메뉴 건너뛰기




Volumn 12, Issue 6, 2010, Pages

Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; CYTOKINE; GREEN FLUORESCENT PROTEIN; MATRIX METALLOPROTEINASE;

EID: 78049386105     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3182     Document Type: Article
Times cited : (128)

References (43)
  • 1
    • 0023943445 scopus 로고
    • Human intervertebral disc: structure and function
    • 10.1002/ar.1092200402, 3289416
    • Humzah MD, Soames RW. Human intervertebral disc: structure and function. Anat Rec 1988, 220:337-356. 10.1002/ar.1092200402, 3289416.
    • (1988) Anat Rec , vol.220 , pp. 337-356
    • Humzah, M.D.1    Soames, R.W.2
  • 2
    • 0021854119 scopus 로고
    • Low back pain
    • 1306303, 2930949
    • Reuler J. Low back pain. West J Med 1985, 143:259-265. 1306303, 2930949.
    • (1985) West J Med , vol.143 , pp. 259-265
    • Reuler, J.1
  • 3
    • 0035253293 scopus 로고    scopus 로고
    • Low back pain
    • 10.1056/NEJM200102013440508, 11172169
    • Deyo R, Weinstein J. Low back pain. N Engl J Med 2001, 344:363-370. 10.1056/NEJM200102013440508, 11172169.
    • (2001) N Engl J Med , vol.344 , pp. 363-370
    • Deyo, R.1    Weinstein, J.2
  • 4
    • 1642579717 scopus 로고    scopus 로고
    • In vivo growth factor treatment of degenerated intervertebral discs
    • Walsh A, Bradford D, Lotz J. In vivo growth factor treatment of degenerated intervertebral discs. Spine (Phila Pa 1976) 2004, 29:156-163.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 156-163
    • Walsh, A.1    Bradford, D.2    Lotz, J.3
  • 5
    • 33645765778 scopus 로고    scopus 로고
    • Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model
    • 10.1097/01.brs.0000206358.66412.7b, 16582847
    • Masuda K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, Thonar E, Andersson G, An HS. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine 2006, 31:742-754. 10.1097/01.brs.0000206358.66412.7b, 16582847.
    • (2006) Spine , vol.31 , pp. 742-754
    • Masuda, K.1    Imai, Y.2    Okuma, M.3    Muehleman, C.4    Nakagawa, K.5    Akeda, K.6    Thonar, E.7    Andersson, G.8    An, H.S.9
  • 6
    • 43749083304 scopus 로고    scopus 로고
    • Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression
    • 10.1016/j.spinee.2007.05.012, 17974491
    • Cui M, Wan Y, Anderson D, Shen F, Leo B, Laurencin C, Balian G, Li X. Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression. Spine J 2008, 8:287-295. 10.1016/j.spinee.2007.05.012, 17974491.
    • (2008) Spine J , vol.8 , pp. 287-295
    • Cui, M.1    Wan, Y.2    Anderson, D.3    Shen, F.4    Leo, B.5    Laurencin, C.6    Balian, G.7    Li, X.8
  • 7
    • 0034909033 scopus 로고    scopus 로고
    • Nucleus pulposus allograft retards intervertebral disc degeneration
    • 10.1097/00003086-200108000-00015, 11501830
    • Nomura T, Mochida J, Okuma M, Nishimura K, Sakabe K. Nucleus pulposus allograft retards intervertebral disc degeneration. Clin Orthop Relat Res 2001, 94-101. 10.1097/00003086-200108000-00015, 11501830.
    • (2001) Clin Orthop Relat Res , pp. 94-101
    • Nomura, T.1    Mochida, J.2    Okuma, M.3    Nishimura, K.4    Sakabe, K.5
  • 8
    • 2942536282 scopus 로고    scopus 로고
    • Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs
    • 10.1023/B:ABME.0000017545.84833.7c, 15095817
    • Crevensten G, Walsh A, Ananthakrishnan D, Page P, Wahba G, Lotz J, Berven S. Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs. Ann Biomed Eng 2004, 32:430-434. 10.1023/B:ABME.0000017545.84833.7c, 15095817.
