메뉴 건너뛰기




Volumn 4, Issue SUPPL.2, 2013, Pages

Molecular and genetic advances in the regeneration of the intervertebral disc

Author keywords

Disc tissue engineering; growth factors; intervertebral disc regeneration; scaffolds; stem cells

Indexed keywords

ADENOVIRUS VECTOR; AGGRECANASE 2; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN TYPE 2; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; GLYCOPROTEIN; GROWTH DIFFERENTIATION FACTOR; GROWTH DIFFERENTIATION FACTOR 5; GROWTH DIFFERENTIATION FACTOR 6; INTERSTITIAL COLLAGENASE; LACTOFERRICIN; LIM PROTEIN; MACROGOL; MITOGEN ACTIVATED PROTEIN KINASE; PARVOVIRUS VECTOR; PLATELET DERIVED GROWTH FACTOR; PROTEOGLYCAN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT OSTEOGENIC PROTEIN 1; SIMVASTATIN; SOMATOMEDIN C; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE SCAFFOLD; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; TUMOR NECROSIS FACTOR ALPHA STIMULATED GENE PRODUCT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84877936874     PISSN: None     EISSN: 21527806     Source Type: Journal    
DOI: 10.4103/2152-7806.109449     Document Type: Article
Times cited : (18)

References (91)
  • 1
    • 84871090952 scopus 로고    scopus 로고
    • Regenerative potential of TGFbeta3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells
    • Abbott RD, Purmessur D, Monsey RD, Iatridis JC. Regenerative potential of TGFbeta3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells. J Orthop Res 2012;30:482-8.
    • (2012) J Orthop Res , vol.30 , pp. 482-488
    • Abbott, R.D.1    Purmessur, D.2    Monsey, R.D.3    Iatridis, J.C.4
  • 2
    • 0033540274 scopus 로고    scopus 로고
    • Notochordal cells interact with nucleus pulposus cells: Regulation of proteoglycan synthesis
    • Aguiar DJ, Johnson SL, Oegema TR. Notochordal cells interact with nucleus pulposus cells: Regulation of proteoglycan synthesis. Exp Cell Res 1999;246:129-37.
    • (1999) Exp Cell Res , vol.246 , pp. 129-137
    • Aguiar, D.J.1    Johnson, S.L.2    Oegema, T.R.3
  • 3
    • 77957555605 scopus 로고    scopus 로고
    • Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation
    • Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. Ann Rheum Dis 2010;69:2189-98.
    • (2010) Ann Rheum Dis , vol.69 , pp. 2189-2198
    • Barter, M.J.1    Hui, W.2    Lakey, R.L.3    Catterall, J.B.4    Cawston, T.E.5    Young, D.A.6
  • 4
    • 0028126646 scopus 로고
    • Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development
    • Chang SC, Hoang B, Thomas J, Vukicevic S, Luyten FP, Ryba N, et al. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem 1994;269:28227-34.
    • (1994) J Biol Chem , vol.269 , pp. 28227-28234
    • Chang, S.C.1    Hoang, B.2    Thomas, J.3    Vukicevic, S.4    Luyten, F.P.5    Ryba, N.6
  • 5
    • 67651152771 scopus 로고    scopus 로고
    • Coculture of Synovium-Derived Stem Cells and Nucleus Pulposus Cells in Serum-Free Defined Medium with Supplementation of Transforming Growth Factor-β1: A Potential Application of Tissue-Specific Stem Cells in Disc Regeneration
    • Chen S, Emery SE, Pei M. Coculture of Synovium-Derived Stem Cells and Nucleus Pulposus Cells in Serum-Free Defined Medium With Supplementation of Transforming Growth Factor-β1: A Potential Application of Tissue-Specific Stem Cells in Disc Regeneration. Spine (Phila Pa 1976) 2009;34:1272-80.
    • (2009) Spine (Phila Pa 1976) , vol.34 , pp. 1272-1280
    • Chen, S.1    Emery, S.E.2    Pei, M.3
  • 6
    • 33845352083 scopus 로고    scopus 로고
    • Effects of Growth Differentiation Factor-5 on the Intervertebral Disc - In vitro Bovine Study and in vivo Rabbit Disc Degeneration Model Study
    • Chujo T, An HS, Akeda K, Miyamoto K, Muehleman C, Attawia M, et al. Effects of Growth Differentiation Factor-5 on the Intervertebral Disc - In vitro Bovine Study and In vivo Rabbit Disc Degeneration Model Study. Spine (Phila Pa 1976) 2006;31:2909-17.
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 2909-2917
    • Chujo, T.1    An, H.S.2    Akeda, K.3    Miyamoto, K.4    Muehleman, C.5    Attawia, M.6
  • 7
    • 34250830225 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, dose-response pilot study evaluating intradiscal etanercept in patients with chronic discogenic low back pain or lumbosacral radiculopathy
    • Cohen SP, Wenzell D, Hurley RW, Kurihara C, Buckenmaier III CC, Griffith S, et al. A double-blind, placebo-controlled, dose-response pilot study evaluating intradiscal etanercept in patients with chronic discogenic low back pain or lumbosacral radiculopathy. Anesthesiology 2007;107:99-105.
