Growth factor osteogenic protein-1: Differing effects on cells from three distinct zones in the bovine intervertebral disc

American Journal of Physical Medicine and Rehabilitation

Volumn 83, Issue 7, 2004, Pages 515-521

  Zhang, Yejia ^a,b   An, Howard S ^a   Song, Shiwen ^a   Toofanfard, Marc ^a   Masuda, Koichi ^a   Andersson, Gunnar B J ^a   Thonar, Eugene J M A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b 1471 Jelke Building ^*  (United States)

Author keywords

Intervertebral Disc; Low Back Pain; Osteogenic Protein 1; Proteoglycan

Indexed keywords

OSTEOGENIC PROTEIN 1; PROTEOGLYCAN;

ANIMAL CELL; ARTICLE; CATTLE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; INTERVERTEBRAL DISK; NONHUMAN; NUCLEUS PULPOSUS; PROTEOGLYCAN SYNTHESIS;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CATTLE; CELL CULTURE TECHNIQUES; CELL DIVISION; INTERVERTEBRAL DISK; LUMBAR VERTEBRAE; NEUROPROTECTIVE AGENTS; PROTEOGLYCANS; TRANSFORMING GROWTH FACTOR BETA;

EID: 3042665703     PISSN: 08949115     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PHM.0000130031.64343.59     Document Type: Article

References (29)

1. Herzog RJ: The radiologic assessment for a lumbar disc herniation. Spine, 1996;21(24 suppl):19S-38S.
2. Boos R, Weissbach S, Rohrbach H, et al: Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in Basic Science. Spine 2002;27:2631-44
3. Antoniou J, Steffen T, Nelson F, et al: The human lumbar intervertebral disc: Evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 1996;98:996-1003
4. Cole TC, Ghosh P, Taylor TK: Variations of the proteoglycans of the canine intervertebral disc with ageing. Biochim Biophys Acta 1986;880:209-19
5. Chelberg MK, Banks GM, Geiger DF, et al: Identification of heterogenous cell populations in normal human intervertebral disc. J Anat 1995;186:43-53
6. Guo J, Jourdian GW, MacCallum DK: Culture and growth characteristics of chondrocytes encapsulated in alginate beads. Connect Tissue Res 1989;19:277-97
7. Hauselmann HJ, Fernandes RJ, Mok SS, et al: Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads. J Cell Sci 1994;107:17-27
8. Mok SS, Masuda K, Hauselmann HJ, et al: Aggrecan synthesized by mature bovine chondrocytes suspended in alginate: Identification of two distinct matrix pools. J Biol Chem 1994;269:33021-7
9. Horner HA, Roberts S, Bielby RC, et al: Cells from different regions of the intervertebral disc: Effect of culture system on matrix expression and cell phenotype. Spine 2002;27:1018-28
10. Chiba K, Andersson GB, Masuda K, et al: Metabolism of the extracellular matrix formed by intervertebral disc cells cultured in alginate. Spine 1997;22:2885-93
11. Masuda K, Takegami K, An H, et al: Recombinant osteogenic protein-1 up-regulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads. J Orthop Res 2003;21:922-30
12. Wozney JM, Rosen V, Celeste AJ, et al: Novel regulators of bone formation: molecular clones and activities. Science 1988;242:1528-34
13. Chang SC, Hoang B, Thomas JT, et al: Cartilage-derived morphogenetic proteins: New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem 1994;269:28227-34
14. Sampath TK, Malikal JC, Hauschka PV, et al: Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 1992;267:20352-60
15. Thompson JP, Oegema TJ, Bradford DS: Stimulation of mature canine intervertebral disc by growth factors. Spine 1991;16:253-60
16. Asahina I, Sampath TK, Nishimura I, et al: Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J Cell Biol 1993;123:921-33
17. Chen P, Vukicevic S, Sampath TK, et al: Osteogenic protein-1 promotes growth and maturation of chick sternal chondrocytes in serum-free cultures. J Cell Sci 1995;108(Pt 1):105-14
18. Chen P, Vukicevic S, Sampath TK, et al: Bovine articular chondrocytes do not undergo hypertrophy when cultured in the presence of serum and osteogenic protein-1. Biochem Biophys Res Commun 1993;197:1253-9
19. Chandrasekhar S, Esterman MA, Hoffman HA: Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Anal Biochem 1987;161:103-8
20. 35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates. Anal Biochem 1994;217:167-75
21. Cs-Szabo G, Ragasa-San Juan D, Turumella V, et al: Changes in mRNA and protein levels of proteoglycans of the annulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine 2002;27:2212-9
22. Aguiar DJ, Johnson SL, Oegema TR: Notochordal cells interact with nucleus pulposus cells: Regulation of proteoglycan synthesis. Exp Cell Res 1999;246:129-37
23. Takegami K, Thonar EJ, An HS, et al: Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine 2002;27:1318-25
24. Bogduk N, Tynan W, Wilson AS: The nerve supply to the human lumbar intervertebral discs. J Anat 1981;132:39-56
25. Melrose J, Roberts S, Smith SB, et al: Increased nerve and blood vessel in-growth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Spine 2002;27:1278-85
26. Palmgren T, Grönblad M, Virri J, et al: Immunohistochemical demonstration of sensory and autonomic severe terminals in herniated lumbar disc tissues. Spine 1996;21:1301-6
27. Ahmed M, Bjurholm A, Kreichbergs A, et al: SP and CGRP immunoreactive nerve fibres in the rat lumbar spine. Neurol Orthop 1991;12:19-28
28. Freemont AJ, Peacock TE, Goupille P: Nerve in-growth into the diseased intervertebral disc in chronic back pain. Lancet 1997;350:178-81
29. An HS, Thonar JMA, Masuda K: Biologic repair of intervertebral disc. Spine 2003;28:S86-92