Preferential glutathione conjugation of a reverse diol epoxide compared with a bay region diol epoxide of benzo[a]pyrene in human hepatocytes

Drug Metabolism and Disposition

Volumn 38, Issue 9, 2010, Pages 1397-1402

  Upadhyaya, Pramod ^a   Hochalter, J Bradley ^a   Balbo, Silvia ^a   McIntee, Edward J ^a   Hecht, Stephen S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; ACETYLCYSTEINE; ACETYLCYSTEINE DERIVATIVE; BENZO[A]PYRENE; CARCINOGEN; DIHYDROXYBENZO[A]PYRENE OXIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE M1; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; BAY REGION BINDING SITE; CARCINOGENESIS; CLINICAL ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; GENOTYPE; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; LIVER CELL; NEOPLASM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNTHESIS; URINE;

BENZO(A)PYRENE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPOXY COMPOUNDS; GLUTATHIONE; HEPATOCYTES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY;

EID: 77955993032     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.034181     Document Type: Article

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