    • (2007) Anesthesiology , vol.107 , pp. 99-105
    • Cohen, S.P.1    Wenzell, D.2    Hurley, R.W.3    Kurihara, C.4    Buckenmaier Iii, C.C.5    Griffith, S.6
  • 8
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-7.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 9
    • 84855169648 scopus 로고    scopus 로고
    • Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: Implications for the mechanisms of intervertebral disc degeneration
    • Erwin WM, Islam D, Inman RD, Fehlings MG, Tsui FW. Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: Implications for the mechanisms of intervertebral disc degeneration. Arthritis Res Ther 2011;13:R215.
    • (2011) Arthritis Res Ther , vol.13
    • Erwin, W.M.1    Islam, D.2    Inman, R.D.3    Fehlings, M.G.4    Tsui, F.W.5
  • 10
    • 70349845897 scopus 로고    scopus 로고
    • Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: Experiments in a canine model
    • Ganey T, Hutton WC, Moseley T, Hedrick M, Meisel HJ. Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: Experiments in a canine model. Spine (Phila Pa 1976) 2009;34:2297-304.
    • (2009) Spine (Phila Pa 1976) , vol.34 , pp. 2297-2304
    • Ganey, T.1    Hutton, W.C.2    Moseley, T.3    Hedrick, M.4    Meisel, H.J.5
  • 11
    • 0345411874 scopus 로고    scopus 로고
    • Disc chondrocyte transplantation in a canine model: A treatment for degenerated or damaged intervertebral disc
    • Ganey T, Libera J, Moos V, Alasevic O, Fritsch KG, Joerg Meisel H, et al. Disc chondrocyte transplantation in a canine model: A treatment for degenerated or damaged intervertebral disc. Spine (Phila Pa 1976) 2003;28:2609-20.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 2609-2620
    • Ganey, T.1    Libera, J.2    Moos, V.3    Alasevic, O.4    Fritsch, K.G.5    Joerg Meisel, H.6
  • 12
    • 33748099695 scopus 로고    scopus 로고
    • Increased urinary type II collagen helical and C telopeptide levels are independently associated with a rapidly destructive hip osteoarthritis
    • Garnero P, Charni N, Juillet F, Conrozier T, Vignon E. Increased urinary type II collagen helical and C telopeptide levels are independently associated with a rapidly destructive hip osteoarthritis. Ann Rheum Dis 2006;65:1639-44.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1639-1644
    • Garnero, P.1    Charni, N.2    Juillet, F.3    Conrozier, T.4    Vignon, E.5
  • 14
    • 0031586347 scopus 로고    scopus 로고
    • Human intervertebral disc cells from the annulus: Three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1
    • Gruber HE, Fisher EC, Jr., Desai B, Stasky AA, Hoelscher G, Hanley EN, Jr. Human intervertebral disc cells from the annulus: Three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Exp Cell Res 1997;235:13-21.
    • (1997) Exp Cell Res , vol.235 , pp. 13-21
    • Gruber, H.E.1    Fisher Jr., E.C.2    Desai, B.3    Stasky, A.A.4    Hoelscher, G.5    Hanley Jr., E.N.6
  • 15
    • 0034282695 scopus 로고    scopus 로고
    • Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro
    • Gruber HE, Norton HJ, Hanley Jr EN. Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine (Phila Pa 1976) 2000;25:2153-7.
    • (2000) Spine (Phila Pa 1976) , vol.25 , pp. 2153-2157
    • Gruber, H.E.1    Norton, H.J.2    Hanley Jr., E.N.3
  • 16
    • 80052507787 scopus 로고    scopus 로고
    • The response of foetal annulus fibrosus cells to growth factors: Modulation of matrix synthesis by TGF-beta1 and IGF-1
    • Hayes AJ, Ralphs Jr. The response of foetal annulus fibrosus cells to growth factors: Modulation of matrix synthesis by TGF-beta1 and IGF-1. Histochem Cell Biol 2011;136:163-75.
    • (2011) Histochem Cell Biol , vol.136 , pp. 163-175
    • Hayes, A.J.1    Ralphs, J.R.2
  • 17
    • 84858798112 scopus 로고    scopus 로고
    • Rejuvenation of Nucleus Pulposus Cells Using Extracellular Matrix Deposited by Synovium-Derived Stem Cells
    • He F, Pei M. Rejuvenation of Nucleus Pulposus Cells Using Extracellular Matrix Deposited by Synovium-Derived Stem Cells. Spine (Phila Pa 1976) 2012;37:459-69.
    • (2012) Spine (Phila Pa 1976) , vol.37 , pp. 459-469
    • He, F.1    Pei, M.2
  • 18
    • 64049111281 scopus 로고    scopus 로고
    • Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model
    • Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A, et al. Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model. Spine (Phila Pa 1976) 2009;34:141-8.
    • (2009) Spine (Phila Pa 1976) , vol.34 , pp. 141-148
    • Henriksson, H.B.1    Svanvik, T.2    Jonsson, M.3    Hagman, M.4    Horn, M.5    Lindahl, A.6
  • 19
    • 43649093152 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells in a canine disc degeneration model
    • Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, et al. Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res 2008;26:589-600.
