Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Chiu, Chien Chih ^a   Haung, Jo Wen ^a   Chang, Fang Rong ^a   Huang, Kuang Jing ^a   Huang, Hsuan Min ^a   Huang, Hurng Wern ^b   Chou, Chon Kit ^a   Wu, Yang Chang ^a,c,d   Chang, Hsueh Wei ^a,e  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

4BETA HYDROXYWITHANOLIDE E; ANTINEOPLASTIC AGENT; CASPASE 9; CHECKPOINT KINASE RAD3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHYSALIS PERUVIANA EXTRACT; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER THERAPY; CELL CYCLE G1 PHASE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUTH CANCER; PHYSALIS PERUVIANA; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HISTONES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, BIOLOGICAL; MOUTH NEOPLASMS; PHYSALIS; PROPIDIUM; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; WITHANOLIDES;

EID: 84877932516     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064739     Document Type: Article

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