Selective targeting of tumorigenic cancer cell lines by microtubule inhibitors

PLoS ONE

Volumn 4, Issue 2, 2009, Pages

  Abdullah, Newaj M ^a   Rosania, Gus R ^a,b   Shedden, Kerby ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Michigan Alliance for Cheminformatics Exploration (MACE)   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; MAYTANSINE; MICROTUBULE PROTEIN INHIBITOR; PACLITAXEL; RHIZOXIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOGENICITY; CELL DIVISION; CELL KILLING; CELL POPULATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 84887212527     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004470     Document Type: Article

References (25)

1. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414: 105-111.
2. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988.
3. Ricci-Vitini L, Lombardi DG, Pilozzi E, Biffoni M, Todardo M, et al. (2007) Identification and expression of human colon cancer-initiating cells. Nature 445: 111-115.
4. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, et al. (2004) Identification of human brain tumor initiating cells. Nature 432: 396-401.
5. Monga M, Sausville EA (2002) Developmental Therapeutics Program at the NCI: molecular target and drug discovery process. Leukemia 16: 520-526.
6. Teicher BA (1997) In Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval; Eds. Totowa, NJ: Humana. pp 104-108.
7. Shoemaker RH (2006) The NCI60 human tumour cell line anticancer drug screen. Nature reviews 6: 813-823.
8. Boyd MR (1989) In Cancer: Principles and Practive of Oncology. DeVita VT Jr, Hellman S, Rosenber SA, eds. Philadelphia, PA: Lippincott; Vol. 3, pp 1-12.
9. Weinstein JN, Kohn KW, Grever MR, Viswanadhan VN, Rubinstein LV, et al. (1992) Neural computing in cancer drug development: Predicting mechanism of action. Science 258: 447-451.
10. van Osdol WW, Myers TG, Paull KD, Kohn KW, Weinstein JN (1994) Use of the Kohonean self-organizing map to study the mechanism of action of chemotheapeutic agents. Journal of National Cancer Institute 86: 1855-1859.
11. Chen K, Kuo SC, Hsieh MC, Mauger A, Lin CM, et al. (1997) Antitumor agents. 174, 2′,3′,4′,5,6,7-Substituted 2-Phynyl-1,8-naphthyridin-4-ones: Their Sysnthesis, Cytotoxicity, and Inhibition of Tubulin Polymerimerization. Journal of Medicinal Chemistry 40: 2266-2275.
12. Chen K, Kuo SC, Hsieh MC, Mauger A, Lin CM, et al. (1997) Antitumor agents. 178. Synthesis and Biological Evaluation of Substituted 2-Aryl-1,8-naphthyridin-4(1H)-ones as Antitumor Agents that Inhibit Tublulin Polymerization. Journal of Medicinal Chemistry 40: 3049-3056.
13. Kou SC, Lee HZ, Juang JP, Lin YT, Wu TS, et al. (1993) Synthesis and Cytotoxicity of 1, 6, 7, 8-Substituted 2-(4′-Subsituted phenyl)-4-quinolones and Related compounds: Identificatin as Antimitotic Agents Interacting with Tubulin. Journal of Medicinal Chemistry 36: 1146-1156.
14. Li L, Wang HK, Kuo SC, Wu TS, Lednicer D, et al. (1994) Antitumor agents. 150. 2′,3′,4′,5′,5,6,7-Substituted 2-Phenyl-4-quinolones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization. Journal of Medical Chemistry 37: 1126-1135.
15. Li L, Wang HK, Kuo SC, Wu TS, Mauger A, Lin CM, et al. (1994) Antitumor Agents 155. Synthesis and Biological Evaluation of 3′,6,7-Substituted 2-Phynyl-4-quinolones as Antimicrotubule Agents. Journal of Medicinal Chemistry 37: 3400-3407.
16. Xia Y, Yang ZY, Xia P, Bastow KF, Tachibana Y, et al. (1998) Antitumor Agents. 181. Synthesis and Biological Evaluation of 6,7,2′,3′,4′-Substituted-1,2,3,4- tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents. Journal of Medicinal Chemistry 41: 1155-1162.
17. Xia Y, Yang ZY, Xia P, Hackl T, Hamel E, Mauger A, et al. (2001) Antitumor Agents. 211. Fluorinated 2-Phenyl-4-quinolone Derivates as Antimitotic Antitumor Agents. Journal of Medicinal Chemistry 44: 3932-3936.
18. Pettit GR, Singh SB, Boyd MR, Hamel E, Pettit RK, et al. (1995) Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6. Journal of Medicinal Chemistry 38: 1666-1672.
19. Paul KD, Shoemaker RH, Hodes L, Monks AP, Scudiero DA, et al. (1989) Display and analysis of patterns of differential acticity of drugs against tumor cell lines: Development of mean graph and COMPARE algorithm. J Natl Cancer Inst 81: 1088-1092.
20. Hammond JW, Cai D, Verhey KJ (2008) Tubulin modifications and their cellular functions. Current Opinion in Cell Biology 20: 71-76.
21. Verhey KJ, Gaertig J (2007) The Tubulin Code. Cell Cycle 6: 2152-5160.
22. Westermann S, Weber K (2003) Post-translational modifications regulate microtubule function. Nat Rev Mol Cell Biol 4: 938-947.
23. Schatten G, Simerly C, Asai DJ, Szoke E, Kooke P, Schatten H (1986) Acetylated a-Tubulin in Microtubules during Mouse Fertilization and Early Development. Developmental Biology 130: 74-86.
24. Warn RM, Harrison A, Planques V, Robert-Nicould N, Wehland J (1990) Distribution of Microtubules Containing Post-Translationally Modified a-Tubulin During Drosophila Embryogenesis. Cell Motility and the Cytoskeleton 17: 34-45.
25. Wilson PG, Zheng Y, Oakley CE, Oakley BR, Borisy GG, et al. (1997) Differential Expression of Two g-Tubulin Isoforms during Gametogenesis and Development in Drosophila. Developmental Biology 184: 207-221.