    • (2008) J Orthop Res , vol.26 , pp. 589-600
    • Hiyama, A.1    Mochida, J.2    Iwashina, T.3    Omi, H.4    Watanabe, T.5    Serigano, K.6
  • 20
    • 83255181831 scopus 로고    scopus 로고
    • Regeneration of the intervertebral disc with nucleus pulposus cell-seeded collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer constructs in a rabbit disc degeneration model
    • Huang B, Zhuang Y, Li CQ, Liu LT, Zhou Y. Regeneration of the intervertebral disc with nucleus pulposus cell-seeded collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer constructs in a rabbit disc degeneration model. Spine (Phila Pa 1976) 2011;36:2252-9.
    • (2011) Spine (Phila Pa 1976) , vol.36 , pp. 2252-2259
    • Huang, B.1    Zhuang, Y.2    Li, C.Q.3    Liu, L.T.4    Zhou, Y.5
  • 21
    • 0038491555 scopus 로고    scopus 로고
    • Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment-and interleukin-1β-stimulated matrix metalloproteinase-13 expression in human chondrocytes
    • Im HJ, Pacione C, Chubinskaya S, van Wijnen AJ, Sun Y, Loeser RF. Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment-and interleukin-1β-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem 2003;278:25386-94.
    • (2003) J Biol Chem , vol.278 , pp. 25386-25394
    • Im, H.J.1    Pacione, C.2    Chubinskaya, S.3    Van Wijnen, A.J.4    Sun, Y.5    Loeser, R.F.6
  • 22
    • 34248347420 scopus 로고    scopus 로고
    • Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC
    • Imai Y, Okuma M, An HS, Nakagawa K, Yamada M, Muehleman C, et al. Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC. Spine (Phila Pa 1976) 2007;32:1197-205.
    • (2007) Spine (Phila Pa 1976) , vol.32 , pp. 1197-1205
    • Imai, Y.1    Okuma, M.2    An, H.S.3    Nakagawa, K.4    Yamada, M.5    Muehleman, C.6
  • 23
    • 33751168064 scopus 로고    scopus 로고
    • Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue
    • Izadpanah R, Trygg C, Patel B, Kriedt C, Dufour J, Gimble JM, et al. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 2006;99:1285-97.
    • (2006) J Cell Biochem , vol.99 , pp. 1285-1297
    • Izadpanah, R.1    Trygg, C.2    Patel, B.3    Kriedt, C.4    Dufour, J.5    Gimble, J.M.6
  • 24
    • 0346120077 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells
    • Kim DJ, Moon SH, Kim H, Kwon UH, Park MS, Han KJ, et al. Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine (Phila Pa 1976) 2003;28:2679-84.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 2679-2684
    • Kim, D.J.1    Moon, S.H.2    Kim, H.3    Kwon, U.H.4    Park, M.S.5    Han, K.J.6
  • 25
    • 78649835304 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 Synergizes with BMP7-Mediated Anabolism in Bovine Intervertebral Disc Cells
    • Kim J, Ellman MB, An HS, van Wijnen AJ, Borgia JA, Im HJ, et al. Insulin-like growth factor 1 Synergizes with BMP7-Mediated Anabolism In Bovine Intervertebral Disc Cells. Arthritis Rheum 2010;62:3706-15.
    • (2010) Arthritis Rheum , vol.62 , pp. 3706-3715
    • Kim, J.1    Ellman, M.B.2    An, H.S.3    Van Wijnen, A.J.4    Borgia, J.A.5    Im, H.J.6
  • 26
    • 84862938484 scopus 로고    scopus 로고
    • Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc
    • Kim JS, Ellman MB, An HS, Yan D, van Wijnen AJ, Murphy G, et al. Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc. J Cell Physiol 2012;227:1512-20.
    • (2012) J Cell Physiol , vol.227 , pp. 1512-1520
    • Kim, J.S.1    Ellman, M.B.2    An, H.S.3    Yan, D.4    Van Wijnen, A.J.5    Murphy, G.6
  • 28
    • 78650903073 scopus 로고    scopus 로고
    • Research Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype
    • Korecki CL, Taboas JM, Tuan RS, Iatridis JC. Research Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther 2010;1:18.
    • (2010) Stem Cell Res Ther , vol.1 , pp. 18
    • Korecki, C.L.1    Taboas, J.M.2    Tuan, R.S.3    Iatridis, J.C.4
  • 29
    • 32444449516 scopus 로고    scopus 로고
    • Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells
    • Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T, et al. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum 2006;54:433-42.
    • (2006) Arthritis Rheum , vol.54 , pp. 433-442
    • Kuroda, R.1    Usas, A.2    Kubo, S.3    Corsi, K.4    Peng, H.5    Rose, T.6
  • 30
    • 0041885332 scopus 로고    scopus 로고
    • The effects of TIMP-1 and-2 on canine chondrocytes cultured in three-dimensional agarose culture system
    • Kuroki K, Cook J, Kreeger J, Tomlinson J. The effects of TIMP-1 and-2 on canine chondrocytes cultured in three-dimensional agarose culture system. Osteoarthritis Cartilage 2003;11:625-35.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 625-635
    • Kuroki, K.1    Cook, J.2    Kreeger, J.3    Tomlinson, J.4
  • 31
    • 61449135224 scopus 로고    scopus 로고
    • An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue
    • Le Maitre CL, Baird P, Freemont AJ, Hoyland JA. An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue. Arthritis Res Ther 2010;11:20.