    • (2004) Ann Biomed Eng , vol.32 , pp. 430-434
    • Crevensten, G.1    Walsh, A.2    Ananthakrishnan, D.3    Page, P.4    Wahba, G.5    Lotz, J.6    Berven, S.7
  • 9
    • 11844266479 scopus 로고    scopus 로고
    • Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans
    • 10.1097/01.blo.0000146534.31120.cf, 15662327
    • Zhang YG, Guo X, Xu P, Kang LL, Li J. Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. Clin Orthop Relat Res 2005, 219-226. 10.1097/01.blo.0000146534.31120.cf, 15662327.
    • (2005) Clin Orthop Relat Res , pp. 219-226
    • Zhang, Y.G.1    Guo, X.2    Xu, P.3    Kang, L.L.4    Li, J.5
  • 10
    • 26844531456 scopus 로고    scopus 로고
    • Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc
    • 10.1016/j.biomaterials.2005.06.038, 16112726
    • Sakai D, Mochida J, Iwashina T, Hiyama A, Omi H, Imai M, Nakai T, Ando K, Hotta T. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials 2006, 27:335-345. 10.1016/j.biomaterials.2005.06.038, 16112726.
    • (2006) Biomaterials , vol.27 , pp. 335-345
    • Sakai, D.1    Mochida, J.2    Iwashina, T.3    Hiyama, A.4    Omi, H.5    Imai, M.6    Nakai, T.7    Ando, K.8    Hotta, T.9
  • 11
    • 23644456193 scopus 로고    scopus 로고
    • Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
    • 10.1002/art.21212, 16052568
    • Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005, 52:2521-2529. 10.1002/art.21212, 16052568.
    • (2005) Arthritis Rheum , vol.52 , pp. 2521-2529
    • Sakaguchi, Y.1    Sekiya, I.2    Yagishita, K.3    Muneta, T.4
  • 12
    • 33644896782 scopus 로고    scopus 로고
    • Higher chondrogenic potential of fibrous synovium- and adipose synovium-derived cells compared with subcutaneous fat-derived cells: distinguishing properties of mesenchymal stem cells in humans
    • 10.1002/art.21651, 16508965
    • Mochizuki T, Muneta T, Sakaguchi Y, Nimura A, Yokoyama A, Koga H, Sekiya I. Higher chondrogenic potential of fibrous synovium- and adipose synovium-derived cells compared with subcutaneous fat-derived cells: distinguishing properties of mesenchymal stem cells in humans. Arthritis Rheum 2006, 54:843-853. 10.1002/art.21651, 16508965.
    • (2006) Arthritis Rheum , vol.54 , pp. 843-853
    • Mochizuki, T.1    Muneta, T.2    Sakaguchi, Y.3    Nimura, A.4    Yokoyama, A.5    Koga, H.6    Sekiya, I.7
  • 13
    • 33846935035 scopus 로고    scopus 로고
    • Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle
    • 10.1007/s00441-006-0308-z, 17053900
    • Yoshimura H, Muneta T, Nimura A, Yokoyama A, Koga H, Sekiya I. Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Cell Tissue Res 2007, 327:449-462. 10.1007/s00441-006-0308-z, 17053900.
    • (2007) Cell Tissue Res , vol.327 , pp. 449-462
    • Yoshimura, H.1    Muneta, T.2    Nimura, A.3    Yokoyama, A.4    Koga, H.5    Sekiya, I.6
  • 14
    • 48149096383 scopus 로고    scopus 로고
    • Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit
    • 10.1007/s00441-008-0633-5, 18560897
    • Koga H, Muneta T, Nagase T, Nimura A, Ju Y, Mochizuki T, Sekiya I. Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit. Cell Tissue Res 2008, 333:207-215. 10.1007/s00441-008-0633-5, 18560897.
    • (2008) Cell Tissue Res , vol.333 , pp. 207-215
    • Koga, H.1    Muneta, T.2    Nagase, T.3    Nimura, A.4    Ju, Y.5    Mochizuki, T.6    Sekiya, I.7
  • 15
    • 39749154084 scopus 로고    scopus 로고
    • Increased proliferation of human synovial mesenchymal stem cells with autologous human serum: comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum
    • 10.1002/art.23219, 18240254
    • Nimura A, Muneta T, Koga H, Mochizuki T, Suzuki K, Makino H, Umezawa A, Sekiya I. Increased proliferation of human synovial mesenchymal stem cells with autologous human serum: comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum. Arthritis Rheum 2008, 58:501-510. 10.1002/art.23219, 18240254.
