Structural basis for the design and synthesis of selective HDAC inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 13, 2013, Pages 3795-3807

  Di Micco, Simone ^a   Chini, Maria Giovanna ^a   Terracciano, Stefania ^a   Bruno, Ines ^a   Riccio, Raffaele ^a   Bifulco, Giuseppe ^a  

^a UNIVERSITY OF SALERNO   (Italy)

Author keywords

Antitumor agents; Deacetylase; DFT; HDAC selective inhibitors; Histone; Molecular modeling

Indexed keywords

[HYDROXY 3,5 BIS[(THIAZOL 2 YLMETHYL)AMINO]PHENYL]PYRROLIDIN 1 YL METHANONE; BIS[(FURAN 2 YLMETHYL)AMINO] 4 HYDROXY N NAPHTHALEN 2 YLMETHYLBENZAMIDE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; N BENZYL 2 [4 HYDROXY 3,5 BIS[(THIOPEN 2 YLMETHYL)AMINO]PHENYL]ACETAMIDE; TRICHOSTATIN A; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE; ISOPROTEIN; LIGAND;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; STRUCTURE ANALYSIS; CHEMISTRY; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; DRUG DESIGN; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; LIGANDS; MOLECULAR DOCKING SIMULATION; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878551168     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.036     Document Type: Article

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