    • (2010) Arthritis Res Ther , vol.11 , pp. 20
    • Le Maitre, C.L.1    Baird, P.2    Freemont, A.J.3    Hoyland, J.A.4
  • 32
    • 33644951210 scopus 로고    scopus 로고
    • A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA. A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 2006;87:17-28.
    • (2006) Int J Exp Pathol , vol.87 , pp. 17-28
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 33
    • 34848893110 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: An in situ zymographic and gene therapy study
    • Le Maitre CL, Hoyland JA, Freemont AJ. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: An in situ zymographic and gene therapy study. Arthritis Res Ther 2007;9:83.
    • (2007) Arthritis Res Ther , vol.9 , pp. 83
    • Le Maitre, C.L.1    Hoyland, J.A.2    Freemont, A.J.3
  • 35
    • 12744261378 scopus 로고    scopus 로고
    • Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells
    • Li J, Yoon ST, Hutton WC. Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J Spinal Disord Tech 2004;17:423-8.
    • (2004) J Spinal Disord Tech , vol.17 , pp. 423-428
    • Li, J.1    Yoon, S.T.2    Hutton, W.C.3
  • 36
    • 14944356298 scopus 로고    scopus 로고
    • Collagen and proteoglycan abnormalities in the GDF-5-deficient mice and molecular changes when treating disk cells with recombinant growth factor
    • Li X, Leo BM, Beck G, Balian G, Anderson GD. Collagen and proteoglycan abnormalities in the GDF-5-deficient mice and molecular changes when treating disk cells with recombinant growth factor. Spine (Phila Pa 1976) 2004;29:2229-34.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 2229-2234
    • Li, X.1    Leo, B.M.2    Beck, G.3    Balian, G.4    Anderson, G.D.5
  • 37
    • 42449106024 scopus 로고    scopus 로고
    • Articular cartilage repair using dedifferentiated articular chondrocytes and bone morphogenetic protein 4 in a rabbit model of articular cartilage defects
    • Lin L, Zhou C, Wei X, Hou Y, Zhao L, Fu X, et al. Articular cartilage repair using dedifferentiated articular chondrocytes and bone morphogenetic protein 4 in a rabbit model of articular cartilage defects. Arthritis Rheum 2008;58:1067-75.
    • (2008) Arthritis Rheum , vol.58 , pp. 1067-1075
    • Lin, L.1    Zhou, C.2    Wei, X.3    Hou, Y.4    Zhao, L.5    Fu, X.6
  • 38
    • 33746682471 scopus 로고    scopus 로고
    • The chondrocyte: Biology and clinical application
    • Lin Z, Willers C, Xu J, Zheng MH. The chondrocyte: Biology and clinical application. Tissue Eng 2006;12:1971-84.
    • (2006) Tissue Eng , vol.12 , pp. 1971-1984
    • Lin, Z.1    Willers, C.2    Xu, J.3    Zheng, M.H.4
  • 39
    • 0033579358 scopus 로고    scopus 로고
    • Gene therapy death prompts review of adenovirus vector
    • Marshall E. Gene therapy death prompts review of adenovirus vector. Science 1999;286:2244-5.
    • (1999) Science , vol.286 , pp. 2244-2245
    • Marshall, E.1
  • 40
    • 33645765778 scopus 로고    scopus 로고
    • Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model
    • Masuda K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, et al. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine (Phila Pa 1976) 2006;31:742-54.
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 742-754
    • Masuda, K.1    Imai, Y.2    Okuma, M.3    Muehleman, C.4    Nakagawa, K.5    Akeda, K.6
  • 41
    • 0042388216 scopus 로고    scopus 로고
    • Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads
    • Masuda K, Takegami K, An H, Kumano F, Chiba K, Andersson G, et al. Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads. J Orthop Res 2003;21:922-30.
    • (2003) J Orthop Res , vol.21 , pp. 922-930
    • Masuda, K.1    Takegami, K.2    An, H.3    Kumano, F.4    Chiba, K.5    Andersson, G.6
  • 42
    • 0037218780 scopus 로고    scopus 로고
    • Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs
    • Matsunaga S, Nagano S, Onishi T, Morimoto N, Suzuki S, Komiya S. Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs. J Neurosurg 2003;98:63-7.
    • (2003) J Neurosurg , vol.98 , pp. 63-67
    • Matsunaga, S.1    Nagano, S.2    Onishi, T.3    Morimoto, N.4    Suzuki, S.5    Komiya, S.6
  • 43
    • 83255162014 scopus 로고    scopus 로고
    • Modeling Nucleus Pulposus Regeneration in vitro: Mesenchymal Stem Cells, Alginate Beads, Hypoxia, Bone Morphogenetic Protein-2, and Synthetic Peptide B2A
    • McCanless JD, Cole JA, Slack SM, Bumgardner JD, Zamora PO, Haggard WO. Modeling Nucleus Pulposus Regeneration In vitro: Mesenchymal Stem Cells, Alginate Beads, Hypoxia, Bone Morphogenetic Protein-2, and Synthetic Peptide B2A. Spine (Phila Pa 1976) 2011;36:2275-85.