    • (2008) Arthritis Rheum , vol.58 , pp. 501-510
    • Nimura, A.1    Muneta, T.2    Koga, H.3    Mochizuki, T.4    Suzuki, K.5    Makino, H.6    Umezawa, A.7    Sekiya, I.8
  • 17
    • 0031410873 scopus 로고    scopus 로고
    • Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics. An in vivo biomechanical, radiologic, and histologic canine study
    • discussion 1834-1825
    • Lü D, Shono Y, Oda I, Abumi K, Kaneda K. Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics. An in vivo biomechanical, radiologic, and histologic canine study. Spine (Phila Pa 1976) 1997, 22:1828-1834. discussion 1834-1825.
    • (1997) Spine (Phila Pa 1976) , vol.22 , pp. 1828-1834
    • Lü, D.1    Shono, Y.2    Oda, I.3    Abumi, K.4    Kaneda, K.5
  • 18
    • 0642277951 scopus 로고    scopus 로고
    • Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006
    • 10.1186/1471-2172-4-8, 183869, 12887736
    • Kato A, Homma T, Batchelor J, Hashimoto N, Imai S, Wakiguchi H, Saito H, Matsumoto K. Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006. BMC Immunol 2003, 4:8. 10.1186/1471-2172-4-8, 183869, 12887736.
    • (2003) BMC Immunol , vol.4 , pp. 8
    • Kato, A.1    Homma, T.2    Batchelor, J.3    Hashimoto, N.4    Imai, S.5    Wakiguchi, H.6    Saito, H.7    Matsumoto, K.8
  • 19
    • 84870532154 scopus 로고    scopus 로고
    • Gene Expression Omnibus
    • Gene Expression Omnibus. , http://www.ncbi.nlm.nih.gov/projects/geo/
  • 20
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • 10.1080/14653240600855905, 16923606
    • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8:315-317. 10.1080/14653240600855905, 16923606.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6    Deans, R.7    Keating, A.8    Prockop, D.9    Horwitz, E.10
  • 21
    • 14044269226 scopus 로고    scopus 로고
    • Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy
    • 10.1097/01.brs.0000146462.92171.7f, 15564911
    • Risbud MV, Albert TJ, Guttapalli A, Vresilovic EJ, Hillibrand AS, Vaccaro AR, Shapiro IM. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine 2004, 29:2627-2632. 10.1097/01.brs.0000146462.92171.7f, 15564911.
    • (2004) Spine , vol.29 , pp. 2627-2632
    • Risbud, M.V.1    Albert, T.J.2    Guttapalli, A.3    Vresilovic, E.J.4    Hillibrand, A.S.5    Vaccaro, A.R.6    Shapiro, I.M.7
  • 22
    • 15544381999 scopus 로고    scopus 로고
    • Induction of intervertebral disc-like cells from adult mesenchymal stem cells
    • 10.1634/stemcells.2004-0107, 15749935
    • Steck E, Bertram H, Abel R, Chen B, Winter A, Richter W. Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells 2005, 23:403-411. 10.1634/stemcells.2004-0107, 15749935.
    • (2005) Stem Cells , vol.23 , pp. 403-411
    • Steck, E.1    Bertram, H.2    Abel, R.3    Chen, B.4    Winter, A.5    Richter, W.6
  • 23
    • 35348971546 scopus 로고    scopus 로고
    • Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels
    • 10.1016/j.biomaterials.2007.09.018, 17920676
    • Richardson S, Hughes N, Hunt J, Freemont A, Hoyland J. Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials 2008, 29:85-93. 10.1016/j.biomaterials.2007.09.018, 17920676.
    • (2008) Biomaterials , vol.29 , pp. 85-93
    • Richardson, S.1    Hughes, N.2    Hunt, J.3    Freemont, A.4    Hoyland, J.5
  • 24
    • 67651152771 scopus 로고    scopus 로고
    • Coculture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of transforming growth factor-beta1: a potential application of tissue-specific stem cells in disc regeneration
    • Chen S, Emery S, Pei M. Coculture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of transforming growth factor-beta1: a potential application of tissue-specific stem cells in disc regeneration. Spine (Phila Pa 1976) 2009, 34:1272-1280.
