Antihepatoma activity of Physalis angulata and P. peruviana extracts and their effects on apoptosis in human Hep G2 cells

Life Sciences

Volumn 74, Issue 16, 2004, Pages 2061-2073

  Wu, Shu Jing ^a,b   Ng, Lean Teik ^c   Chen, Ching Hsein ^d   Lin, Doung Liang ^e   Wang, Shyh Shyan ^e   Lin, Chun Ching ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^c TAJEN INSTITUTE OF TECHNOLOGY   (Taiwan)

^d FOOYIN UNIVERSITY   (Taiwan)

^e Tainan Dist Agric Improvement Stn   (Taiwan)

Author keywords

Apoptosis; P. peruviana; Physalis angulata; Reactive oxygen species; m

Indexed keywords

ALPHA TOCOPHEROL; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; PHOSPHATIDYLSERINE; PHYSALIS ANGULATA EXTRACT; PHYSALIS PERUVIANA EXTRACT; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SERINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CELL PROTECTION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; METABOLISM; METASTASIS INHIBITION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PHYSALIS; PHYSALIS ANGULATA; PHYSALIS PERUVIANA;

PHYSALIS; PHYSALIS ANGULATA; PHYSALIS PERUVIANA;

EID: 1142285297     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.09.058     Document Type: Article

References (31)

1. Armstrong J.S., Steinauer K., Lecane P.M., Birell G., Peehl D., Knox S.J. Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death and Differentiation. 9:2002;252-263.
2. Castedo M., Hirsch F., Susin S.A., Zamzami N., Marchetti P., Macho A., Kroemer G. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. Journal of Immunology. 157:1996;512-521.
3. Chang W.H., Chen C.H., Lu F.J. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Planta Medica. 68:2002;128-132.
4. Chiang H.C., Jaw S.M., Chen P.M. Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro. Anticancer Research. 12:1992;1155-1162.
5. Chiang H.C., Jaw S.M., Chen C.F., Kan W.S. Antitumor agent, physalin F from Physalis angulata L. Anticancer Research. 12:1992;837-843.
6. Goodwin C.J., Holt S.J., Downes S., Marshall N.J. Microculture tetrazolium assays: a comparison between two new tetrazolium salts, XTT and MTS. Journal of Immunological Methods. 179:1995;95-103.
7. Gosslau A., Rensing L. Oxidative stress, age-dependent cell damage and antioxidative mechanisms. Zeitschrift fur Gerontologie und Geriatrie. 35:2002;139-150.
8. Ismail N., Alam M. A novel cytotoxic flavonoid glycoside from Physalis angulata. Fitoterapia. 72:2001;676-679.
9. Jin Q., Kang C., Soh Y., Sohn N.W., Lee J., Cho Y.H., Baik H.H., Kang I. Tetrandrine cytotoxicity and its dual effect on oxidative stress-induced apoptosis through modulating cellular redox states in Neuro 2a mouse neuroblastoma cells. Life Science. 71:2002;2053-2066.
10. 2+ influx in the mechanism of tamoxifen-induced apoptosis in Hep G2 human hepatoblastoma cells. Cancer Letters. 147:1999;115-123.
11. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nature Medicine. 6:2002;513-519.
12. Kurosawa K., Hayashi N., Sato N., Kamada T., Tagawa K. Transport of glutathione across the mitochondrial membranes. Biochemical and Biophysical Research Communication. 167:1990;367-372.
13. Li N., Ragheb K., Lawler G., Sturgis J., Rajwa B., Melendez J.A., Robinson J.P. DPI induces mitochondrial superoxide-mediated apoptosis. Free Radical Biology and Medicine. 34:2003;465-477.
14. Lin Y.S., Chiang H.C., Kan W.S., Hone E., Shih S.J., Won M.H. Immunomodulatory activity of various fractions derived from Physalis angulata L. extract. American Journal of Chinese Medicine. 20:1992;233-243.
15. Liu J., Shen H.M., Ong C.N. Salvia Miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG2 cells. Cancer Letters. 153:2000;85-93.
16. Liu J., Shen H.M., Ong C.N. Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia Miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells. Life Science. 69:2001;1833-1850.
17. Mari M., Bai J., Cederbaum A.I. Toxicity by pyruvate in Hep G2 cells depleted of glutathione: role of mitochondria. Free Radical Biology and Medicine. 32:2002;73-83.
18. Martin S.J., Reutelingsperger C.P.M., McGahon A.J., Rader J.A., Schie R.C.A.A., LaFace D.M., Green D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. Journal of Experimental Medicine. 182:1995;1545-1556.
19. Minamikawa T., Williams D.A., Bowser D.N., Nagley P. Mitochondrial permeability transition and swelling can occur reversibly without inducing cell death in intact human cells. Experimental Cell Research. 246:1999;26-37.
20. Nakamura Y., Kawakami M., Yoshihiro M.A., Miyoshi N., Ohigashi H., Kawai K., Osawa T., Uchida K. Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. Journal of Biological Chemistry. 277:2002;8492-8499.
21. Park W.H., Lee M.S., Park K., Kim E.S., Kim B.K., Lee Y.Y. Monensin-mediated growth inhibition in acute myelogenous leukemia cells via cell cycle arrest and apoptosis. International Journal of Cancer. 101:2002;235-242.
22. Pietro R.C., Kashima S., Sato D.N., Januario A.H., Franca S.C. In vitro antimy-cobacterial activities of Physalis angulata L. Phytomedicine. 7:2000;335-338.
23. Sakurai K., Cederbaum A.I. Oxidative stress and cytotoxicity induced by ferric-nitrilo-triacetate in Hep G2 cells that express cytochrome P450 2E1. Molecular Pharmacology. 54:1998;1024-1035.
24. Schulze-Osthoff K., Ferrari D., Los M., Wesselborg S., Peter M.E. Apoptosis signaling by death receptors. European Journal of Biochemistry. 254:1998;439-459.
25. Scudiero D.A., Shoemaker R.H., Paull K.D., Monks A., Tierney S., Nofziger T.H., Currens M.J., Seniff D., Boyd M.R. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Research. 48:1998;4827-4833.
26. Siraki A.G., Pourahmad J., Chan T.S., Khan S., O'Brien P.J. Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes. Free Radical Biology and Medicine. 32:2002;2-10.
27. Soares M.B.P., Bellintani M.C., Ribeiro I.M., Tomassini T.C.B., Santos R.R. Inhibition of macrophage activation and lipopolysaccharide-induced death by seco-steroids purified from Physalis angulata L. Euopean Journal of Pharmacology. 459:2003;107-112.
28. Ueda S., Nakamura H., Masutani H., Sasada T., Takabayashi A., Yamaoka Y., Yodoi J. Baicalin induces apoptosis via mitochondrial pathway as prooxidant. Molecular Immunology. 38:2001;781-791.
29. Wu X., Cao S., Goh S., Hsu A., Tan B.K.H. Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by Gaudichaudione A, a cytotoxic xanthone. Planta Medica. 68:2002;198-203.
30. Yang W.L., Addona T., Nair D.G., Qi L., Ravikumar T.S. Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. International Journal of Cancer. 103:2003;360-369.
31. Zhu H., Bannenberg G.L., Moldeus P., Shertzer H.G. Oxidation pathways for the intracellular probe 2′, 7′-dichlorofluorescein. Archives of Toxicology. 68:1994;582-587.