    • (2011) Spine (Phila Pa 1976) , vol.36 , pp. 2275-2285
    • McCanless, J.D.1    Cole, J.A.2    Slack, S.M.3    Bumgardner, J.D.4    Zamora, P.O.5    Haggard, W.O.6
  • 44
    • 50949105736 scopus 로고    scopus 로고
    • Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells
    • Miljkovic ND, Cooper GM, Marra KG. Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells. Osteoarthritis Cartilage 2008;16:1121-30.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1121-1130
    • Miljkovic, N.D.1    Cooper, G.M.2    Marra, K.G.3
  • 45
    • 0037769541 scopus 로고    scopus 로고
    • TSG-6: A multifunctional protein associated with inflammation
    • Milner CM, Day AJ. TSG-6: A multifunctional protein associated with inflammation. J Cell Sci 2003;116:1863-73.
    • (2003) J Cell Sci , vol.116 , pp. 1863-1873
    • Milner, C.M.1    Day, A.J.2
  • 46
    • 0038689386 scopus 로고    scopus 로고
    • Mechanism of bone formation with gene transfer of the cDNA encoding for the intracellular protein LMP-1
    • Minamide A, Boden SD, Viggeswarapu M, Hair GA, Oliver C, Titus L. Mechanism of bone formation with gene transfer of the cDNA encoding for the intracellular protein LMP-1. J Bone Joint Surg Am2003;85:1030-9.
    • (2003) J Bone Joint Surg Am , vol.85 , pp. 1030-1039
    • Minamide, A.1    Boden, S.D.2    Viggeswarapu, M.3    Hair, G.A.4    Oliver, C.5    Titus, L.6
  • 47
    • 78049386105 scopus 로고    scopus 로고
    • Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits
    • Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito H, Tsuji K, et al. Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. Arthritis Res Ther 2010;12:R206.
    • (2010) Arthritis Res Ther , vol.12
    • Miyamoto, T.1    Muneta, T.2    Tabuchi, T.3    Matsumoto, K.4    Saito, H.5    Tsuji, K.6
  • 49
    • 0033521078 scopus 로고    scopus 로고
    • Stimulation of bone formation in vitro and in rodents by statins
    • Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999;286:1946-9.
    • (1999) Science , vol.286 , pp. 1946-1949
    • Mundy, G.1    Garrett, R.2    Harris, S.3    Chan, J.4    Chen, D.5    Rossini, G.6
  • 50
    • 67649818853 scopus 로고    scopus 로고
    • Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model
    • Murrell W, Sanford E, Anderberg L, Cavanagh B, Mackay-Sim A. Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model. Spine J 2009;9:585-94.
    • (2009) Spine J , vol.9 , pp. 585-594
    • Murrell, W.1    Sanford, E.2    Anderberg, L.3    Cavanagh, B.4    Mackay-Sim, A.5
  • 51
    • 33846644391 scopus 로고    scopus 로고
    • Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres
    • Nagae M, Ikeda T, Mikami Y, Hase H, Ozawa H, Matsuda KI, et al. Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres. Tissue Eng 2007;13:147-58.
    • (2007) Tissue Eng , vol.13 , pp. 147-158
    • Nagae, M.1    Ikeda, T.2    Mikami, Y.3    Hase, H.4    Ozawa, H.5    Matsuda, K.I.6
  • 52
    • 0033404813 scopus 로고    scopus 로고
    • Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: An in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene
    • Nishida K, Kang JD, Gilbertson L, Moon S, Suh J, Vogt M, et al. Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: An in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene. Spine (Phila Pa 1976) 1999;24:2419-25.
    • (1999) Spine (Phila Pa 1976) , vol.24 , pp. 2419-2425
    • Nishida, K.1    Kang, J.D.2    Gilbertson, L.3    Moon, S.4    Suh, J.5    Vogt, M.6
  • 53
    • 0035890099 scopus 로고    scopus 로고
    • Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells
    • Okuda S, Myoui A, Ariga K, Nakase T, Yonenobu K, Yoshikawa H. Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells. Spine (Phila Pa 1976) 2001;26:2421-6.
    • (2001) Spine (Phila Pa 1976) , vol.26 , pp. 2421-2426
    • Okuda, S.1    Myoui, A.2    Ariga, K.3    Nakase, T.4    Yonenobu, K.5    Yoshikawa, H.6
  • 54
    • 0034462292 scopus 로고    scopus 로고
    • Age-dependent expression of transforming growth factor β1 (TGF-β1) and its receptors, and age-related stimulatory effect of TGF-β1 on proteoglycan synthesis in rat intervertebral discs (Redo typing)
    • Okuda Sy, Nakase T, Yonenobu K, Ariga K, Meng W, Ochi T, et al. Age-dependent expression of transforming growth factor β1 (TGF-β1) and its receptors, and age-related stimulatory effect of TGF-β1 on proteoglycan synthesis in rat intervertebral discs (Redo typing). J Musculoskelet Res 2000;4:151-9.
