Gingerol metabolite and a synthetic analogue Capsarol™ inhibit macrophage NF-κB-mediated iNOS gene expression and enzyme activity

Planta Medica

Volumn 72, Issue 8, 2006, Pages 727-734

  Aktan, Fugen ^a,b   Henness, Sheridan ^a   Tran, Van H ^a   Duke, Colin C ^a   Roufogalis, Basil D ^a   Ammit, Alaina J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Capsarols ; Gingerol analogues; Gingerols; iNOS; Macrophage cell line; NF B transcription; Nitric oxide; Zingiber officinale; Zingiberaceae

Indexed keywords

CAPSAICIN; CAPSAROL; GINGEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; RAC 2 HYDROXY 1 (4 HYDROXY 3 METHOXYPHENYL)DODECAN 3 ONE; RAC[6]DIHYDROPARADOL; UNCLASSIFIED DRUG; ZTX 42;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; GINGER; IC 50; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FATTY ALCOHOLS; GENE EXPRESSION REGULATION; GINGER; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY;

MURINAE; ZINGIBER OFFICINALE;

EID: 33746043756     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-931588     Document Type: Article

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