Peroxidase-dependent bioactivation and oxidation of DNA and protein in benzo[A]pyrene-initiated micronucleus formation

Free Radical Biology and Medicine

Volumn 23, Issue 4, 1997, Pages 579-596

  Kim, Perry M ^a   Deboni, Umberto ^a   Wells, Peter G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Benzo a pyrene; Bioactivation; Cytochromes P450; Lipoxygenase; Micronuclei; Prostaglandin H synthase; Reactive intermediates; Reactive oxygen species

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BENZO[A]PYRENE; CYTOCHROME P450; DNA; LIPOXYGENASE; PEROXIDASE; PROSTAGLANDIN SYNTHASE; PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CARCINOGENESIS; CHEMOLUMINESCENCE; DRUG ACTIVITY; ENZYME ACTIVITY; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; LIVER MICROSOME; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SKIN FIBROBLAST;

ANIMALS; BENZO(A)PYRENE; CELL NUCLEUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHALASIN B; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DNA; ENZYME INHIBITORS; FIBROBLASTS; MALE; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; OXIDATION-REDUCTION; PEROXIDASE; PROTEINS; RATS; RATS, WISTAR; TETRACHLORODIBENZODIOXIN;

ANIMALIA;

EID: 0030837889     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00012-9     Document Type: Article

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