    • (2000) J Musculoskelet Res , vol.4 , pp. 151-159
    • Sy, O.1    Nakase, T.2    Yonenobu, K.3    Ariga, K.4    Meng, W.5    Ochi, T.6
  • 55
    • 33748555487 scopus 로고    scopus 로고
    • Oral administration of esculetin prodrug inhibits intervertebral disc degeneration in the rabbit annular needle puncture model
    • Okuma M, An H, Nakagawa K, Akeda K, Muehleman C, Masuda K. Oral administration of esculetin prodrug inhibits intervertebral disc degeneration in the rabbit annular needle puncture model. Orthop Res Soc 2005:370.
    • (2005) Orthop Res Soc , pp. 370
    • Okuma, M.1    An, H.2    Nakagawa, K.3    Akeda, K.4    Muehleman, C.5    Masuda, K.6
  • 57
    • 84855668642 scopus 로고    scopus 로고
    • In vitro response of human chondrocytes to a combination of growth factors and a proteinase inhibitor
    • Pifer M, Kibuule L, Maerz T, Studzinski D, Baker K, Herkowitz H. In vitro response of human chondrocytes to a combination of growth factors and a proteinase inhibitor. Orthopedics 2012;35:35-42.
    • (2012) Orthopedics , vol.35 , pp. 35-42
    • Pifer, M.1    Kibuule, L.2    Maerz, T.3    Studzinski, D.4    Baker, K.5    Herkowitz, H.6
  • 58
    • 33645580919 scopus 로고    scopus 로고
    • Biologic markers and disc degeneration
    • Poole AR. Biologic markers and disc degeneration. J Bone Joint Surg Am2006;88:72-5.
    • (2006) J Bone Joint Surg Am , vol.88 , pp. 72-75
    • Poole, A.R.1
  • 60
    • 14044269226 scopus 로고    scopus 로고
    • Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: Implications for cell-based transplantation therapy
    • Risbud MV, Albert TJ, Guttapalli A, Vresilovic EJ, Hillibrand AS, Vaccaro AR, et al. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: Implications for cell-based transplantation therapy. Spine (Phila Pa 1976) 2004;29:2627-32.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 2627-2632
    • Risbud, M.V.1    Albert, T.J.2    Guttapalli, A.3    Vresilovic, E.J.4    Hillibrand, A.S.5    Vaccaro, A.R.6
  • 61
    • 33646442480 scopus 로고    scopus 로고
    • Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling
    • Risbud MV, Di Martino A, Guttapalli A, Seghatoleslami R, Denaro V, Vaccaro AR, et al. Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine (Phila Pa 1976) 2006;31:884-90.
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 884-890
    • Risbud, M.V.1    Di Martino, A.2    Guttapalli, A.3    Seghatoleslami, R.4    Denaro, V.5    Vaccaro, A.R.6
  • 62
    • 20144378989 scopus 로고    scopus 로고
    • TNFa-stimulated gene product (TSG-6) and its binding protein, IaI, in the human intervertebral disc: New molecules for the disc
    • Roberts S, Evans H, Menage J, Urban J, Bayliss M, Eisenstein S, et al. TNFa-stimulated gene product (TSG-6) and its binding protein, IaI, in the human intervertebral disc: New molecules for the disc. Eur Spine J 2005;14:36-42.
    • (2005) Eur Spine J , vol.14 , pp. 36-42
    • Roberts, S.1    Evans, H.2    Menage, J.3    Urban, J.4    Bayliss, M.5    Eisenstein, S.6
  • 63
    • 77954528317 scopus 로고    scopus 로고
    • Experimental intervertebral disc regeneration with tissue-engineered composite in a canine model
    • Ruan DK, Xin H, Zhang C, Wang C, Xu C, Li C, et al. Experimental intervertebral disc regeneration with tissue-engineered composite in a canine model. Tissue Eng Part A 2010;16:2381-9.
    • (2010) Tissue Eng Part A , vol.16 , pp. 2381-2389
    • Ruan, D.K.1    Xin, H.2    Zhang, C.3    Wang, C.4    Xu, C.5    Li, C.6
  • 65
    • 26844531456 scopus 로고    scopus 로고
    • Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc
    • Sakai D, Mochida J, Iwashina T, Hiyama A, Omi H, Imai M, et al. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials 2006;27:335-45.