    • (2009) Spine (Phila Pa 1976) , vol.34 , pp. 1272-1280
    • Chen, S.1    Emery, S.2    Pei, M.3
  • 25
    • 0037672521 scopus 로고    scopus 로고
    • Neural crest contributions to the lamprey head
    • 10.1242/dev.00451, 12702647
    • McCauley D, Bronner-Fraser M. Neural crest contributions to the lamprey head. Development 2003, 130:2317-2327. 10.1242/dev.00451, 12702647.
    • (2003) Development , vol.130 , pp. 2317-2327
    • McCauley, D.1    Bronner-Fraser, M.2
  • 26
    • 12844282237 scopus 로고    scopus 로고
    • Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat
    • 10.1016/j.neuroscience.2004.10.011, 15680701
    • Mothe A, Tator C. Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat. Neuroscience 2005, 131:177-187. 10.1016/j.neuroscience.2004.10.011, 15680701.
    • (2005) Neuroscience , vol.131 , pp. 177-187
    • Mothe, A.1    Tator, C.2
  • 27
    • 0025945970 scopus 로고
    • Toxicity in vital fluorescence microscopy: effect of dimethylsulfoxide, rhodamine-123, and DiI-low density lipoprotein on fibroblast growth in vitro
    • 10.1007/BF02631106, 1917780
    • Crawford J, Braunwald N. Toxicity in vital fluorescence microscopy: effect of dimethylsulfoxide, rhodamine-123, and DiI-low density lipoprotein on fibroblast growth in vitro. In Vitro Cell Dev Biol 1991, 27A:633-638. 10.1007/BF02631106, 1917780.
    • (1991) In Vitro Cell Dev Biol , vol.27 A , pp. 633-638
    • Crawford, J.1    Braunwald, N.2
  • 28
    • 0030583228 scopus 로고    scopus 로고
    • The use of the lipophilic fluorochrome CM-DiI for tracking the migration of lymphocytes
    • 10.1016/0022-1759(96)00083-X, 8765171
    • Andrade W, Seabrook T, Johnston M, Hay J. The use of the lipophilic fluorochrome CM-DiI for tracking the migration of lymphocytes. J Immunol Methods 1996, 194:181-189. 10.1016/0022-1759(96)00083-X, 8765171.
    • (1996) J Immunol Methods , vol.194 , pp. 181-189
    • Andrade, W.1    Seabrook, T.2    Johnston, M.3    Hay, J.4
  • 29
    • 0031931853 scopus 로고    scopus 로고
    • Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages
    • 10.1007/s004280050136, 9463590
    • Nerlich A, Boos N, Wiest I, Aebi M. Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages. Virchows Arch 1998, 432:67-76. 10.1007/s004280050136, 9463590.
    • (1998) Virchows Arch , vol.432 , pp. 67-76
    • Nerlich, A.1    Boos, N.2    Wiest, I.3    Aebi, M.4
  • 30
    • 0031863733 scopus 로고    scopus 로고
    • The relationship between height, shape and histological changes in early degeneration of the lower lumbar discs
    • 10.1007/s005860050058, 9684954
    • Berlemann U, Gries N, Moore R. The relationship between height, shape and histological changes in early degeneration of the lower lumbar discs. Eur Spine J 1998, 7:212-217. 10.1007/s005860050058, 9684954.
    • (1998) Eur Spine J , vol.7 , pp. 212-217
    • Berlemann, U.1    Gries, N.2    Moore, R.3
  • 31
    • 13444306157 scopus 로고    scopus 로고
    • Disc degeneration in the rabbit: a biochemical and radiological comparison between four disc injury models
    • Kim K, Yoon S, Li J, Park J, Hutton W. Disc degeneration in the rabbit: a biochemical and radiological comparison between four disc injury models. Spine (Phila Pa 1976) 2005, 30:33-37.
    • (2005) Spine (Phila Pa 1976) , vol.30 , pp. 33-37
    • Kim, K.1    Yoon, S.2    Li, J.3    Park, J.4    Hutton, W.5
  • 32
    • 33847636174 scopus 로고    scopus 로고
    • Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration
    • 10.1634/stemcells.2006-0281, 17138960
    • Koga H, Muneta T, Ju YJ, Nagase T, Nimura A, Mochizuki T, Ichinose S, von der Mark K, Sekiya I. Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration. Stem Cells 2007, 25:689-696. 10.1634/stemcells.2006-0281, 17138960.
