishna, C H ^a   Mallikarjuna, K ^b   Reddy, K Sathyavelu ^a  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b UNIVERSITY OF TAIPEI   (Taiwan)

Author keywords

Alcohol; Antioxidants; Histopathology; Kidney; Oxidative stress; Rats

Indexed keywords

RATTUS; ZINGIBER OFFICINALE;

ALCOHOL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; GINGER; HUMAN; KIDNEY; MALE; METABOLISM; PATHOLOGY; RAT; WISTAR RAT;

ANIMALS; ETHANOL; GINGER; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; KIDNEY; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

EID: 77952991832     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Lieber C S, Hepatic and metabolic effects of ethanol: Pathogenesis and prevention, Ann Med, 26 (1994) 325.
2. Lieber C S, Biochemical and molecular basis of alcohol induced injury to liver and others tissues, N Engl J Med, 319 (1988) 1639.
3. Brzoska M M, Moniuszko-Jakoniuk J, Pilat-Marcinkiewicz B & Sawicki B, Liver and kidney function and histology in rats exposed to cadmium and ethanol, Alcohol, 38 (2003) 2.
4. Cecchin E & De Marchi S, Alcohol misuse and renal damage, Addict Biol, 1 (1996) 7.
5. Das S K & Vasudevan D M, Effect of ethanol on liver antioxidant defence system: A dose dependent study, Indian J Clin Biochem, 20 (2005) 80.
6. Potter J F, Bannan L T & Beevers D G, Alcohol and hypertension, Brit J Addict, 79 (1984) 365.
7. De Marchi S & Cecchin E, Alcohol withdrawal and hypertension: evidence for a kidney abnormality, Clin Sci, 69 (1985) 239.
8. Heidland A, Horl W H, Schaefer R M, Teschner M, Weipert J & Heidbreder E, Role of alcohol in clinical nephrology. Klin Wochenschr, 63 (1985) 948.
9. Rodrigo R, Thielemann L, Olea M, Muñoz P, Cereceda M & Orellana M, Effect of ethanol ingestion on renal regulation of water and electrolytes, Arch Med Res, 29 (1998) 209.
10. Rodrigo R, Trujillo S, Bosco C, Orellana M, Thielemann L & Araya J, Changes in (Na+K)-adenosine triphosphatase activity and ultra structure of lung and kidney associated with oxidative stress induced by acute ethanol intoxication, Chest, 121 (2002) 589.
11. Zima T, Fialova L, Mestek O, Janebova M, Crkovska J, Malbohan I, Stipek S, Mikulikova L & Popov P, Oxidative stress, metabolism of ethanol and alcohol-related diseases, J Biomed Sci, 8 (2001) 59.
12. Ajith T A, Nivitha V & Usha S, Zingiber qfficinale Roscoe alone and in combination with a-tocopherol protect the kidney against cisplatin-induced acute renal failure, Food & Chem Toxicol, 45 (2007) 921.
13. Ahmed R S, Seth V & Banerjee B D, Influence of dietary ginger (Zingiber qfficinale Rosc) on antioxidant defence system in rat: Comparison with ascorbic acid, Indian J Exp Biol, 38 (2000) 604.
14. Dahanukar S A, Kulkarni R A & Rege N N, Pharmacology of medicinal plants and natural products, Indian J Pharmacol, 32 (2000) S81.
15. st edn. (Briza Publications Pretoria, South Africa) 2003, 349.
16. Jiang H, Xie Z, Koo H J, McLaughlin S P, Timmermann B N & Gang D R, Metabolic profiling and phylogenetic analysis of medicinal Zingiber species: Tools for authentication of ginger (Zingiber qfficinale Rosc), Phytochemistry, 67 (2006) 232.
17. Young H V, Luo Y L, Cheng H Y, Hsieh W C, Liao J C & Peng W C, Analgesic and anti-inflammatory activities of [6]-gingerol, J Ethnopharmacol, 96 (2005) 207.
18. Bhandari U, Kanojia R & Pillai K K, Effect of ethanolic extract of Zingiber qfficinale on dyslipidaemia in diabetic rats, J Ethnopharmacol, 97 (2005) 227.
19. Mallikarjuna K, Sahitya Chetan P, Sathyavelu Reddy K & Rajendra W, Ethanol toxicity: Rehabilitation of hepatic antioxidant defense system with dietary ginger, Fitoterapia, 79 (2008) 174.
20. Misra H P & Fridovich I, The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase, J Biol Chem, 247 (1972) 3170.