    • (2006) Biomaterials , vol.27 , pp. 335-345
    • Sakai, D.1    Mochida, J.2    Iwashina, T.3    Hiyama, A.4    Omi, H.5    Imai, M.6
  • 66
    • 0037444159 scopus 로고    scopus 로고
    • An experimental study of the regeneration of the intervertebral disc with an allograft of cultured annulus fibrosus cells using a tissue-engineering method
    • Sato M, Asazuma T, Ishihara M, Kikuchi T, Kikuchi M, Fujikawa K. An experimental study of the regeneration of the intervertebral disc with an allograft of cultured annulus fibrosus cells using a tissue-engineering method. Spine (Phila Pa 1976) 2003;28:548-53.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 548-553
    • Sato, M.1    Asazuma, T.2    Ishihara, M.3    Kikuchi, T.4    Kikuchi, M.5    Fujikawa, K.6
  • 67
    • 72049121634 scopus 로고    scopus 로고
    • Characterization of in vivo effects of platelet-rich plasma and biodegradable gelatin hydrogel microspheres on degenerated intervertebral discs
    • Sawamura K, Ikeda T, Nagae M, Okamoto S, Mikami Y, Hase H, et al. Characterization of in vivo effects of platelet-rich plasma and biodegradable gelatin hydrogel microspheres on degenerated intervertebral discs. Tissue Engineering Part A 2009;15:3719-27.
    • (2009) Tissue Engineering Part A , vol.15 , pp. 3719-3727
    • Sawamura, K.1    Ikeda, T.2    Nagae, M.3    Okamoto, S.4    Mikami, Y.5    Hase, H.6
  • 69
    • 33749078198 scopus 로고    scopus 로고
    • Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases
    • Son BR, Marquez-Curtis LA, Kucia M, Wysoczynski M, Turner AR, Ratajczak J, et al. Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 2006;24:1254-64.
    • (2006) Stem Cells , vol.24 , pp. 1254-1264
    • Son, B.R.1    Marquez-Curtis, L.A.2    Kucia, M.3    Wysoczynski, M.4    Turner, A.R.5    Ratajczak, J.6
  • 70
    • 79955570301 scopus 로고    scopus 로고
    • In vitro and in vivo testing of a novel regulatory system for gene therapy for intervertebral disc degeneration
    • Sowa G, Westrick E, Pacek C, Coelho P, Patel D, Vadala G, et al. In vitro and in vivo testing of a novel regulatory system for gene therapy for intervertebral disc degeneration. Spine (Phila Pa 1976) 2011;36:E623-8.
    • (2011) Spine (Phila Pa 1976) , vol.36
    • Sowa, G.1    Westrick, E.2    Pacek, C.3    Coelho, P.4    Patel, D.5    Vadala, G.6
  • 71
    • 18144375592 scopus 로고    scopus 로고
    • Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis
    • Takegami K, An HS, Kumano F, Chiba K, Thonar EJ, Singh K, et al. Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J 2005;5:231-8.
    • (2005) Spine J , vol.5 , pp. 231-238
    • Takegami, K.1    An, H.S.2    Kumano, F.3    Chiba, K.4    Thonar, E.J.5    Singh, K.6
  • 74
    • 18144418144 scopus 로고    scopus 로고
    • Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels
    • Turner NA, O'Regan DJ, Ball SG, Porter KE. Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. FASEB J 2005;19:804-6.
    • (2005) FASEB J , vol.19 , pp. 804-806
    • Turner, N.A.1    O'regan, D.J.2    Ball, S.G.3    Porter, K.E.4
  • 76
    • 0142023955 scopus 로고    scopus 로고
    • Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs
    • Wallach CJ, Sobajima S, Watanabe Y, Kim JS, Georgescu HI, Robbins P, et al. Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs. Spine (Phila Pa 1976) 2003;28:2331-7.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 2331-2337
    • Wallach, C.J.1    Sobajima, S.2    Watanabe, Y.3    Kim, J.S.4    Georgescu, H.I.5    Robbins, P.6
  • 77
    • 1642579717 scopus 로고    scopus 로고
    • In vivo growth factor treatment of degenerated intervertebral discs
    • Walsh AJL, Bradford DS, Lotz JC. In vivo growth factor treatment of degenerated intervertebral discs. Spine (Phila Pa 1976) 2004;29:156-63.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 156-163
    • Ajl, W.1    Bradford, D.S.2    Lotz, J.C.3
  • 78
    • 1542284506 scopus 로고    scopus 로고
    • Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells
    • Wang H, Kroeber M, Hanke M, Ries R, Schmid C, Poller W, et al. Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. J Mol Med 2004;82:126-34.
    • (2004) J Mol Med , vol.82 , pp. 126-134
    • Wang, H.1    Kroeber, M.2    Hanke, M.3    Ries, R.4    Schmid, C.5    Poller, W.6
  • 79
    • 0043245080 scopus 로고    scopus 로고
    • Effect of reinsertion of activated nucleus pulposus on disc degeneration: An experimental study on various types of collagen in degenerative discs
    • Watanabe K, Mochida J, Nomura T, Okuma M, Sakabe K, Seiki K. Effect of reinsertion of activated nucleus pulposus on disc degeneration: An experimental study on various types of collagen in degenerative discs. Connect Tissue Res 2003;44:104-8.
    • (2003) Connect Tissue Res , vol.44 , pp. 104-108
    • Watanabe, K.1    Mochida, J.2    Nomura, T.3    Okuma, M.4    Sakabe, K.5    Seiki, K.6
  • 80
    • 84877970500 scopus 로고    scopus 로고
    • Off-label use of rhBMP-2
    • Watts C. Off-label use of rhBMP-2. Surg Neurol Int 2011;2:40.
