Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro

Spine

Volumn 25, Issue 17, 2000, Pages 2153-2157

  Gruber, Helen E ^a   Norton, H James ^a   Hanley Jr , Edward N ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Intervertebral disc; Programmed cell death; Rescue; Tissue culture

Indexed keywords

INSULIN; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN C;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK DISEASE; MONOLAYER CULTURE; PRIORITY JOURNAL; TISSUE CULTURE; TRANSMISSION ELECTRON MICROSCOPY;

ADOLESCENT; ADULT; AGED; APOPTOSIS; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CHONDROCYTES; FEMALE; HUMANS; IN SITU NICK-END LABELING; INFANT; INFANT, NEWBORN; INSULIN-LIKE GROWTH FACTOR I; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; MALE; MIDDLE AGED; PLATELET-DERIVED GROWTH FACTOR;

EID: 0034282695     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200009010-00002     Document Type: Article

References (31)

1. Morphological and biochemical characterization and analysis of apoptosis
2. HGF receptor associated with the anti-apoptotic protein BAG-1 and prevents cell death
3. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques
4. Aging and degeneration of the human intervertebral disc
5. Cardioprotective effect of insulin-like growth factor 1 in myocardial ischemia followed by reperfusion
6. Anti-apoptotic actions of cytokines in mammalian cells
7. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
8. Characterization of platelet-derived growth factor (PDGF) action on a mouse neuroblastoma cell line, NB41, by introduction of an antisense PDGF beta-receptor RNA
9. Analysis of aging and degeneration of the human intervertebral disc: Comparison of surgical specimens with 'normal' controls
10. Human intervertebral disc cells from the annulus: Three-dimensional culture in agarose or alginate and responsiveness to TGF-β
11. Characterization and phenotypic stability of human disc cells in vitro
12. Detection of apoptotic cells in vitro: A practical standardized experimental protocol using human fibroblasts for initial laboratory studies
13. Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: Growth factors protect against c-myc-independent apoptosis
14. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
15. To die or not to die. An overview of apoptosis and its role in disease
16. Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice
17. Multiple extracellular signals promote osteoblast survival and apoptosis
18. IL-4 and insulin-like growth factor-1 inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors
19. Apoptosis of human erythroid colony-forming cells is decreased by stem cell factor and insulin-like growth factor 1 as well as erythropoietin
20. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
21. Apoptosis and hepatobiliary disease
22. Insulin-like growth factor-1 inhibits apoptosis in IL-3-dependent hemopoietic cells
23. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
24. Insulin-like growth factor-1 prevents apoptosis in sympathetic neurons exposed to high glucose
25. Insulin-like growth factor-2 is an autocrine survival factor for differentiating myoblasts
26. Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats
27. Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats
28. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc
29. Molecular and clinical aspects of apoptosis
30. Activation of the insulin-like growth factor-1 receptor inhibits tumor necrosis factor-induced cell death