Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models

Xenobiotica

Volumn 42, Issue 6, 2012, Pages 526-537

  Götz, Christine ^a   Hewitt, Nicola J ^b   Jermann, Erich ^a   Tigges, Julia ^a   Kohne, Zippora ^a   Hübenthal, Ulrike ^a   Krutmann, Jean ^a   Merk, Hans F ^c   Fritsche, Ellen ^a,c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b SWS ^*  (Germany)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

7ethoxyresorufin O deethylation; CYP; glutathione S transferases; induction; Skin metabolism; UDP glucuronosyltransferases

Indexed keywords

BENZO[A]PYRENE; CHEMICAL COMPOUND; CYCLOPHOSPHAMIDE; ETHOXYRESORUFIN DEETHYLASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; TESTOSTERONE;

ARTICLE; BIOASSAY; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MICRONUCLEUS TEST; MOLECULAR MIMICRY; SKIN; TESTOSTERONE METABOLISM;

ADMINISTRATION, CUTANEOUS; BENZO(A)PYRENE; CYCLOPHOSPHAMIDE; CYTOCHROME P-450 CYP1A1; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HUMANS; MICRONUCLEUS TESTS; MODELS, BIOLOGICAL; MUTAGENS; SKIN; STEROID HYDROXYLASES;

EID: 84860559790     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.643255     Document Type: Article

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