    • (2011) Surg Neurol Int , vol.2 , pp. 40
    • Watts, C.1
  • 81
    • 0031005786 scopus 로고    scopus 로고
    • Transfer of genes to chondrocytic cells of the lumbar spine: Proposal for a treatment strategy of spinal disorders by local gene therapy
    • Wehling P, Schulitz KP, Robbins PD, Evans CH, Reinecke JA. Transfer of genes to chondrocytic cells of the lumbar spine: Proposal for a treatment strategy of spinal disorders by local gene therapy. Spine (Phila Pa 1976) 1997;22:1092-7.
    • (1997) Spine (Phila Pa 1976) , vol.22 , pp. 1092-1097
    • Wehling, P.1    Schulitz, K.P.2    Robbins, P.D.3    Evans, C.H.4    Reinecke, J.A.5
  • 82
    • 70350517130 scopus 로고    scopus 로고
    • Differentiation of rodent bone marrow mesenchymal stem cells into intervertebral disc-like cells following coculture with rat disc tissue
    • Wei A, Chung SA, Tao H, Brisby H, Lin Z, Shen B, et al. Differentiation of rodent bone marrow mesenchymal stem cells into intervertebral disc-like cells following coculture with rat disc tissue. Tissue Engineering Part A 2009;15:2581-93.
    • (2009) Tissue Engineering Part A , vol.15 , pp. 2581-2593
    • Wei, A.1    Chung, S.A.2    Tao, H.3    Brisby, H.4    Lin, Z.5    Shen, B.6
  • 83
    • 0030056876 scopus 로고    scopus 로고
    • TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo
    • Wisniewski HG, Hua J, Poppers DM, Naime D, Vilcek J, Cronstein BN. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. J Immunol 1996;156:1609-15.
    • (1996) J Immunol , vol.156 , pp. 1609-1615
    • Wisniewski, H.G.1    Hua, J.2    Poppers, D.M.3    Naime, D.4    Vilcek, J.5    Cronstein, B.N.6
  • 84
    • 84871343959 scopus 로고    scopus 로고
    • Tissue-engineered allograft intervertebral disc transplantation for the treatment of degenerative disc disease: Experimental study in a beagle model
    • Xin H, Zhang C, Wang D, Shi Z, Gu T, Wang C, et al. Tissue-engineered allograft intervertebral disc transplantation for the treatment of degenerative disc disease: Experimental study in a beagle model. Tissue Eng 2013;19:143-51.
    • (2013) Tissue Eng , vol.19 , pp. 143-151
    • Xin, H.1    Zhang, C.2    Wang, D.3    Shi, Z.4    Gu, T.5    Wang, C.6
  • 85
    • 14844338710 scopus 로고    scopus 로고
    • ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo
    • Yoon ST, Park JS, Kim KS, Li J, Attallah-Wasif ES, Hutton WC, et al. ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo. Spine (Phila Pa 1976) 2004;29:2603-11.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 2603-2611
    • Yoon, S.T.1    Park, J.S.2    Kim, K.S.3    Li, J.4    Attallah-Wasif, E.S.5    Hutton, W.C.6
  • 87
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nature medicine 2003;9:964-8.
    • (2003) Nature Medicine , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6
  • 88
    • 58149129547 scopus 로고    scopus 로고
    • Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway
    • Zhang H, Lin CY. Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway. Spine (Phila Pa 1976) 2008;33:E525-31.
    • (2008) Spine (Phila Pa 1976) , vol.33
    • Zhang, H.1    Lin, C.Y.2
  • 89
    • 77952495558 scopus 로고    scopus 로고
    • Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury
    • Zhang H, Wang L, Park JB, Park P, Yang VC, Hollister SJ, et al. Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis Res Ther 2009;11:R172.
    • (2009) Arthritis Res Ther , vol.11
    • Zhang, H.1    Wang, L.2    Park, J.B.3    Park, P.4    Yang, V.C.5    Hollister, S.J.6
  • 90
    • 3042665703 scopus 로고    scopus 로고
    • Growth factor osteogenic protein-1: Differing effects on cells from three distinct zones in the bovine intervertebral disc
    • Zhang Y, An HS, Song S, Toofanfard M, Masuda K, Andersson GB, et al. Growth factor osteogenic protein-1: Differing effects on cells from three distinct zones in the bovine intervertebral disc. Am J Phys Med Rehabil 2004;83:515-21.
    • (2004) Am J Phys Med Rehabil , vol.83 , pp. 515-521
    • Zhang, Y.1    An, H.S.2    Song, S.3    Toofanfard, M.4    Masuda, K.5    Andersson, G.B.6
  • 91
    • 33748351805 scopus 로고    scopus 로고
    • Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells
    • Zhang Y, An HS, Thonar EJ, Chubinskaya S, He TC, Phillips FM. Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells. Spine (Phila Pa 1976) 2006;31:2173-9.
    • (2006) Spine (Phila Pa 1976) , vol.31 , pp. 2173-2179
    • Zhang, Y.1    An, H.S.2    Thonar, E.J.3    Chubinskaya, S.4    He, T.C.5    Phillips, F.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.