21. Habig W H, Pabst M J & Jakoby W B, Glutathione-s-transferases: The first enzymatic step in mercapturic acid formation, J Biol Chem, 249 (1974) 7130.
22. Srikanthan T W & Krishnamurthy C. Tetrazolium test for dehydrogenases, J Sci Ind Res, 14 (1955) 206.
23. Omaye S T, Turnbull J D & Sauberlich H E, Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids, Methods Enzymol, 62 (1979) 3.
24. Martinek R G, Methods for the determination of uric acid, J Am Med Tech, 32 (1970) 283.
25. Lowry O H, Rosebrough N J, Farr A L & Randall R J, Protein measurement with the folin phenol reagent, J Biol Chem, 193 (1951) 265.
26. Akerboom T P M & Sies H, Assay of glutathione, glutathione disulfide and glutathione mixed disulfides in biological samples. Methods Enzymol, 77 (1981) 373.
27. Befrits R, Hedman M, Blomquist L, Allander T, Grillner L, Kinnman N, Rubio C & Hultcrantz R, Chronic hepatitis C in alcoholic patients: Prevalence, genotypes, and correlation to liver disease, Scand J Gastroenterol, 30 (1995) 1113.
28. Husain K, Scott B R, Reddy S K & Somani S M, Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system, Alcohol, 25 (2001) 89.
29. Ozaras R, Tahan V, Aydin S, Uzun H, Kaya S & Senturk H, N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat, World J Gastroenterol, 9 (2003) 125.
30. Dinu D, Nechifor MT, & Movileanu L, Ethanol-induced alterations of the antioxidant defense system in rat kidney, J Biochem Mol Toxicol, 19 (2005) 386.
31. Toda S, Kumura M & Ohnishi M, Effects of phenolcarboxylic acids on superoxide anion and lipid peroxidation induced by superoxide anion, Planta Med, 57 (1991) 8.
32. Cao Z F, Chen Z G, Guo P, Zhang S M, Lian L X, Luo L & Hu WM, Scavenging effects of ginger on superoxide anion and hydroxyl radical, Zhongguo Zhong Yao Za Zhi, 18 (1993) 750.
33. Iizuka T, Sato T & Sucimoto M, Glutathione -S- transferase in alcoholic fatty liver, Jpn J Alcohol Drug Depend, 26 (1991) 428.
34. Aniya Y & Daido A, Activation of microsomal glutathione -s-transferase tetra-butylhydroperoxide-induced oxidative stress of isolated rat liver, Jpn J Pahrmacol, 66 (1994) 123.
35. ICMR Bulletin, Ginger: its role in xenobiotic metabolism, 33 (2003) 6.
36. Abbondanza A, Battelli M G, Soffritti M & Cessi C, Xanthine oxidase status in ethanol-intoxicated rat liver, Alcohol Clin Exp Res, 13 (1989) 841.
37. Zima T, Novak L & Stipek S, Plasma xanthine oxidase level and alcohol administration, Alcohol Alcoholi, 28 (1993) 693.
38. Nordmann R, Ribiere C & Rouach H, Implication of free radical mechanisms in ethanol-induced cellular injury, Free Radic Biol Med, 12 (1992) 219.
39. Kode A, Rajagopalan R, Penumathsa S V & Menon V P, Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil-induced oxidative stress, Fund Clin Pharmacol,18 (2004) 565.
40. Balasubramaniyan V, Kalaivani Sailaja J & Nalini N, Role of leptin on alcohol-induced oxidative stress in Swiss mice, Pharmacolog Res, 47 (2003) 211.
41. Weber P, Bendich A & Schalch W, Vitamin C and human health-A review of recent data relevant to human requirements, Int J Vitamin Nutrition Res, 66 (1996) 19.
42. Ip SC & Ko KM, The crucial antioxidant action of Schisandrin B in protecting against CCl hepatotoxicity in mice: A comparative study with butylated hydroxytoluene, Biochem Pharmacol, 52 (1996) 1687.
43. Yu B P, Cellular defences against damage from reactive oxygen species, Physiol Rev, 74 (1994) 139.
44. Howell R R & Wyngaarden J B, On the mechanism of peroxidation of uric acids by hemoproteins, J Biol Chem, 235 (1960) 3544.
45. Pushpalatha K, Interaction of exercise training and ethanol on myocardial antioxidant defense system in two different age groups of male albino rats. PhD thesis, (S.V. University, Tirupati, 517502 India) 2006.
46. Puig J G & Fox I H, Ethanol induced activation of adenine nucleotide turnover. Evidence for a role of acetate, J Clin Invest, 74 (1984) 936.