    • (2007) Stem Cells , vol.25 , pp. 689-696
    • Koga, H.1    Muneta, T.2    Ju, Y.J.3    Nagase, T.4    Nimura, A.5    Mochizuki, T.6    Ichinose, S.7    von der Mark, K.8    Sekiya, I.9
  • 35
    • 0036118038 scopus 로고    scopus 로고
    • The characterization of versican and its message in human articular cartilage and intervertebral disc
    • 10.1016/S0736-0266(01)00110-3, 11918305
    • Sztrolovics R, Grover J, Cs-Szabo G, Shi S, Zhang Y, Mort J, Roughley P. The characterization of versican and its message in human articular cartilage and intervertebral disc. J Orthop Res 2002, 20:257-266. 10.1016/S0736-0266(01)00110-3, 11918305.
    • (2002) J Orthop Res , vol.20 , pp. 257-266
    • Sztrolovics, R.1    Grover, J.2    Cs-Szabo, G.3    Shi, S.4    Zhang, Y.5    Mort, J.6    Roughley, P.7
  • 36
    • 14844362345 scopus 로고    scopus 로고
    • Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix
    • Roughley P. Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine (Phila Pa 1976) 2004, 29:2691-2699.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 2691-2699
    • Roughley, P.1
  • 37
    • 0034406875 scopus 로고    scopus 로고
    • Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc
    • Roberts S, Caterson B, Menage J, Evans E, Jaffray D, Eisenstein S. Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc. Spine (Phila Pa 1976) 2000, 25:3005-3013.
    • (2000) Spine (Phila Pa 1976) , vol.25 , pp. 3005-3013
    • Roberts, S.1    Caterson, B.2    Menage, J.3    Evans, E.4    Jaffray, D.5    Eisenstein, S.6
  • 38
    • 4544272466 scopus 로고    scopus 로고
    • Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc
    • 10.1002/path.1608, 15307137
    • Le Maitre C, Freemont A, Hoyland J. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 2004, 204:47-54. 10.1002/path.1608, 15307137.
    • (2004) J Pathol , vol.204 , pp. 47-54
    • Le Maitre, C.1    Freemont, A.2    Hoyland, J.3
  • 39
    • 29744447597 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
    • 10.1186/ar1732, 1175026, 15987475
    • Le Maitre C, Freemont A, Hoyland J. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005, 7:R732-745. 10.1186/ar1732, 1175026, 15987475.
    • (2005) Arthritis Res Ther , vol.7
    • Le Maitre, C.1    Freemont, A.2    Hoyland, J.3
  • 40
    • 0036375458 scopus 로고    scopus 로고
    • 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption
    • 10.1007/s00586-002-0472-0, 12193991
    • Weiler C, Nerlich A, Zipperer J, Bachmeier B, Boos N. 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J 2002, 11:308-320. 10.1007/s00586-002-0472-0, 12193991.
    • (2002) Eur Spine J , vol.11 , pp. 308-320
    • Weiler, C.1    Nerlich, A.2    Zipperer, J.3    Bachmeier, B.4    Boos, N.5
  • 41
    • 39649114343 scopus 로고    scopus 로고
    • TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration
    • Séguin C, Pilliar R, Madri J, Kandel R. TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration. Spine (Phila Pa 1976) 2008, 33:356-365.
    • (2008) Spine (Phila Pa 1976) , vol.33 , pp. 356-365
    • Séguin, C.1    Pilliar, R.2    Madri, J.3    Kandel, R.4
  • 42
    • 0042360337 scopus 로고    scopus 로고
    • The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering
    • 10.1089/107632703768247368, 13678445
    • Hunter C, Matyas J, Duncan N. The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering. Tissue Eng 2003, 9:667-677. 10.1089/107632703768247368, 13678445.
    • (2003) Tissue Eng , vol.9 , pp. 667-677
    • Hunter, C.1    Matyas, J.2    Duncan, N.3
  • 43
    • 72049125623 scopus 로고    scopus 로고
    • A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?
    • 10.1089/ten.tea.2009.0250, 19681728
    • Miyazaki T, Kobayashi S, Takeno K, Meir A, Urban J, Baba H. A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?. Tissue Eng Part A 2009, 15:3835-3846. 10.1089/ten.tea.2009.0250, 19681728.
    • (2009) Tissue Eng Part A , vol.15 , pp. 3835-3846
    • Miyazaki, T.1    Kobayashi, S.2    Takeno, K.3    Meir, A.4    Urban, J.5    Baba, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.