Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3252-3260

  Terracciano, Stefania ^a   Di Micco, Simone ^a   Bifulco, Giuseppe ^a   Gallinari, Paola ^b   Riccio, Raffaele ^a   Bruno, Ines ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b IRBM   (Italy)

Author keywords

Anticancer drugs; Cyclopeptides; HDAC; Molecular docking; Olefin metathesis

Indexed keywords

CYCLOTETRAPEPTIDE DERIVATIVE; FR 235222; HISTONE DEACETYLASE INHIBITOR; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BIOLOGICAL ACTIVITY; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; MALE; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE; COMPUTER SIMULATION; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; PROTEIN ISOFORMS;

EID: 77951207678     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.022     Document Type: Article

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